Amino acid dipepetide frequency for Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.454AlaAla: 3.454 ± 0.07	0.512AlaCys: 0.512 ± 0.023	2.646AlaAsp: 2.646 ± 0.052	3.536AlaGlu: 3.536 ± 0.061	2.629AlaPhe: 2.629 ± 0.058	4.203AlaGly: 4.203 ± 0.08	0.823AlaHis: 0.823 ± 0.031	4.239AlaIle: 4.239 ± 0.071	3.75AlaLys: 3.75 ± 0.059	5.422AlaLeu: 5.422 ± 0.086	1.151AlaMet: 1.151 ± 0.037	2.407AlaAsn: 2.407 ± 0.053	1.64AlaPro: 1.64 ± 0.043	1.499AlaGln: 1.499 ± 0.042	2.334AlaArg: 2.334 ± 0.052	3.897AlaSer: 3.897 ± 0.065	2.57AlaThr: 2.57 ± 0.058	3.31AlaVal: 3.31 ± 0.061	0.58AlaTrp: 0.58 ± 0.021	1.778AlaTyr: 1.778 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.445CysAla: 0.445 ± 0.02	0.086CysCys: 0.086 ± 0.009	0.386CysAsp: 0.386 ± 0.017	0.491CysGlu: 0.491 ± 0.02	0.529CysPhe: 0.529 ± 0.02	0.756CysGly: 0.756 ± 0.026	0.187CysHis: 0.187 ± 0.012	0.756CysIle: 0.756 ± 0.023	0.7CysLys: 0.7 ± 0.024	0.817CysLeu: 0.817 ± 0.029	0.192CysMet: 0.192 ± 0.013	0.445CysAsn: 0.445 ± 0.02	0.379CysPro: 0.379 ± 0.02	0.207CysGln: 0.207 ± 0.013	0.306CysArg: 0.306 ± 0.015	0.736CysSer: 0.736 ± 0.025	0.424CysThr: 0.424 ± 0.024	0.5CysVal: 0.5 ± 0.022	0.101CysTrp: 0.101 ± 0.009	0.351CysTyr: 0.351 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.244AspAla: 2.244 ± 0.047	0.497AspCys: 0.497 ± 0.023	1.714AspAsp: 1.714 ± 0.039	2.866AspGlu: 2.866 ± 0.059	3.29AspPhe: 3.29 ± 0.057	2.896AspGly: 2.896 ± 0.057	0.92AspHis: 0.92 ± 0.036	3.17AspIle: 3.17 ± 0.062	3.149AspLys: 3.149 ± 0.056	5.944AspLeu: 5.944 ± 0.08	0.851AspMet: 0.851 ± 0.029	1.626AspAsn: 1.626 ± 0.039	2.538AspPro: 2.538 ± 0.05	1.752AspGln: 1.752 ± 0.039	2.456AspArg: 2.456 ± 0.052	4.195AspSer: 4.195 ± 0.059	2.076AspThr: 2.076 ± 0.042	2.482AspVal: 2.482 ± 0.052	0.701AspTrp: 0.701 ± 0.027	1.941AspTyr: 1.941 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.557GluAla: 3.557 ± 0.063	0.487GluCys: 0.487 ± 0.022	3.338GluAsp: 3.338 ± 0.055	6.287GluGlu: 6.287 ± 0.114	3.651GluPhe: 3.651 ± 0.059	3.733GluGly: 3.733 ± 0.061	0.914GluHis: 0.914 ± 0.033	7.036GluIle: 7.036 ± 0.096	7.075GluLys: 7.075 ± 0.098	6.66GluLeu: 6.66 ± 0.092	1.518GluMet: 1.518 ± 0.038	4.402GluAsn: 4.402 ± 0.07	1.787GluPro: 1.787 ± 0.038	1.907GluGln: 1.907 ± 0.046	2.987GluArg: 2.987 ± 0.053	4.906GluSer: 4.906 ± 0.062	3.924GluThr: 3.924 ± 0.071	4.044GluVal: 4.044 ± 0.067	0.793GluTrp: 0.793 ± 0.027	2.451GluTyr: 2.451 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.859PheAla: 2.859 ± 0.057	0.691PheCys: 0.691 ± 0.026	2.382PheAsp: 2.382 ± 0.048	3.213PheGlu: 3.213 ± 0.057	3.824PhePhe: 3.824 ± 0.08	3.582PheGly: 3.582 ± 0.064	1.232PheHis: 1.232 ± 0.034	3.815PheIle: 3.815 ± 0.06	3.244PheLys: 3.244 ± 0.053	7.225PheLeu: 7.225 ± 0.117	0.942PheMet: 0.942 ± 0.033	2.125PheAsn: 2.125 ± 0.048	2.662PhePro: 2.662 ± 0.06	2.686PheGln: 2.686 ± 0.05	2.857PheArg: 2.857 ± 0.055	4.992PheSer: 4.992 ± 0.073	2.783PheThr: 2.783 ± 0.05	2.962PheVal: 2.962 ± 0.051	0.84PheTrp: 0.84 ± 0.033	2.424PheTyr: 2.424 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.654GlyAla: 3.654 ± 0.071	0.591GlyCys: 0.591 ± 0.022	2.936GlyAsp: 2.936 ± 0.059	4.046GlyGlu: 4.046 ± 0.066	3.724GlyPhe: 3.724 ± 0.06	4.319GlyGly: 4.319 ± 0.089	1.089GlyHis: 1.089 ± 0.036	6.338GlyIle: 6.338 ± 0.1	5.892GlyLys: 5.892 ± 0.08	5.825GlyLeu: 5.825 ± 0.087	1.536GlyMet: 1.536 ± 0.042	3.55GlyAsn: 3.55 ± 0.076	1.677GlyPro: 1.677 ± 0.044	1.746GlyGln: 1.746 ± 0.055	2.526GlyArg: 2.526 ± 0.052	4.46GlySer: 4.46 ± 0.084	3.56GlyThr: 3.56 ± 0.07	3.991GlyVal: 3.991 ± 0.074	0.721GlyTrp: 0.721 ± 0.027	2.438GlyTyr: 2.438 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.732HisAla: 0.732 ± 0.025	0.219HisCys: 0.219 ± 0.015	0.613HisAsp: 0.613 ± 0.022	0.878HisGlu: 0.878 ± 0.03	1.148HisPhe: 1.148 ± 0.032	1.121HisGly: 1.121 ± 0.035	0.426HisHis: 0.426 ± 0.022	1.15HisIle: 1.15 ± 0.037	1.206HisLys: 1.206 ± 0.036	1.854HisLeu: 1.854 ± 0.045	0.236HisMet: 0.236 ± 0.013	0.733HisAsn: 0.733 ± 0.031	1.087HisPro: 1.087 ± 0.03	0.456HisGln: 0.456 ± 0.021	0.779HisArg: 0.779 ± 0.029	1.669HisSer: 1.669 ± 0.045	0.917HisThr: 0.917 ± 0.031	0.81HisVal: 0.81 ± 0.025	0.25HisTrp: 0.25 ± 0.014	0.633HisTyr: 0.633 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.563IleAla: 4.563 ± 0.073	0.78IleCys: 0.78 ± 0.025	3.531IleAsp: 3.531 ± 0.06	5.218IleGlu: 5.218 ± 0.073	4.769IlePhe: 4.769 ± 0.086	5.154IleGly: 5.154 ± 0.077	1.711IleHis: 1.711 ± 0.042	4.347IleIle: 4.347 ± 0.074	4.282IleLys: 4.282 ± 0.066	10.952IleLeu: 10.952 ± 0.115	1.074IleMet: 1.074 ± 0.035	2.933IleAsn: 2.933 ± 0.055	4.101IlePro: 4.101 ± 0.066	3.84IleGln: 3.84 ± 0.061	4.51IleArg: 4.51 ± 0.079	6.964IleSer: 6.964 ± 0.089	3.754IleThr: 3.754 ± 0.066	4.647IleVal: 4.647 ± 0.067	0.874IleTrp: 0.874 ± 0.026	2.765IleTyr: 2.765 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	3.66LysAla: 3.66 ± 0.064	0.386LysCys: 0.386 ± 0.02	4.172LysAsp: 4.172 ± 0.057	7.419LysGlu: 7.419 ± 0.088	3.336LysPhe: 3.336 ± 0.05	4.053LysGly: 4.053 ± 0.073	1.118LysHis: 1.118 ± 0.033	7.665LysIle: 7.665 ± 0.087	7.757LysLys: 7.757 ± 0.106	6.632LysLeu: 6.632 ± 0.08	1.698LysMet: 1.698 ± 0.034	5.406LysAsn: 5.406 ± 0.073	2.479LysPro: 2.479 ± 0.046	2.288LysGln: 2.288 ± 0.054	3.29LysArg: 3.29 ± 0.056	5.145LysSer: 5.145 ± 0.084	4.463LysThr: 4.463 ± 0.061	4.158LysVal: 4.158 ± 0.062	0.605LysTrp: 0.605 ± 0.023	2.462LysTyr: 2.462 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	5.42LeuAla: 5.42 ± 0.076	0.903LeuCys: 0.903 ± 0.029	5.242LeuAsp: 5.242 ± 0.083	8.035LeuGlu: 8.035 ± 0.11	6.118LeuPhe: 6.118 ± 0.091	6.668LeuGly: 6.668 ± 0.086	1.581LeuHis: 1.581 ± 0.041	7.898LeuIle: 7.898 ± 0.099	9.13LeuLys: 9.13 ± 0.103	9.837LeuLeu: 9.837 ± 0.119	1.847LeuMet: 1.847 ± 0.04	5.595LeuAsn: 5.595 ± 0.076	4.21LeuPro: 4.21 ± 0.07	3.364LeuGln: 3.364 ± 0.077	4.211LeuArg: 4.211 ± 0.071	8.602LeuSer: 8.602 ± 0.099	5.076LeuThr: 5.076 ± 0.08	5.574LeuVal: 5.574 ± 0.084	0.994LeuTrp: 0.994 ± 0.031	3.557LeuTyr: 3.557 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.191MetAla: 1.191 ± 0.034	0.102MetCys: 0.102 ± 0.009	1.11MetAsp: 1.11 ± 0.032	1.512MetGlu: 1.512 ± 0.036	0.779MetPhe: 0.779 ± 0.026	1.392MetGly: 1.392 ± 0.039	0.228MetHis: 0.228 ± 0.016	1.844MetIle: 1.844 ± 0.042	1.922MetLys: 1.922 ± 0.041	1.45MetLeu: 1.45 ± 0.04	0.424MetMet: 0.424 ± 0.018	1.324MetAsn: 1.324 ± 0.035	0.635MetPro: 0.635 ± 0.023	0.523MetGln: 0.523 ± 0.022	0.752MetArg: 0.752 ± 0.024	1.279MetSer: 1.279 ± 0.034	0.999MetThr: 0.999 ± 0.026	0.998MetVal: 0.998 ± 0.031	0.122MetTrp: 0.122 ± 0.011	0.439MetTyr: 0.439 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.55AsnAla: 2.55 ± 0.063	0.54AsnCys: 0.54 ± 0.022	2.013AsnAsp: 2.013 ± 0.048	2.952AsnGlu: 2.952 ± 0.053	2.932AsnPhe: 2.932 ± 0.051	3.215AsnGly: 3.215 ± 0.069	1.023AsnHis: 1.023 ± 0.032	3.353AsnIle: 3.353 ± 0.058	2.835AsnLys: 2.835 ± 0.055	6.264AsnLeu: 6.264 ± 0.085	0.8AsnMet: 0.8 ± 0.024	1.874AsnAsn: 1.874 ± 0.053	2.832AsnPro: 2.832 ± 0.046	2.294AsnGln: 2.294 ± 0.055	2.799AsnArg: 2.799 ± 0.051	4.472AsnSer: 4.472 ± 0.069	2.461AsnThr: 2.461 ± 0.061	2.933AsnVal: 2.933 ± 0.051	0.694AsnTrp: 0.694 ± 0.027	1.844AsnTyr: 1.844 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	1.98ProAla: 1.98 ± 0.044	0.242ProCys: 0.242 ± 0.016	2.398ProAsp: 2.398 ± 0.049	3.694ProGlu: 3.694 ± 0.054	2.223ProPhe: 2.223 ± 0.052	2.981ProGly: 2.981 ± 0.047	0.56ProHis: 0.56 ± 0.022	3.226ProIle: 3.226 ± 0.057	2.743ProLys: 2.743 ± 0.059	3.287ProLeu: 3.287 ± 0.057	0.754ProMet: 0.754 ± 0.026	2.213ProAsn: 2.213 ± 0.049	1.336ProPro: 1.336 ± 0.036	1.002ProGln: 1.002 ± 0.029	1.113ProArg: 1.113 ± 0.03	2.814ProSer: 2.814 ± 0.057	1.909ProThr: 1.909 ± 0.049	2.556ProVal: 2.556 ± 0.05	0.438ProTrp: 0.438 ± 0.021	1.287ProTyr: 1.287 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.764GlnAla: 1.764 ± 0.043	0.24GlnCys: 0.24 ± 0.014	1.62GlnAsp: 1.62 ± 0.036	2.724GlnGlu: 2.724 ± 0.056	1.592GlnPhe: 1.592 ± 0.033	1.919GlnGly: 1.919 ± 0.04	0.418GlnHis: 0.418 ± 0.028	3.131GlnIle: 3.131 ± 0.055	3.463GlnLys: 3.463 ± 0.059	2.67GlnLeu: 2.67 ± 0.073	0.679GlnMet: 0.679 ± 0.024	2.37GlnAsn: 2.37 ± 0.054	0.906GlnPro: 0.906 ± 0.03	0.68GlnGln: 0.68 ± 0.029	1.345GlnArg: 1.345 ± 0.045	2.287GlnSer: 2.287 ± 0.047	1.975GlnThr: 1.975 ± 0.047	1.802GlnVal: 1.802 ± 0.041	0.326GlnTrp: 0.326 ± 0.018	1.068GlnTyr: 1.068 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.162ArgAla: 2.162 ± 0.044	0.341ArgCys: 0.341 ± 0.018	2.046ArgAsp: 2.046 ± 0.044	3.274ArgGlu: 3.274 ± 0.055	2.741ArgPhe: 2.741 ± 0.053	2.289ArgGly: 2.289 ± 0.048	0.625ArgHis: 0.625 ± 0.025	4.395ArgIle: 4.395 ± 0.065	4.197ArgLys: 4.197 ± 0.073	4.188ArgLeu: 4.188 ± 0.069	1.086ArgMet: 1.086 ± 0.034	2.559ArgAsn: 2.559 ± 0.043	1.344ArgPro: 1.344 ± 0.034	1.162ArgGln: 1.162 ± 0.036	1.849ArgArg: 1.849 ± 0.048	2.952ArgSer: 2.952 ± 0.052	2.211ArgThr: 2.211 ± 0.048	2.425ArgVal: 2.425 ± 0.052	0.541ArgTrp: 0.541 ± 0.026	1.786ArgTyr: 1.786 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.025SerAla: 4.025 ± 0.061	0.695SerCys: 0.695 ± 0.027	3.678SerAsp: 3.678 ± 0.068	5.493SerGlu: 5.493 ± 0.094	4.826SerPhe: 4.826 ± 0.08	5.975SerGly: 5.975 ± 0.084	1.236SerHis: 1.236 ± 0.035	6.444SerIle: 6.444 ± 0.077	6.029SerLys: 6.029 ± 0.087	8.268SerLeu: 8.268 ± 0.09	1.507SerMet: 1.507 ± 0.034	3.629SerAsn: 3.629 ± 0.074	2.883SerPro: 2.883 ± 0.058	2.37SerGln: 2.37 ± 0.053	3.186SerArg: 3.186 ± 0.054	6.387SerSer: 6.387 ± 0.097	3.491SerThr: 3.491 ± 0.059	4.57SerVal: 4.57 ± 0.082	0.857SerTrp: 0.857 ± 0.027	2.858SerTyr: 2.858 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	2.774ThrAla: 2.774 ± 0.055	0.391ThrCys: 0.391 ± 0.021	2.443ThrAsp: 2.443 ± 0.044	3.253ThrGlu: 3.253 ± 0.061	2.789ThrPhe: 2.789 ± 0.057	3.928ThrGly: 3.928 ± 0.063	0.917ThrHis: 0.917 ± 0.028	4.272ThrIle: 4.272 ± 0.07	3.322ThrLys: 3.322 ± 0.058	5.294ThrLeu: 5.294 ± 0.083	0.814ThrMet: 0.814 ± 0.025	2.468ThrAsn: 2.468 ± 0.058	2.182ThrPro: 2.182 ± 0.052	1.644ThrGln: 1.644 ± 0.051	1.951ThrArg: 1.951 ± 0.047	3.896ThrSer: 3.896 ± 0.069	2.805ThrThr: 2.805 ± 0.076	3.107ThrVal: 3.107 ± 0.059	0.627ThrTrp: 0.627 ± 0.025	1.668ThrTyr: 1.668 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	3.148ValAla: 3.148 ± 0.06	0.596ValCys: 0.596 ± 0.02	2.691ValAsp: 2.691 ± 0.05	3.54ValGlu: 3.54 ± 0.059	3.489ValPhe: 3.489 ± 0.06	3.515ValGly: 3.515 ± 0.062	1.009ValHis: 1.009 ± 0.026	4.204ValIle: 4.204 ± 0.072	3.644ValLys: 3.644 ± 0.067	6.416ValLeu: 6.416 ± 0.087	1.055ValMet: 1.055 ± 0.032	2.481ValAsn: 2.481 ± 0.05	2.284ValPro: 2.284 ± 0.047	1.906ValGln: 1.906 ± 0.046	2.759ValArg: 2.759 ± 0.051	4.908ValSer: 4.908 ± 0.059	2.853ValThr: 2.853 ± 0.066	3.528ValVal: 3.528 ± 0.069	0.645ValTrp: 0.645 ± 0.022	2.081ValTyr: 2.081 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.485TrpAla: 0.485 ± 0.021	0.091TrpCys: 0.091 ± 0.008	0.601TrpAsp: 0.601 ± 0.024	0.807TrpGlu: 0.807 ± 0.027	0.57TrpPhe: 0.57 ± 0.024	0.705TrpGly: 0.705 ± 0.027	0.158TrpHis: 0.158 ± 0.012	1.242TrpIle: 1.242 ± 0.04	1.297TrpLys: 1.297 ± 0.038	0.921TrpLeu: 0.921 ± 0.028	0.277TrpMet: 0.277 ± 0.016	0.848TrpAsn: 0.848 ± 0.029	0.257TrpPro: 0.257 ± 0.016	0.258TrpGln: 0.258 ± 0.017	0.404TrpArg: 0.404 ± 0.019	0.702TrpSer: 0.702 ± 0.026	0.593TrpThr: 0.593 ± 0.024	0.634TrpVal: 0.634 ± 0.024	0.116TrpTrp: 0.116 ± 0.01	0.311TrpTyr: 0.311 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.712TyrAla: 1.712 ± 0.042	0.408TyrCys: 0.408 ± 0.02	1.749TyrAsp: 1.749 ± 0.051	2.218TyrGlu: 2.218 ± 0.052	2.381TyrPhe: 2.381 ± 0.052	2.213TyrGly: 2.213 ± 0.045	0.742TyrHis: 0.742 ± 0.027	2.246TyrIle: 2.246 ± 0.043	2.558TyrLys: 2.558 ± 0.052	3.934TyrLeu: 3.934 ± 0.065	0.583TyrMet: 0.583 ± 0.024	1.691TyrAsn: 1.691 ± 0.052	1.537TyrPro: 1.537 ± 0.033	1.396TyrGln: 1.396 ± 0.038	1.757TyrArg: 1.757 ± 0.044	3.145TyrSer: 3.145 ± 0.052	1.7TyrThr: 1.7 ± 0.043	1.721TyrVal: 1.721 ± 0.04	0.451TyrTrp: 0.451 ± 0.023	1.627TyrTyr: 1.627 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3676 proteins (1159747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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