Amino acid dipepetide frequency for Mycobacterium virus Ibhubesi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.836AlaAla: 15.836 ± 1.986
1.075AlaCys: 1.075 ± 0.211
7.409AlaAsp: 7.409 ± 0.617
7.409AlaGlu: 7.409 ± 0.722
2.828AlaPhe: 2.828 ± 0.383
10.916AlaGly: 10.916 ± 1.316
2.206AlaHis: 2.206 ± 0.36
4.581AlaIle: 4.581 ± 0.608
4.412AlaLys: 4.412 ± 0.426
8.484AlaLeu: 8.484 ± 0.826
2.771AlaMet: 2.771 ± 0.41
2.828AlaAsn: 2.828 ± 0.454
4.694AlaPro: 4.694 ± 0.504
3.62AlaGln: 3.62 ± 0.424
6.844AlaArg: 6.844 ± 0.635
5.203AlaSer: 5.203 ± 0.743
6.73AlaThr: 6.73 ± 0.639
6.73AlaVal: 6.73 ± 0.647
2.771AlaTrp: 2.771 ± 0.65
2.206AlaTyr: 2.206 ± 0.338
0.0AlaXaa: 0.0 ± 0.0
Cys
1.075CysAla: 1.075 ± 0.248
0.113CysCys: 0.113 ± 0.077
1.357CysAsp: 1.357 ± 0.345
0.792CysGlu: 0.792 ± 0.218
0.283CysPhe: 0.283 ± 0.118
1.697CysGly: 1.697 ± 0.343
0.226CysHis: 0.226 ± 0.123
0.0CysIle: 0.0 ± 0.0
0.452CysLys: 0.452 ± 0.148
0.735CysLeu: 0.735 ± 0.215
0.057CysMet: 0.057 ± 0.049
0.339CysAsn: 0.339 ± 0.154
1.188CysPro: 1.188 ± 0.293
0.396CysGln: 0.396 ± 0.149
0.792CysArg: 0.792 ± 0.228
0.735CysSer: 0.735 ± 0.228
0.848CysThr: 0.848 ± 0.245
0.622CysVal: 0.622 ± 0.182
0.396CysTrp: 0.396 ± 0.139
0.113CysTyr: 0.113 ± 0.072
0.0CysXaa: 0.0 ± 0.0
Asp
6.844AspAla: 6.844 ± 0.636
0.961AspCys: 0.961 ± 0.215
4.412AspAsp: 4.412 ± 0.612
3.62AspGlu: 3.62 ± 0.464
1.866AspPhe: 1.866 ± 0.306
6.617AspGly: 6.617 ± 0.602
1.357AspHis: 1.357 ± 0.261
2.036AspIle: 2.036 ± 0.36
1.866AspLys: 1.866 ± 0.317
5.543AspLeu: 5.543 ± 0.657
1.131AspMet: 1.131 ± 0.298
1.527AspAsn: 1.527 ± 0.366
4.864AspPro: 4.864 ± 0.6
2.545AspGln: 2.545 ± 0.348
4.807AspArg: 4.807 ± 0.603
3.28AspSer: 3.28 ± 0.497
4.298AspThr: 4.298 ± 0.521
4.921AspVal: 4.921 ± 0.519
1.527AspTrp: 1.527 ± 0.255
1.697AspTyr: 1.697 ± 0.281
0.0AspXaa: 0.0 ± 0.0
Glu
6.052GluAla: 6.052 ± 0.755
1.357GluCys: 1.357 ± 0.324
2.658GluAsp: 2.658 ± 0.37
2.602GluGlu: 2.602 ± 0.527
2.093GluPhe: 2.093 ± 0.326
3.846GluGly: 3.846 ± 0.433
1.527GluHis: 1.527 ± 0.337
2.432GluIle: 2.432 ± 0.399
1.64GluLys: 1.64 ± 0.26
5.26GluLeu: 5.26 ± 0.68
1.414GluMet: 1.414 ± 0.344
2.093GluAsn: 2.093 ± 0.258
3.393GluPro: 3.393 ± 0.464
2.658GluGln: 2.658 ± 0.423
4.977GluArg: 4.977 ± 0.641
3.054GluSer: 3.054 ± 0.504
4.072GluThr: 4.072 ± 0.602
3.28GluVal: 3.28 ± 0.449
1.584GluTrp: 1.584 ± 0.256
1.584GluTyr: 1.584 ± 0.326
0.0GluXaa: 0.0 ± 0.0
Phe
2.828PheAla: 2.828 ± 0.395
0.226PheCys: 0.226 ± 0.126
2.149PheAsp: 2.149 ± 0.421
1.697PheGlu: 1.697 ± 0.267
1.075PhePhe: 1.075 ± 0.292
2.884PheGly: 2.884 ± 0.751
0.452PheHis: 0.452 ± 0.152
1.188PheIle: 1.188 ± 0.365
0.792PheLys: 0.792 ± 0.232
1.866PheLeu: 1.866 ± 0.308
0.566PheMet: 0.566 ± 0.194
1.301PheAsn: 1.301 ± 0.372
1.584PhePro: 1.584 ± 0.324
1.131PheGln: 1.131 ± 0.297
1.98PheArg: 1.98 ± 0.31
1.527PheSer: 1.527 ± 0.262
2.432PheThr: 2.432 ± 0.32
2.206PheVal: 2.206 ± 0.271
0.452PheTrp: 0.452 ± 0.136
0.905PheTyr: 0.905 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
8.88GlyAla: 8.88 ± 1.185
1.018GlyCys: 1.018 ± 0.257
6.108GlyAsp: 6.108 ± 0.568
3.62GlyGlu: 3.62 ± 0.528
2.828GlyPhe: 2.828 ± 0.442
10.972GlyGly: 10.972 ± 2.363
1.697GlyHis: 1.697 ± 0.265
4.412GlyIle: 4.412 ± 0.589
2.828GlyLys: 2.828 ± 0.398
5.43GlyLeu: 5.43 ± 0.588
2.658GlyMet: 2.658 ± 0.478
2.771GlyAsn: 2.771 ± 0.421
4.807GlyPro: 4.807 ± 0.675
2.149GlyGln: 2.149 ± 0.574
5.373GlyArg: 5.373 ± 0.684
6.221GlySer: 6.221 ± 0.963
6.674GlyThr: 6.674 ± 0.845
6.617GlyVal: 6.617 ± 0.572
2.489GlyTrp: 2.489 ± 0.365
1.923GlyTyr: 1.923 ± 0.314
0.0GlyXaa: 0.0 ± 0.0
His
2.262HisAla: 2.262 ± 0.416
0.452HisCys: 0.452 ± 0.184
0.905HisAsp: 0.905 ± 0.244
1.131HisGlu: 1.131 ± 0.271
0.452HisPhe: 0.452 ± 0.149
1.414HisGly: 1.414 ± 0.252
0.792HisHis: 0.792 ± 0.265
1.414HisIle: 1.414 ± 0.245
0.679HisLys: 0.679 ± 0.22
1.584HisLeu: 1.584 ± 0.259
0.622HisMet: 0.622 ± 0.173
0.792HisAsn: 0.792 ± 0.197
1.527HisPro: 1.527 ± 0.287
0.848HisGln: 0.848 ± 0.258
2.093HisArg: 2.093 ± 0.379
0.961HisSer: 0.961 ± 0.25
1.527HisThr: 1.527 ± 0.376
1.357HisVal: 1.357 ± 0.334
0.566HisTrp: 0.566 ± 0.181
0.848HisTyr: 0.848 ± 0.17
0.0HisXaa: 0.0 ± 0.0
Ile
5.995IleAla: 5.995 ± 0.568
0.509IleCys: 0.509 ± 0.177
3.733IleAsp: 3.733 ± 0.55
2.884IleGlu: 2.884 ± 0.436
0.622IlePhe: 0.622 ± 0.225
3.959IleGly: 3.959 ± 0.502
1.471IleHis: 1.471 ± 0.374
1.527IleIle: 1.527 ± 0.304
1.188IleLys: 1.188 ± 0.281
2.036IleLeu: 2.036 ± 0.433
0.396IleMet: 0.396 ± 0.136
1.923IleAsn: 1.923 ± 0.265
2.489IlePro: 2.489 ± 0.311
1.697IleGln: 1.697 ± 0.321
2.432IleArg: 2.432 ± 0.445
1.753IleSer: 1.753 ± 0.407
3.62IleThr: 3.62 ± 0.42
3.337IleVal: 3.337 ± 0.372
1.075IleTrp: 1.075 ± 0.258
1.018IleTyr: 1.018 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
3.959LysAla: 3.959 ± 0.575
0.509LysCys: 0.509 ± 0.177
1.527LysAsp: 1.527 ± 0.308
1.81LysGlu: 1.81 ± 0.262
1.301LysPhe: 1.301 ± 0.248
2.545LysGly: 2.545 ± 0.364
1.131LysHis: 1.131 ± 0.284
1.018LysIle: 1.018 ± 0.213
1.301LysLys: 1.301 ± 0.36
2.375LysLeu: 2.375 ± 0.485
0.509LysMet: 0.509 ± 0.158
0.848LysAsn: 0.848 ± 0.238
2.036LysPro: 2.036 ± 0.35
1.471LysGln: 1.471 ± 0.223
2.036LysArg: 2.036 ± 0.366
2.262LysSer: 2.262 ± 0.348
1.923LysThr: 1.923 ± 0.344
2.771LysVal: 2.771 ± 0.473
0.792LysTrp: 0.792 ± 0.229
1.131LysTyr: 1.131 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
7.862LeuAla: 7.862 ± 0.7
0.679LeuCys: 0.679 ± 0.17
4.864LeuAsp: 4.864 ± 0.548
4.016LeuGlu: 4.016 ± 0.515
2.093LeuPhe: 2.093 ± 0.304
5.203LeuGly: 5.203 ± 0.563
1.188LeuHis: 1.188 ± 0.296
3.054LeuIle: 3.054 ± 0.405
2.149LeuLys: 2.149 ± 0.358
4.921LeuLeu: 4.921 ± 0.585
1.81LeuMet: 1.81 ± 0.332
2.715LeuAsn: 2.715 ± 0.375
5.203LeuPro: 5.203 ± 0.768
2.771LeuGln: 2.771 ± 0.426
5.147LeuArg: 5.147 ± 0.652
4.807LeuSer: 4.807 ± 0.492
5.26LeuThr: 5.26 ± 0.639
4.864LeuVal: 4.864 ± 0.559
1.188LeuTrp: 1.188 ± 0.226
2.036LeuTyr: 2.036 ± 0.338
0.0LeuXaa: 0.0 ± 0.0
Met
2.489MetAla: 2.489 ± 0.346
0.283MetCys: 0.283 ± 0.134
1.244MetAsp: 1.244 ± 0.27
1.075MetGlu: 1.075 ± 0.211
0.622MetPhe: 0.622 ± 0.209
1.64MetGly: 1.64 ± 0.272
0.17MetHis: 0.17 ± 0.084
0.735MetIle: 0.735 ± 0.228
0.566MetLys: 0.566 ± 0.168
1.866MetLeu: 1.866 ± 0.269
0.509MetMet: 0.509 ± 0.21
0.792MetAsn: 0.792 ± 0.199
1.244MetPro: 1.244 ± 0.228
0.566MetGln: 0.566 ± 0.137
1.357MetArg: 1.357 ± 0.265
2.715MetSer: 2.715 ± 0.347
1.98MetThr: 1.98 ± 0.328
1.414MetVal: 1.414 ± 0.308
0.339MetTrp: 0.339 ± 0.125
0.283MetTyr: 0.283 ± 0.112
0.0MetXaa: 0.0 ± 0.0
Asn
3.676AsnAla: 3.676 ± 0.481
0.226AsnCys: 0.226 ± 0.114
1.81AsnAsp: 1.81 ± 0.288
1.98AsnGlu: 1.98 ± 0.41
0.735AsnPhe: 0.735 ± 0.237
3.902AsnGly: 3.902 ± 0.498
0.905AsnHis: 0.905 ± 0.185
1.584AsnIle: 1.584 ± 0.49
0.961AsnLys: 0.961 ± 0.252
2.319AsnLeu: 2.319 ± 0.34
0.509AsnMet: 0.509 ± 0.157
1.753AsnAsn: 1.753 ± 0.334
2.828AsnPro: 2.828 ± 0.354
0.961AsnGln: 0.961 ± 0.359
1.697AsnArg: 1.697 ± 0.348
1.923AsnSer: 1.923 ± 0.347
2.036AsnThr: 2.036 ± 0.282
1.98AsnVal: 1.98 ± 0.422
0.848AsnTrp: 0.848 ± 0.183
1.018AsnTyr: 1.018 ± 0.206
0.0AsnXaa: 0.0 ± 0.0
Pro
5.486ProAla: 5.486 ± 0.649
0.622ProCys: 0.622 ± 0.177
4.525ProAsp: 4.525 ± 0.533
4.412ProGlu: 4.412 ± 0.509
1.866ProPhe: 1.866 ± 0.304
6.674ProGly: 6.674 ± 0.711
1.527ProHis: 1.527 ± 0.322
1.98ProIle: 1.98 ± 0.329
2.093ProLys: 2.093 ± 0.309
4.468ProLeu: 4.468 ± 0.552
1.471ProMet: 1.471 ± 0.323
1.866ProAsn: 1.866 ± 0.315
4.921ProPro: 4.921 ± 0.66
1.923ProGln: 1.923 ± 0.393
2.884ProArg: 2.884 ± 0.477
3.167ProSer: 3.167 ± 0.372
3.28ProThr: 3.28 ± 0.498
4.581ProVal: 4.581 ± 0.59
1.357ProTrp: 1.357 ± 0.282
1.697ProTyr: 1.697 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
4.525GlnAla: 4.525 ± 0.595
0.339GlnCys: 0.339 ± 0.178
1.471GlnAsp: 1.471 ± 0.295
1.753GlnGlu: 1.753 ± 0.277
1.244GlnPhe: 1.244 ± 0.246
2.489GlnGly: 2.489 ± 0.497
0.735GlnHis: 0.735 ± 0.227
1.98GlnIle: 1.98 ± 0.375
1.301GlnLys: 1.301 ± 0.238
2.998GlnLeu: 2.998 ± 0.414
0.566GlnMet: 0.566 ± 0.198
0.848GlnAsn: 0.848 ± 0.287
2.036GlnPro: 2.036 ± 0.385
1.301GlnGln: 1.301 ± 0.327
2.771GlnArg: 2.771 ± 0.369
2.036GlnSer: 2.036 ± 0.409
1.866GlnThr: 1.866 ± 0.314
2.206GlnVal: 2.206 ± 0.338
0.792GlnTrp: 0.792 ± 0.203
0.905GlnTyr: 0.905 ± 0.261
0.0GlnXaa: 0.0 ± 0.0
Arg
6.73ArgAla: 6.73 ± 0.746
0.961ArgCys: 0.961 ± 0.272
4.468ArgAsp: 4.468 ± 0.573
4.638ArgGlu: 4.638 ± 0.656
1.923ArgPhe: 1.923 ± 0.316
3.62ArgGly: 3.62 ± 0.511
1.64ArgHis: 1.64 ± 0.344
3.959ArgIle: 3.959 ± 0.576
2.319ArgLys: 2.319 ± 0.412
4.355ArgLeu: 4.355 ± 0.546
2.262ArgMet: 2.262 ± 0.39
2.884ArgAsn: 2.884 ± 0.45
3.224ArgPro: 3.224 ± 0.426
1.584ArgGln: 1.584 ± 0.35
5.486ArgArg: 5.486 ± 0.758
3.507ArgSer: 3.507 ± 0.446
3.676ArgThr: 3.676 ± 0.569
5.26ArgVal: 5.26 ± 0.594
2.093ArgTrp: 2.093 ± 0.368
1.98ArgTyr: 1.98 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
6.561SerAla: 6.561 ± 1.184
0.509SerCys: 0.509 ± 0.175
4.072SerAsp: 4.072 ± 0.487
2.432SerGlu: 2.432 ± 0.422
1.753SerPhe: 1.753 ± 0.307
6.221SerGly: 6.221 ± 1.134
1.244SerHis: 1.244 ± 0.334
2.715SerIle: 2.715 ± 0.424
2.319SerLys: 2.319 ± 0.408
3.393SerLeu: 3.393 ± 0.431
1.244SerMet: 1.244 ± 0.252
2.658SerAsn: 2.658 ± 0.459
3.62SerPro: 3.62 ± 0.368
1.697SerGln: 1.697 ± 0.296
3.45SerArg: 3.45 ± 0.411
3.507SerSer: 3.507 ± 0.629
3.62SerThr: 3.62 ± 0.494
4.581SerVal: 4.581 ± 0.544
1.414SerTrp: 1.414 ± 0.293
1.414SerTyr: 1.414 ± 0.252
0.0SerXaa: 0.0 ± 0.0
Thr
6.844ThrAla: 6.844 ± 0.538
0.679ThrCys: 0.679 ± 0.225
4.185ThrAsp: 4.185 ± 0.56
3.959ThrGlu: 3.959 ± 0.394
1.866ThrPhe: 1.866 ± 0.368
6.165ThrGly: 6.165 ± 0.617
1.64ThrHis: 1.64 ± 0.269
3.846ThrIle: 3.846 ± 0.477
2.093ThrLys: 2.093 ± 0.385
4.525ThrLeu: 4.525 ± 0.565
1.188ThrMet: 1.188 ± 0.282
2.206ThrAsn: 2.206 ± 0.36
4.921ThrPro: 4.921 ± 0.671
2.206ThrGln: 2.206 ± 0.325
3.846ThrArg: 3.846 ± 0.569
4.016ThrSer: 4.016 ± 0.477
4.864ThrThr: 4.864 ± 0.735
5.995ThrVal: 5.995 ± 0.776
1.131ThrTrp: 1.131 ± 0.26
1.64ThrTyr: 1.64 ± 0.3
0.0ThrXaa: 0.0 ± 0.0
Val
7.522ValAla: 7.522 ± 0.564
1.301ValCys: 1.301 ± 0.261
5.373ValAsp: 5.373 ± 0.468
4.977ValGlu: 4.977 ± 0.471
2.432ValPhe: 2.432 ± 0.431
5.543ValGly: 5.543 ± 0.769
1.414ValHis: 1.414 ± 0.316
2.771ValIle: 2.771 ± 0.425
2.602ValLys: 2.602 ± 0.451
5.373ValLeu: 5.373 ± 0.653
0.961ValMet: 0.961 ± 0.202
2.093ValAsn: 2.093 ± 0.311
4.129ValPro: 4.129 ± 0.386
2.998ValGln: 2.998 ± 0.341
4.129ValArg: 4.129 ± 0.581
4.694ValSer: 4.694 ± 0.58
5.26ValThr: 5.26 ± 0.643
6.278ValVal: 6.278 ± 0.741
1.866ValTrp: 1.866 ± 0.333
1.188ValTyr: 1.188 ± 0.288
0.0ValXaa: 0.0 ± 0.0
Trp
1.866TrpAla: 1.866 ± 0.28
0.17TrpCys: 0.17 ± 0.09
1.753TrpAsp: 1.753 ± 0.303
1.188TrpGlu: 1.188 ± 0.306
0.679TrpPhe: 0.679 ± 0.163
1.075TrpGly: 1.075 ± 0.233
0.509TrpHis: 0.509 ± 0.18
1.131TrpIle: 1.131 ± 0.21
0.792TrpLys: 0.792 ± 0.197
2.206TrpLeu: 2.206 ± 0.385
1.075TrpMet: 1.075 ± 0.262
0.622TrpAsn: 0.622 ± 0.245
0.961TrpPro: 0.961 ± 0.278
0.848TrpGln: 0.848 ± 0.236
2.432TrpArg: 2.432 ± 0.417
1.98TrpSer: 1.98 ± 0.507
1.866TrpThr: 1.866 ± 0.378
1.697TrpVal: 1.697 ± 0.4
1.018TrpTrp: 1.018 ± 0.207
0.509TrpTyr: 0.509 ± 0.175
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.262TyrAla: 2.262 ± 0.382
0.226TyrCys: 0.226 ± 0.105
1.697TyrAsp: 1.697 ± 0.34
1.584TyrGlu: 1.584 ± 0.288
0.679TyrPhe: 0.679 ± 0.171
2.093TyrGly: 2.093 ± 0.397
0.396TyrHis: 0.396 ± 0.126
1.301TyrIle: 1.301 ± 0.252
0.905TyrLys: 0.905 ± 0.247
2.093TyrLeu: 2.093 ± 0.342
0.113TyrMet: 0.113 ± 0.072
0.792TyrAsn: 0.792 ± 0.189
1.131TyrPro: 1.131 ± 0.227
0.792TyrGln: 0.792 ± 0.216
2.036TyrArg: 2.036 ± 0.349
1.075TyrSer: 1.075 ± 0.231
2.036TyrThr: 2.036 ± 0.41
2.206TyrVal: 2.206 ± 0.322
0.679TyrTrp: 0.679 ± 0.194
0.566TyrTyr: 0.566 ± 0.159
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 103 proteins (17682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski