Amino acid dipepetide frequency for Klebsiella phage KPN U2874

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.383AlaAla: 12.383 ± 1.347
0.978AlaCys: 0.978 ± 0.325
6.246AlaAsp: 6.246 ± 0.467
7.549AlaGlu: 7.549 ± 0.764
3.748AlaPhe: 3.748 ± 0.533
8.147AlaGly: 8.147 ± 0.623
1.303AlaHis: 1.303 ± 0.266
5.54AlaIle: 5.54 ± 0.64
6.355AlaLys: 6.355 ± 0.92
7.712AlaLeu: 7.712 ± 0.666
3.041AlaMet: 3.041 ± 0.455
3.856AlaAsn: 3.856 ± 0.426
3.585AlaPro: 3.585 ± 0.387
4.834AlaGln: 4.834 ± 0.587
4.997AlaArg: 4.997 ± 0.498
4.888AlaSer: 4.888 ± 0.691
5.703AlaThr: 5.703 ± 0.708
7.169AlaVal: 7.169 ± 0.917
1.412AlaTrp: 1.412 ± 0.353
3.748AlaTyr: 3.748 ± 0.362
0.0AlaXaa: 0.0 ± 0.0
Cys
1.032CysAla: 1.032 ± 0.203
0.272CysCys: 0.272 ± 0.121
0.706CysAsp: 0.706 ± 0.29
0.597CysGlu: 0.597 ± 0.169
0.543CysPhe: 0.543 ± 0.16
0.923CysGly: 0.923 ± 0.209
0.217CysHis: 0.217 ± 0.097
0.597CysIle: 0.597 ± 0.169
0.38CysLys: 0.38 ± 0.142
0.543CysLeu: 0.543 ± 0.168
0.272CysMet: 0.272 ± 0.152
0.434CysAsn: 0.434 ± 0.197
0.597CysPro: 0.597 ± 0.273
0.163CysGln: 0.163 ± 0.091
1.141CysArg: 1.141 ± 0.259
0.543CysSer: 0.543 ± 0.181
0.597CysThr: 0.597 ± 0.191
0.434CysVal: 0.434 ± 0.153
0.109CysTrp: 0.109 ± 0.071
0.163CysTyr: 0.163 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
6.952AspAla: 6.952 ± 0.619
0.597AspCys: 0.597 ± 0.212
5.486AspAsp: 5.486 ± 0.733
5.051AspGlu: 5.051 ± 0.631
2.553AspPhe: 2.553 ± 0.346
5.268AspGly: 5.268 ± 0.528
0.706AspHis: 0.706 ± 0.2
3.965AspIle: 3.965 ± 0.499
2.77AspLys: 2.77 ± 0.377
4.779AspLeu: 4.779 ± 0.659
1.955AspMet: 1.955 ± 0.283
2.172AspAsn: 2.172 ± 0.32
3.096AspPro: 3.096 ± 0.339
1.901AspGln: 1.901 ± 0.251
3.041AspArg: 3.041 ± 0.449
3.041AspSer: 3.041 ± 0.422
4.019AspThr: 4.019 ± 0.397
4.291AspVal: 4.291 ± 0.504
1.955AspTrp: 1.955 ± 0.388
2.01AspTyr: 2.01 ± 0.385
0.0AspXaa: 0.0 ± 0.0
Glu
5.486GluAla: 5.486 ± 0.573
0.489GluCys: 0.489 ± 0.172
3.91GluAsp: 3.91 ± 0.491
4.834GluGlu: 4.834 ± 0.665
2.227GluPhe: 2.227 ± 0.428
4.291GluGly: 4.291 ± 0.466
0.706GluHis: 0.706 ± 0.22
3.639GluIle: 3.639 ± 0.455
3.476GluLys: 3.476 ± 0.755
5.214GluLeu: 5.214 ± 0.599
2.281GluMet: 2.281 ± 0.379
2.553GluAsn: 2.553 ± 0.436
1.847GluPro: 1.847 ± 0.375
2.172GluGln: 2.172 ± 0.454
3.639GluArg: 3.639 ± 0.444
3.096GluSer: 3.096 ± 0.326
2.444GluThr: 2.444 ± 0.374
4.617GluVal: 4.617 ± 0.46
1.249GluTrp: 1.249 ± 0.235
2.281GluTyr: 2.281 ± 0.344
0.0GluXaa: 0.0 ± 0.0
Phe
3.802PheAla: 3.802 ± 0.469
0.38PheCys: 0.38 ± 0.173
2.335PheAsp: 2.335 ± 0.35
1.955PheGlu: 1.955 ± 0.258
1.303PhePhe: 1.303 ± 0.322
2.879PheGly: 2.879 ± 0.412
0.434PheHis: 0.434 ± 0.143
2.39PheIle: 2.39 ± 0.317
1.738PheLys: 1.738 ± 0.437
2.498PheLeu: 2.498 ± 0.429
1.032PheMet: 1.032 ± 0.265
1.629PheAsn: 1.629 ± 0.342
1.629PhePro: 1.629 ± 0.315
1.141PheGln: 1.141 ± 0.225
2.444PheArg: 2.444 ± 0.362
2.227PheSer: 2.227 ± 0.369
2.227PheThr: 2.227 ± 0.439
1.901PheVal: 1.901 ± 0.403
0.597PheTrp: 0.597 ± 0.213
0.923PheTyr: 0.923 ± 0.202
0.0PheXaa: 0.0 ± 0.0
Gly
6.952GlyAla: 6.952 ± 0.813
0.978GlyCys: 0.978 ± 0.278
4.617GlyAsp: 4.617 ± 0.495
4.399GlyGlu: 4.399 ± 0.46
2.118GlyPhe: 2.118 ± 0.42
5.214GlyGly: 5.214 ± 0.643
1.249GlyHis: 1.249 ± 0.287
4.182GlyIle: 4.182 ± 0.458
4.399GlyLys: 4.399 ± 0.571
6.843GlyLeu: 6.843 ± 0.788
2.01GlyMet: 2.01 ± 0.338
2.661GlyAsn: 2.661 ± 0.422
2.172GlyPro: 2.172 ± 0.316
2.172GlyGln: 2.172 ± 0.37
5.757GlyArg: 5.757 ± 0.496
4.236GlySer: 4.236 ± 0.631
4.834GlyThr: 4.834 ± 0.761
5.323GlyVal: 5.323 ± 0.53
1.955GlyTrp: 1.955 ± 0.312
3.422GlyTyr: 3.422 ± 0.461
0.0GlyXaa: 0.0 ± 0.0
His
1.249HisAla: 1.249 ± 0.321
0.272HisCys: 0.272 ± 0.118
0.923HisAsp: 0.923 ± 0.243
0.76HisGlu: 0.76 ± 0.173
0.489HisPhe: 0.489 ± 0.174
1.303HisGly: 1.303 ± 0.314
0.109HisHis: 0.109 ± 0.092
1.086HisIle: 1.086 ± 0.251
0.978HisLys: 0.978 ± 0.218
1.249HisLeu: 1.249 ± 0.25
0.434HisMet: 0.434 ± 0.169
0.597HisAsn: 0.597 ± 0.189
0.706HisPro: 0.706 ± 0.231
0.326HisGln: 0.326 ± 0.128
1.195HisArg: 1.195 ± 0.253
0.815HisSer: 0.815 ± 0.196
0.923HisThr: 0.923 ± 0.231
0.815HisVal: 0.815 ± 0.211
0.217HisTrp: 0.217 ± 0.104
0.815HisTyr: 0.815 ± 0.213
0.0HisXaa: 0.0 ± 0.0
Ile
5.431IleAla: 5.431 ± 0.469
0.489IleCys: 0.489 ± 0.159
3.856IleAsp: 3.856 ± 0.396
2.933IleGlu: 2.933 ± 0.397
1.575IlePhe: 1.575 ± 0.32
4.236IleGly: 4.236 ± 0.535
1.141IleHis: 1.141 ± 0.295
3.585IleIle: 3.585 ± 0.396
3.53IleLys: 3.53 ± 0.455
2.987IleLeu: 2.987 ± 0.333
1.195IleMet: 1.195 ± 0.27
2.498IleAsn: 2.498 ± 0.332
2.227IlePro: 2.227 ± 0.343
1.358IleGln: 1.358 ± 0.268
4.128IleArg: 4.128 ± 0.503
3.041IleSer: 3.041 ± 0.374
3.367IleThr: 3.367 ± 0.427
3.91IleVal: 3.91 ± 0.49
0.38IleTrp: 0.38 ± 0.146
1.684IleTyr: 1.684 ± 0.324
0.0IleXaa: 0.0 ± 0.0
Lys
6.192LysAla: 6.192 ± 0.696
0.543LysCys: 0.543 ± 0.185
2.933LysAsp: 2.933 ± 0.381
3.367LysGlu: 3.367 ± 0.526
1.847LysPhe: 1.847 ± 0.296
3.585LysGly: 3.585 ± 0.395
1.141LysHis: 1.141 ± 0.255
2.335LysIle: 2.335 ± 0.423
3.802LysLys: 3.802 ± 0.609
3.367LysLeu: 3.367 ± 0.432
1.575LysMet: 1.575 ± 0.352
2.716LysAsn: 2.716 ± 0.437
2.498LysPro: 2.498 ± 0.308
1.629LysGln: 1.629 ± 0.334
3.639LysArg: 3.639 ± 0.517
2.77LysSer: 2.77 ± 0.358
3.802LysThr: 3.802 ± 0.557
3.53LysVal: 3.53 ± 0.486
1.249LysTrp: 1.249 ± 0.359
1.466LysTyr: 1.466 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
8.038LeuAla: 8.038 ± 0.899
1.195LeuCys: 1.195 ± 0.227
4.997LeuAsp: 4.997 ± 0.581
3.802LeuGlu: 3.802 ± 0.474
2.933LeuPhe: 2.933 ± 0.36
4.508LeuGly: 4.508 ± 0.697
0.652LeuHis: 0.652 ± 0.182
4.182LeuIle: 4.182 ± 0.451
4.182LeuLys: 4.182 ± 0.54
5.594LeuLeu: 5.594 ± 0.69
2.661LeuMet: 2.661 ± 0.531
3.693LeuAsn: 3.693 ± 0.528
3.693LeuPro: 3.693 ± 0.44
3.53LeuGln: 3.53 ± 0.639
5.54LeuArg: 5.54 ± 0.568
4.617LeuSer: 4.617 ± 0.517
4.942LeuThr: 4.942 ± 0.599
4.562LeuVal: 4.562 ± 0.414
1.412LeuTrp: 1.412 ± 0.259
2.335LeuTyr: 2.335 ± 0.323
0.0LeuXaa: 0.0 ± 0.0
Met
3.476MetAla: 3.476 ± 0.437
0.38MetCys: 0.38 ± 0.193
1.738MetAsp: 1.738 ± 0.402
1.412MetGlu: 1.412 ± 0.271
0.652MetPhe: 0.652 ± 0.191
1.738MetGly: 1.738 ± 0.3
0.434MetHis: 0.434 ± 0.155
1.303MetIle: 1.303 ± 0.242
1.955MetLys: 1.955 ± 0.323
2.281MetLeu: 2.281 ± 0.441
0.706MetMet: 0.706 ± 0.19
1.466MetAsn: 1.466 ± 0.293
1.249MetPro: 1.249 ± 0.268
0.815MetGln: 0.815 ± 0.147
2.227MetArg: 2.227 ± 0.325
2.064MetSer: 2.064 ± 0.32
2.444MetThr: 2.444 ± 0.409
2.39MetVal: 2.39 ± 0.345
0.38MetTrp: 0.38 ± 0.139
0.869MetTyr: 0.869 ± 0.195
0.0MetXaa: 0.0 ± 0.0
Asn
4.779AsnAla: 4.779 ± 0.5
0.326AsnCys: 0.326 ± 0.129
2.01AsnAsp: 2.01 ± 0.365
2.118AsnGlu: 2.118 ± 0.368
1.195AsnPhe: 1.195 ± 0.205
4.399AsnGly: 4.399 ± 0.435
0.543AsnHis: 0.543 ± 0.236
2.444AsnIle: 2.444 ± 0.428
1.629AsnLys: 1.629 ± 0.335
3.15AsnLeu: 3.15 ± 0.383
1.412AsnMet: 1.412 ± 0.307
1.358AsnAsn: 1.358 ± 0.279
2.553AsnPro: 2.553 ± 0.354
0.978AsnGln: 0.978 ± 0.234
2.39AsnArg: 2.39 ± 0.432
2.444AsnSer: 2.444 ± 0.495
2.553AsnThr: 2.553 ± 0.396
2.227AsnVal: 2.227 ± 0.433
1.249AsnTrp: 1.249 ± 0.261
2.064AsnTyr: 2.064 ± 0.373
0.0AsnXaa: 0.0 ± 0.0
Pro
4.671ProAla: 4.671 ± 0.656
0.434ProCys: 0.434 ± 0.204
3.639ProAsp: 3.639 ± 0.505
3.422ProGlu: 3.422 ± 0.475
1.847ProPhe: 1.847 ± 0.284
3.313ProGly: 3.313 ± 0.501
0.923ProHis: 0.923 ± 0.207
1.358ProIle: 1.358 ± 0.308
1.629ProLys: 1.629 ± 0.337
2.824ProLeu: 2.824 ± 0.316
1.086ProMet: 1.086 ± 0.311
1.847ProAsn: 1.847 ± 0.324
1.575ProPro: 1.575 ± 0.38
1.412ProGln: 1.412 ± 0.283
2.227ProArg: 2.227 ± 0.412
2.553ProSer: 2.553 ± 0.328
2.498ProThr: 2.498 ± 0.343
3.639ProVal: 3.639 ± 0.447
0.815ProTrp: 0.815 ± 0.239
1.684ProTyr: 1.684 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
3.693GlnAla: 3.693 ± 0.833
0.272GlnCys: 0.272 ± 0.126
2.118GlnAsp: 2.118 ± 0.364
1.412GlnGlu: 1.412 ± 0.227
1.086GlnPhe: 1.086 ± 0.174
1.955GlnGly: 1.955 ± 0.322
0.597GlnHis: 0.597 ± 0.172
1.847GlnIle: 1.847 ± 0.323
1.466GlnLys: 1.466 ± 0.321
3.422GlnLeu: 3.422 ± 0.547
1.521GlnMet: 1.521 ± 0.336
1.575GlnAsn: 1.575 ± 0.335
1.249GlnPro: 1.249 ± 0.196
1.901GlnGln: 1.901 ± 0.774
2.77GlnArg: 2.77 ± 0.408
1.738GlnSer: 1.738 ± 0.273
1.955GlnThr: 1.955 ± 0.264
2.444GlnVal: 2.444 ± 0.383
0.869GlnTrp: 0.869 ± 0.242
1.141GlnTyr: 1.141 ± 0.239
0.0GlnXaa: 0.0 ± 0.0
Arg
6.517ArgAla: 6.517 ± 0.67
0.597ArgCys: 0.597 ± 0.21
4.834ArgAsp: 4.834 ± 0.486
3.422ArgGlu: 3.422 ± 0.365
2.281ArgPhe: 2.281 ± 0.406
4.236ArgGly: 4.236 ± 0.521
1.141ArgHis: 1.141 ± 0.244
3.096ArgIle: 3.096 ± 0.382
3.53ArgLys: 3.53 ± 0.38
4.888ArgLeu: 4.888 ± 0.551
1.412ArgMet: 1.412 ± 0.294
2.987ArgAsn: 2.987 ± 0.384
3.15ArgPro: 3.15 ± 0.424
2.553ArgGln: 2.553 ± 0.399
4.128ArgArg: 4.128 ± 0.673
2.281ArgSer: 2.281 ± 0.365
2.77ArgThr: 2.77 ± 0.426
5.105ArgVal: 5.105 ± 0.566
0.815ArgTrp: 0.815 ± 0.181
2.172ArgTyr: 2.172 ± 0.388
0.0ArgXaa: 0.0 ± 0.0
Ser
5.377SerAla: 5.377 ± 0.48
0.543SerCys: 0.543 ± 0.186
3.313SerAsp: 3.313 ± 0.413
2.39SerGlu: 2.39 ± 0.372
2.335SerPhe: 2.335 ± 0.387
5.214SerGly: 5.214 ± 0.54
0.706SerHis: 0.706 ± 0.166
2.824SerIle: 2.824 ± 0.352
2.607SerLys: 2.607 ± 0.492
4.834SerLeu: 4.834 ± 0.531
1.412SerMet: 1.412 ± 0.25
2.335SerAsn: 2.335 ± 0.351
2.281SerPro: 2.281 ± 0.381
1.629SerGln: 1.629 ± 0.257
2.661SerArg: 2.661 ± 0.33
3.585SerSer: 3.585 ± 0.721
2.879SerThr: 2.879 ± 0.474
4.562SerVal: 4.562 ± 0.429
0.978SerTrp: 0.978 ± 0.223
1.684SerTyr: 1.684 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
5.431ThrAla: 5.431 ± 0.633
0.326ThrCys: 0.326 ± 0.112
3.748ThrAsp: 3.748 ± 0.425
3.259ThrGlu: 3.259 ± 0.362
2.118ThrPhe: 2.118 ± 0.445
5.214ThrGly: 5.214 ± 0.734
0.978ThrHis: 0.978 ± 0.237
2.716ThrIle: 2.716 ± 0.422
2.879ThrLys: 2.879 ± 0.474
5.648ThrLeu: 5.648 ± 0.519
1.466ThrMet: 1.466 ± 0.309
2.172ThrAsn: 2.172 ± 0.373
3.204ThrPro: 3.204 ± 0.448
2.227ThrGln: 2.227 ± 0.423
2.661ThrArg: 2.661 ± 0.383
3.041ThrSer: 3.041 ± 0.382
3.802ThrThr: 3.802 ± 0.626
5.594ThrVal: 5.594 ± 0.492
1.358ThrTrp: 1.358 ± 0.267
1.629ThrTyr: 1.629 ± 0.273
0.0ThrXaa: 0.0 ± 0.0
Val
6.626ValAla: 6.626 ± 0.628
0.706ValCys: 0.706 ± 0.223
4.073ValAsp: 4.073 ± 0.411
4.454ValGlu: 4.454 ± 0.392
2.607ValPhe: 2.607 ± 0.331
4.942ValGly: 4.942 ± 0.487
1.249ValHis: 1.249 ± 0.286
4.073ValIle: 4.073 ± 0.485
4.291ValLys: 4.291 ± 0.519
5.16ValLeu: 5.16 ± 0.543
3.096ValMet: 3.096 ± 0.428
3.041ValAsn: 3.041 ± 0.473
2.987ValPro: 2.987 ± 0.446
2.172ValGln: 2.172 ± 0.331
4.236ValArg: 4.236 ± 0.491
4.562ValSer: 4.562 ± 0.546
4.562ValThr: 4.562 ± 0.49
5.16ValVal: 5.16 ± 0.581
1.303ValTrp: 1.303 ± 0.24
1.792ValTyr: 1.792 ± 0.3
0.0ValXaa: 0.0 ± 0.0
Trp
2.118TrpAla: 2.118 ± 0.33
0.38TrpCys: 0.38 ± 0.152
1.629TrpAsp: 1.629 ± 0.365
1.141TrpGlu: 1.141 ± 0.298
1.141TrpPhe: 1.141 ± 0.22
1.086TrpGly: 1.086 ± 0.269
0.489TrpHis: 0.489 ± 0.193
0.923TrpIle: 0.923 ± 0.205
1.032TrpLys: 1.032 ± 0.171
1.575TrpLeu: 1.575 ± 0.354
0.272TrpMet: 0.272 ± 0.111
0.489TrpAsn: 0.489 ± 0.14
1.303TrpPro: 1.303 ± 0.321
0.76TrpGln: 0.76 ± 0.182
0.815TrpArg: 0.815 ± 0.205
0.978TrpSer: 0.978 ± 0.203
1.141TrpThr: 1.141 ± 0.285
1.195TrpVal: 1.195 ± 0.277
0.38TrpTrp: 0.38 ± 0.127
0.38TrpTyr: 0.38 ± 0.125
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.987TyrAla: 2.987 ± 0.337
0.109TyrCys: 0.109 ± 0.07
2.498TyrAsp: 2.498 ± 0.406
2.172TyrGlu: 2.172 ± 0.359
0.869TyrPhe: 0.869 ± 0.239
3.041TyrGly: 3.041 ± 0.48
0.543TyrHis: 0.543 ± 0.188
1.466TyrIle: 1.466 ± 0.297
1.358TyrLys: 1.358 ± 0.282
2.498TyrLeu: 2.498 ± 0.463
1.086TyrMet: 1.086 ± 0.271
1.738TyrAsn: 1.738 ± 0.305
1.792TyrPro: 1.792 ± 0.389
1.358TyrGln: 1.358 ± 0.285
2.281TyrArg: 2.281 ± 0.31
1.629TyrSer: 1.629 ± 0.338
2.01TyrThr: 2.01 ± 0.386
2.281TyrVal: 2.281 ± 0.349
0.543TyrTrp: 0.543 ± 0.226
1.303TyrTyr: 1.303 ± 0.28
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (18413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski