Amino acid dipepetide frequency for Pocillopora damicornis (Cauliflower coral) (Millepora damicornis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.489AlaAla: 4.489 ± 0.034	1.234AlaCys: 1.234 ± 0.012	3.049AlaAsp: 3.049 ± 0.019	3.914AlaGlu: 3.914 ± 0.03	2.612AlaPhe: 2.612 ± 0.02	3.474AlaGly: 3.474 ± 0.032	1.215AlaHis: 1.215 ± 0.012	3.495AlaIle: 3.495 ± 0.024	4.014AlaLys: 4.014 ± 0.026	5.819AlaLeu: 5.819 ± 0.037	1.464AlaMet: 1.464 ± 0.013	2.574AlaAsn: 2.574 ± 0.017	2.427AlaPro: 2.427 ± 0.024	2.181AlaGln: 2.181 ± 0.017	3.101AlaArg: 3.101 ± 0.027	5.07AlaSer: 5.07 ± 0.027	3.539AlaThr: 3.539 ± 0.022	4.673AlaVal: 4.673 ± 0.03	0.712AlaTrp: 0.712 ± 0.01	1.565AlaTyr: 1.565 ± 0.015	0.004AlaXaa: 0.004 ± 0.001
Cys	1.195CysAla: 1.195 ± 0.014	0.648CysCys: 0.648 ± 0.012	1.237CysAsp: 1.237 ± 0.017	1.324CysGlu: 1.324 ± 0.016	0.992CysPhe: 0.992 ± 0.011	1.494CysGly: 1.494 ± 0.018	0.628CysHis: 0.628 ± 0.011	1.09CysIle: 1.09 ± 0.012	1.47CysLys: 1.47 ± 0.017	2.079CysLeu: 2.079 ± 0.016	0.426CysMet: 0.426 ± 0.007	1.051CysAsn: 1.051 ± 0.014	1.196CysPro: 1.196 ± 0.037	0.989CysGln: 0.989 ± 0.015	1.211CysArg: 1.211 ± 0.013	1.995CysSer: 1.995 ± 0.019	1.208CysThr: 1.208 ± 0.018	1.477CysVal: 1.477 ± 0.015	0.319CysTrp: 0.319 ± 0.007	0.75CysTyr: 0.75 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	2.919AspAla: 2.919 ± 0.02	1.136AspCys: 1.136 ± 0.015	3.568AspAsp: 3.568 ± 0.029	4.291AspGlu: 4.291 ± 0.031	2.361AspPhe: 2.361 ± 0.016	3.641AspGly: 3.641 ± 0.029	1.192AspHis: 1.192 ± 0.011	3.059AspIle: 3.059 ± 0.019	3.406AspLys: 3.406 ± 0.023	4.791AspLeu: 4.791 ± 0.024	1.137AspMet: 1.137 ± 0.012	2.343AspAsn: 2.343 ± 0.016	2.322AspPro: 2.322 ± 0.018	1.859AspGln: 1.859 ± 0.015	2.568AspArg: 2.568 ± 0.025	4.273AspSer: 4.273 ± 0.029	2.59AspThr: 2.59 ± 0.016	3.682AspVal: 3.682 ± 0.024	0.648AspTrp: 0.648 ± 0.009	1.596AspTyr: 1.596 ± 0.016	0.004AspXaa: 0.004 ± 0.001
Glu	4.102GluAla: 4.102 ± 0.031	1.311GluCys: 1.311 ± 0.017	4.151GluAsp: 4.151 ± 0.027	6.528GluGlu: 6.528 ± 0.06	2.407GluPhe: 2.407 ± 0.017	3.779GluGly: 3.779 ± 0.026	1.419GluHis: 1.419 ± 0.013	3.816GluIle: 3.816 ± 0.023	5.483GluLys: 5.483 ± 0.046	5.769GluLeu: 5.769 ± 0.042	1.676GluMet: 1.676 ± 0.017	3.701GluAsn: 3.701 ± 0.026	2.198GluPro: 2.198 ± 0.018	2.606GluGln: 2.606 ± 0.028	3.912GluArg: 3.912 ± 0.034	4.698GluSer: 4.698 ± 0.035	3.71GluThr: 3.71 ± 0.025	4.15GluVal: 4.15 ± 0.027	0.735GluTrp: 0.735 ± 0.009	1.791GluTyr: 1.791 ± 0.017	0.004GluXaa: 0.004 ± 0.001
Phe	2.408PheAla: 2.408 ± 0.019	1.047PheCys: 1.047 ± 0.012	2.238PheAsp: 2.238 ± 0.016	2.353PheGlu: 2.353 ± 0.017	1.923PhePhe: 1.923 ± 0.018	2.598PheGly: 2.598 ± 0.021	1.143PheHis: 1.143 ± 0.013	2.338PheIle: 2.338 ± 0.018	2.506PheLys: 2.506 ± 0.016	4.179PheLeu: 4.179 ± 0.029	0.904PheMet: 0.904 ± 0.011	1.855PheAsn: 1.855 ± 0.014	1.897PhePro: 1.897 ± 0.014	1.672PheGln: 1.672 ± 0.014	2.056PheArg: 2.056 ± 0.016	3.614PheSer: 3.614 ± 0.022	2.528PheThr: 2.528 ± 0.018	2.983PheVal: 2.983 ± 0.019	0.56PheTrp: 0.56 ± 0.008	1.468PheTyr: 1.468 ± 0.015	0.002PheXaa: 0.002 ± 0.0
Gly	3.313GlyAla: 3.313 ± 0.029	1.282GlyCys: 1.282 ± 0.015	3.335GlyAsp: 3.335 ± 0.027	3.797GlyGlu: 3.797 ± 0.029	2.657GlyPhe: 2.657 ± 0.021	4.265GlyGly: 4.265 ± 0.06	1.481GlyHis: 1.481 ± 0.016	3.203GlyIle: 3.203 ± 0.02	4.383GlyLys: 4.383 ± 0.025	4.673GlyLeu: 4.673 ± 0.026	1.285GlyMet: 1.285 ± 0.015	3.254GlyAsn: 3.254 ± 0.023	2.258GlyPro: 2.258 ± 0.028	2.218GlyGln: 2.218 ± 0.02	3.25GlyArg: 3.25 ± 0.031	5.025GlySer: 5.025 ± 0.042	3.387GlyThr: 3.387 ± 0.031	3.795GlyVal: 3.795 ± 0.026	0.8GlyTrp: 0.8 ± 0.011	1.994GlyTyr: 1.994 ± 0.021	0.004GlyXaa: 0.004 ± 0.001
His	1.241HisAla: 1.241 ± 0.011	0.646HisCys: 0.646 ± 0.009	1.129HisAsp: 1.129 ± 0.011	1.385HisGlu: 1.385 ± 0.014	1.121HisPhe: 1.121 ± 0.011	1.506HisGly: 1.506 ± 0.014	0.748HisHis: 0.748 ± 0.01	1.195HisIle: 1.195 ± 0.013	1.359HisLys: 1.359 ± 0.012	2.315HisLeu: 2.315 ± 0.017	0.506HisMet: 0.506 ± 0.007	1.019HisAsn: 1.019 ± 0.012	1.2HisPro: 1.2 ± 0.011	0.998HisGln: 0.998 ± 0.012	1.332HisArg: 1.332 ± 0.015	1.948HisSer: 1.948 ± 0.014	1.135HisThr: 1.135 ± 0.013	1.595HisVal: 1.595 ± 0.012	0.314HisTrp: 0.314 ± 0.005	0.797HisTyr: 0.797 ± 0.01	0.001HisXaa: 0.001 ± 0.0
Ile	3.409IleAla: 3.409 ± 0.024	1.258IleCys: 1.258 ± 0.013	2.679IleAsp: 2.679 ± 0.019	3.099IleGlu: 3.099 ± 0.02	2.366IlePhe: 2.366 ± 0.019	2.928IleGly: 2.928 ± 0.026	1.277IleHis: 1.277 ± 0.013	2.899IleIle: 2.899 ± 0.019	3.266IleLys: 3.266 ± 0.019	4.934IleLeu: 4.934 ± 0.026	1.101IleMet: 1.101 ± 0.01	2.315IleAsn: 2.315 ± 0.015	2.671IlePro: 2.671 ± 0.018	2.124IleGln: 2.124 ± 0.015	2.694IleArg: 2.694 ± 0.02	4.515IleSer: 4.515 ± 0.026	3.302IleThr: 3.302 ± 0.023	3.461IleVal: 3.461 ± 0.022	0.61IleTrp: 0.61 ± 0.009	1.576IleTyr: 1.576 ± 0.015	0.003IleXaa: 0.003 ± 0.001
Lys	4.17LysAla: 4.17 ± 0.03	1.438LysCys: 1.438 ± 0.018	3.782LysAsp: 3.782 ± 0.024	5.578LysGlu: 5.578 ± 0.042	2.379LysPhe: 2.379 ± 0.017	3.619LysGly: 3.619 ± 0.026	1.502LysHis: 1.502 ± 0.014	3.561LysIle: 3.561 ± 0.022	5.399LysLys: 5.399 ± 0.039	5.784LysLeu: 5.784 ± 0.03	1.561LysMet: 1.561 ± 0.014	3.121LysAsn: 3.121 ± 0.019	2.926LysPro: 2.926 ± 0.022	2.711LysGln: 2.711 ± 0.018	4.18LysArg: 4.18 ± 0.028	4.828LysSer: 4.828 ± 0.026	3.986LysThr: 3.986 ± 0.027	3.986LysVal: 3.986 ± 0.023	0.769LysTrp: 0.769 ± 0.009	1.951LysTyr: 1.951 ± 0.017	0.005LysXaa: 0.005 ± 0.001
Leu	5.665LeuAla: 5.665 ± 0.031	2.04LeuCys: 2.04 ± 0.018	4.43LeuAsp: 4.43 ± 0.026	6.1LeuGlu: 6.1 ± 0.047	3.781LeuPhe: 3.781 ± 0.027	4.876LeuGly: 4.876 ± 0.036	2.308LeuHis: 2.308 ± 0.018	4.385LeuIle: 4.385 ± 0.024	6.339LeuLys: 6.339 ± 0.038	8.749LeuLeu: 8.749 ± 0.052	1.956LeuMet: 1.956 ± 0.015	4.118LeuAsn: 4.118 ± 0.021	4.453LeuPro: 4.453 ± 0.022	4.326LeuGln: 4.326 ± 0.029	5.175LeuArg: 5.175 ± 0.032	7.545LeuSer: 7.545 ± 0.038	5.097LeuThr: 5.097 ± 0.023	5.684LeuVal: 5.684 ± 0.032	1.049LeuTrp: 1.049 ± 0.012	2.574LeuTyr: 2.574 ± 0.017	0.006LeuXaa: 0.006 ± 0.001
Met	1.897MetAla: 1.897 ± 0.014	0.416MetCys: 0.416 ± 0.007	1.183MetAsp: 1.183 ± 0.012	1.684MetGlu: 1.684 ± 0.014	0.943MetPhe: 0.943 ± 0.01	1.084MetGly: 1.084 ± 0.013	0.408MetHis: 0.408 ± 0.007	1.104MetIle: 1.104 ± 0.01	1.636MetLys: 1.636 ± 0.014	1.823MetLeu: 1.823 ± 0.012	0.567MetMet: 0.567 ± 0.009	1.042MetAsn: 1.042 ± 0.01	0.902MetPro: 0.902 ± 0.011	0.805MetGln: 0.805 ± 0.01	1.104MetArg: 1.104 ± 0.011	1.71MetSer: 1.71 ± 0.016	1.293MetThr: 1.293 ± 0.013	1.328MetVal: 1.328 ± 0.012	0.252MetTrp: 0.252 ± 0.005	0.624MetTyr: 0.624 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	2.652AsnAla: 2.652 ± 0.018	1.203AsnCys: 1.203 ± 0.016	2.411AsnAsp: 2.411 ± 0.02	2.996AsnGlu: 2.996 ± 0.021	1.996AsnPhe: 1.996 ± 0.015	3.239AsnGly: 3.239 ± 0.028	1.07AsnHis: 1.07 ± 0.012	2.662AsnIle: 2.662 ± 0.016	2.875AsnLys: 2.875 ± 0.02	4.177AsnLeu: 4.177 ± 0.025	1.023AsnMet: 1.023 ± 0.01	2.339AsnAsn: 2.339 ± 0.02	2.255AsnPro: 2.255 ± 0.018	1.786AsnGln: 1.786 ± 0.016	2.317AsnArg: 2.317 ± 0.018	4.022AsnSer: 4.022 ± 0.025	2.575AsnThr: 2.575 ± 0.017	3.02AsnVal: 3.02 ± 0.021	0.548AsnTrp: 0.548 ± 0.009	1.422AsnTyr: 1.422 ± 0.014	0.003AsnXaa: 0.003 ± 0.0
Pro	2.682ProAla: 2.682 ± 0.023	0.99ProCys: 0.99 ± 0.018	2.35ProAsp: 2.35 ± 0.016	2.912ProGlu: 2.912 ± 0.022	1.879ProPhe: 1.879 ± 0.016	2.944ProGly: 2.944 ± 0.039	1.004ProHis: 1.004 ± 0.009	1.934ProIle: 1.934 ± 0.017	2.709ProLys: 2.709 ± 0.02	4.034ProLeu: 4.034 ± 0.024	0.837ProMet: 0.837 ± 0.011	1.938ProAsn: 1.938 ± 0.015	3.332ProPro: 3.332 ± 0.038	1.857ProGln: 1.857 ± 0.019	2.382ProArg: 2.382 ± 0.021	4.457ProSer: 4.457 ± 0.031	2.675ProThr: 2.675 ± 0.031	3.25ProVal: 3.25 ± 0.022	0.544ProTrp: 0.544 ± 0.009	1.285ProTyr: 1.285 ± 0.012	0.003ProXaa: 0.003 ± 0.0
Gln	2.524GlnAla: 2.524 ± 0.017	0.848GlnCys: 0.848 ± 0.014	2.011GlnAsp: 2.011 ± 0.015	3.013GlnGlu: 3.013 ± 0.027	1.481GlnPhe: 1.481 ± 0.013	2.373GlnGly: 2.373 ± 0.021	0.959GlnHis: 0.959 ± 0.011	2.027GlnIle: 2.027 ± 0.015	2.596GlnLys: 2.596 ± 0.023	3.666GlnLeu: 3.666 ± 0.026	0.934GlnMet: 0.934 ± 0.009	1.908GlnAsn: 1.908 ± 0.013	1.812GlnPro: 1.812 ± 0.021	2.213GlnGln: 2.213 ± 0.033	2.496GlnArg: 2.496 ± 0.018	3.007GlnSer: 3.007 ± 0.02	2.289GlnThr: 2.289 ± 0.016	2.477GlnVal: 2.477 ± 0.015	0.524GlnTrp: 0.524 ± 0.011	1.1GlnTyr: 1.1 ± 0.012	0.002GlnXaa: 0.002 ± 0.0
Arg	3.0ArgAla: 3.0 ± 0.021	1.203ArgCys: 1.203 ± 0.015	2.851ArgAsp: 2.851 ± 0.021	3.806ArgGlu: 3.806 ± 0.032	2.15ArgPhe: 2.15 ± 0.016	3.118ArgGly: 3.118 ± 0.025	1.365ArgHis: 1.365 ± 0.011	2.804ArgIle: 2.804 ± 0.019	4.284ArgLys: 4.284 ± 0.03	4.761ArgLeu: 4.761 ± 0.028	1.175ArgMet: 1.175 ± 0.01	2.737ArgAsn: 2.737 ± 0.019	2.28ArgPro: 2.28 ± 0.023	2.316ArgGln: 2.316 ± 0.017	4.073ArgArg: 4.073 ± 0.093	4.198ArgSer: 4.198 ± 0.027	2.889ArgThr: 2.889 ± 0.018	3.208ArgVal: 3.208 ± 0.02	0.652ArgTrp: 0.652 ± 0.01	1.694ArgTyr: 1.694 ± 0.018	0.003ArgXaa: 0.003 ± 0.001
Ser	4.891SerAla: 4.891 ± 0.027	2.009SerCys: 2.009 ± 0.021	4.401SerAsp: 4.401 ± 0.026	4.989SerGlu: 4.989 ± 0.032	3.644SerPhe: 3.644 ± 0.021	5.136SerGly: 5.136 ± 0.042	1.915SerHis: 1.915 ± 0.016	3.864SerIle: 3.864 ± 0.021	4.962SerLys: 4.962 ± 0.03	7.982SerLeu: 7.982 ± 0.038	1.609SerMet: 1.609 ± 0.014	3.657SerAsn: 3.657 ± 0.022	4.299SerPro: 4.299 ± 0.035	3.247SerGln: 3.247 ± 0.019	4.324SerArg: 4.324 ± 0.023	9.102SerSer: 9.102 ± 0.068	4.865SerThr: 4.865 ± 0.04	5.438SerVal: 5.438 ± 0.034	1.03SerTrp: 1.03 ± 0.012	2.465SerTyr: 2.465 ± 0.018	0.005SerXaa: 0.005 ± 0.001
Thr	3.828ThrAla: 3.828 ± 0.025	1.441ThrCys: 1.441 ± 0.02	2.917ThrAsp: 2.917 ± 0.022	3.665ThrGlu: 3.665 ± 0.026	2.484ThrPhe: 2.484 ± 0.018	3.513ThrGly: 3.513 ± 0.03	1.16ThrHis: 1.16 ± 0.011	2.934ThrIle: 2.934 ± 0.023	3.524ThrLys: 3.524 ± 0.025	5.097ThrLeu: 5.097 ± 0.028	1.185ThrMet: 1.185 ± 0.01	2.513ThrAsn: 2.513 ± 0.018	2.915ThrPro: 2.915 ± 0.024	2.09ThrGln: 2.09 ± 0.015	2.782ThrArg: 2.782 ± 0.017	5.221ThrSer: 5.221 ± 0.039	3.662ThrThr: 3.662 ± 0.034	4.147ThrVal: 4.147 ± 0.032	0.725ThrTrp: 0.725 ± 0.01	1.562ThrTyr: 1.562 ± 0.016	0.004ThrXaa: 0.004 ± 0.001
Val	4.118ValAla: 4.118 ± 0.027	1.517ValCys: 1.517 ± 0.015	3.502ValAsp: 3.502 ± 0.026	4.136ValGlu: 4.136 ± 0.028	3.041ValPhe: 3.041 ± 0.02	3.497ValGly: 3.497 ± 0.029	1.505ValHis: 1.505 ± 0.013	3.777ValIle: 3.777 ± 0.027	4.234ValLys: 4.234 ± 0.024	6.042ValLeu: 6.042 ± 0.033	1.493ValMet: 1.493 ± 0.013	3.041ValAsn: 3.041 ± 0.02	2.953ValPro: 2.953 ± 0.02	2.539ValGln: 2.539 ± 0.017	3.139ValArg: 3.139 ± 0.023	5.241ValSer: 5.241 ± 0.033	4.325ValThr: 4.325 ± 0.028	4.708ValVal: 4.708 ± 0.035	0.756ValTrp: 0.756 ± 0.01	2.0ValTyr: 2.0 ± 0.017	0.004ValXaa: 0.004 ± 0.001
Trp	0.578TrpAla: 0.578 ± 0.009	0.293TrpCys: 0.293 ± 0.007	0.591TrpAsp: 0.591 ± 0.008	0.68TrpGlu: 0.68 ± 0.01	0.55TrpPhe: 0.55 ± 0.008	0.612TrpGly: 0.612 ± 0.009	0.285TrpHis: 0.285 ± 0.005	0.748TrpIle: 0.748 ± 0.011	0.959TrpLys: 0.959 ± 0.011	1.19TrpLeu: 1.19 ± 0.014	0.336TrpMet: 0.336 ± 0.006	0.661TrpAsn: 0.661 ± 0.009	0.448TrpPro: 0.448 ± 0.008	0.471TrpGln: 0.471 ± 0.007	0.766TrpArg: 0.766 ± 0.011	0.986TrpSer: 0.986 ± 0.013	0.721TrpThr: 0.721 ± 0.011	0.677TrpVal: 0.677 ± 0.011	0.195TrpTrp: 0.195 ± 0.005	0.423TrpTyr: 0.423 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.539TyrAla: 1.539 ± 0.013	0.82TyrCys: 0.82 ± 0.017	1.566TyrAsp: 1.566 ± 0.014	1.691TyrGlu: 1.691 ± 0.018	1.503TyrPhe: 1.503 ± 0.015	1.961TyrGly: 1.961 ± 0.02	0.907TyrHis: 0.907 ± 0.017	1.587TyrIle: 1.587 ± 0.013	1.828TyrLys: 1.828 ± 0.016	2.786TyrLeu: 2.786 ± 0.021	0.629TyrMet: 0.629 ± 0.008	1.399TyrAsn: 1.399 ± 0.014	1.251TyrPro: 1.251 ± 0.016	1.251TyrGln: 1.251 ± 0.012	1.702TyrArg: 1.702 ± 0.016	2.373TyrSer: 2.373 ± 0.019	1.591TyrThr: 1.591 ± 0.013	1.827TyrVal: 1.827 ± 0.014	0.425TyrTrp: 0.425 ± 0.009	1.09TyrTyr: 1.09 ± 0.014	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.004XaaGlu: 0.004 ± 0.001	0.003XaaPhe: 0.003 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.004XaaIle: 0.004 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.001	0.003XaaPro: 0.003 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.003XaaArg: 0.003 ± 0.0	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	1.501XaaXaa: 1.501 ± 0.113

Statistics based on 25411 proteins (11566979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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