Amino acid dipepetide frequency for Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.298AlaAla: 13.298 ± 0.173	0.803AlaCys: 0.803 ± 0.028	6.686AlaAsp: 6.686 ± 0.094	7.185AlaGlu: 7.185 ± 0.115	3.378AlaPhe: 3.378 ± 0.057	10.093AlaGly: 10.093 ± 0.112	2.312AlaHis: 2.312 ± 0.054	5.052AlaIle: 5.052 ± 0.082	2.617AlaLys: 2.617 ± 0.06	10.888AlaLeu: 10.888 ± 0.129	2.58AlaMet: 2.58 ± 0.052	2.432AlaAsn: 2.432 ± 0.059	5.288AlaPro: 5.288 ± 0.085	3.745AlaGln: 3.745 ± 0.062	7.272AlaArg: 7.272 ± 0.101	5.613AlaSer: 5.613 ± 0.075	7.16AlaThr: 7.16 ± 0.088	9.584AlaVal: 9.584 ± 0.116	1.446AlaTrp: 1.446 ± 0.036	2.083AlaTyr: 2.083 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.728CysAla: 0.728 ± 0.029	0.103CysCys: 0.103 ± 0.011	0.438CysAsp: 0.438 ± 0.021	0.35CysGlu: 0.35 ± 0.02	0.23CysPhe: 0.23 ± 0.016	0.762CysGly: 0.762 ± 0.034	0.231CysHis: 0.231 ± 0.016	0.302CysIle: 0.302 ± 0.016	0.113CysLys: 0.113 ± 0.009	0.591CysLeu: 0.591 ± 0.029	0.126CysMet: 0.126 ± 0.011	0.182CysAsn: 0.182 ± 0.015	0.433CysPro: 0.433 ± 0.022	0.214CysGln: 0.214 ± 0.015	0.486CysArg: 0.486 ± 0.023	0.495CysSer: 0.495 ± 0.023	0.514CysThr: 0.514 ± 0.027	0.572CysVal: 0.572 ± 0.024	0.104CysTrp: 0.104 ± 0.01	0.143CysTyr: 0.143 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.625AspAla: 6.625 ± 0.097	0.396AspCys: 0.396 ± 0.021	3.651AspAsp: 3.651 ± 0.077	4.17AspGlu: 4.17 ± 0.065	1.983AspPhe: 1.983 ± 0.048	5.087AspGly: 5.087 ± 0.079	1.591AspHis: 1.591 ± 0.048	3.152AspIle: 3.152 ± 0.066	1.633AspLys: 1.633 ± 0.041	6.105AspLeu: 6.105 ± 0.08	1.178AspMet: 1.178 ± 0.036	1.771AspAsn: 1.771 ± 0.042	4.014AspPro: 4.014 ± 0.075	1.916AspGln: 1.916 ± 0.043	3.975AspArg: 3.975 ± 0.076	2.936AspSer: 2.936 ± 0.056	3.896AspThr: 3.896 ± 0.07	4.562AspVal: 4.562 ± 0.072	0.884AspTrp: 0.884 ± 0.034	1.476AspTyr: 1.476 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.321GluAla: 6.321 ± 0.094	0.32GluCys: 0.32 ± 0.021	3.616GluAsp: 3.616 ± 0.081	4.354GluGlu: 4.354 ± 0.088	2.024GluPhe: 2.024 ± 0.049	4.399GluGly: 4.399 ± 0.081	1.569GluHis: 1.569 ± 0.045	3.51GluIle: 3.51 ± 0.069	2.166GluLys: 2.166 ± 0.059	6.654GluLeu: 6.654 ± 0.099	1.377GluMet: 1.377 ± 0.036	1.82GluAsn: 1.82 ± 0.051	2.788GluPro: 2.788 ± 0.075	2.638GluGln: 2.638 ± 0.056	4.05GluArg: 4.05 ± 0.072	2.996GluSer: 2.996 ± 0.057	3.401GluThr: 3.401 ± 0.061	5.133GluVal: 5.133 ± 0.079	0.781GluTrp: 0.781 ± 0.03	1.297GluTyr: 1.297 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.378PheAla: 3.378 ± 0.067	0.266PheCys: 0.266 ± 0.019	2.226PheAsp: 2.226 ± 0.051	1.797PheGlu: 1.797 ± 0.046	1.192PhePhe: 1.192 ± 0.044	3.245PheGly: 3.245 ± 0.063	0.805PheHis: 0.805 ± 0.031	1.813PheIle: 1.813 ± 0.046	0.652PheLys: 0.652 ± 0.028	3.086PheLeu: 3.086 ± 0.063	0.674PheMet: 0.674 ± 0.031	0.967PheAsn: 0.967 ± 0.034	1.611PhePro: 1.611 ± 0.044	0.896PheGln: 0.896 ± 0.031	1.853PheArg: 1.853 ± 0.042	2.004PheSer: 2.004 ± 0.05	2.454PheThr: 2.454 ± 0.046	2.263PheVal: 2.263 ± 0.048	0.47PheTrp: 0.47 ± 0.022	0.798PheTyr: 0.798 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.659GlyAla: 8.659 ± 0.113	0.723GlyCys: 0.723 ± 0.033	4.881GlyAsp: 4.881 ± 0.075	5.44GlyGlu: 5.44 ± 0.086	3.164GlyPhe: 3.164 ± 0.063	7.464GlyGly: 7.464 ± 0.144	2.007GlyHis: 2.007 ± 0.049	4.896GlyIle: 4.896 ± 0.086	2.443GlyLys: 2.443 ± 0.059	8.181GlyLeu: 8.181 ± 0.105	2.41GlyMet: 2.41 ± 0.055	2.146GlyAsn: 2.146 ± 0.053	3.548GlyPro: 3.548 ± 0.073	2.949GlyGln: 2.949 ± 0.057	5.605GlyArg: 5.605 ± 0.087	5.096GlySer: 5.096 ± 0.075	5.555GlyThr: 5.555 ± 0.081	7.533GlyVal: 7.533 ± 0.098	1.521GlyTrp: 1.521 ± 0.045	2.23GlyTyr: 2.23 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.194HisAla: 2.194 ± 0.053	0.191HisCys: 0.191 ± 0.014	1.324HisAsp: 1.324 ± 0.038	1.192HisGlu: 1.192 ± 0.038	0.668HisPhe: 0.668 ± 0.028	2.049HisGly: 2.049 ± 0.05	0.827HisHis: 0.827 ± 0.039	1.085HisIle: 1.085 ± 0.03	0.423HisLys: 0.423 ± 0.024	2.406HisLeu: 2.406 ± 0.056	0.491HisMet: 0.491 ± 0.021	0.639HisAsn: 0.639 ± 0.028	1.812HisPro: 1.812 ± 0.045	0.794HisGln: 0.794 ± 0.03	1.902HisArg: 1.902 ± 0.053	1.154HisSer: 1.154 ± 0.042	1.374HisThr: 1.374 ± 0.039	1.523HisVal: 1.523 ± 0.04	0.291HisTrp: 0.291 ± 0.018	0.551HisTyr: 0.551 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.115IleAla: 6.115 ± 0.091	0.358IleCys: 0.358 ± 0.02	3.624IleAsp: 3.624 ± 0.07	3.02IleGlu: 3.02 ± 0.057	1.573IlePhe: 1.573 ± 0.04	4.539IleGly: 4.539 ± 0.083	1.14IleHis: 1.14 ± 0.037	2.963IleIle: 2.963 ± 0.064	1.172IleLys: 1.172 ± 0.037	4.697IleLeu: 4.697 ± 0.074	1.107IleMet: 1.107 ± 0.038	1.734IleAsn: 1.734 ± 0.044	3.118IlePro: 3.118 ± 0.056	1.348IleGln: 1.348 ± 0.038	3.292IleArg: 3.292 ± 0.067	3.074IleSer: 3.074 ± 0.057	3.94IleThr: 3.94 ± 0.059	3.88IleVal: 3.88 ± 0.062	0.63IleTrp: 0.63 ± 0.027	1.02IleTyr: 1.02 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.766LysAla: 2.766 ± 0.064	0.111LysCys: 0.111 ± 0.01	1.447LysAsp: 1.447 ± 0.047	1.414LysGlu: 1.414 ± 0.038	0.752LysPhe: 0.752 ± 0.027	1.863LysGly: 1.863 ± 0.049	0.574LysHis: 0.574 ± 0.024	1.415LysIle: 1.415 ± 0.041	1.389LysLys: 1.389 ± 0.046	2.51LysLeu: 2.51 ± 0.06	0.676LysMet: 0.676 ± 0.026	0.957LysAsn: 0.957 ± 0.035	1.452LysPro: 1.452 ± 0.048	0.959LysGln: 0.959 ± 0.031	1.871LysArg: 1.871 ± 0.05	1.374LysSer: 1.374 ± 0.039	1.677LysThr: 1.677 ± 0.045	2.039LysVal: 2.039 ± 0.047	0.367LysTrp: 0.367 ± 0.019	0.573LysTyr: 0.573 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.435LeuAla: 11.435 ± 0.137	0.695LeuCys: 0.695 ± 0.026	6.167LeuAsp: 6.167 ± 0.091	5.251LeuGlu: 5.251 ± 0.079	2.953LeuPhe: 2.953 ± 0.07	8.661LeuGly: 8.661 ± 0.119	1.979LeuHis: 1.979 ± 0.05	5.388LeuIle: 5.388 ± 0.086	2.489LeuLys: 2.489 ± 0.055	9.203LeuLeu: 9.203 ± 0.119	2.085LeuMet: 2.085 ± 0.042	2.595LeuAsn: 2.595 ± 0.055	5.432LeuPro: 5.432 ± 0.085	2.621LeuGln: 2.621 ± 0.052	6.271LeuArg: 6.271 ± 0.096	5.859LeuSer: 5.859 ± 0.078	6.453LeuThr: 6.453 ± 0.08	8.02LeuVal: 8.02 ± 0.099	1.178LeuTrp: 1.178 ± 0.041	1.743LeuTyr: 1.743 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.625MetAla: 2.625 ± 0.059	0.175MetCys: 0.175 ± 0.015	1.244MetAsp: 1.244 ± 0.039	1.2MetGlu: 1.2 ± 0.041	0.76MetPhe: 0.76 ± 0.027	1.887MetGly: 1.887 ± 0.056	0.432MetHis: 0.432 ± 0.022	1.294MetIle: 1.294 ± 0.038	0.715MetLys: 0.715 ± 0.028	2.23MetLeu: 2.23 ± 0.051	0.579MetMet: 0.579 ± 0.03	0.757MetAsn: 0.757 ± 0.027	1.209MetPro: 1.209 ± 0.032	0.617MetGln: 0.617 ± 0.024	1.486MetArg: 1.486 ± 0.04	1.747MetSer: 1.747 ± 0.04	1.805MetThr: 1.805 ± 0.042	1.875MetVal: 1.875 ± 0.046	0.293MetTrp: 0.293 ± 0.018	0.349MetTyr: 0.349 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.73AsnAla: 2.73 ± 0.06	0.229AsnCys: 0.229 ± 0.016	1.434AsnAsp: 1.434 ± 0.041	1.442AsnGlu: 1.442 ± 0.038	0.815AsnPhe: 0.815 ± 0.032	2.167AsnGly: 2.167 ± 0.055	0.656AsnHis: 0.656 ± 0.026	1.446AsnIle: 1.446 ± 0.038	0.788AsnLys: 0.788 ± 0.031	2.613AsnLeu: 2.613 ± 0.064	0.583AsnMet: 0.583 ± 0.026	0.921AsnAsn: 0.921 ± 0.032	2.232AsnPro: 2.232 ± 0.048	0.997AsnGln: 0.997 ± 0.038	1.998AsnArg: 1.998 ± 0.048	1.513AsnSer: 1.513 ± 0.044	1.672AsnThr: 1.672 ± 0.042	1.87AsnVal: 1.87 ± 0.045	0.416AsnTrp: 0.416 ± 0.021	0.707AsnTyr: 0.707 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.112ProAla: 6.112 ± 0.084	0.282ProCys: 0.282 ± 0.016	3.854ProAsp: 3.854 ± 0.073	4.456ProGlu: 4.456 ± 0.081	1.582ProPhe: 1.582 ± 0.039	5.34ProGly: 5.34 ± 0.096	1.277ProHis: 1.277 ± 0.037	2.067ProIle: 2.067 ± 0.043	1.269ProLys: 1.269 ± 0.036	4.575ProLeu: 4.575 ± 0.073	1.173ProMet: 1.173 ± 0.034	1.287ProAsn: 1.287 ± 0.036	2.363ProPro: 2.363 ± 0.07	1.724ProGln: 1.724 ± 0.043	3.129ProArg: 3.129 ± 0.058	2.779ProSer: 2.779 ± 0.055	3.765ProThr: 3.765 ± 0.072	5.105ProVal: 5.105 ± 0.083	0.785ProTrp: 0.785 ± 0.029	1.042ProTyr: 1.042 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.665GlnAla: 3.665 ± 0.071	0.197GlnCys: 0.197 ± 0.014	1.655GlnAsp: 1.655 ± 0.039	1.823GlnGlu: 1.823 ± 0.046	0.945GlnPhe: 0.945 ± 0.028	2.373GlnGly: 2.373 ± 0.048	0.76GlnHis: 0.76 ± 0.032	1.823GlnIle: 1.823 ± 0.045	0.929GlnLys: 0.929 ± 0.032	3.545GlnLeu: 3.545 ± 0.06	0.81GlnMet: 0.81 ± 0.029	0.795GlnAsn: 0.795 ± 0.029	1.74GlnPro: 1.74 ± 0.052	1.466GlnGln: 1.466 ± 0.045	2.391GlnArg: 2.391 ± 0.045	1.526GlnSer: 1.526 ± 0.04	1.607GlnThr: 1.607 ± 0.04	2.772GlnVal: 2.772 ± 0.052	0.559GlnTrp: 0.559 ± 0.022	0.648GlnTyr: 0.648 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.782ArgAla: 6.782 ± 0.093	0.444ArgCys: 0.444 ± 0.021	4.025ArgAsp: 4.025 ± 0.083	4.644ArgGlu: 4.644 ± 0.078	2.271ArgPhe: 2.271 ± 0.049	5.209ArgGly: 5.209 ± 0.082	1.558ArgHis: 1.558 ± 0.04	3.651ArgIle: 3.651 ± 0.064	2.014ArgLys: 2.014 ± 0.054	5.92ArgLeu: 5.92 ± 0.084	1.823ArgMet: 1.823 ± 0.04	1.861ArgAsn: 1.861 ± 0.044	3.172ArgPro: 3.172 ± 0.052	2.291ArgGln: 2.291 ± 0.05	5.556ArgArg: 5.556 ± 0.1	3.659ArgSer: 3.659 ± 0.058	3.997ArgThr: 3.997 ± 0.073	5.084ArgVal: 5.084 ± 0.082	1.098ArgTrp: 1.098 ± 0.034	1.575ArgTyr: 1.575 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.722SerAla: 5.722 ± 0.088	0.446SerCys: 0.446 ± 0.024	3.012SerAsp: 3.012 ± 0.064	2.904SerGlu: 2.904 ± 0.059	1.927SerPhe: 1.927 ± 0.041	5.332SerGly: 5.332 ± 0.075	1.215SerHis: 1.215 ± 0.038	2.845SerIle: 2.845 ± 0.058	1.305SerLys: 1.305 ± 0.04	5.265SerLeu: 5.265 ± 0.079	1.62SerMet: 1.62 ± 0.041	1.504SerAsn: 1.504 ± 0.038	3.225SerPro: 3.225 ± 0.061	1.77SerGln: 1.77 ± 0.044	3.852SerArg: 3.852 ± 0.062	3.632SerSer: 3.632 ± 0.077	4.045SerThr: 4.045 ± 0.069	4.436SerVal: 4.436 ± 0.083	0.944SerTrp: 0.944 ± 0.035	1.314SerTyr: 1.314 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	7.301ThrAla: 7.301 ± 0.097	0.441ThrCys: 0.441 ± 0.02	3.905ThrAsp: 3.905 ± 0.056	3.4ThrGlu: 3.4 ± 0.075	2.017ThrPhe: 2.017 ± 0.049	6.427ThrGly: 6.427 ± 0.086	1.474ThrHis: 1.474 ± 0.038	3.292ThrIle: 3.292 ± 0.069	1.263ThrLys: 1.263 ± 0.036	6.082ThrLeu: 6.082 ± 0.075	1.366ThrMet: 1.366 ± 0.036	1.621ThrAsn: 1.621 ± 0.037	4.568ThrPro: 4.568 ± 0.069	1.793ThrGln: 1.793 ± 0.044	4.219ThrArg: 4.219 ± 0.078	3.747ThrSer: 3.747 ± 0.067	5.08ThrThr: 5.08 ± 0.094	6.004ThrVal: 6.004 ± 0.076	0.984ThrTrp: 0.984 ± 0.031	1.352ThrTyr: 1.352 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.439ValAla: 9.439 ± 0.112	0.592ValCys: 0.592 ± 0.026	5.742ValAsp: 5.742 ± 0.082	5.212ValGlu: 5.212 ± 0.086	2.811ValPhe: 2.811 ± 0.049	6.599ValGly: 6.599 ± 0.103	1.704ValHis: 1.704 ± 0.042	4.615ValIle: 4.615 ± 0.071	1.94ValLys: 1.94 ± 0.042	8.088ValLeu: 8.088 ± 0.111	1.845ValMet: 1.845 ± 0.049	2.162ValAsn: 2.162 ± 0.055	4.144ValPro: 4.144 ± 0.072	2.066ValGln: 2.066 ± 0.049	4.846ValArg: 4.846 ± 0.076	4.834ValSer: 4.834 ± 0.064	5.775ValThr: 5.775 ± 0.084	7.746ValVal: 7.746 ± 0.101	1.046ValTrp: 1.046 ± 0.038	1.569ValTyr: 1.569 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.478TrpAla: 1.478 ± 0.043	0.156TrpCys: 0.156 ± 0.014	0.753TrpAsp: 0.753 ± 0.029	0.775TrpGlu: 0.775 ± 0.03	0.588TrpPhe: 0.588 ± 0.024	1.051TrpGly: 1.051 ± 0.033	0.298TrpHis: 0.298 ± 0.016	0.838TrpIle: 0.838 ± 0.028	0.421TrpLys: 0.421 ± 0.021	1.559TrpLeu: 1.559 ± 0.043	0.394TrpMet: 0.394 ± 0.017	0.459TrpAsn: 0.459 ± 0.022	0.654TrpPro: 0.654 ± 0.028	0.519TrpGln: 0.519 ± 0.022	0.98TrpArg: 0.98 ± 0.031	0.87TrpSer: 0.87 ± 0.029	0.792TrpThr: 0.792 ± 0.029	1.253TrpVal: 1.253 ± 0.04	0.392TrpTrp: 0.392 ± 0.02	0.295TrpTyr: 0.295 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.143TyrAla: 2.143 ± 0.046	0.189TyrCys: 0.189 ± 0.014	1.317TyrAsp: 1.317 ± 0.034	1.184TyrGlu: 1.184 ± 0.037	0.816TyrPhe: 0.816 ± 0.033	1.904TyrGly: 1.904 ± 0.042	0.478TyrHis: 0.478 ± 0.023	0.899TyrIle: 0.899 ± 0.036	0.447TyrLys: 0.447 ± 0.022	2.28TyrLeu: 2.28 ± 0.046	0.381TyrMet: 0.381 ± 0.022	0.619TyrAsn: 0.619 ± 0.025	1.164TyrPro: 1.164 ± 0.037	0.709TyrGln: 0.709 ± 0.028	1.598TyrArg: 1.598 ± 0.045	1.407TyrSer: 1.407 ± 0.043	1.372TyrThr: 1.372 ± 0.038	1.522TyrVal: 1.522 ± 0.036	0.335TyrTrp: 0.335 ± 0.02	0.502TyrTyr: 0.502 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2946 proteins (959932 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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