Amino acid dipepetide frequency for Erysipelotrichaceae bacterium MTC7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.56AlaAla: 4.56 ± 0.107	1.027AlaCys: 1.027 ± 0.046	3.592AlaAsp: 3.592 ± 0.075	3.459AlaGlu: 3.459 ± 0.087	3.189AlaPhe: 3.189 ± 0.06	4.558AlaGly: 4.558 ± 0.102	1.145AlaHis: 1.145 ± 0.045	6.231AlaIle: 6.231 ± 0.106	6.026AlaLys: 6.026 ± 0.114	6.996AlaLeu: 6.996 ± 0.109	2.257AlaMet: 2.257 ± 0.055	3.926AlaAsn: 3.926 ± 0.085	1.692AlaPro: 1.692 ± 0.052	2.369AlaGln: 2.369 ± 0.056	2.445AlaArg: 2.445 ± 0.063	4.416AlaSer: 4.416 ± 0.092	4.205AlaThr: 4.205 ± 0.113	4.392AlaVal: 4.392 ± 0.086	0.632AlaTrp: 0.632 ± 0.031	3.309AlaTyr: 3.309 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.766CysAla: 0.766 ± 0.04	0.156CysCys: 0.156 ± 0.016	0.636CysAsp: 0.636 ± 0.028	0.716CysGlu: 0.716 ± 0.032	0.511CysPhe: 0.511 ± 0.025	0.913CysGly: 0.913 ± 0.037	0.244CysHis: 0.244 ± 0.016	0.978CysIle: 0.978 ± 0.042	0.764CysLys: 0.764 ± 0.039	0.89CysLeu: 0.89 ± 0.037	0.335CysMet: 0.335 ± 0.023	0.509CysAsn: 0.509 ± 0.029	0.457CysPro: 0.457 ± 0.029	0.306CysGln: 0.306 ± 0.022	0.339CysArg: 0.339 ± 0.02	0.646CysSer: 0.646 ± 0.031	0.561CysThr: 0.561 ± 0.029	0.766CysVal: 0.766 ± 0.035	0.041CysTrp: 0.041 ± 0.008	0.387CysTyr: 0.387 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.772AspAla: 4.772 ± 0.096	0.595AspCys: 0.595 ± 0.033	3.64AspAsp: 3.64 ± 0.068	5.073AspGlu: 5.073 ± 0.091	2.949AspPhe: 2.949 ± 0.062	4.179AspGly: 4.179 ± 0.092	1.183AspHis: 1.183 ± 0.041	4.825AspIle: 4.825 ± 0.094	3.954AspLys: 3.954 ± 0.084	5.086AspLeu: 5.086 ± 0.089	1.857AspMet: 1.857 ± 0.053	2.463AspAsn: 2.463 ± 0.064	1.84AspPro: 1.84 ± 0.056	1.847AspGln: 1.847 ± 0.05	2.053AspArg: 2.053 ± 0.06	2.975AspSer: 2.975 ± 0.064	3.244AspThr: 3.244 ± 0.073	4.913AspVal: 4.913 ± 0.082	0.499AspTrp: 0.499 ± 0.028	2.964AspTyr: 2.964 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	5.305GluAla: 5.305 ± 0.099	0.518GluCys: 0.518 ± 0.026	4.123GluAsp: 4.123 ± 0.078	5.374GluGlu: 5.374 ± 0.109	2.367GluPhe: 2.367 ± 0.056	3.902GluGly: 3.902 ± 0.083	1.532GluHis: 1.532 ± 0.049	5.498GluIle: 5.498 ± 0.102	5.731GluLys: 5.731 ± 0.107	6.634GluLeu: 6.634 ± 0.114	2.324GluMet: 2.324 ± 0.061	3.989GluAsn: 3.989 ± 0.075	1.708GluPro: 1.708 ± 0.051	2.819GluGln: 2.819 ± 0.067	2.796GluArg: 2.796 ± 0.068	3.496GluSer: 3.496 ± 0.074	3.797GluThr: 3.797 ± 0.074	5.374GluVal: 5.374 ± 0.108	0.458GluTrp: 0.458 ± 0.026	2.574GluTyr: 2.574 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.18PheAla: 3.18 ± 0.072	0.481PheCys: 0.481 ± 0.029	3.01PheAsp: 3.01 ± 0.079	2.878PheGlu: 2.878 ± 0.066	1.837PhePhe: 1.837 ± 0.058	2.856PheGly: 2.856 ± 0.078	0.872PheHis: 0.872 ± 0.038	3.3PheIle: 3.3 ± 0.082	2.672PheLys: 2.672 ± 0.061	3.542PheLeu: 3.542 ± 0.07	1.205PheMet: 1.205 ± 0.043	1.913PheAsn: 1.913 ± 0.05	1.248PhePro: 1.248 ± 0.041	1.303PheGln: 1.303 ± 0.045	1.308PheArg: 1.308 ± 0.043	2.86PheSer: 2.86 ± 0.066	2.683PheThr: 2.683 ± 0.053	3.422PheVal: 3.422 ± 0.066	0.339PheTrp: 0.339 ± 0.024	1.739PheTyr: 1.739 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.119GlyAla: 4.119 ± 0.101	0.846GlyCys: 0.846 ± 0.038	3.507GlyAsp: 3.507 ± 0.081	3.784GlyGlu: 3.784 ± 0.077	3.118GlyPhe: 3.118 ± 0.067	4.322GlyGly: 4.322 ± 0.113	1.179GlyHis: 1.179 ± 0.042	5.371GlyIle: 5.371 ± 0.104	4.757GlyLys: 4.757 ± 0.079	5.642GlyLeu: 5.642 ± 0.105	2.086GlyMet: 2.086 ± 0.056	2.993GlyAsn: 2.993 ± 0.07	1.237GlyPro: 1.237 ± 0.048	1.917GlyGln: 1.917 ± 0.054	2.236GlyArg: 2.236 ± 0.063	3.801GlySer: 3.801 ± 0.078	3.824GlyThr: 3.824 ± 0.093	4.895GlyVal: 4.895 ± 0.089	0.59GlyTrp: 0.59 ± 0.034	3.03GlyTyr: 3.03 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	1.506HisAla: 1.506 ± 0.049	0.225HisCys: 0.225 ± 0.017	1.235HisAsp: 1.235 ± 0.042	1.427HisGlu: 1.427 ± 0.046	0.846HisPhe: 0.846 ± 0.036	1.401HisGly: 1.401 ± 0.05	0.55HisHis: 0.55 ± 0.031	1.506HisIle: 1.506 ± 0.051	1.24HisLys: 1.24 ± 0.045	1.65HisLeu: 1.65 ± 0.047	0.595HisMet: 0.595 ± 0.029	0.875HisAsn: 0.875 ± 0.036	0.904HisPro: 0.904 ± 0.04	0.78HisGln: 0.78 ± 0.038	0.692HisArg: 0.692 ± 0.03	1.013HisSer: 1.013 ± 0.037	1.111HisThr: 1.111 ± 0.034	1.537HisVal: 1.537 ± 0.046	0.163HisTrp: 0.163 ± 0.015	0.88HisTyr: 0.88 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.132IleAla: 6.132 ± 0.101	0.99IleCys: 0.99 ± 0.036	5.271IleAsp: 5.271 ± 0.112	5.634IleGlu: 5.634 ± 0.081	2.974IlePhe: 2.974 ± 0.086	4.732IleGly: 4.732 ± 0.087	1.606IleHis: 1.606 ± 0.054	5.404IleIle: 5.404 ± 0.102	4.959IleLys: 4.959 ± 0.092	6.709IleLeu: 6.709 ± 0.107	1.972IleMet: 1.972 ± 0.057	3.476IleAsn: 3.476 ± 0.084	2.911IlePro: 2.911 ± 0.07	2.938IleGln: 2.938 ± 0.073	2.934IleArg: 2.934 ± 0.071	4.907IleSer: 4.907 ± 0.085	4.219IleThr: 4.219 ± 0.074	5.906IleVal: 5.906 ± 0.098	0.532IleTrp: 0.532 ± 0.033	2.949IleTyr: 2.949 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.36LysAla: 5.36 ± 0.104	0.465LysCys: 0.465 ± 0.024	5.201LysAsp: 5.201 ± 0.104	6.871LysGlu: 6.871 ± 0.101	1.885LysPhe: 1.885 ± 0.052	4.06LysGly: 4.06 ± 0.071	1.536LysHis: 1.536 ± 0.044	4.869LysIle: 4.869 ± 0.086	6.285LysLys: 6.285 ± 0.126	6.045LysLeu: 6.045 ± 0.09	2.319LysMet: 2.319 ± 0.057	3.747LysAsn: 3.747 ± 0.075	2.172LysPro: 2.172 ± 0.063	3.542LysGln: 3.542 ± 0.081	3.28LysArg: 3.28 ± 0.078	3.518LysSer: 3.518 ± 0.072	4.104LysThr: 4.104 ± 0.081	5.157LysVal: 5.157 ± 0.088	0.455LysTrp: 0.455 ± 0.025	2.681LysTyr: 2.681 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	6.822LeuAla: 6.822 ± 0.112	1.152LeuCys: 1.152 ± 0.048	5.755LeuAsp: 5.755 ± 0.096	6.28LeuGlu: 6.28 ± 0.102	3.793LeuPhe: 3.793 ± 0.083	5.62LeuGly: 5.62 ± 0.095	2.124LeuHis: 2.124 ± 0.053	6.03LeuIle: 6.03 ± 0.107	6.073LeuLys: 6.073 ± 0.096	8.825LeuLeu: 8.825 ± 0.165	2.511LeuMet: 2.511 ± 0.063	3.939LeuAsn: 3.939 ± 0.082	3.233LeuPro: 3.233 ± 0.077	3.843LeuGln: 3.843 ± 0.074	3.322LeuArg: 3.322 ± 0.092	6.003LeuSer: 6.003 ± 0.1	4.927LeuThr: 4.927 ± 0.104	6.376LeuVal: 6.376 ± 0.1	0.69LeuTrp: 0.69 ± 0.031	3.384LeuTyr: 3.384 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.855MetAla: 1.855 ± 0.056	0.295MetCys: 0.295 ± 0.021	1.968MetAsp: 1.968 ± 0.059	1.994MetGlu: 1.994 ± 0.055	1.204MetPhe: 1.204 ± 0.042	1.751MetGly: 1.751 ± 0.058	0.613MetHis: 0.613 ± 0.028	2.271MetIle: 2.271 ± 0.047	2.687MetLys: 2.687 ± 0.065	2.579MetLeu: 2.579 ± 0.062	0.986MetMet: 0.986 ± 0.038	1.78MetAsn: 1.78 ± 0.048	0.935MetPro: 0.935 ± 0.041	1.294MetGln: 1.294 ± 0.048	1.124MetArg: 1.124 ± 0.042	1.868MetSer: 1.868 ± 0.054	1.146MetThr: 1.146 ± 0.041	1.958MetVal: 1.958 ± 0.05	0.152MetTrp: 0.152 ± 0.015	1.1MetTyr: 1.1 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	3.306AsnAla: 3.306 ± 0.08	0.487AsnCys: 0.487 ± 0.028	2.977AsnAsp: 2.977 ± 0.074	3.627AsnGlu: 3.627 ± 0.081	1.953AsnPhe: 1.953 ± 0.056	3.298AsnGly: 3.298 ± 0.088	1.064AsnHis: 1.064 ± 0.044	3.908AsnIle: 3.908 ± 0.085	3.501AsnLys: 3.501 ± 0.073	4.198AsnLeu: 4.198 ± 0.084	1.36AsnMet: 1.36 ± 0.046	2.256AsnAsn: 2.256 ± 0.075	1.987AsnPro: 1.987 ± 0.057	2.083AsnGln: 2.083 ± 0.067	2.011AsnArg: 2.011 ± 0.058	2.343AsnSer: 2.343 ± 0.063	2.561AsnThr: 2.561 ± 0.07	3.543AsnVal: 3.543 ± 0.078	0.414AsnTrp: 0.414 ± 0.025	2.246AsnTyr: 2.246 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.84ProAla: 1.84 ± 0.052	0.287ProCys: 0.287 ± 0.022	1.612ProAsp: 1.612 ± 0.046	2.39ProGlu: 2.39 ± 0.069	1.569ProPhe: 1.569 ± 0.053	1.693ProGly: 1.693 ± 0.053	0.536ProHis: 0.536 ± 0.028	2.501ProIle: 2.501 ± 0.063	2.239ProLys: 2.239 ± 0.057	2.638ProLeu: 2.638 ± 0.064	0.875ProMet: 0.875 ± 0.031	1.71ProAsn: 1.71 ± 0.049	0.602ProPro: 0.602 ± 0.035	0.995ProGln: 0.995 ± 0.039	0.92ProArg: 0.92 ± 0.038	1.907ProSer: 1.907 ± 0.053	1.98ProThr: 1.98 ± 0.052	2.338ProVal: 2.338 ± 0.063	0.306ProTrp: 0.306 ± 0.019	1.496ProTyr: 1.496 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.041GlnAla: 3.041 ± 0.081	0.248GlnCys: 0.248 ± 0.018	2.018GlnAsp: 2.018 ± 0.059	2.753GlnGlu: 2.753 ± 0.062	1.385GlnPhe: 1.385 ± 0.044	2.072GlnGly: 2.072 ± 0.053	0.714GlnHis: 0.714 ± 0.036	2.752GlnIle: 2.752 ± 0.069	2.703GlnLys: 2.703 ± 0.065	3.642GlnLeu: 3.642 ± 0.078	1.25GlnMet: 1.25 ± 0.047	1.781GlnAsn: 1.781 ± 0.059	1.127GlnPro: 1.127 ± 0.044	1.647GlnGln: 1.647 ± 0.066	1.438GlnArg: 1.438 ± 0.054	2.083GlnSer: 2.083 ± 0.057	2.086GlnThr: 2.086 ± 0.055	2.737GlnVal: 2.737 ± 0.063	0.289GlnTrp: 0.289 ± 0.033	1.305GlnTyr: 1.305 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.088ArgAla: 2.088 ± 0.058	0.37ArgCys: 0.37 ± 0.024	1.937ArgAsp: 1.937 ± 0.058	2.496ArgGlu: 2.496 ± 0.065	1.785ArgPhe: 1.785 ± 0.055	1.905ArgGly: 1.905 ± 0.051	0.601ArgHis: 0.601 ± 0.029	3.154ArgIle: 3.154 ± 0.076	3.374ArgLys: 3.374 ± 0.066	3.461ArgLeu: 3.461 ± 0.076	1.234ArgMet: 1.234 ± 0.047	2.069ArgAsn: 2.069 ± 0.065	1.004ArgPro: 1.004 ± 0.042	1.315ArgGln: 1.315 ± 0.048	1.545ArgArg: 1.545 ± 0.057	1.98ArgSer: 1.98 ± 0.058	1.815ArgThr: 1.815 ± 0.05	2.541ArgVal: 2.541 ± 0.055	0.313ArgTrp: 0.313 ± 0.022	1.847ArgTyr: 1.847 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	3.592SerAla: 3.592 ± 0.071	0.609SerCys: 0.609 ± 0.029	3.372SerAsp: 3.372 ± 0.067	3.765SerGlu: 3.765 ± 0.083	3.022SerPhe: 3.022 ± 0.069	4.103SerGly: 4.103 ± 0.096	1.112SerHis: 1.112 ± 0.041	4.803SerIle: 4.803 ± 0.085	4.304SerLys: 4.304 ± 0.087	5.556SerLeu: 5.556 ± 0.096	1.68SerMet: 1.68 ± 0.047	2.963SerAsn: 2.963 ± 0.076	1.518SerPro: 1.518 ± 0.049	2.014SerGln: 2.014 ± 0.06	2.01SerArg: 2.01 ± 0.057	3.492SerSer: 3.492 ± 0.083	3.239SerThr: 3.239 ± 0.074	3.975SerVal: 3.975 ± 0.073	0.487SerTrp: 0.487 ± 0.024	2.73SerTyr: 2.73 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	3.289ThrAla: 3.289 ± 0.077	0.636ThrCys: 0.636 ± 0.031	2.785ThrAsp: 2.785 ± 0.075	2.84ThrGlu: 2.84 ± 0.074	2.727ThrPhe: 2.727 ± 0.069	3.716ThrGly: 3.716 ± 0.064	1.087ThrHis: 1.087 ± 0.043	4.774ThrIle: 4.774 ± 0.092	3.954ThrLys: 3.954 ± 0.086	5.529ThrLeu: 5.529 ± 0.094	1.484ThrMet: 1.484 ± 0.043	2.964ThrAsn: 2.964 ± 0.072	2.123ThrPro: 2.123 ± 0.062	1.582ThrGln: 1.582 ± 0.048	1.869ThrArg: 1.869 ± 0.051	3.638ThrSer: 3.638 ± 0.093	3.533ThrThr: 3.533 ± 0.104	3.705ThrVal: 3.705 ± 0.103	0.522ThrTrp: 0.522 ± 0.033	2.87ThrTyr: 2.87 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	5.361ValAla: 5.361 ± 0.108	0.994ValCys: 0.994 ± 0.035	4.891ValAsp: 4.891 ± 0.089	5.25ValGlu: 5.25 ± 0.099	3.206ValPhe: 3.206 ± 0.07	4.824ValGly: 4.824 ± 0.078	1.383ValHis: 1.383 ± 0.05	5.404ValIle: 5.404 ± 0.1	4.936ValLys: 4.936 ± 0.098	6.71ValLeu: 6.71 ± 0.107	1.957ValMet: 1.957 ± 0.056	3.348ValAsn: 3.348 ± 0.078	2.107ValPro: 2.107 ± 0.058	2.389ValGln: 2.389 ± 0.058	2.575ValArg: 2.575 ± 0.068	4.759ValSer: 4.759 ± 0.079	3.657ValThr: 3.657 ± 0.103	5.493ValVal: 5.493 ± 0.104	0.477ValTrp: 0.477 ± 0.028	2.851ValTyr: 2.851 ± 0.068	0.0ValXaa: 0.0 ± 0.0
Trp	0.431TrpAla: 0.431 ± 0.029	0.097TrpCys: 0.097 ± 0.012	0.474TrpAsp: 0.474 ± 0.026	0.476TrpGlu: 0.476 ± 0.027	0.374TrpPhe: 0.374 ± 0.027	0.516TrpGly: 0.516 ± 0.032	0.128TrpHis: 0.128 ± 0.013	0.616TrpIle: 0.616 ± 0.032	0.607TrpLys: 0.607 ± 0.03	0.764TrpLeu: 0.764 ± 0.036	0.234TrpMet: 0.234 ± 0.02	0.474TrpAsn: 0.474 ± 0.027	0.177TrpPro: 0.177 ± 0.016	0.335TrpGln: 0.335 ± 0.021	0.278TrpArg: 0.278 ± 0.019	0.461TrpSer: 0.461 ± 0.024	0.394TrpThr: 0.394 ± 0.024	0.533TrpVal: 0.533 ± 0.027	0.088TrpTrp: 0.088 ± 0.012	0.361TrpTyr: 0.361 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.102TyrAla: 3.102 ± 0.065	0.442TyrCys: 0.442 ± 0.024	2.907TyrAsp: 2.907 ± 0.063	3.232TyrGlu: 3.232 ± 0.065	1.954TyrPhe: 1.954 ± 0.062	2.834TyrGly: 2.834 ± 0.067	0.927TyrHis: 0.927 ± 0.035	2.962TyrIle: 2.962 ± 0.067	2.783TyrLys: 2.783 ± 0.073	3.606TyrLeu: 3.606 ± 0.082	1.039TyrMet: 1.039 ± 0.038	1.947TyrAsn: 1.947 ± 0.055	1.455TyrPro: 1.455 ± 0.046	1.754TyrGln: 1.754 ± 0.06	1.656TyrArg: 1.656 ± 0.046	2.177TyrSer: 2.177 ± 0.059	2.542TyrThr: 2.542 ± 0.061	3.012TyrVal: 3.012 ± 0.074	0.37TyrTrp: 0.37 ± 0.031	1.892TyrTyr: 1.892 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2314 proteins (729312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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