Amino acid dipepetide frequency for Rhodococcus sp. B7740

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.179AlaAla: 18.179 ± 0.167	0.836AlaCys: 0.836 ± 0.024	8.018AlaAsp: 8.018 ± 0.08	7.493AlaGlu: 7.493 ± 0.081	3.547AlaPhe: 3.547 ± 0.043	10.796AlaGly: 10.796 ± 0.085	2.386AlaHis: 2.386 ± 0.035	5.163AlaIle: 5.163 ± 0.059	2.766AlaLys: 2.766 ± 0.053	13.258AlaLeu: 13.258 ± 0.113	2.68AlaMet: 2.68 ± 0.05	2.271AlaAsn: 2.271 ± 0.045	5.749AlaPro: 5.749 ± 0.068	3.596AlaGln: 3.596 ± 0.052	8.132AlaArg: 8.132 ± 0.073	7.157AlaSer: 7.157 ± 0.069	7.199AlaThr: 7.199 ± 0.079	11.956AlaVal: 11.956 ± 0.107	1.482AlaTrp: 1.482 ± 0.03	2.199AlaTyr: 2.199 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.023	0.086CysCys: 0.086 ± 0.007	0.432CysAsp: 0.432 ± 0.015	0.352CysGlu: 0.352 ± 0.016	0.224CysPhe: 0.224 ± 0.012	0.82CysGly: 0.82 ± 0.024	0.154CysHis: 0.154 ± 0.01	0.278CysIle: 0.278 ± 0.012	0.106CysLys: 0.106 ± 0.008	0.551CysLeu: 0.551 ± 0.018	0.122CysMet: 0.122 ± 0.009	0.145CysAsn: 0.145 ± 0.009	0.39CysPro: 0.39 ± 0.017	0.144CysGln: 0.144 ± 0.009	0.517CysArg: 0.517 ± 0.019	0.564CysSer: 0.564 ± 0.02	0.469CysThr: 0.469 ± 0.017	0.573CysVal: 0.573 ± 0.018	0.101CysTrp: 0.101 ± 0.009	0.133CysTyr: 0.133 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.487AspAla: 8.487 ± 0.084	0.4AspCys: 0.4 ± 0.018	4.151AspAsp: 4.151 ± 0.061	4.011AspGlu: 4.011 ± 0.056	1.78AspPhe: 1.78 ± 0.034	6.098AspGly: 6.098 ± 0.062	1.402AspHis: 1.402 ± 0.03	2.861AspIle: 2.861 ± 0.042	1.267AspLys: 1.267 ± 0.029	6.316AspLeu: 6.316 ± 0.067	0.961AspMet: 0.961 ± 0.022	1.232AspAsn: 1.232 ± 0.028	4.196AspPro: 4.196 ± 0.051	1.512AspGln: 1.512 ± 0.03	5.007AspArg: 5.007 ± 0.057	3.812AspSer: 3.812 ± 0.055	3.534AspThr: 3.534 ± 0.05	5.66AspVal: 5.66 ± 0.075	0.842AspTrp: 0.842 ± 0.024	1.265AspTyr: 1.265 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.679GluAla: 5.679 ± 0.072	0.353GluCys: 0.353 ± 0.015	2.714GluAsp: 2.714 ± 0.046	2.472GluGlu: 2.472 ± 0.051	1.969GluPhe: 1.969 ± 0.036	3.441GluGly: 3.441 ± 0.056	1.547GluHis: 1.547 ± 0.034	2.704GluIle: 2.704 ± 0.04	1.568GluLys: 1.568 ± 0.041	6.693GluLeu: 6.693 ± 0.08	1.074GluMet: 1.074 ± 0.027	1.492GluAsn: 1.492 ± 0.031	2.925GluPro: 2.925 ± 0.047	2.312GluGln: 2.312 ± 0.036	4.339GluArg: 4.339 ± 0.058	3.593GluSer: 3.593 ± 0.051	2.923GluThr: 2.923 ± 0.039	4.307GluVal: 4.307 ± 0.056	0.808GluTrp: 0.808 ± 0.022	1.202GluTyr: 1.202 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.108PheAla: 4.108 ± 0.056	0.279PheCys: 0.279 ± 0.013	2.701PheAsp: 2.701 ± 0.043	1.806PheGlu: 1.806 ± 0.04	1.087PhePhe: 1.087 ± 0.026	3.625PheGly: 3.625 ± 0.048	0.615PheHis: 0.615 ± 0.018	0.897PheIle: 0.897 ± 0.027	0.484PheLys: 0.484 ± 0.019	2.671PheLeu: 2.671 ± 0.043	0.485PheMet: 0.485 ± 0.016	0.557PheAsn: 0.557 ± 0.018	1.392PhePro: 1.392 ± 0.031	0.677PheGln: 0.677 ± 0.022	1.738PheArg: 1.738 ± 0.031	1.783PheSer: 1.783 ± 0.034	2.053PheThr: 2.053 ± 0.031	3.204PheVal: 3.204 ± 0.046	0.418PheTrp: 0.418 ± 0.018	0.692PheTyr: 0.692 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.503GlyAla: 9.503 ± 0.084	0.707GlyCys: 0.707 ± 0.024	4.874GlyAsp: 4.874 ± 0.066	4.374GlyGlu: 4.374 ± 0.059	3.171GlyPhe: 3.171 ± 0.049	7.596GlyGly: 7.596 ± 0.092	1.919GlyHis: 1.919 ± 0.036	4.598GlyIle: 4.598 ± 0.061	2.452GlyLys: 2.452 ± 0.045	8.552GlyLeu: 8.552 ± 0.085	1.925GlyMet: 1.925 ± 0.036	1.973GlyAsn: 1.973 ± 0.039	4.161GlyPro: 4.161 ± 0.051	2.308GlyGln: 2.308 ± 0.046	6.167GlyArg: 6.167 ± 0.059	6.247GlySer: 6.247 ± 0.068	5.893GlyThr: 5.893 ± 0.062	7.666GlyVal: 7.666 ± 0.078	1.496GlyTrp: 1.496 ± 0.029	2.252GlyTyr: 2.252 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.213HisAla: 2.213 ± 0.038	0.207HisCys: 0.207 ± 0.011	1.303HisAsp: 1.303 ± 0.028	1.117HisGlu: 1.117 ± 0.026	0.637HisPhe: 0.637 ± 0.021	1.957HisGly: 1.957 ± 0.04	0.613HisHis: 0.613 ± 0.021	0.824HisIle: 0.824 ± 0.021	0.345HisLys: 0.345 ± 0.015	2.039HisLeu: 2.039 ± 0.035	0.367HisMet: 0.367 ± 0.016	0.438HisAsn: 0.438 ± 0.014	1.463HisPro: 1.463 ± 0.032	0.513HisGln: 0.513 ± 0.018	1.848HisArg: 1.848 ± 0.038	1.313HisSer: 1.313 ± 0.029	1.126HisThr: 1.126 ± 0.029	1.677HisVal: 1.677 ± 0.033	0.335HisTrp: 0.335 ± 0.014	0.446HisTyr: 0.446 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.731IleAla: 6.731 ± 0.073	0.35IleCys: 0.35 ± 0.016	3.867IleAsp: 3.867 ± 0.049	2.971IleGlu: 2.971 ± 0.045	1.088IlePhe: 1.088 ± 0.027	4.901IleGly: 4.901 ± 0.066	0.758IleHis: 0.758 ± 0.022	1.44IleIle: 1.44 ± 0.037	0.801IleLys: 0.801 ± 0.021	3.507IleLeu: 3.507 ± 0.053	0.66IleMet: 0.66 ± 0.024	0.916IleAsn: 0.916 ± 0.025	2.307IlePro: 2.307 ± 0.04	0.768IleGln: 0.768 ± 0.021	2.561IleArg: 2.561 ± 0.039	2.662IleSer: 2.662 ± 0.041	2.83IleThr: 2.83 ± 0.048	4.48IleVal: 4.48 ± 0.063	0.434IleTrp: 0.434 ± 0.018	0.788IleTyr: 0.788 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.656LysAla: 2.656 ± 0.051	0.107LysCys: 0.107 ± 0.009	1.17LysAsp: 1.17 ± 0.03	0.949LysGlu: 0.949 ± 0.027	0.702LysPhe: 0.702 ± 0.024	1.577LysGly: 1.577 ± 0.033	0.485LysHis: 0.485 ± 0.022	1.18LysIle: 1.18 ± 0.029	0.887LysLys: 0.887 ± 0.029	2.131LysLeu: 2.131 ± 0.036	0.508LysMet: 0.508 ± 0.02	0.623LysAsn: 0.623 ± 0.025	1.305LysPro: 1.305 ± 0.032	0.704LysGln: 0.704 ± 0.022	1.508LysArg: 1.508 ± 0.041	1.442LysSer: 1.442 ± 0.035	1.456LysThr: 1.456 ± 0.031	1.839LysVal: 1.839 ± 0.035	0.329LysTrp: 0.329 ± 0.016	0.554LysTyr: 0.554 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.323LeuAla: 13.323 ± 0.108	0.737LeuCys: 0.737 ± 0.021	7.315LeuAsp: 7.315 ± 0.085	4.745LeuGlu: 4.745 ± 0.056	2.891LeuPhe: 2.891 ± 0.05	9.22LeuGly: 9.22 ± 0.083	1.943LeuHis: 1.943 ± 0.031	4.241LeuIle: 4.241 ± 0.06	1.684LeuLys: 1.684 ± 0.037	9.539LeuLeu: 9.539 ± 0.091	1.739LeuMet: 1.739 ± 0.037	1.871LeuAsn: 1.871 ± 0.037	5.429LeuPro: 5.429 ± 0.06	2.333LeuGln: 2.333 ± 0.038	6.977LeuArg: 6.977 ± 0.075	6.042LeuSer: 6.042 ± 0.061	6.413LeuThr: 6.413 ± 0.062	8.987LeuVal: 8.987 ± 0.074	1.163LeuTrp: 1.163 ± 0.028	1.669LeuTyr: 1.669 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.212MetAla: 2.212 ± 0.038	0.133MetCys: 0.133 ± 0.01	0.963MetAsp: 0.963 ± 0.025	0.721MetGlu: 0.721 ± 0.021	0.697MetPhe: 0.697 ± 0.026	1.402MetGly: 1.402 ± 0.034	0.425MetHis: 0.425 ± 0.017	1.021MetIle: 1.021 ± 0.028	0.504MetLys: 0.504 ± 0.018	2.003MetLeu: 2.003 ± 0.037	0.399MetMet: 0.399 ± 0.017	0.609MetAsn: 0.609 ± 0.022	1.088MetPro: 1.088 ± 0.027	0.543MetGln: 0.543 ± 0.02	1.413MetArg: 1.413 ± 0.028	1.679MetSer: 1.679 ± 0.033	1.911MetThr: 1.911 ± 0.038	1.624MetVal: 1.624 ± 0.035	0.249MetTrp: 0.249 ± 0.013	0.361MetTyr: 0.361 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.515AsnAla: 2.515 ± 0.042	0.158AsnCys: 0.158 ± 0.009	1.284AsnAsp: 1.284 ± 0.027	1.022AsnGlu: 1.022 ± 0.028	0.711AsnPhe: 0.711 ± 0.02	2.007AsnGly: 2.007 ± 0.037	0.401AsnHis: 0.401 ± 0.016	1.013AsnIle: 1.013 ± 0.026	0.524AsnLys: 0.524 ± 0.02	2.001AsnLeu: 2.001 ± 0.038	0.426AsnMet: 0.426 ± 0.016	0.529AsnAsn: 0.529 ± 0.017	1.577AsnPro: 1.577 ± 0.034	0.559AsnGln: 0.559 ± 0.021	1.452AsnArg: 1.452 ± 0.028	1.402AsnSer: 1.402 ± 0.028	1.385AsnThr: 1.385 ± 0.033	1.739AsnVal: 1.739 ± 0.033	0.353AsnTrp: 0.353 ± 0.016	0.562AsnTyr: 0.562 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.344ProAla: 6.344 ± 0.066	0.247ProCys: 0.247 ± 0.013	4.054ProAsp: 4.054 ± 0.05	3.574ProGlu: 3.574 ± 0.047	1.581ProPhe: 1.581 ± 0.025	4.786ProGly: 4.786 ± 0.056	1.076ProHis: 1.076 ± 0.031	2.317ProIle: 2.317 ± 0.042	1.298ProLys: 1.298 ± 0.028	4.561ProLeu: 4.561 ± 0.054	1.09ProMet: 1.09 ± 0.029	1.277ProAsn: 1.277 ± 0.031	2.533ProPro: 2.533 ± 0.051	1.511ProGln: 1.511 ± 0.031	3.147ProArg: 3.147 ± 0.043	3.398ProSer: 3.398 ± 0.045	3.691ProThr: 3.691 ± 0.047	4.834ProVal: 4.834 ± 0.06	0.752ProTrp: 0.752 ± 0.023	1.06ProTyr: 1.06 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.03GlnAla: 3.03 ± 0.04	0.185GlnCys: 0.185 ± 0.011	1.256GlnAsp: 1.256 ± 0.031	1.124GlnGlu: 1.124 ± 0.024	0.94GlnPhe: 0.94 ± 0.024	1.957GlnGly: 1.957 ± 0.039	0.634GlnHis: 0.634 ± 0.021	1.445GlnIle: 1.445 ± 0.029	0.68GlnLys: 0.68 ± 0.021	2.988GlnLeu: 2.988 ± 0.046	0.63GlnMet: 0.63 ± 0.021	0.719GlnAsn: 0.719 ± 0.021	1.44GlnPro: 1.44 ± 0.033	1.213GlnGln: 1.213 ± 0.029	2.227GlnArg: 2.227 ± 0.039	1.615GlnSer: 1.615 ± 0.032	1.322GlnThr: 1.322 ± 0.029	2.304GlnVal: 2.304 ± 0.039	0.569GlnTrp: 0.569 ± 0.022	0.638GlnTyr: 0.638 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.787ArgAla: 7.787 ± 0.082	0.517ArgCys: 0.517 ± 0.017	3.822ArgAsp: 3.822 ± 0.052	3.892ArgGlu: 3.892 ± 0.053	2.249ArgPhe: 2.249 ± 0.036	5.014ArgGly: 5.014 ± 0.053	1.565ArgHis: 1.565 ± 0.033	3.684ArgIle: 3.684 ± 0.047	1.715ArgLys: 1.715 ± 0.039	6.437ArgLeu: 6.437 ± 0.079	1.753ArgMet: 1.753 ± 0.033	1.645ArgAsn: 1.645 ± 0.033	3.483ArgPro: 3.483 ± 0.044	1.932ArgGln: 1.932 ± 0.035	5.973ArgArg: 5.973 ± 0.082	4.954ArgSer: 4.954 ± 0.058	4.924ArgThr: 4.924 ± 0.052	5.473ArgVal: 5.473 ± 0.058	1.211ArgTrp: 1.211 ± 0.032	1.63ArgTyr: 1.63 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.951SerAla: 7.951 ± 0.079	0.401SerCys: 0.401 ± 0.017	4.036SerAsp: 4.036 ± 0.05	3.308SerGlu: 3.308 ± 0.041	1.944SerPhe: 1.944 ± 0.037	6.181SerGly: 6.181 ± 0.063	1.061SerHis: 1.061 ± 0.022	3.115SerIle: 3.115 ± 0.05	1.41SerLys: 1.41 ± 0.03	5.556SerLeu: 5.556 ± 0.063	1.681SerMet: 1.681 ± 0.032	1.412SerAsn: 1.412 ± 0.029	3.161SerPro: 3.161 ± 0.044	1.468SerGln: 1.468 ± 0.034	4.056SerArg: 4.056 ± 0.054	4.278SerSer: 4.278 ± 0.058	4.44SerThr: 4.44 ± 0.047	5.792SerVal: 5.792 ± 0.062	0.929SerTrp: 0.929 ± 0.026	1.325SerTyr: 1.325 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.127ThrAla: 8.127 ± 0.07	0.392ThrCys: 0.392 ± 0.018	4.193ThrAsp: 4.193 ± 0.05	3.58ThrGlu: 3.58 ± 0.048	1.984ThrPhe: 1.984 ± 0.033	5.87ThrGly: 5.87 ± 0.055	1.167ThrHis: 1.167 ± 0.03	2.659ThrIle: 2.659 ± 0.048	1.274ThrLys: 1.274 ± 0.031	5.964ThrLeu: 5.964 ± 0.056	1.202ThrMet: 1.202 ± 0.029	1.231ThrAsn: 1.231 ± 0.029	3.772ThrPro: 3.772 ± 0.054	1.484ThrGln: 1.484 ± 0.028	3.759ThrArg: 3.759 ± 0.048	3.894ThrSer: 3.894 ± 0.054	4.442ThrThr: 4.442 ± 0.068	6.839ThrVal: 6.839 ± 0.078	0.838ThrTrp: 0.838 ± 0.02	1.306ThrTyr: 1.306 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.399ValAla: 11.399 ± 0.093	0.707ValCys: 0.707 ± 0.02	6.573ValAsp: 6.573 ± 0.072	4.934ValGlu: 4.934 ± 0.057	2.765ValPhe: 2.765 ± 0.047	7.619ValGly: 7.619 ± 0.078	1.978ValHis: 1.978 ± 0.042	3.916ValIle: 3.916 ± 0.06	1.639ValLys: 1.639 ± 0.032	9.774ValLeu: 9.774 ± 0.092	1.617ValMet: 1.617 ± 0.03	1.801ValAsn: 1.801 ± 0.035	4.954ValPro: 4.954 ± 0.058	2.259ValGln: 2.259 ± 0.04	6.134ValArg: 6.134 ± 0.062	5.353ValSer: 5.353 ± 0.061	5.799ValThr: 5.799 ± 0.062	9.397ValVal: 9.397 ± 0.099	1.003ValTrp: 1.003 ± 0.026	1.473ValTyr: 1.473 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.423TrpAla: 1.423 ± 0.027	0.123TrpCys: 0.123 ± 0.008	0.731TrpAsp: 0.731 ± 0.022	0.572TrpGlu: 0.572 ± 0.019	0.554TrpPhe: 0.554 ± 0.019	0.976TrpGly: 0.976 ± 0.027	0.296TrpHis: 0.296 ± 0.015	0.737TrpIle: 0.737 ± 0.022	0.357TrpLys: 0.357 ± 0.015	1.505TrpLeu: 1.505 ± 0.031	0.351TrpMet: 0.351 ± 0.014	0.45TrpAsn: 0.45 ± 0.015	0.69TrpPro: 0.69 ± 0.025	0.513TrpGln: 0.513 ± 0.018	1.011TrpArg: 1.011 ± 0.026	0.994TrpSer: 0.994 ± 0.024	0.988TrpThr: 0.988 ± 0.026	1.076TrpVal: 1.076 ± 0.028	0.327TrpTrp: 0.327 ± 0.014	0.284TrpTyr: 0.284 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.269TyrAla: 2.269 ± 0.039	0.164TyrCys: 0.164 ± 0.009	1.34TyrAsp: 1.34 ± 0.032	1.097TyrGlu: 1.097 ± 0.03	0.751TyrPhe: 0.751 ± 0.023	1.988TyrGly: 1.988 ± 0.039	0.358TyrHis: 0.358 ± 0.013	0.731TyrIle: 0.731 ± 0.02	0.351TyrLys: 0.351 ± 0.015	2.213TyrLeu: 2.213 ± 0.043	0.284TyrMet: 0.284 ± 0.014	0.43TyrAsn: 0.43 ± 0.017	1.114TyrPro: 1.114 ± 0.033	0.564TyrGln: 0.564 ± 0.018	1.695TyrArg: 1.695 ± 0.033	1.323TyrSer: 1.323 ± 0.028	1.18TyrThr: 1.18 ± 0.025	1.666TyrVal: 1.666 ± 0.039	0.321TyrTrp: 0.321 ± 0.015	0.404TyrTyr: 0.404 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5193 proteins (1625198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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