Amino acid dipepetide frequency for Streptomyces ipomoeae 91-03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.159AlaAla: 19.159 ± 0.131
1.082AlaCys: 1.082 ± 0.021
8.12AlaAsp: 8.12 ± 0.061
8.86AlaGlu: 8.86 ± 0.081
3.352AlaPhe: 3.352 ± 0.034
11.888AlaGly: 11.888 ± 0.075
2.918AlaHis: 2.918 ± 0.039
3.544AlaIle: 3.544 ± 0.041
2.856AlaLys: 2.856 ± 0.037
13.608AlaLeu: 13.608 ± 0.088
2.413AlaMet: 2.413 ± 0.025
2.014AlaAsn: 2.014 ± 0.029
6.88AlaPro: 6.88 ± 0.058
3.612AlaGln: 3.612 ± 0.036
9.998AlaArg: 9.998 ± 0.08
5.911AlaSer: 5.911 ± 0.049
7.076AlaThr: 7.076 ± 0.058
11.573AlaVal: 11.573 ± 0.085
1.86AlaTrp: 1.86 ± 0.027
2.753AlaTyr: 2.753 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
1.086CysAla: 1.086 ± 0.02
0.108CysCys: 0.108 ± 0.007
0.48CysAsp: 0.48 ± 0.013
0.439CysGlu: 0.439 ± 0.012
0.231CysPhe: 0.231 ± 0.008
0.985CysGly: 0.985 ± 0.021
0.212CysHis: 0.212 ± 0.009
0.164CysIle: 0.164 ± 0.007
0.132CysLys: 0.132 ± 0.007
0.763CysLeu: 0.763 ± 0.015
0.122CysMet: 0.122 ± 0.007
0.117CysAsn: 0.117 ± 0.007
0.542CysPro: 0.542 ± 0.013
0.183CysGln: 0.183 ± 0.009
0.691CysArg: 0.691 ± 0.016
0.472CysSer: 0.472 ± 0.014
0.513CysThr: 0.513 ± 0.013
0.688CysVal: 0.688 ± 0.017
0.139CysTrp: 0.139 ± 0.007
0.162CysTyr: 0.162 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.368AspAla: 7.368 ± 0.057
0.451AspCys: 0.451 ± 0.011
3.835AspAsp: 3.835 ± 0.042
3.986AspGlu: 3.986 ± 0.036
1.688AspPhe: 1.688 ± 0.023
6.424AspGly: 6.424 ± 0.053
1.526AspHis: 1.526 ± 0.02
2.044AspIle: 2.044 ± 0.028
1.284AspLys: 1.284 ± 0.024
6.171AspLeu: 6.171 ± 0.052
0.84AspMet: 0.84 ± 0.017
1.017AspAsn: 1.017 ± 0.021
4.45AspPro: 4.45 ± 0.043
1.622AspGln: 1.622 ± 0.024
4.988AspArg: 4.988 ± 0.054
2.754AspSer: 2.754 ± 0.032
3.432AspThr: 3.432 ± 0.039
4.664AspVal: 4.664 ± 0.043
1.064AspTrp: 1.064 ± 0.019
1.142AspTyr: 1.142 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
7.458GluAla: 7.458 ± 0.067
0.369GluCys: 0.369 ± 0.011
2.902GluAsp: 2.902 ± 0.032
3.73GluGlu: 3.73 ± 0.044
1.494GluPhe: 1.494 ± 0.025
4.491GluGly: 4.491 ± 0.047
1.565GluHis: 1.565 ± 0.025
2.251GluIle: 2.251 ± 0.029
1.559GluLys: 1.559 ± 0.025
6.751GluLeu: 6.751 ± 0.064
0.934GluMet: 0.934 ± 0.017
1.132GluAsn: 1.132 ± 0.021
3.586GluPro: 3.586 ± 0.044
2.277GluGln: 2.277 ± 0.033
5.594GluArg: 5.594 ± 0.049
2.717GluSer: 2.717 ± 0.03
3.048GluThr: 3.048 ± 0.032
4.429GluVal: 4.429 ± 0.045
0.877GluTrp: 0.877 ± 0.016
1.227GluTyr: 1.227 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.449PheAla: 3.449 ± 0.036
0.259PheCys: 0.259 ± 0.01
1.945PheAsp: 1.945 ± 0.027
1.472PheGlu: 1.472 ± 0.024
0.854PhePhe: 0.854 ± 0.017
2.948PheGly: 2.948 ± 0.034
0.632PheHis: 0.632 ± 0.015
0.727PheIle: 0.727 ± 0.017
0.531PheLys: 0.531 ± 0.016
2.55PheLeu: 2.55 ± 0.037
0.407PheMet: 0.407 ± 0.012
0.575PheAsn: 0.575 ± 0.015
1.388PhePro: 1.388 ± 0.021
0.671PheGln: 0.671 ± 0.016
1.887PheArg: 1.887 ± 0.023
1.446PheSer: 1.446 ± 0.027
2.003PheThr: 2.003 ± 0.029
2.163PheVal: 2.163 ± 0.028
0.431PheTrp: 0.431 ± 0.013
0.578PheTyr: 0.578 ± 0.014
0.0PheXaa: 0.0 ± 0.0
Gly
10.552GlyAla: 10.552 ± 0.072
0.856GlyCys: 0.856 ± 0.019
5.277GlyAsp: 5.277 ± 0.046
5.219GlyGlu: 5.219 ± 0.047
2.77GlyPhe: 2.77 ± 0.034
8.9GlyGly: 8.9 ± 0.073
2.387GlyHis: 2.387 ± 0.03
3.435GlyIle: 3.435 ± 0.038
2.512GlyLys: 2.512 ± 0.033
8.948GlyLeu: 8.948 ± 0.059
1.945GlyMet: 1.945 ± 0.027
1.799GlyAsn: 1.799 ± 0.031
5.109GlyPro: 5.109 ± 0.049
2.562GlyGln: 2.562 ± 0.034
7.866GlyArg: 7.866 ± 0.053
5.465GlySer: 5.465 ± 0.051
6.557GlyThr: 6.557 ± 0.061
7.441GlyVal: 7.441 ± 0.057
1.67GlyTrp: 1.67 ± 0.027
2.222GlyTyr: 2.222 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.683HisAla: 2.683 ± 0.033
0.217HisCys: 0.217 ± 0.009
1.431HisAsp: 1.431 ± 0.023
1.273HisGlu: 1.273 ± 0.02
0.663HisPhe: 0.663 ± 0.015
2.415HisGly: 2.415 ± 0.033
0.755HisHis: 0.755 ± 0.017
0.762HisIle: 0.762 ± 0.016
0.394HisLys: 0.394 ± 0.012
2.476HisLeu: 2.476 ± 0.033
0.354HisMet: 0.354 ± 0.011
0.405HisAsn: 0.405 ± 0.012
1.912HisPro: 1.912 ± 0.031
0.689HisGln: 0.689 ± 0.016
2.256HisArg: 2.256 ± 0.028
1.072HisSer: 1.072 ± 0.018
1.421HisThr: 1.421 ± 0.024
1.691HisVal: 1.691 ± 0.024
0.375HisTrp: 0.375 ± 0.012
0.501HisTyr: 0.501 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.73IleAla: 4.73 ± 0.045
0.31IleCys: 0.31 ± 0.011
2.32IleAsp: 2.32 ± 0.031
2.059IleGlu: 2.059 ± 0.026
0.711IlePhe: 0.711 ± 0.016
3.502IleGly: 3.502 ± 0.035
0.699IleHis: 0.699 ± 0.014
0.893IleIle: 0.893 ± 0.019
0.78IleLys: 0.78 ± 0.017
2.412IleLeu: 2.412 ± 0.031
0.445IleMet: 0.445 ± 0.012
0.708IleAsn: 0.708 ± 0.016
1.88IlePro: 1.88 ± 0.023
0.762IleGln: 0.762 ± 0.018
2.454IleArg: 2.454 ± 0.031
1.731IleSer: 1.731 ± 0.025
2.383IleThr: 2.383 ± 0.032
2.709IleVal: 2.709 ± 0.033
0.4IleTrp: 0.4 ± 0.013
0.541IleTyr: 0.541 ± 0.014
0.0IleXaa: 0.0 ± 0.0
Lys
3.081LysAla: 3.081 ± 0.041
0.123LysCys: 0.123 ± 0.007
1.39LysAsp: 1.39 ± 0.024
1.287LysGlu: 1.287 ± 0.021
0.481LysPhe: 0.481 ± 0.012
1.993LysGly: 1.993 ± 0.032
0.453LysHis: 0.453 ± 0.012
0.863LysIle: 0.863 ± 0.02
0.953LysLys: 0.953 ± 0.027
2.123LysLeu: 2.123 ± 0.027
0.383LysMet: 0.383 ± 0.012
0.597LysAsn: 0.597 ± 0.016
1.445LysPro: 1.445 ± 0.025
0.708LysGln: 0.708 ± 0.017
1.54LysArg: 1.54 ± 0.026
1.238LysSer: 1.238 ± 0.021
1.397LysThr: 1.397 ± 0.029
1.977LysVal: 1.977 ± 0.027
0.305LysTrp: 0.305 ± 0.012
0.505LysTyr: 0.505 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
14.006LeuAla: 14.006 ± 0.097
0.845LeuCys: 0.845 ± 0.017
6.685LeuAsp: 6.685 ± 0.056
4.51LeuGlu: 4.51 ± 0.045
2.524LeuPhe: 2.524 ± 0.033
8.914LeuGly: 8.914 ± 0.069
2.284LeuHis: 2.284 ± 0.026
3.358LeuIle: 3.358 ± 0.039
2.194LeuLys: 2.194 ± 0.031
10.769LeuLeu: 10.769 ± 0.085
1.623LeuMet: 1.623 ± 0.022
1.698LeuAsn: 1.698 ± 0.026
6.417LeuPro: 6.417 ± 0.052
2.166LeuGln: 2.166 ± 0.028
8.648LeuArg: 8.648 ± 0.073
5.354LeuSer: 5.354 ± 0.048
6.911LeuThr: 6.911 ± 0.048
8.4LeuVal: 8.4 ± 0.059
1.344LeuTrp: 1.344 ± 0.024
1.877LeuTyr: 1.877 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
2.246MetAla: 2.246 ± 0.025
0.139MetCys: 0.139 ± 0.007
0.889MetAsp: 0.889 ± 0.017
0.766MetGlu: 0.766 ± 0.015
0.46MetPhe: 0.46 ± 0.016
1.353MetGly: 1.353 ± 0.023
0.356MetHis: 0.356 ± 0.012
0.641MetIle: 0.641 ± 0.015
0.43MetLys: 0.43 ± 0.012
1.605MetLeu: 1.605 ± 0.022
0.301MetMet: 0.301 ± 0.01
0.452MetAsn: 0.452 ± 0.011
1.13MetPro: 1.13 ± 0.018
0.414MetGln: 0.414 ± 0.011
1.482MetArg: 1.482 ± 0.026
1.306MetSer: 1.306 ± 0.021
1.571MetThr: 1.571 ± 0.022
1.298MetVal: 1.298 ± 0.022
0.226MetTrp: 0.226 ± 0.01
0.33MetTyr: 0.33 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.226AsnAla: 2.226 ± 0.029
0.174AsnCys: 0.174 ± 0.008
1.03AsnAsp: 1.03 ± 0.021
0.869AsnGlu: 0.869 ± 0.016
0.49AsnPhe: 0.49 ± 0.013
2.018AsnGly: 2.018 ± 0.031
0.432AsnHis: 0.432 ± 0.012
0.698AsnIle: 0.698 ± 0.018
0.444AsnLys: 0.444 ± 0.014
1.648AsnLeu: 1.648 ± 0.025
0.303AsnMet: 0.303 ± 0.011
0.461AsnAsn: 0.461 ± 0.015
1.415AsnPro: 1.415 ± 0.024
0.526AsnGln: 0.526 ± 0.015
1.362AsnArg: 1.362 ± 0.023
1.065AsnSer: 1.065 ± 0.02
1.218AsnThr: 1.218 ± 0.02
1.403AsnVal: 1.403 ± 0.025
0.313AsnTrp: 0.313 ± 0.011
0.437AsnTyr: 0.437 ± 0.012
0.0AsnXaa: 0.0 ± 0.0
Pro
8.007ProAla: 8.007 ± 0.073
0.393ProCys: 0.393 ± 0.012
4.528ProAsp: 4.528 ± 0.043
4.522ProGlu: 4.522 ± 0.045
1.521ProPhe: 1.521 ± 0.024
6.557ProGly: 6.557 ± 0.065
1.473ProHis: 1.473 ± 0.023
1.391ProIle: 1.391 ± 0.019
1.297ProLys: 1.297 ± 0.022
5.348ProLeu: 5.348 ± 0.046
1.072ProMet: 1.072 ± 0.02
0.979ProAsn: 0.979 ± 0.019
3.758ProPro: 3.758 ± 0.054
1.741ProGln: 1.741 ± 0.027
4.156ProArg: 4.156 ± 0.046
3.45ProSer: 3.45 ± 0.04
3.778ProThr: 3.778 ± 0.04
5.394ProVal: 5.394 ± 0.044
0.925ProTrp: 0.925 ± 0.021
1.482ProTyr: 1.482 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
3.571GlnAla: 3.571 ± 0.04
0.186GlnCys: 0.186 ± 0.009
1.397GlnAsp: 1.397 ± 0.022
1.464GlnGlu: 1.464 ± 0.023
0.686GlnPhe: 0.686 ± 0.016
2.257GlnGly: 2.257 ± 0.029
0.674GlnHis: 0.674 ± 0.015
1.053GlnIle: 1.053 ± 0.019
0.644GlnLys: 0.644 ± 0.016
3.042GlnLeu: 3.042 ± 0.036
0.472GlnMet: 0.472 ± 0.013
0.515GlnAsn: 0.515 ± 0.016
1.75GlnPro: 1.75 ± 0.028
1.202GlnGln: 1.202 ± 0.024
2.412GlnArg: 2.412 ± 0.032
1.316GlnSer: 1.316 ± 0.022
1.354GlnThr: 1.354 ± 0.024
2.248GlnVal: 2.248 ± 0.028
0.485GlnTrp: 0.485 ± 0.013
0.628GlnTyr: 0.628 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
9.691ArgAla: 9.691 ± 0.07
0.678ArgCys: 0.678 ± 0.016
4.367ArgAsp: 4.367 ± 0.041
4.801ArgGlu: 4.801 ± 0.053
2.357ArgPhe: 2.357 ± 0.032
5.996ArgGly: 5.996 ± 0.05
2.305ArgHis: 2.305 ± 0.032
3.246ArgIle: 3.246 ± 0.032
1.763ArgLys: 1.763 ± 0.03
8.883ArgLeu: 8.883 ± 0.078
1.752ArgMet: 1.752 ± 0.024
1.42ArgAsn: 1.42 ± 0.025
5.196ArgPro: 5.196 ± 0.052
2.414ArgGln: 2.414 ± 0.036
8.156ArgArg: 8.156 ± 0.082
4.233ArgSer: 4.233 ± 0.04
5.52ArgThr: 5.52 ± 0.047
5.928ArgVal: 5.928 ± 0.041
1.445ArgTrp: 1.445 ± 0.02
1.83ArgTyr: 1.83 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
6.776SerAla: 6.776 ± 0.061
0.464SerCys: 0.464 ± 0.014
2.856SerAsp: 2.856 ± 0.033
2.573SerGlu: 2.573 ± 0.034
1.482SerPhe: 1.482 ± 0.025
6.117SerGly: 6.117 ± 0.051
1.092SerHis: 1.092 ± 0.019
1.478SerIle: 1.478 ± 0.025
1.097SerLys: 1.097 ± 0.022
4.773SerLeu: 4.773 ± 0.043
1.085SerMet: 1.085 ± 0.02
0.944SerAsn: 0.944 ± 0.019
3.492SerPro: 3.492 ± 0.044
1.265SerGln: 1.265 ± 0.022
3.983SerArg: 3.983 ± 0.045
3.228SerSer: 3.228 ± 0.046
3.363SerThr: 3.363 ± 0.033
4.189SerVal: 4.189 ± 0.034
0.955SerTrp: 0.955 ± 0.018
1.278SerTyr: 1.278 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
9.013ThrAla: 9.013 ± 0.063
0.467ThrCys: 0.467 ± 0.012
3.797ThrAsp: 3.797 ± 0.043
3.521ThrGlu: 3.521 ± 0.033
1.624ThrPhe: 1.624 ± 0.024
6.855ThrGly: 6.855 ± 0.056
1.282ThrHis: 1.282 ± 0.021
1.837ThrIle: 1.837 ± 0.024
1.3ThrLys: 1.3 ± 0.025
5.766ThrLeu: 5.766 ± 0.046
0.972ThrMet: 0.972 ± 0.018
1.143ThrAsn: 1.143 ± 0.022
4.438ThrPro: 4.438 ± 0.052
1.333ThrGln: 1.333 ± 0.023
4.11ThrArg: 4.11 ± 0.033
3.473ThrSer: 3.473 ± 0.041
4.344ThrThr: 4.344 ± 0.061
6.074ThrVal: 6.074 ± 0.049
0.976ThrTrp: 0.976 ± 0.021
1.484ThrTyr: 1.484 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
9.981ValAla: 9.981 ± 0.069
0.759ValCys: 0.759 ± 0.016
4.974ValAsp: 4.974 ± 0.032
4.83ValGlu: 4.83 ± 0.049
2.359ValPhe: 2.359 ± 0.035
6.424ValGly: 6.424 ± 0.05
1.933ValHis: 1.933 ± 0.028
2.931ValIle: 2.931 ± 0.029
1.79ValLys: 1.79 ± 0.024
9.041ValLeu: 9.041 ± 0.068
1.396ValMet: 1.396 ± 0.023
1.665ValAsn: 1.665 ± 0.028
5.132ValPro: 5.132 ± 0.048
1.983ValGln: 1.983 ± 0.028
7.148ValArg: 7.148 ± 0.051
4.277ValSer: 4.277 ± 0.039
5.616ValThr: 5.616 ± 0.05
7.732ValVal: 7.732 ± 0.061
1.172ValTrp: 1.172 ± 0.021
1.586ValTyr: 1.586 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.671TrpAla: 1.671 ± 0.024
0.172TrpCys: 0.172 ± 0.008
0.89TrpAsp: 0.89 ± 0.02
0.793TrpGlu: 0.793 ± 0.018
0.509TrpPhe: 0.509 ± 0.012
1.122TrpGly: 1.122 ± 0.021
0.389TrpHis: 0.389 ± 0.011
0.563TrpIle: 0.563 ± 0.015
0.421TrpLys: 0.421 ± 0.012
1.792TrpLeu: 1.792 ± 0.028
0.296TrpMet: 0.296 ± 0.01
0.444TrpAsn: 0.444 ± 0.011
0.795TrpPro: 0.795 ± 0.018
0.631TrpGln: 0.631 ± 0.015
1.402TrpArg: 1.402 ± 0.022
0.994TrpSer: 0.994 ± 0.019
1.065TrpThr: 1.065 ± 0.02
1.0TrpVal: 1.0 ± 0.016
0.353TrpTrp: 0.353 ± 0.01
0.382TrpTyr: 0.382 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.721TyrAla: 2.721 ± 0.031
0.18TyrCys: 0.18 ± 0.009
1.639TyrAsp: 1.639 ± 0.03
1.413TyrGlu: 1.413 ± 0.025
0.657TyrPhe: 0.657 ± 0.013
2.336TyrGly: 2.336 ± 0.034
0.38TyrHis: 0.38 ± 0.012
0.55TyrIle: 0.55 ± 0.014
0.461TyrLys: 0.461 ± 0.014
2.057TyrLeu: 2.057 ± 0.031
0.279TyrMet: 0.279 ± 0.01
0.447TyrAsn: 0.447 ± 0.016
1.056TyrPro: 1.056 ± 0.022
0.596TyrGln: 0.596 ± 0.016
1.847TyrArg: 1.847 ± 0.026
0.99TyrSer: 0.99 ± 0.019
1.238TyrThr: 1.238 ± 0.023
1.729TyrVal: 1.729 ± 0.023
0.37TyrTrp: 0.37 ± 0.012
0.508TyrTyr: 0.508 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9368 proteins (2932944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski