Amino acid dipepetide frequency for Eubacterium sp. CAG:180

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.351AlaAla: 8.351 ± 0.158
1.157AlaCys: 1.157 ± 0.046
5.101AlaAsp: 5.101 ± 0.118
5.791AlaGlu: 5.791 ± 0.121
3.369AlaPhe: 3.369 ± 0.08
5.288AlaGly: 5.288 ± 0.114
1.072AlaHis: 1.072 ± 0.049
4.849AlaIle: 4.849 ± 0.099
5.497AlaLys: 5.497 ± 0.119
7.471AlaLeu: 7.471 ± 0.148
2.005AlaMet: 2.005 ± 0.056
2.562AlaAsn: 2.562 ± 0.071
2.215AlaPro: 2.215 ± 0.071
1.769AlaGln: 1.769 ± 0.068
2.727AlaArg: 2.727 ± 0.08
4.427AlaSer: 4.427 ± 0.099
3.302AlaThr: 3.302 ± 0.081
8.01AlaVal: 8.01 ± 0.144
0.459AlaTrp: 0.459 ± 0.027
2.712AlaTyr: 2.712 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.245CysAla: 1.245 ± 0.048
0.348CysCys: 0.348 ± 0.025
1.333CysAsp: 1.333 ± 0.045
1.274CysGlu: 1.274 ± 0.045
0.758CysPhe: 0.758 ± 0.035
1.867CysGly: 1.867 ± 0.071
0.314CysHis: 0.314 ± 0.024
1.13CysIle: 1.13 ± 0.046
1.025CysLys: 1.025 ± 0.046
1.145CysLeu: 1.145 ± 0.047
0.361CysMet: 0.361 ± 0.029
0.689CysAsn: 0.689 ± 0.033
0.74CysPro: 0.74 ± 0.045
0.301CysGln: 0.301 ± 0.022
0.76CysArg: 0.76 ± 0.038
1.065CysSer: 1.065 ± 0.039
0.722CysThr: 0.722 ± 0.042
1.176CysVal: 1.176 ± 0.049
0.114CysTrp: 0.114 ± 0.014
0.608CysTyr: 0.608 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
4.194AspAla: 4.194 ± 0.091
1.032AspCys: 1.032 ± 0.047
3.815AspAsp: 3.815 ± 0.084
5.258AspGlu: 5.258 ± 0.104
3.091AspPhe: 3.091 ± 0.082
5.37AspGly: 5.37 ± 0.117
0.63AspHis: 0.63 ± 0.032
5.312AspIle: 5.312 ± 0.091
4.853AspLys: 4.853 ± 0.11
4.115AspLeu: 4.115 ± 0.082
1.852AspMet: 1.852 ± 0.056
2.763AspAsn: 2.763 ± 0.07
1.745AspPro: 1.745 ± 0.062
0.646AspGln: 0.646 ± 0.037
2.455AspArg: 2.455 ± 0.066
3.686AspSer: 3.686 ± 0.095
3.313AspThr: 3.313 ± 0.083
4.296AspVal: 4.296 ± 0.095
0.49AspTrp: 0.49 ± 0.031
2.825AspTyr: 2.825 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
4.735GluAla: 4.735 ± 0.096
0.938GluCys: 0.938 ± 0.042
3.338GluAsp: 3.338 ± 0.078
4.408GluGlu: 4.408 ± 0.106
2.719GluPhe: 2.719 ± 0.072
3.367GluGly: 3.367 ± 0.085
1.134GluHis: 1.134 ± 0.05
5.401GluIle: 5.401 ± 0.101
7.103GluLys: 7.103 ± 0.136
6.288GluLeu: 6.288 ± 0.124
2.037GluMet: 2.037 ± 0.064
4.771GluAsn: 4.771 ± 0.081
1.869GluPro: 1.869 ± 0.06
1.883GluGln: 1.883 ± 0.064
2.961GluArg: 2.961 ± 0.076
3.233GluSer: 3.233 ± 0.082
3.514GluThr: 3.514 ± 0.08
3.748GluVal: 3.748 ± 0.086
0.468GluTrp: 0.468 ± 0.028
2.817GluTyr: 2.817 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
3.222PheAla: 3.222 ± 0.081
0.923PheCys: 0.923 ± 0.043
3.032PheAsp: 3.032 ± 0.068
2.462PheGlu: 2.462 ± 0.07
1.97PhePhe: 1.97 ± 0.065
3.688PheGly: 3.688 ± 0.091
0.595PheHis: 0.595 ± 0.034
3.019PheIle: 3.019 ± 0.077
2.788PheLys: 2.788 ± 0.071
3.481PheLeu: 3.481 ± 0.094
1.074PheMet: 1.074 ± 0.041
1.8PheAsn: 1.8 ± 0.058
1.459PhePro: 1.459 ± 0.055
0.755PheGln: 0.755 ± 0.035
1.549PheArg: 1.549 ± 0.05
3.628PheSer: 3.628 ± 0.098
2.748PheThr: 2.748 ± 0.076
2.983PheVal: 2.983 ± 0.085
0.359PheTrp: 0.359 ± 0.026
1.729PheTyr: 1.729 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.375GlyAla: 5.375 ± 0.119
1.284GlyCys: 1.284 ± 0.06
4.234GlyAsp: 4.234 ± 0.089
4.762GlyGlu: 4.762 ± 0.084
3.389GlyPhe: 3.389 ± 0.082
5.463GlyGly: 5.463 ± 0.135
1.143GlyHis: 1.143 ± 0.049
5.736GlyIle: 5.736 ± 0.112
6.292GlyLys: 6.292 ± 0.108
5.729GlyLeu: 5.729 ± 0.12
2.066GlyMet: 2.066 ± 0.064
3.039GlyAsn: 3.039 ± 0.087
1.301GlyPro: 1.301 ± 0.055
1.384GlyGln: 1.384 ± 0.049
2.883GlyArg: 2.883 ± 0.083
4.389GlySer: 4.389 ± 0.096
4.305GlyThr: 4.305 ± 0.089
5.566GlyVal: 5.566 ± 0.091
0.557GlyTrp: 0.557 ± 0.035
3.066GlyTyr: 3.066 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.871HisAla: 0.871 ± 0.043
0.337HisCys: 0.337 ± 0.023
0.878HisAsp: 0.878 ± 0.049
0.896HisGlu: 0.896 ± 0.034
0.749HisPhe: 0.749 ± 0.037
1.294HisGly: 1.294 ± 0.055
0.339HisHis: 0.339 ± 0.026
1.352HisIle: 1.352 ± 0.051
1.05HisLys: 1.05 ± 0.044
1.257HisLeu: 1.257 ± 0.056
0.361HisMet: 0.361 ± 0.025
0.737HisAsn: 0.737 ± 0.035
0.776HisPro: 0.776 ± 0.04
0.327HisGln: 0.327 ± 0.025
0.693HisArg: 0.693 ± 0.038
0.994HisSer: 0.994 ± 0.048
0.918HisThr: 0.918 ± 0.045
0.816HisVal: 0.816 ± 0.048
0.138HisTrp: 0.138 ± 0.016
0.582HisTyr: 0.582 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.767IleAla: 5.767 ± 0.096
1.468IleCys: 1.468 ± 0.054
4.838IleAsp: 4.838 ± 0.094
4.468IleGlu: 4.468 ± 0.099
2.825IlePhe: 2.825 ± 0.076
5.17IleGly: 5.17 ± 0.107
1.083IleHis: 1.083 ± 0.046
5.517IleIle: 5.517 ± 0.125
5.459IleLys: 5.459 ± 0.115
6.127IleLeu: 6.127 ± 0.106
1.947IleMet: 1.947 ± 0.06
3.304IleAsn: 3.304 ± 0.07
3.062IlePro: 3.062 ± 0.093
1.266IleGln: 1.266 ± 0.049
2.923IleArg: 2.923 ± 0.066
5.268IleSer: 5.268 ± 0.104
4.405IleThr: 4.405 ± 0.096
4.779IleVal: 4.779 ± 0.1
0.457IleTrp: 0.457 ± 0.029
2.629IleTyr: 2.629 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
6.257LysAla: 6.257 ± 0.124
1.021LysCys: 1.021 ± 0.049
4.347LysAsp: 4.347 ± 0.094
5.591LysGlu: 5.591 ± 0.107
2.382LysPhe: 2.382 ± 0.078
4.136LysGly: 4.136 ± 0.091
1.145LysHis: 1.145 ± 0.049
5.892LysIle: 5.892 ± 0.094
7.308LysLys: 7.308 ± 0.121
6.203LysLeu: 6.203 ± 0.115
2.433LysMet: 2.433 ± 0.068
4.837LysAsn: 4.837 ± 0.098
2.353LysPro: 2.353 ± 0.073
1.865LysGln: 1.865 ± 0.059
3.356LysArg: 3.356 ± 0.082
4.496LysSer: 4.496 ± 0.099
4.942LysThr: 4.942 ± 0.106
4.407LysVal: 4.407 ± 0.091
0.584LysTrp: 0.584 ± 0.042
3.373LysTyr: 3.373 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
6.058LeuAla: 6.058 ± 0.114
1.936LeuCys: 1.936 ± 0.063
4.797LeuAsp: 4.797 ± 0.102
4.599LeuGlu: 4.599 ± 0.096
3.861LeuPhe: 3.861 ± 0.099
5.822LeuGly: 5.822 ± 0.122
1.313LeuHis: 1.313 ± 0.051
5.795LeuIle: 5.795 ± 0.121
6.785LeuLys: 6.785 ± 0.111
8.006LeuLeu: 8.006 ± 0.158
2.342LeuMet: 2.342 ± 0.068
4.029LeuAsn: 4.029 ± 0.087
3.617LeuPro: 3.617 ± 0.089
1.84LeuGln: 1.84 ± 0.066
3.73LeuArg: 3.73 ± 0.069
7.759LeuSer: 7.759 ± 0.147
5.014LeuThr: 5.014 ± 0.105
5.067LeuVal: 5.067 ± 0.093
0.635LeuTrp: 0.635 ± 0.036
3.053LeuTyr: 3.053 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.163MetAla: 2.163 ± 0.066
0.425MetCys: 0.425 ± 0.03
1.386MetAsp: 1.386 ± 0.048
1.401MetGlu: 1.401 ± 0.055
1.085MetPhe: 1.085 ± 0.053
1.811MetGly: 1.811 ± 0.063
0.428MetHis: 0.428 ± 0.029
1.803MetIle: 1.803 ± 0.063
2.181MetLys: 2.181 ± 0.055
2.754MetLeu: 2.754 ± 0.066
0.778MetMet: 0.778 ± 0.038
1.348MetAsn: 1.348 ± 0.052
1.257MetPro: 1.257 ± 0.042
0.793MetGln: 0.793 ± 0.042
1.241MetArg: 1.241 ± 0.05
1.921MetSer: 1.921 ± 0.062
1.673MetThr: 1.673 ± 0.05
1.486MetVal: 1.486 ± 0.054
0.178MetTrp: 0.178 ± 0.016
0.936MetTyr: 0.936 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.676AsnAla: 3.676 ± 0.083
0.789AsnCys: 0.789 ± 0.042
2.888AsnAsp: 2.888 ± 0.073
3.061AsnGlu: 3.061 ± 0.074
1.658AsnPhe: 1.658 ± 0.066
4.314AsnGly: 4.314 ± 0.088
0.655AsnHis: 0.655 ± 0.037
3.881AsnIle: 3.881 ± 0.083
3.041AsnLys: 3.041 ± 0.073
3.46AsnLeu: 3.46 ± 0.077
1.442AsnMet: 1.442 ± 0.06
2.059AsnAsn: 2.059 ± 0.073
2.052AsnPro: 2.052 ± 0.071
0.82AsnGln: 0.82 ± 0.04
1.814AsnArg: 1.814 ± 0.054
2.915AsnSer: 2.915 ± 0.079
2.723AsnThr: 2.723 ± 0.072
3.354AsnVal: 3.354 ± 0.075
0.361AsnTrp: 0.361 ± 0.033
1.841AsnTyr: 1.841 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.473ProAla: 2.473 ± 0.071
0.581ProCys: 0.581 ± 0.031
2.578ProAsp: 2.578 ± 0.067
3.046ProGlu: 3.046 ± 0.075
1.631ProPhe: 1.631 ± 0.061
1.943ProGly: 1.943 ± 0.059
0.677ProHis: 0.677 ± 0.036
2.163ProIle: 2.163 ± 0.068
2.262ProLys: 2.262 ± 0.064
2.765ProLeu: 2.765 ± 0.071
0.889ProMet: 0.889 ± 0.035
1.486ProAsn: 1.486 ± 0.047
0.867ProPro: 0.867 ± 0.042
1.083ProGln: 1.083 ± 0.044
1.121ProArg: 1.121 ± 0.048
2.271ProSer: 2.271 ± 0.063
1.722ProThr: 1.722 ± 0.049
2.863ProVal: 2.863 ± 0.077
0.296ProTrp: 0.296 ± 0.021
1.439ProTyr: 1.439 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.395GlnAla: 1.395 ± 0.058
0.274GlnCys: 0.274 ± 0.02
0.956GlnAsp: 0.956 ± 0.045
1.136GlnGlu: 1.136 ± 0.048
0.88GlnPhe: 0.88 ± 0.035
1.299GlnGly: 1.299 ± 0.047
0.356GlnHis: 0.356 ± 0.023
1.803GlnIle: 1.803 ± 0.059
2.277GlnLys: 2.277 ± 0.065
1.872GlnLeu: 1.872 ± 0.058
0.664GlnMet: 0.664 ± 0.035
1.457GlnAsn: 1.457 ± 0.052
0.639GlnPro: 0.639 ± 0.036
0.613GlnGln: 0.613 ± 0.041
0.998GlnArg: 0.998 ± 0.044
1.479GlnSer: 1.479 ± 0.052
1.127GlnThr: 1.127 ± 0.042
1.108GlnVal: 1.108 ± 0.05
0.176GlnTrp: 0.176 ± 0.019
0.909GlnTyr: 0.909 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.09ArgAla: 3.09 ± 0.078
0.57ArgCys: 0.57 ± 0.034
2.456ArgAsp: 2.456 ± 0.065
3.244ArgGlu: 3.244 ± 0.091
1.785ArgPhe: 1.785 ± 0.061
2.585ArgGly: 2.585 ± 0.076
0.749ArgHis: 0.749 ± 0.039
3.037ArgIle: 3.037 ± 0.078
2.952ArgLys: 2.952 ± 0.081
3.871ArgLeu: 3.871 ± 0.105
1.03ArgMet: 1.03 ± 0.039
1.843ArgAsn: 1.843 ± 0.057
1.301ArgPro: 1.301 ± 0.051
1.036ArgGln: 1.036 ± 0.038
2.103ArgArg: 2.103 ± 0.071
2.202ArgSer: 2.202 ± 0.054
2.068ArgThr: 2.068 ± 0.053
2.732ArgVal: 2.732 ± 0.069
0.29ArgTrp: 0.29 ± 0.026
1.665ArgTyr: 1.665 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.693SerAla: 5.693 ± 0.103
0.996SerCys: 0.996 ± 0.039
4.564SerAsp: 4.564 ± 0.096
4.662SerGlu: 4.662 ± 0.099
3.284SerPhe: 3.284 ± 0.085
5.697SerGly: 5.697 ± 0.097
1.056SerHis: 1.056 ± 0.039
3.922SerIle: 3.922 ± 0.082
4.127SerLys: 4.127 ± 0.097
5.98SerLeu: 5.98 ± 0.126
1.551SerMet: 1.551 ± 0.053
2.255SerAsn: 2.255 ± 0.055
2.233SerPro: 2.233 ± 0.065
1.616SerGln: 1.616 ± 0.065
2.607SerArg: 2.607 ± 0.072
4.643SerSer: 4.643 ± 0.134
2.812SerThr: 2.812 ± 0.073
5.78SerVal: 5.78 ± 0.11
0.435SerTrp: 0.435 ± 0.031
2.52SerTyr: 2.52 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
5.446ThrAla: 5.446 ± 0.099
0.617ThrCys: 0.617 ± 0.034
3.984ThrAsp: 3.984 ± 0.093
3.959ThrGlu: 3.959 ± 0.087
2.208ThrPhe: 2.208 ± 0.068
4.583ThrGly: 4.583 ± 0.11
0.905ThrHis: 0.905 ± 0.042
3.124ThrIle: 3.124 ± 0.077
3.231ThrLys: 3.231 ± 0.074
4.964ThrLeu: 4.964 ± 0.105
1.148ThrMet: 1.148 ± 0.051
1.985ThrAsn: 1.985 ± 0.066
2.335ThrPro: 2.335 ± 0.065
1.128ThrGln: 1.128 ± 0.046
1.867ThrArg: 1.867 ± 0.055
3.285ThrSer: 3.285 ± 0.09
2.67ThrThr: 2.67 ± 0.084
5.644ThrVal: 5.644 ± 0.11
0.35ThrTrp: 0.35 ± 0.031
1.919ThrTyr: 1.919 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
4.88ValAla: 4.88 ± 0.084
1.48ValCys: 1.48 ± 0.058
3.906ValAsp: 3.906 ± 0.083
3.77ValGlu: 3.77 ± 0.087
3.44ValPhe: 3.44 ± 0.09
4.63ValGly: 4.63 ± 0.103
0.929ValHis: 0.929 ± 0.038
5.704ValIle: 5.704 ± 0.109
5.526ValLys: 5.526 ± 0.105
6.734ValLeu: 6.734 ± 0.107
1.928ValMet: 1.928 ± 0.058
3.369ValAsn: 3.369 ± 0.08
2.781ValPro: 2.781 ± 0.067
1.313ValGln: 1.313 ± 0.051
2.861ValArg: 2.861 ± 0.076
5.504ValSer: 5.504 ± 0.109
4.574ValThr: 4.574 ± 0.1
4.668ValVal: 4.668 ± 0.117
0.568ValTrp: 0.568 ± 0.031
2.736ValTyr: 2.736 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.499TrpAla: 0.499 ± 0.029
0.142TrpCys: 0.142 ± 0.016
0.508TrpAsp: 0.508 ± 0.032
0.455TrpGlu: 0.455 ± 0.03
0.339TrpPhe: 0.339 ± 0.024
0.564TrpGly: 0.564 ± 0.036
0.196TrpHis: 0.196 ± 0.02
0.457TrpIle: 0.457 ± 0.027
0.419TrpLys: 0.419 ± 0.025
0.706TrpLeu: 0.706 ± 0.043
0.192TrpMet: 0.192 ± 0.02
0.444TrpAsn: 0.444 ± 0.031
0.132TrpPro: 0.132 ± 0.017
0.299TrpGln: 0.299 ± 0.024
0.27TrpArg: 0.27 ± 0.026
0.439TrpSer: 0.439 ± 0.028
0.372TrpThr: 0.372 ± 0.029
0.352TrpVal: 0.352 ± 0.029
0.078TrpTrp: 0.078 ± 0.011
0.403TrpTyr: 0.403 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.745TyrAla: 2.745 ± 0.077
0.657TyrCys: 0.657 ± 0.033
2.801TyrAsp: 2.801 ± 0.08
2.491TyrGlu: 2.491 ± 0.083
1.841TyrPhe: 1.841 ± 0.062
3.073TyrGly: 3.073 ± 0.081
0.648TyrHis: 0.648 ± 0.031
2.865TyrIle: 2.865 ± 0.079
2.752TyrLys: 2.752 ± 0.083
3.131TyrLeu: 3.131 ± 0.082
0.942TyrMet: 0.942 ± 0.041
2.028TyrAsn: 2.028 ± 0.06
1.419TyrPro: 1.419 ± 0.052
0.679TyrGln: 0.679 ± 0.034
1.693TyrArg: 1.693 ± 0.055
2.828TyrSer: 2.828 ± 0.086
2.429TyrThr: 2.429 ± 0.092
2.467TyrVal: 2.467 ± 0.07
0.274TyrTrp: 0.274 ± 0.022
1.928TyrTyr: 1.928 ± 0.099
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1742 proteins (551212 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski