Amino acid dipepetide frequency for Rhodospira trueperi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.735AlaAla: 17.735 ± 0.229	1.238AlaCys: 1.238 ± 0.038	8.115AlaAsp: 8.115 ± 0.098	7.876AlaGlu: 7.876 ± 0.091	4.196AlaPhe: 4.196 ± 0.061	11.001AlaGly: 11.001 ± 0.107	2.543AlaHis: 2.543 ± 0.045	4.896AlaIle: 4.896 ± 0.068	2.64AlaLys: 2.64 ± 0.062	14.918AlaLeu: 14.918 ± 0.163	3.462AlaMet: 3.462 ± 0.051	2.524AlaAsn: 2.524 ± 0.051	6.642AlaPro: 6.642 ± 0.102	3.229AlaGln: 3.229 ± 0.057	11.117AlaArg: 11.117 ± 0.141	5.388AlaSer: 5.388 ± 0.069	6.062AlaThr: 6.062 ± 0.084	10.361AlaVal: 10.361 ± 0.112	1.846AlaTrp: 1.846 ± 0.039	2.286AlaTyr: 2.286 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.03	0.106CysCys: 0.106 ± 0.009	0.592CysAsp: 0.592 ± 0.026	0.444CysGlu: 0.444 ± 0.02	0.278CysPhe: 0.278 ± 0.015	0.936CysGly: 0.936 ± 0.029	0.298CysHis: 0.298 ± 0.016	0.323CysIle: 0.323 ± 0.018	0.172CysLys: 0.172 ± 0.013	0.893CysLeu: 0.893 ± 0.025	0.148CysMet: 0.148 ± 0.011	0.193CysAsn: 0.193 ± 0.013	0.579CysPro: 0.579 ± 0.027	0.238CysGln: 0.238 ± 0.014	0.708CysArg: 0.708 ± 0.025	0.377CysSer: 0.377 ± 0.017	0.422CysThr: 0.422 ± 0.019	0.679CysVal: 0.679 ± 0.024	0.122CysTrp: 0.122 ± 0.01	0.207CysTyr: 0.207 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.832AspAla: 7.832 ± 0.088	0.471AspCys: 0.471 ± 0.018	4.143AspAsp: 4.143 ± 0.084	3.592AspGlu: 3.592 ± 0.062	1.883AspPhe: 1.883 ± 0.037	6.46AspGly: 6.46 ± 0.106	1.549AspHis: 1.549 ± 0.038	2.883AspIle: 2.883 ± 0.05	1.214AspLys: 1.214 ± 0.032	7.475AspLeu: 7.475 ± 0.087	1.518AspMet: 1.518 ± 0.035	1.119AspAsn: 1.119 ± 0.035	4.614AspPro: 4.614 ± 0.073	1.772AspGln: 1.772 ± 0.035	5.346AspArg: 5.346 ± 0.069	2.628AspSer: 2.628 ± 0.052	3.302AspThr: 3.302 ± 0.069	4.657AspVal: 4.657 ± 0.07	1.15AspTrp: 1.15 ± 0.033	1.24AspTyr: 1.24 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.61GluAla: 8.61 ± 0.104	0.381GluCys: 0.381 ± 0.019	3.636GluAsp: 3.636 ± 0.059	3.142GluGlu: 3.142 ± 0.08	1.316GluPhe: 1.316 ± 0.035	4.554GluGly: 4.554 ± 0.068	1.326GluHis: 1.326 ± 0.034	2.861GluIle: 2.861 ± 0.052	1.546GluLys: 1.546 ± 0.046	4.004GluLeu: 4.004 ± 0.06	1.558GluMet: 1.558 ± 0.034	1.328GluAsn: 1.328 ± 0.038	3.045GluPro: 3.045 ± 0.073	1.961GluGln: 1.961 ± 0.047	5.185GluArg: 5.185 ± 0.07	2.654GluSer: 2.654 ± 0.057	4.442GluThr: 4.442 ± 0.059	4.22GluVal: 4.22 ± 0.063	0.619GluTrp: 0.619 ± 0.024	0.907GluTyr: 0.907 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.752PheAla: 3.752 ± 0.058	0.361PheCys: 0.361 ± 0.016	2.388PheAsp: 2.388 ± 0.046	1.928PheGlu: 1.928 ± 0.04	1.148PhePhe: 1.148 ± 0.034	3.199PheGly: 3.199 ± 0.052	0.691PheHis: 0.691 ± 0.023	1.356PheIle: 1.356 ± 0.04	0.784PheLys: 0.784 ± 0.03	3.174PheLeu: 3.174 ± 0.062	0.755PheMet: 0.755 ± 0.023	0.861PheAsn: 0.861 ± 0.027	1.499PhePro: 1.499 ± 0.033	0.955PheGln: 0.955 ± 0.027	2.32PheArg: 2.32 ± 0.044	1.796PheSer: 1.796 ± 0.039	1.785PheThr: 1.785 ± 0.045	2.559PheVal: 2.559 ± 0.051	0.451PheTrp: 0.451 ± 0.02	0.719PheTyr: 0.719 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.22GlyAla: 10.22 ± 0.108	0.937GlyCys: 0.937 ± 0.03	5.072GlyAsp: 5.072 ± 0.102	4.745GlyGlu: 4.745 ± 0.07	3.135GlyPhe: 3.135 ± 0.057	8.123GlyGly: 8.123 ± 0.108	2.233GlyHis: 2.233 ± 0.044	3.718GlyIle: 3.718 ± 0.052	2.257GlyLys: 2.257 ± 0.052	10.01GlyLeu: 10.01 ± 0.113	2.327GlyMet: 2.327 ± 0.05	1.739GlyAsn: 1.739 ± 0.044	4.368GlyPro: 4.368 ± 0.067	2.77GlyGln: 2.77 ± 0.052	7.247GlyArg: 7.247 ± 0.095	4.219GlySer: 4.219 ± 0.06	5.098GlyThr: 5.098 ± 0.085	6.737GlyVal: 6.737 ± 0.088	1.417GlyTrp: 1.417 ± 0.036	2.04GlyTyr: 2.04 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.69HisAla: 2.69 ± 0.058	0.255HisCys: 0.255 ± 0.015	1.502HisAsp: 1.502 ± 0.035	1.058HisGlu: 1.058 ± 0.03	0.726HisPhe: 0.726 ± 0.026	2.311HisGly: 2.311 ± 0.052	0.685HisHis: 0.685 ± 0.027	0.89HisIle: 0.89 ± 0.029	0.415HisLys: 0.415 ± 0.022	2.312HisLeu: 2.312 ± 0.046	0.508HisMet: 0.508 ± 0.021	0.418HisAsn: 0.418 ± 0.017	1.542HisPro: 1.542 ± 0.041	0.61HisGln: 0.61 ± 0.022	1.781HisArg: 1.781 ± 0.037	0.775HisSer: 0.775 ± 0.028	1.031HisThr: 1.031 ± 0.027	1.74HisVal: 1.74 ± 0.044	0.385HisTrp: 0.385 ± 0.017	0.506HisTyr: 0.506 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.485IleAla: 5.485 ± 0.084	0.39IleCys: 0.39 ± 0.016	2.985IleAsp: 2.985 ± 0.049	2.895IleGlu: 2.895 ± 0.049	1.131IlePhe: 1.131 ± 0.034	4.168IleGly: 4.168 ± 0.065	0.896IleHis: 0.896 ± 0.029	1.723IleIle: 1.723 ± 0.045	1.096IleLys: 1.096 ± 0.037	4.247IleLeu: 4.247 ± 0.068	0.911IleMet: 0.911 ± 0.027	1.166IleAsn: 1.166 ± 0.033	2.153IlePro: 2.153 ± 0.047	1.188IleGln: 1.188 ± 0.034	3.009IleArg: 3.009 ± 0.045	2.143IleSer: 2.143 ± 0.043	2.422IleThr: 2.422 ± 0.05	3.453IleVal: 3.453 ± 0.063	0.466IleTrp: 0.466 ± 0.022	0.759IleTyr: 0.759 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.296LysAla: 3.296 ± 0.061	0.131LysCys: 0.131 ± 0.009	1.45LysAsp: 1.45 ± 0.043	1.159LysGlu: 1.159 ± 0.035	0.537LysPhe: 0.537 ± 0.021	2.215LysGly: 2.215 ± 0.051	0.478LysHis: 0.478 ± 0.021	0.941LysIle: 0.941 ± 0.028	0.821LysLys: 0.821 ± 0.035	1.901LysLeu: 1.901 ± 0.048	0.533LysMet: 0.533 ± 0.023	0.574LysAsn: 0.574 ± 0.025	1.458LysPro: 1.458 ± 0.04	0.677LysGln: 0.677 ± 0.024	1.819LysArg: 1.819 ± 0.043	1.236LysSer: 1.236 ± 0.03	1.59LysThr: 1.59 ± 0.039	1.78LysVal: 1.78 ± 0.041	0.214LysTrp: 0.214 ± 0.014	0.451LysTyr: 0.451 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.011LeuAla: 14.011 ± 0.157	0.927LeuCys: 0.927 ± 0.03	7.338LeuAsp: 7.338 ± 0.076	6.042LeuGlu: 6.042 ± 0.073	3.576LeuPhe: 3.576 ± 0.067	9.002LeuGly: 9.002 ± 0.114	2.018LeuHis: 2.018 ± 0.046	4.519LeuIle: 4.519 ± 0.074	2.626LeuLys: 2.626 ± 0.054	9.639LeuLeu: 9.639 ± 0.136	2.56LeuMet: 2.56 ± 0.045	2.414LeuAsn: 2.414 ± 0.043	5.753LeuPro: 5.753 ± 0.085	2.123LeuGln: 2.123 ± 0.041	7.94LeuArg: 7.94 ± 0.094	6.258LeuSer: 6.258 ± 0.087	6.25LeuThr: 6.25 ± 0.081	7.827LeuVal: 7.827 ± 0.104	1.287LeuTrp: 1.287 ± 0.04	1.95LeuTyr: 1.95 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.519MetAla: 3.519 ± 0.056	0.144MetCys: 0.144 ± 0.012	1.414MetAsp: 1.414 ± 0.03	1.27MetGlu: 1.27 ± 0.038	0.625MetPhe: 0.625 ± 0.021	2.071MetGly: 2.071 ± 0.041	0.406MetHis: 0.406 ± 0.018	1.225MetIle: 1.225 ± 0.033	0.693MetLys: 0.693 ± 0.028	2.27MetLeu: 2.27 ± 0.044	0.699MetMet: 0.699 ± 0.021	0.598MetAsn: 0.598 ± 0.02	1.593MetPro: 1.593 ± 0.041	0.574MetGln: 0.574 ± 0.024	1.784MetArg: 1.784 ± 0.04	1.47MetSer: 1.47 ± 0.038	2.14MetThr: 2.14 ± 0.039	2.039MetVal: 2.039 ± 0.043	0.207MetTrp: 0.207 ± 0.012	0.277MetTyr: 0.277 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.873AsnAla: 2.873 ± 0.05	0.193AsnCys: 0.193 ± 0.012	1.34AsnAsp: 1.34 ± 0.043	1.138AsnGlu: 1.138 ± 0.035	0.624AsnPhe: 0.624 ± 0.024	1.973AsnGly: 1.973 ± 0.05	0.448AsnHis: 0.448 ± 0.022	1.009AsnIle: 1.009 ± 0.03	0.526AsnLys: 0.526 ± 0.024	2.097AsnLeu: 2.097 ± 0.044	0.535AsnMet: 0.535 ± 0.023	0.538AsnAsn: 0.538 ± 0.025	1.621AsnPro: 1.621 ± 0.038	0.602AsnGln: 0.602 ± 0.026	1.797AsnArg: 1.797 ± 0.039	0.88AsnSer: 0.88 ± 0.029	1.231AsnThr: 1.231 ± 0.036	1.596AsnVal: 1.596 ± 0.039	0.295AsnTrp: 0.295 ± 0.016	0.44AsnTyr: 0.44 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.908ProAla: 6.908 ± 0.1	0.397ProCys: 0.397 ± 0.019	4.988ProAsp: 4.988 ± 0.075	4.295ProGlu: 4.295 ± 0.072	1.941ProPhe: 1.941 ± 0.038	5.316ProGly: 5.316 ± 0.078	1.211ProHis: 1.211 ± 0.031	2.011ProIle: 2.011 ± 0.04	1.24ProLys: 1.24 ± 0.039	5.419ProLeu: 5.419 ± 0.077	1.417ProMet: 1.417 ± 0.037	1.257ProAsn: 1.257 ± 0.028	3.97ProPro: 3.97 ± 0.1	1.256ProGln: 1.256 ± 0.034	3.681ProArg: 3.681 ± 0.06	2.778ProSer: 2.778 ± 0.053	2.919ProThr: 2.919 ± 0.053	4.762ProVal: 4.762 ± 0.066	1.001ProTrp: 1.001 ± 0.03	1.063ProTyr: 1.063 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.02GlnAla: 4.02 ± 0.065	0.198GlnCys: 0.198 ± 0.014	1.597GlnAsp: 1.597 ± 0.038	1.346GlnGlu: 1.346 ± 0.037	0.819GlnPhe: 0.819 ± 0.027	2.344GlnGly: 2.344 ± 0.051	0.542GlnHis: 0.542 ± 0.021	1.264GlnIle: 1.264 ± 0.034	0.728GlnLys: 0.728 ± 0.028	1.861GlnLeu: 1.861 ± 0.049	0.734GlnMet: 0.734 ± 0.024	0.6GlnAsn: 0.6 ± 0.024	1.571GlnPro: 1.571 ± 0.03	0.833GlnGln: 0.833 ± 0.03	2.283GlnArg: 2.283 ± 0.046	1.368GlnSer: 1.368 ± 0.035	1.739GlnThr: 1.739 ± 0.038	2.254GlnVal: 2.254 ± 0.038	0.338GlnTrp: 0.338 ± 0.015	0.518GlnTyr: 0.518 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.164ArgAla: 10.164 ± 0.125	0.631ArgCys: 0.631 ± 0.026	5.152ArgAsp: 5.152 ± 0.067	4.411ArgGlu: 4.411 ± 0.064	2.888ArgPhe: 2.888 ± 0.052	5.362ArgGly: 5.362 ± 0.072	2.161ArgHis: 2.161 ± 0.045	3.504ArgIle: 3.504 ± 0.055	1.918ArgLys: 1.918 ± 0.05	9.465ArgLeu: 9.465 ± 0.114	1.976ArgMet: 1.976 ± 0.04	1.547ArgAsn: 1.547 ± 0.036	4.764ArgPro: 4.764 ± 0.07	2.435ArgGln: 2.435 ± 0.053	7.177ArgArg: 7.177 ± 0.094	3.291ArgSer: 3.291 ± 0.059	3.859ArgThr: 3.859 ± 0.058	6.195ArgVal: 6.195 ± 0.082	1.086ArgTrp: 1.086 ± 0.032	1.558ArgTyr: 1.558 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.501SerAla: 5.501 ± 0.076	0.374SerCys: 0.374 ± 0.015	2.99SerAsp: 2.99 ± 0.054	2.481SerGlu: 2.481 ± 0.051	1.652SerPhe: 1.652 ± 0.036	5.101SerGly: 5.101 ± 0.069	1.022SerHis: 1.022 ± 0.028	2.072SerIle: 2.072 ± 0.044	1.002SerLys: 1.002 ± 0.033	5.123SerLeu: 5.123 ± 0.08	1.322SerMet: 1.322 ± 0.038	1.096SerAsn: 1.096 ± 0.033	2.769SerPro: 2.769 ± 0.05	1.342SerGln: 1.342 ± 0.037	3.542SerArg: 3.542 ± 0.055	2.282SerSer: 2.282 ± 0.048	2.436SerThr: 2.436 ± 0.049	3.98SerVal: 3.98 ± 0.057	0.611SerTrp: 0.611 ± 0.022	1.011SerTyr: 1.011 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.99ThrAla: 6.99 ± 0.087	0.474ThrCys: 0.474 ± 0.023	3.476ThrAsp: 3.476 ± 0.069	3.092ThrGlu: 3.092 ± 0.052	1.91ThrPhe: 1.91 ± 0.042	5.399ThrGly: 5.399 ± 0.085	1.17ThrHis: 1.17 ± 0.037	2.37ThrIle: 2.37 ± 0.057	1.07ThrLys: 1.07 ± 0.03	6.742ThrLeu: 6.742 ± 0.095	1.199ThrMet: 1.199 ± 0.031	1.171ThrAsn: 1.171 ± 0.038	3.766ThrPro: 3.766 ± 0.061	1.397ThrGln: 1.397 ± 0.038	3.963ThrArg: 3.963 ± 0.064	2.239ThrSer: 2.239 ± 0.045	2.941ThrThr: 2.941 ± 0.062	5.373ThrVal: 5.373 ± 0.08	0.766ThrTrp: 0.766 ± 0.029	1.138ThrTyr: 1.138 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.862ValAla: 9.862 ± 0.11	0.788ValCys: 0.788 ± 0.026	4.531ValAsp: 4.531 ± 0.069	4.793ValGlu: 4.793 ± 0.061	2.955ValPhe: 2.955 ± 0.054	6.07ValGly: 6.07 ± 0.077	1.559ValHis: 1.559 ± 0.042	3.739ValIle: 3.739 ± 0.066	1.726ValLys: 1.726 ± 0.04	8.852ValLeu: 8.852 ± 0.099	2.043ValMet: 2.043 ± 0.042	1.798ValAsn: 1.798 ± 0.042	4.37ValPro: 4.37 ± 0.063	1.934ValGln: 1.934 ± 0.042	5.798ValArg: 5.798 ± 0.077	4.267ValSer: 4.267 ± 0.066	5.072ValThr: 5.072 ± 0.084	6.705ValVal: 6.705 ± 0.091	1.021ValTrp: 1.021 ± 0.029	1.465ValTyr: 1.465 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.393TrpAla: 1.393 ± 0.043	0.153TrpCys: 0.153 ± 0.012	0.782TrpAsp: 0.782 ± 0.032	0.578TrpGlu: 0.578 ± 0.025	0.446TrpPhe: 0.446 ± 0.023	1.018TrpGly: 1.018 ± 0.033	0.39TrpHis: 0.39 ± 0.019	0.628TrpIle: 0.628 ± 0.023	0.301TrpLys: 0.301 ± 0.017	1.665TrpLeu: 1.665 ± 0.042	0.39TrpMet: 0.39 ± 0.02	0.332TrpAsn: 0.332 ± 0.015	0.814TrpPro: 0.814 ± 0.029	0.456TrpGln: 0.456 ± 0.022	1.39TrpArg: 1.39 ± 0.038	0.773TrpSer: 0.773 ± 0.027	0.906TrpThr: 0.906 ± 0.029	0.941TrpVal: 0.941 ± 0.028	0.257TrpTrp: 0.257 ± 0.017	0.247TrpTyr: 0.247 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.165TyrAla: 2.165 ± 0.045	0.215TyrCys: 0.215 ± 0.015	1.358TyrAsp: 1.358 ± 0.037	1.009TyrGlu: 1.009 ± 0.03	0.696TyrPhe: 0.696 ± 0.026	1.788TyrGly: 1.788 ± 0.039	0.515TyrHis: 0.515 ± 0.023	0.751TyrIle: 0.751 ± 0.023	0.483TyrLys: 0.483 ± 0.018	1.993TyrLeu: 1.993 ± 0.038	0.422TyrMet: 0.422 ± 0.021	0.487TyrAsn: 0.487 ± 0.021	0.939TyrPro: 0.939 ± 0.031	0.602TyrGln: 0.602 ± 0.023	1.658TyrArg: 1.658 ± 0.039	0.887TyrSer: 0.887 ± 0.03	1.0TyrThr: 1.0 ± 0.033	1.494TyrVal: 1.494 ± 0.032	0.32TyrTrp: 0.32 ± 0.018	0.53TyrTyr: 0.53 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3690 proteins (1220506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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