Amino acid dipepetide frequency for Candidatus Nitrosotalea sinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.645AlaAla: 4.645 ± 0.137
0.657AlaCys: 0.657 ± 0.038
3.047AlaAsp: 3.047 ± 0.094
3.417AlaGlu: 3.417 ± 0.093
2.486AlaPhe: 2.486 ± 0.086
4.508AlaGly: 4.508 ± 0.108
1.077AlaHis: 1.077 ± 0.047
6.025AlaIle: 6.025 ± 0.137
5.458AlaLys: 5.458 ± 0.114
5.744AlaLeu: 5.744 ± 0.129
1.754AlaMet: 1.754 ± 0.063
2.866AlaAsn: 2.866 ± 0.1
1.924AlaPro: 1.924 ± 0.078
2.114AlaGln: 2.114 ± 0.069
2.675AlaArg: 2.675 ± 0.093
4.612AlaSer: 4.612 ± 0.116
4.123AlaThr: 4.123 ± 0.108
4.531AlaVal: 4.531 ± 0.11
0.561AlaTrp: 0.561 ± 0.036
2.003AlaTyr: 2.003 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.029
0.118CysCys: 0.118 ± 0.016
0.547CysAsp: 0.547 ± 0.035
0.432CysGlu: 0.432 ± 0.032
0.368CysPhe: 0.368 ± 0.028
0.937CysGly: 0.937 ± 0.05
0.2CysHis: 0.2 ± 0.019
0.711CysIle: 0.711 ± 0.04
0.794CysLys: 0.794 ± 0.037
0.665CysLeu: 0.665 ± 0.04
0.247CysMet: 0.247 ± 0.023
0.542CysAsn: 0.542 ± 0.038
0.547CysPro: 0.547 ± 0.038
0.274CysGln: 0.274 ± 0.023
0.355CysArg: 0.355 ± 0.029
0.694CysSer: 0.694 ± 0.043
0.648CysThr: 0.648 ± 0.043
0.609CysVal: 0.609 ± 0.035
0.077CysTrp: 0.077 ± 0.012
0.306CysTyr: 0.306 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.782AspAla: 3.782 ± 0.087
0.542AspCys: 0.542 ± 0.035
2.835AspAsp: 2.835 ± 0.074
3.427AspGlu: 3.427 ± 0.102
2.473AspPhe: 2.473 ± 0.067
3.606AspGly: 3.606 ± 0.1
0.9AspHis: 0.9 ± 0.042
4.635AspIle: 4.635 ± 0.095
4.404AspLys: 4.404 ± 0.105
4.921AspLeu: 4.921 ± 0.114
1.467AspMet: 1.467 ± 0.064
2.403AspAsn: 2.403 ± 0.074
2.357AspPro: 2.357 ± 0.067
1.773AspGln: 1.773 ± 0.065
1.912AspArg: 1.912 ± 0.066
4.082AspSer: 4.082 ± 0.107
3.059AspThr: 3.059 ± 0.088
4.109AspVal: 4.109 ± 0.102
0.507AspTrp: 0.507 ± 0.033
1.941AspTyr: 1.941 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
3.356GluAla: 3.356 ± 0.12
0.495GluCys: 0.495 ± 0.031
2.727GluAsp: 2.727 ± 0.073
3.766GluGlu: 3.766 ± 0.122
2.644GluPhe: 2.644 ± 0.074
2.839GluGly: 2.839 ± 0.075
1.253GluHis: 1.253 ± 0.05
5.913GluIle: 5.913 ± 0.108
6.029GluLys: 6.029 ± 0.133
4.965GluLeu: 4.965 ± 0.136
1.767GluMet: 1.767 ± 0.06
3.346GluAsn: 3.346 ± 0.089
1.752GluPro: 1.752 ± 0.067
2.006GluGln: 2.006 ± 0.067
2.297GluArg: 2.297 ± 0.08
3.997GluSer: 3.997 ± 0.095
2.872GluThr: 2.872 ± 0.08
3.3GluVal: 3.3 ± 0.095
0.549GluTrp: 0.549 ± 0.036
1.935GluTyr: 1.935 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
3.034PheAla: 3.034 ± 0.09
0.474PheCys: 0.474 ± 0.036
2.824PheAsp: 2.824 ± 0.075
2.531PheGlu: 2.531 ± 0.077
1.725PhePhe: 1.725 ± 0.078
3.398PheGly: 3.398 ± 0.097
0.848PheHis: 0.848 ± 0.041
2.527PheIle: 2.527 ± 0.075
2.39PheLys: 2.39 ± 0.068
3.629PheLeu: 3.629 ± 0.107
0.971PheMet: 0.971 ± 0.056
1.548PheAsn: 1.548 ± 0.059
1.525PhePro: 1.525 ± 0.064
1.328PheGln: 1.328 ± 0.055
1.359PheArg: 1.359 ± 0.055
3.442PheSer: 3.442 ± 0.085
2.531PheThr: 2.531 ± 0.082
3.369PheVal: 3.369 ± 0.078
0.399PheTrp: 0.399 ± 0.029
1.444PheTyr: 1.444 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.263GlyAla: 4.263 ± 0.117
0.648GlyCys: 0.648 ± 0.039
3.269GlyAsp: 3.269 ± 0.101
2.98GlyGlu: 2.98 ± 0.087
3.134GlyPhe: 3.134 ± 0.097
4.591GlyGly: 4.591 ± 0.127
1.316GlyHis: 1.316 ± 0.057
6.615GlyIle: 6.615 ± 0.125
5.566GlyLys: 5.566 ± 0.11
5.89GlyLeu: 5.89 ± 0.111
2.097GlyMet: 2.097 ± 0.075
3.163GlyAsn: 3.163 ± 0.114
2.274GlyPro: 2.274 ± 0.131
2.326GlyGln: 2.326 ± 0.098
2.544GlyArg: 2.544 ± 0.077
4.849GlySer: 4.849 ± 0.116
4.238GlyThr: 4.238 ± 0.111
4.504GlyVal: 4.504 ± 0.09
0.665GlyTrp: 0.665 ± 0.04
2.442GlyTyr: 2.442 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.251HisAla: 1.251 ± 0.048
0.229HisCys: 0.229 ± 0.022
1.212HisAsp: 1.212 ± 0.049
1.118HisGlu: 1.118 ± 0.051
0.852HisPhe: 0.852 ± 0.044
1.38HisGly: 1.38 ± 0.053
0.534HisHis: 0.534 ± 0.034
1.405HisIle: 1.405 ± 0.052
1.228HisLys: 1.228 ± 0.053
1.669HisLeu: 1.669 ± 0.051
0.58HisMet: 0.58 ± 0.036
0.923HisAsn: 0.923 ± 0.044
1.029HisPro: 1.029 ± 0.05
0.621HisGln: 0.621 ± 0.033
0.742HisArg: 0.742 ± 0.045
1.174HisSer: 1.174 ± 0.048
1.112HisThr: 1.112 ± 0.05
1.548HisVal: 1.548 ± 0.061
0.208HisTrp: 0.208 ± 0.017
0.709HisTyr: 0.709 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.006IleAla: 6.006 ± 0.115
0.802IleCys: 0.802 ± 0.043
4.738IleAsp: 4.738 ± 0.107
5.038IleGlu: 5.038 ± 0.119
3.265IlePhe: 3.265 ± 0.088
5.842IleGly: 5.842 ± 0.131
1.748IleHis: 1.748 ± 0.076
6.829IleIle: 6.829 ± 0.144
6.035IleLys: 6.035 ± 0.117
7.821IleLeu: 7.821 ± 0.157
2.058IleMet: 2.058 ± 0.075
3.485IleAsn: 3.485 ± 0.096
4.387IlePro: 4.387 ± 0.098
2.86IleGln: 2.86 ± 0.083
3.331IleArg: 3.331 ± 0.093
7.172IleSer: 7.172 ± 0.129
5.37IleThr: 5.37 ± 0.106
6.062IleVal: 6.062 ± 0.11
0.594IleTrp: 0.594 ± 0.037
2.07IleTyr: 2.07 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.063LysAla: 4.063 ± 0.102
0.729LysCys: 0.729 ± 0.041
4.179LysAsp: 4.179 ± 0.099
5.329LysGlu: 5.329 ± 0.13
3.234LysPhe: 3.234 ± 0.085
4.233LysGly: 4.233 ± 0.129
1.347LysHis: 1.347 ± 0.059
8.833LysIle: 8.833 ± 0.163
7.806LysLys: 7.806 ± 0.156
6.118LysLeu: 6.118 ± 0.114
2.546LysMet: 2.546 ± 0.082
4.741LysAsn: 4.741 ± 0.101
2.795LysPro: 2.795 ± 0.088
2.538LysGln: 2.538 ± 0.072
2.935LysArg: 2.935 ± 0.085
5.302LysSer: 5.302 ± 0.117
4.782LysThr: 4.782 ± 0.111
4.529LysVal: 4.529 ± 0.109
0.673LysTrp: 0.673 ± 0.038
2.706LysTyr: 2.706 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
6.461LeuAla: 6.461 ± 0.128
0.777LeuCys: 0.777 ± 0.039
5.659LeuAsp: 5.659 ± 0.117
5.909LeuGlu: 5.909 ± 0.131
3.188LeuPhe: 3.188 ± 0.104
6.337LeuGly: 6.337 ± 0.123
1.654LeuHis: 1.654 ± 0.064
5.649LeuIle: 5.649 ± 0.108
6.395LeuLys: 6.395 ± 0.157
7.054LeuLeu: 7.054 ± 0.146
1.823LeuMet: 1.823 ± 0.058
3.519LeuAsn: 3.519 ± 0.101
3.284LeuPro: 3.284 ± 0.09
3.184LeuGln: 3.184 ± 0.082
3.793LeuArg: 3.793 ± 0.11
6.646LeuSer: 6.646 ± 0.092
4.483LeuThr: 4.483 ± 0.092
7.052LeuVal: 7.052 ± 0.124
0.727LeuTrp: 0.727 ± 0.042
2.554LeuTyr: 2.554 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.723MetAla: 1.723 ± 0.066
0.218MetCys: 0.218 ± 0.019
1.309MetAsp: 1.309 ± 0.058
1.345MetGlu: 1.345 ± 0.057
0.981MetPhe: 0.981 ± 0.046
1.671MetGly: 1.671 ± 0.068
0.563MetHis: 0.563 ± 0.036
2.407MetIle: 2.407 ± 0.074
2.222MetLys: 2.222 ± 0.062
2.378MetLeu: 2.378 ± 0.085
0.896MetMet: 0.896 ± 0.051
1.262MetAsn: 1.262 ± 0.052
1.255MetPro: 1.255 ± 0.059
0.993MetGln: 0.993 ± 0.046
1.056MetArg: 1.056 ± 0.049
2.128MetSer: 2.128 ± 0.07
1.785MetThr: 1.785 ± 0.068
1.868MetVal: 1.868 ± 0.06
0.258MetTrp: 0.258 ± 0.023
0.74MetTyr: 0.74 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.151AsnAla: 3.151 ± 0.1
0.48AsnCys: 0.48 ± 0.035
2.384AsnAsp: 2.384 ± 0.079
2.301AsnGlu: 2.301 ± 0.072
2.035AsnPhe: 2.035 ± 0.076
3.088AsnGly: 3.088 ± 0.095
0.939AsnHis: 0.939 ± 0.042
3.824AsnIle: 3.824 ± 0.094
3.327AsnLys: 3.327 ± 0.089
4.489AsnLeu: 4.489 ± 0.112
1.54AsnMet: 1.54 ± 0.056
2.405AsnAsn: 2.405 ± 0.108
2.475AsnPro: 2.475 ± 0.078
1.754AsnGln: 1.754 ± 0.078
1.656AsnArg: 1.656 ± 0.056
3.631AsnSer: 3.631 ± 0.121
2.997AsnThr: 2.997 ± 0.105
3.203AsnVal: 3.203 ± 0.081
0.463AsnTrp: 0.463 ± 0.034
1.642AsnTyr: 1.642 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.236ProAla: 2.236 ± 0.071
0.272ProCys: 0.272 ± 0.025
2.486ProAsp: 2.486 ± 0.071
2.612ProGlu: 2.612 ± 0.088
1.6ProPhe: 1.6 ± 0.059
2.635ProGly: 2.635 ± 0.101
0.883ProHis: 0.883 ± 0.041
3.057ProIle: 3.057 ± 0.087
2.872ProLys: 2.872 ± 0.093
3.159ProLeu: 3.159 ± 0.088
0.9ProMet: 0.9 ± 0.041
1.841ProAsn: 1.841 ± 0.063
1.515ProPro: 1.515 ± 0.075
1.654ProGln: 1.654 ± 0.088
1.378ProArg: 1.378 ± 0.054
3.149ProSer: 3.149 ± 0.091
2.467ProThr: 2.467 ± 0.071
3.063ProVal: 3.063 ± 0.083
0.355ProTrp: 0.355 ± 0.026
1.347ProTyr: 1.347 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.066GlnAla: 2.066 ± 0.081
0.241GlnCys: 0.241 ± 0.023
1.767GlnAsp: 1.767 ± 0.07
1.949GlnGlu: 1.949 ± 0.063
1.501GlnPhe: 1.501 ± 0.059
2.03GlnGly: 2.03 ± 0.103
0.636GlnHis: 0.636 ± 0.039
3.178GlnIle: 3.178 ± 0.083
3.176GlnLys: 3.176 ± 0.076
2.442GlnLeu: 2.442 ± 0.08
1.079GlnMet: 1.079 ± 0.047
2.232GlnAsn: 2.232 ± 0.077
0.935GlnPro: 0.935 ± 0.043
1.23GlnGln: 1.23 ± 0.075
1.284GlnArg: 1.284 ± 0.059
2.427GlnSer: 2.427 ± 0.082
2.145GlnThr: 2.145 ± 0.082
2.479GlnVal: 2.479 ± 0.085
0.326GlnTrp: 0.326 ± 0.026
1.328GlnTyr: 1.328 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
2.078ArgAla: 2.078 ± 0.075
0.357ArgCys: 0.357 ± 0.027
2.064ArgAsp: 2.064 ± 0.069
2.54ArgGlu: 2.54 ± 0.096
1.731ArgPhe: 1.731 ± 0.059
2.403ArgGly: 2.403 ± 0.073
0.748ArgHis: 0.748 ± 0.038
3.44ArgIle: 3.44 ± 0.088
3.471ArgLys: 3.471 ± 0.1
3.55ArgLeu: 3.55 ± 0.098
1.101ArgMet: 1.101 ± 0.052
1.914ArgAsn: 1.914 ± 0.068
1.395ArgPro: 1.395 ± 0.077
1.376ArgGln: 1.376 ± 0.054
1.756ArgArg: 1.756 ± 0.075
2.415ArgSer: 2.415 ± 0.07
2.014ArgThr: 2.014 ± 0.06
2.386ArgVal: 2.386 ± 0.077
0.38ArgTrp: 0.38 ± 0.028
1.413ArgTyr: 1.413 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.431SerAla: 4.431 ± 0.118
0.736SerCys: 0.736 ± 0.041
4.317SerAsp: 4.317 ± 0.105
4.119SerGlu: 4.119 ± 0.091
2.895SerPhe: 2.895 ± 0.088
5.624SerGly: 5.624 ± 0.115
1.488SerHis: 1.488 ± 0.058
6.212SerIle: 6.212 ± 0.112
5.9SerLys: 5.9 ± 0.107
6.646SerLeu: 6.646 ± 0.124
2.003SerMet: 2.003 ± 0.061
3.519SerAsn: 3.519 ± 0.114
2.754SerPro: 2.754 ± 0.069
2.75SerGln: 2.75 ± 0.084
2.693SerArg: 2.693 ± 0.07
5.965SerSer: 5.965 ± 0.15
4.911SerThr: 4.911 ± 0.144
4.961SerVal: 4.961 ± 0.118
0.715SerTrp: 0.715 ± 0.049
2.34SerTyr: 2.34 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
3.739ThrAla: 3.739 ± 0.12
0.594ThrCys: 0.594 ± 0.041
3.167ThrAsp: 3.167 ± 0.081
3.022ThrGlu: 3.022 ± 0.094
2.319ThrPhe: 2.319 ± 0.071
4.63ThrGly: 4.63 ± 0.127
1.112ThrHis: 1.112 ± 0.048
5.493ThrIle: 5.493 ± 0.118
4.394ThrLys: 4.394 ± 0.105
5.198ThrLeu: 5.198 ± 0.12
1.528ThrMet: 1.528 ± 0.058
2.932ThrAsn: 2.932 ± 0.093
2.745ThrPro: 2.745 ± 0.087
1.968ThrGln: 1.968 ± 0.069
2.396ThrArg: 2.396 ± 0.075
4.506ThrSer: 4.506 ± 0.143
3.82ThrThr: 3.82 ± 0.119
4.362ThrVal: 4.362 ± 0.119
0.584ThrTrp: 0.584 ± 0.038
1.843ThrTyr: 1.843 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
4.633ValAla: 4.633 ± 0.104
0.732ValCys: 0.732 ± 0.041
3.88ValAsp: 3.88 ± 0.1
3.776ValGlu: 3.776 ± 0.096
3.032ValPhe: 3.032 ± 0.076
4.707ValGly: 4.707 ± 0.1
1.245ValHis: 1.245 ± 0.054
6.129ValIle: 6.129 ± 0.129
5.183ValLys: 5.183 ± 0.108
6.054ValLeu: 6.054 ± 0.12
1.688ValMet: 1.688 ± 0.062
3.055ValAsn: 3.055 ± 0.095
2.881ValPro: 2.881 ± 0.081
2.242ValGln: 2.242 ± 0.072
2.583ValArg: 2.583 ± 0.084
5.622ValSer: 5.622 ± 0.108
4.689ValThr: 4.689 ± 0.108
4.842ValVal: 4.842 ± 0.12
0.542ValTrp: 0.542 ± 0.041
2.234ValTyr: 2.234 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.538TrpAla: 0.538 ± 0.034
0.096TrpCys: 0.096 ± 0.014
0.476TrpAsp: 0.476 ± 0.035
0.436TrpGlu: 0.436 ± 0.033
0.401TrpPhe: 0.401 ± 0.031
0.561TrpGly: 0.561 ± 0.033
0.233TrpHis: 0.233 ± 0.02
0.804TrpIle: 0.804 ± 0.043
0.74TrpLys: 0.74 ± 0.043
0.788TrpLeu: 0.788 ± 0.042
0.316TrpMet: 0.316 ± 0.027
0.574TrpAsn: 0.574 ± 0.035
0.299TrpPro: 0.299 ± 0.024
0.301TrpGln: 0.301 ± 0.027
0.339TrpArg: 0.339 ± 0.026
0.582TrpSer: 0.582 ± 0.036
0.517TrpThr: 0.517 ± 0.036
0.636TrpVal: 0.636 ± 0.041
0.123TrpTrp: 0.123 ± 0.019
0.306TrpTyr: 0.306 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.228TyrAla: 2.228 ± 0.077
0.414TyrCys: 0.414 ± 0.032
2.249TyrAsp: 2.249 ± 0.074
1.758TyrGlu: 1.758 ± 0.062
1.434TyrPhe: 1.434 ± 0.055
2.351TyrGly: 2.351 ± 0.075
0.8TyrHis: 0.8 ± 0.046
1.831TyrIle: 1.831 ± 0.062
2.028TyrLys: 2.028 ± 0.068
2.968TyrLeu: 2.968 ± 0.087
0.696TyrMet: 0.696 ± 0.042
1.515TyrAsn: 1.515 ± 0.06
1.355TyrPro: 1.355 ± 0.057
1.16TyrGln: 1.16 ± 0.049
1.446TyrArg: 1.446 ± 0.054
2.587TyrSer: 2.587 ± 0.083
1.789TyrThr: 1.789 ± 0.064
2.336TyrVal: 2.336 ± 0.076
0.357TyrTrp: 0.357 ± 0.029
1.191TyrTyr: 1.191 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1881 proteins (481166 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski