Amino acid dipepetide frequency for Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.214AlaAla: 9.214 ± 1.809
0.329AlaCys: 0.329 ± 0.165
2.632AlaAsp: 2.632 ± 1.096
2.303AlaGlu: 2.303 ± 0.545
1.645AlaPhe: 1.645 ± 1.33
9.214AlaGly: 9.214 ± 4.729
1.316AlaHis: 1.316 ± 0.661
4.936AlaIle: 4.936 ± 1.098
2.962AlaLys: 2.962 ± 0.849
2.632AlaLeu: 2.632 ± 1.096
1.974AlaMet: 1.974 ± 1.328
4.278AlaAsn: 4.278 ± 0.809
5.923AlaPro: 5.923 ± 2.596
2.632AlaGln: 2.632 ± 0.536
4.607AlaArg: 4.607 ± 1.09
8.226AlaSer: 8.226 ± 3.211
6.91AlaThr: 6.91 ± 1.72
5.265AlaVal: 5.265 ± 1.001
0.329AlaTrp: 0.329 ± 0.165
2.303AlaTyr: 2.303 ± 1.15
0.0AlaXaa: 0.0 ± 0.0
Cys
1.645CysAla: 1.645 ± 0.826
0.658CysCys: 0.658 ± 0.331
0.987CysAsp: 0.987 ± 0.496
0.329CysGlu: 0.329 ± 0.165
0.329CysPhe: 0.329 ± 0.165
2.632CysGly: 2.632 ± 1.322
0.329CysHis: 0.329 ± 0.165
0.329CysIle: 0.329 ± 0.165
0.329CysLys: 0.329 ± 0.165
2.303CysLeu: 2.303 ± 1.157
0.0CysMet: 0.0 ± 0.0
1.316CysAsn: 1.316 ± 0.268
0.658CysPro: 0.658 ± 0.331
0.329CysGln: 0.329 ± 0.165
0.329CysArg: 0.329 ± 0.165
1.974CysSer: 1.974 ± 0.992
1.645CysThr: 1.645 ± 0.826
1.316CysVal: 1.316 ± 0.661
0.329CysTrp: 0.329 ± 0.165
0.658CysTyr: 0.658 ± 0.331
0.0CysXaa: 0.0 ± 0.0
Asp
3.291AspAla: 3.291 ± 1.014
0.987AspCys: 0.987 ± 0.496
2.303AspAsp: 2.303 ± 1.157
2.962AspGlu: 2.962 ± 1.488
1.645AspPhe: 1.645 ± 0.304
3.62AspGly: 3.62 ± 0.834
1.316AspHis: 1.316 ± 0.268
1.645AspIle: 1.645 ± 0.304
3.62AspLys: 3.62 ± 1.818
5.923AspLeu: 5.923 ± 1.698
1.645AspMet: 1.645 ± 0.304
2.632AspAsn: 2.632 ± 0.536
3.291AspPro: 3.291 ± 0.608
2.962AspGln: 2.962 ± 1.065
2.303AspArg: 2.303 ± 0.545
3.291AspSer: 3.291 ± 1.007
0.987AspThr: 0.987 ± 0.496
5.265AspVal: 5.265 ± 1.001
0.658AspTrp: 0.658 ± 0.331
1.316AspTyr: 1.316 ± 0.661
0.0AspXaa: 0.0 ± 0.0
Glu
1.316GluAla: 1.316 ± 0.268
0.0GluCys: 0.0 ± 0.0
1.974GluAsp: 1.974 ± 0.409
2.632GluGlu: 2.632 ± 1.322
2.962GluPhe: 2.962 ± 1.065
3.62GluGly: 3.62 ± 1.167
0.329GluHis: 0.329 ± 0.165
2.303GluIle: 2.303 ± 0.573
0.658GluLys: 0.658 ± 0.331
4.607GluLeu: 4.607 ± 0.792
0.329GluMet: 0.329 ± 0.165
1.645GluAsn: 1.645 ± 1.314
1.974GluPro: 1.974 ± 0.409
0.329GluGln: 0.329 ± 0.165
1.316GluArg: 1.316 ± 0.661
1.645GluSer: 1.645 ± 1.33
2.632GluThr: 2.632 ± 0.536
2.303GluVal: 2.303 ± 1.15
0.658GluTrp: 0.658 ± 0.331
1.974GluTyr: 1.974 ± 0.992
0.0GluXaa: 0.0 ± 0.0
Phe
2.303PheAla: 2.303 ± 1.198
0.329PheCys: 0.329 ± 0.165
1.316PheAsp: 1.316 ± 0.661
1.974PheGlu: 1.974 ± 0.409
1.645PhePhe: 1.645 ± 0.304
4.278PheGly: 4.278 ± 1.216
0.658PheHis: 0.658 ± 0.331
2.962PheIle: 2.962 ± 1.065
0.987PheLys: 0.987 ± 0.496
1.974PheLeu: 1.974 ± 1.328
2.303PheMet: 2.303 ± 0.545
3.291PheAsn: 3.291 ± 1.014
1.974PhePro: 1.974 ± 0.652
0.987PheGln: 0.987 ± 0.496
0.987PheArg: 0.987 ± 0.326
3.291PheSer: 3.291 ± 1.014
1.974PheThr: 1.974 ± 0.652
7.239PheVal: 7.239 ± 1.403
0.987PheTrp: 0.987 ± 0.326
2.303PheTyr: 2.303 ± 0.573
0.0PheXaa: 0.0 ± 0.0
Gly
7.239GlyAla: 7.239 ± 0.697
2.303GlyCys: 2.303 ± 1.157
3.949GlyAsp: 3.949 ± 0.805
2.962GlyGlu: 2.962 ± 1.065
6.91GlyPhe: 6.91 ± 1.569
4.607GlyGly: 4.607 ± 2.395
0.0GlyHis: 0.0 ± 0.0
4.278GlyIle: 4.278 ± 1.524
5.923GlyLys: 5.923 ± 1.698
9.543GlyLeu: 9.543 ± 3.464
1.974GlyMet: 1.974 ± 0.652
2.962GlyAsn: 2.962 ± 1.125
4.607GlyPro: 4.607 ± 1.147
1.974GlyGln: 1.974 ± 0.652
2.632GlyArg: 2.632 ± 1.096
6.91GlySer: 6.91 ± 3.593
6.581GlyThr: 6.581 ± 3.033
7.897GlyVal: 7.897 ± 1.127
2.632GlyTrp: 2.632 ± 1.08
1.645GlyTyr: 1.645 ± 0.304
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.329HisCys: 0.329 ± 0.165
0.658HisAsp: 0.658 ± 0.331
0.0HisGlu: 0.0 ± 0.0
0.329HisPhe: 0.329 ± 0.165
0.987HisGly: 0.987 ± 0.496
0.329HisHis: 0.329 ± 0.165
0.987HisIle: 0.987 ± 0.496
0.329HisLys: 0.329 ± 0.165
2.632HisLeu: 2.632 ± 1.322
0.658HisMet: 0.658 ± 0.331
1.645HisAsn: 1.645 ± 1.33
1.974HisPro: 1.974 ± 0.409
0.0HisGln: 0.0 ± 0.0
1.316HisArg: 1.316 ± 0.268
1.316HisSer: 1.316 ± 0.268
0.987HisThr: 0.987 ± 0.496
0.987HisVal: 0.987 ± 0.326
0.987HisTrp: 0.987 ± 0.326
0.329HisTyr: 0.329 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
3.62IleAla: 3.62 ± 1.167
0.987IleCys: 0.987 ± 0.496
5.265IleAsp: 5.265 ± 1.541
2.303IleGlu: 2.303 ± 0.545
0.987IlePhe: 0.987 ± 0.496
4.278IleGly: 4.278 ± 1.524
0.987IleHis: 0.987 ± 0.496
1.974IleIle: 1.974 ± 0.409
1.316IleLys: 1.316 ± 1.352
3.949IleLeu: 3.949 ± 1.329
0.987IleMet: 0.987 ± 0.326
2.632IleAsn: 2.632 ± 0.694
1.974IlePro: 1.974 ± 0.652
1.316IleGln: 1.316 ± 0.268
2.632IleArg: 2.632 ± 1.096
4.278IleSer: 4.278 ± 0.809
4.278IleThr: 4.278 ± 0.809
4.278IleVal: 4.278 ± 0.973
1.316IleTrp: 1.316 ± 0.268
1.316IleTyr: 1.316 ± 1.418
0.0IleXaa: 0.0 ± 0.0
Lys
3.62LysAla: 3.62 ± 1.08
0.658LysCys: 0.658 ± 0.331
1.645LysAsp: 1.645 ± 0.826
0.987LysGlu: 0.987 ± 0.496
1.316LysPhe: 1.316 ± 0.661
2.962LysGly: 2.962 ± 1.488
1.316LysHis: 1.316 ± 0.661
2.962LysIle: 2.962 ± 2.677
3.291LysLys: 3.291 ± 1.514
3.62LysLeu: 3.62 ± 1.818
0.987LysMet: 0.987 ± 0.496
2.632LysAsn: 2.632 ± 1.096
0.987LysPro: 0.987 ± 0.496
1.316LysGln: 1.316 ± 1.352
1.974LysArg: 1.974 ± 0.992
4.936LysSer: 4.936 ± 0.815
3.62LysThr: 3.62 ± 1.167
3.62LysVal: 3.62 ± 1.818
0.658LysTrp: 0.658 ± 0.331
0.658LysTyr: 0.658 ± 0.331
0.0LysXaa: 0.0 ± 0.0
Leu
4.607LeuAla: 4.607 ± 1.922
2.303LeuCys: 2.303 ± 1.157
4.936LeuAsp: 4.936 ± 2.479
4.278LeuGlu: 4.278 ± 0.95
1.974LeuPhe: 1.974 ± 0.409
6.581LeuGly: 6.581 ± 3.542
1.645LeuHis: 1.645 ± 0.826
4.278LeuIle: 4.278 ± 0.809
3.291LeuLys: 3.291 ± 1.514
5.594LeuLeu: 5.594 ± 1.604
2.303LeuMet: 2.303 ± 1.15
3.949LeuAsn: 3.949 ± 0.848
3.291LeuPro: 3.291 ± 1.007
3.291LeuGln: 3.291 ± 2.904
3.291LeuArg: 3.291 ± 1.06
4.936LeuSer: 4.936 ± 2.625
7.568LeuThr: 7.568 ± 1.515
5.923LeuVal: 5.923 ± 0.723
1.316LeuTrp: 1.316 ± 0.661
2.303LeuTyr: 2.303 ± 0.545
0.0LeuXaa: 0.0 ± 0.0
Met
2.303MetAla: 2.303 ± 1.15
0.329MetCys: 0.329 ± 0.165
1.974MetAsp: 1.974 ± 0.409
1.645MetGlu: 1.645 ± 1.661
0.987MetPhe: 0.987 ± 0.326
0.658MetGly: 0.658 ± 0.331
0.329MetHis: 0.329 ± 1.527
1.974MetIle: 1.974 ± 0.409
0.987MetLys: 0.987 ± 0.496
0.329MetLeu: 0.329 ± 0.165
0.329MetMet: 0.329 ± 0.165
0.329MetAsn: 0.329 ± 0.165
1.974MetPro: 1.974 ± 0.652
0.658MetGln: 0.658 ± 0.442
0.329MetArg: 0.329 ± 0.165
1.974MetSer: 1.974 ± 1.223
2.962MetThr: 2.962 ± 1.488
2.632MetVal: 2.632 ± 1.322
0.329MetTrp: 0.329 ± 0.165
1.645MetTyr: 1.645 ± 0.758
0.0MetXaa: 0.0 ± 0.0
Asn
4.278AsnAla: 4.278 ± 2.896
0.658AsnCys: 0.658 ± 0.331
2.632AsnAsp: 2.632 ± 1.248
0.987AsnGlu: 0.987 ± 1.393
2.962AsnPhe: 2.962 ± 0.849
5.594AsnGly: 5.594 ± 2.777
0.329AsnHis: 0.329 ± 0.165
1.316AsnIle: 1.316 ± 0.661
2.632AsnLys: 2.632 ± 1.322
6.581AsnLeu: 6.581 ± 1.216
2.303AsnMet: 2.303 ± 1.15
3.62AsnAsn: 3.62 ± 1.264
4.607AsnPro: 4.607 ± 2.759
1.316AsnGln: 1.316 ± 0.661
2.303AsnArg: 2.303 ± 0.573
4.278AsnSer: 4.278 ± 2.542
3.291AsnThr: 3.291 ± 1.014
3.291AsnVal: 3.291 ± 4.244
0.0AsnTrp: 0.0 ± 0.0
0.658AsnTyr: 0.658 ± 0.442
0.0AsnXaa: 0.0 ± 0.0
Pro
4.278ProAla: 4.278 ± 1.524
1.645ProCys: 1.645 ± 0.826
4.278ProAsp: 4.278 ± 1.216
0.658ProGlu: 0.658 ± 0.331
3.291ProPhe: 3.291 ± 0.893
9.543ProGly: 9.543 ± 3.999
0.987ProHis: 0.987 ± 0.326
2.632ProIle: 2.632 ± 0.536
0.987ProLys: 0.987 ± 0.496
3.291ProLeu: 3.291 ± 1.007
0.658ProMet: 0.658 ± 0.331
2.962ProAsn: 2.962 ± 1.571
1.974ProPro: 1.974 ± 0.652
3.291ProGln: 3.291 ± 1.517
2.632ProArg: 2.632 ± 0.536
3.291ProSer: 3.291 ± 0.893
3.949ProThr: 3.949 ± 0.805
7.568ProVal: 7.568 ± 1.63
0.0ProTrp: 0.0 ± 0.0
0.329ProTyr: 0.329 ± 0.165
0.0ProXaa: 0.0 ± 0.0
Gln
3.291GlnAla: 3.291 ± 1.06
0.329GlnCys: 0.329 ± 0.165
0.329GlnAsp: 0.329 ± 0.165
1.645GlnGlu: 1.645 ± 1.314
3.949GlnPhe: 3.949 ± 1.303
1.316GlnGly: 1.316 ± 0.268
1.974GlnHis: 1.974 ± 0.409
1.316GlnIle: 1.316 ± 0.268
1.316GlnLys: 1.316 ± 1.352
3.62GlnLeu: 3.62 ± 2.488
0.987GlnMet: 0.987 ± 0.326
1.645GlnAsn: 1.645 ± 0.758
2.962GlnPro: 2.962 ± 1.638
3.291GlnGln: 3.291 ± 0.608
0.329GlnArg: 0.329 ± 0.165
0.0GlnSer: 0.0 ± 0.0
2.303GlnThr: 2.303 ± 0.545
4.278GlnVal: 4.278 ± 0.809
0.329GlnTrp: 0.329 ± 0.165
1.316GlnTyr: 1.316 ± 0.268
0.0GlnXaa: 0.0 ± 0.0
Arg
3.62ArgAla: 3.62 ± 0.834
0.658ArgCys: 0.658 ± 0.331
2.303ArgAsp: 2.303 ± 1.157
0.987ArgGlu: 0.987 ± 0.496
2.303ArgPhe: 2.303 ± 0.573
2.962ArgGly: 2.962 ± 0.849
1.645ArgHis: 1.645 ± 0.304
1.316ArgIle: 1.316 ± 0.268
1.974ArgLys: 1.974 ± 1.328
4.278ArgLeu: 4.278 ± 2.415
0.329ArgMet: 0.329 ± 0.165
0.658ArgAsn: 0.658 ± 0.331
4.607ArgPro: 4.607 ± 1.147
2.962ArgGln: 2.962 ± 1.065
3.291ArgArg: 3.291 ± 1.014
2.632ArgSer: 2.632 ± 0.694
2.632ArgThr: 2.632 ± 0.536
1.974ArgVal: 1.974 ± 0.992
0.987ArgTrp: 0.987 ± 0.326
0.658ArgTyr: 0.658 ± 0.331
0.0ArgXaa: 0.0 ± 0.0
Ser
4.936SerAla: 4.936 ± 2.962
1.974SerCys: 1.974 ± 0.992
3.62SerAsp: 3.62 ± 1.818
1.974SerGlu: 1.974 ± 1.223
2.632SerPhe: 2.632 ± 1.096
6.581SerGly: 6.581 ± 1.787
0.987SerHis: 0.987 ± 0.496
4.936SerIle: 4.936 ± 1.098
3.949SerLys: 3.949 ± 0.818
2.632SerLeu: 2.632 ± 1.248
0.329SerMet: 0.329 ± 0.165
4.278SerAsn: 4.278 ± 5.586
3.291SerPro: 3.291 ± 0.893
2.962SerGln: 2.962 ± 0.977
2.303SerArg: 2.303 ± 1.157
4.278SerSer: 4.278 ± 2.896
6.581SerThr: 6.581 ± 1.787
7.897SerVal: 7.897 ± 3.743
1.316SerTrp: 1.316 ± 0.661
2.303SerTyr: 2.303 ± 0.573
0.0SerXaa: 0.0 ± 0.0
Thr
7.239ThrAla: 7.239 ± 2.809
1.645ThrCys: 1.645 ± 0.304
2.303ThrAsp: 2.303 ± 0.545
1.645ThrGlu: 1.645 ± 0.304
2.962ThrPhe: 2.962 ± 0.849
7.568ThrGly: 7.568 ± 1.972
0.987ThrHis: 0.987 ± 0.496
3.949ThrIle: 3.949 ± 0.818
3.291ThrLys: 3.291 ± 1.653
6.581ThrLeu: 6.581 ± 1.493
1.645ThrMet: 1.645 ± 0.304
3.949ThrAsn: 3.949 ± 0.805
6.252ThrPro: 6.252 ± 1.865
1.645ThrGln: 1.645 ± 0.304
1.974ThrArg: 1.974 ± 0.409
5.265ThrSer: 5.265 ± 1.001
10.53ThrThr: 10.53 ± 2.075
5.265ThrVal: 5.265 ± 1.541
1.645ThrTrp: 1.645 ± 0.758
2.632ThrTyr: 2.632 ± 0.536
0.0ThrXaa: 0.0 ± 0.0
Val
7.897ValAla: 7.897 ± 1.448
2.303ValCys: 2.303 ± 1.157
5.594ValAsp: 5.594 ± 1.108
3.291ValGlu: 3.291 ± 1.007
3.949ValPhe: 3.949 ± 0.805
6.252ValGly: 6.252 ± 1.192
0.658ValHis: 0.658 ± 0.331
5.594ValIle: 5.594 ± 0.548
3.291ValLys: 3.291 ± 2.659
5.265ValLeu: 5.265 ± 2.495
4.278ValMet: 4.278 ± 0.333
3.949ValAsn: 3.949 ± 1.125
4.936ValPro: 4.936 ± 1.098
2.962ValGln: 2.962 ± 0.549
5.265ValArg: 5.265 ± 1.038
1.974ValSer: 1.974 ± 0.992
6.581ValThr: 6.581 ± 1.787
6.252ValVal: 6.252 ± 0.571
0.658ValTrp: 0.658 ± 0.442
3.949ValTyr: 3.949 ± 1.125
0.0ValXaa: 0.0 ± 0.0
Trp
1.316TrpAla: 1.316 ± 0.268
0.0TrpCys: 0.0 ± 0.0
0.658TrpAsp: 0.658 ± 0.331
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.329TrpGly: 0.329 ± 0.165
0.0TrpHis: 0.0 ± 0.0
0.329TrpIle: 0.329 ± 0.165
0.658TrpLys: 0.658 ± 0.331
0.658TrpLeu: 0.658 ± 0.331
0.329TrpMet: 0.329 ± 0.165
2.303TrpAsn: 2.303 ± 1.198
0.329TrpPro: 0.329 ± 0.165
1.316TrpGln: 1.316 ± 0.268
1.974TrpArg: 1.974 ± 0.409
2.303TrpSer: 2.303 ± 0.573
0.329TrpThr: 0.329 ± 0.165
1.316TrpVal: 1.316 ± 0.268
0.329TrpTrp: 0.329 ± 0.165
0.987TrpTyr: 0.987 ± 0.326
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.62TyrAla: 3.62 ± 1.404
0.0TyrCys: 0.0 ± 0.0
2.303TyrAsp: 2.303 ± 1.157
1.645TyrGlu: 1.645 ± 0.304
0.987TyrPhe: 0.987 ± 0.326
3.949TyrGly: 3.949 ± 0.818
0.658TyrHis: 0.658 ± 0.442
0.658TyrIle: 0.658 ± 0.331
1.974TyrLys: 1.974 ± 0.992
1.645TyrLeu: 1.645 ± 0.826
0.0TyrMet: 0.0 ± 0.0
2.962TyrAsn: 2.962 ± 4.342
0.658TyrPro: 0.658 ± 0.331
0.987TyrGln: 0.987 ± 0.496
0.987TyrArg: 0.987 ± 0.496
2.962TyrSer: 2.962 ± 0.549
2.632TyrThr: 2.632 ± 0.536
0.658TyrVal: 0.658 ± 0.442
0.0TyrTrp: 0.0 ± 0.0
0.658TyrTyr: 0.658 ± 0.442
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski