Amino acid dipepetide frequency for Olavius algarvensis spirochete endosymbiont

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.099AlaAla: 7.099 ± 0.131	0.759AlaCys: 0.759 ± 0.035	4.323AlaAsp: 4.323 ± 0.083	5.141AlaGlu: 5.141 ± 0.095	3.009AlaPhe: 3.009 ± 0.073	6.508AlaGly: 6.508 ± 0.118	1.229AlaHis: 1.229 ± 0.039	5.686AlaIle: 5.686 ± 0.096	3.881AlaLys: 3.881 ± 0.077	8.583AlaLeu: 8.583 ± 0.13	1.963AlaMet: 1.963 ± 0.051	2.82AlaAsn: 2.82 ± 0.073	2.432AlaPro: 2.432 ± 0.065	2.314AlaGln: 2.314 ± 0.064	4.82AlaArg: 4.82 ± 0.092	5.097AlaSer: 5.097 ± 0.092	3.392AlaThr: 3.392 ± 0.071	5.456AlaVal: 5.456 ± 0.098	1.044AlaTrp: 1.044 ± 0.051	2.247AlaTyr: 2.247 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.669CysAla: 0.669 ± 0.033	0.132CysCys: 0.132 ± 0.015	0.542CysAsp: 0.542 ± 0.03	0.543CysGlu: 0.543 ± 0.028	0.416CysPhe: 0.416 ± 0.032	0.874CysGly: 0.874 ± 0.042	0.216CysHis: 0.216 ± 0.019	0.597CysIle: 0.597 ± 0.031	0.403CysLys: 0.403 ± 0.024	0.815CysLeu: 0.815 ± 0.045	0.158CysMet: 0.158 ± 0.017	0.287CysAsn: 0.287 ± 0.023	0.469CysPro: 0.469 ± 0.033	0.2CysGln: 0.2 ± 0.019	0.669CysArg: 0.669 ± 0.034	0.695CysSer: 0.695 ± 0.035	0.379CysThr: 0.379 ± 0.025	0.515CysVal: 0.515 ± 0.03	0.113CysTrp: 0.113 ± 0.014	0.29CysTyr: 0.29 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.165AspAla: 4.165 ± 0.1	0.456AspCys: 0.456 ± 0.028	2.809AspAsp: 2.809 ± 0.08	4.371AspGlu: 4.371 ± 0.107	2.927AspPhe: 2.927 ± 0.08	4.294AspGly: 4.294 ± 0.108	0.644AspHis: 0.644 ± 0.035	4.233AspIle: 4.233 ± 0.084	2.942AspLys: 2.942 ± 0.068	4.474AspLeu: 4.474 ± 0.082	1.376AspMet: 1.376 ± 0.047	2.064AspAsn: 2.064 ± 0.055	1.963AspPro: 1.963 ± 0.056	1.064AspGln: 1.064 ± 0.039	3.103AspArg: 3.103 ± 0.077	4.3AspSer: 4.3 ± 0.099	2.562AspThr: 2.562 ± 0.066	3.465AspVal: 3.465 ± 0.084	0.877AspTrp: 0.877 ± 0.044	2.034AspTyr: 2.034 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.577GluAla: 5.577 ± 0.093	0.456GluCys: 0.456 ± 0.027	3.498GluAsp: 3.498 ± 0.085	4.947GluGlu: 4.947 ± 0.11	2.626GluPhe: 2.626 ± 0.064	4.654GluGly: 4.654 ± 0.088	1.13GluHis: 1.13 ± 0.043	5.841GluIle: 5.841 ± 0.109	4.508GluLys: 4.508 ± 0.105	7.335GluLeu: 7.335 ± 0.117	1.631GluMet: 1.631 ± 0.046	3.603GluAsn: 3.603 ± 0.086	1.937GluPro: 1.937 ± 0.057	1.92GluGln: 1.92 ± 0.061	4.201GluArg: 4.201 ± 0.094	4.506GluSer: 4.506 ± 0.094	3.589GluThr: 3.589 ± 0.08	4.27GluVal: 4.27 ± 0.088	0.771GluTrp: 0.771 ± 0.038	2.193GluTyr: 2.193 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.254PheAla: 3.254 ± 0.077	0.462PheCys: 0.462 ± 0.028	2.605PheAsp: 2.605 ± 0.062	2.832PheGlu: 2.832 ± 0.066	2.143PhePhe: 2.143 ± 0.058	3.226PheGly: 3.226 ± 0.08	0.849PheHis: 0.849 ± 0.039	2.635PheIle: 2.635 ± 0.071	1.792PheLys: 1.792 ± 0.054	4.486PheLeu: 4.486 ± 0.093	0.836PheMet: 0.836 ± 0.034	1.851PheAsn: 1.851 ± 0.052	1.975PhePro: 1.975 ± 0.06	1.251PheGln: 1.251 ± 0.048	2.671PheArg: 2.671 ± 0.069	3.522PheSer: 3.522 ± 0.08	2.023PheThr: 2.023 ± 0.057	2.685PheVal: 2.685 ± 0.065	0.551PheTrp: 0.551 ± 0.026	1.316PheTyr: 1.316 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.608GlyAla: 5.608 ± 0.11	0.714GlyCys: 0.714 ± 0.036	3.63GlyAsp: 3.63 ± 0.084	4.817GlyGlu: 4.817 ± 0.093	3.619GlyPhe: 3.619 ± 0.078	5.479GlyGly: 5.479 ± 0.143	1.277GlyHis: 1.277 ± 0.047	6.066GlyIle: 6.066 ± 0.104	4.494GlyLys: 4.494 ± 0.082	7.099GlyLeu: 7.099 ± 0.119	1.966GlyMet: 1.966 ± 0.056	3.373GlyAsn: 3.373 ± 0.088	2.061GlyPro: 2.061 ± 0.056	1.868GlyGln: 1.868 ± 0.059	4.612GlyArg: 4.612 ± 0.097	5.158GlySer: 5.158 ± 0.101	4.197GlyThr: 4.197 ± 0.09	5.169GlyVal: 5.169 ± 0.102	0.951GlyTrp: 0.951 ± 0.043	2.528GlyTyr: 2.528 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.249HisAla: 1.249 ± 0.047	0.191HisCys: 0.191 ± 0.02	0.808HisAsp: 0.808 ± 0.035	1.069HisGlu: 1.069 ± 0.044	0.83HisPhe: 0.83 ± 0.035	1.359HisGly: 1.359 ± 0.048	0.453HisHis: 0.453 ± 0.031	1.249HisIle: 1.249 ± 0.041	0.804HisLys: 0.804 ± 0.041	1.943HisLeu: 1.943 ± 0.071	0.369HisMet: 0.369 ± 0.024	0.658HisAsn: 0.658 ± 0.033	1.133HisPro: 1.133 ± 0.047	0.607HisGln: 0.607 ± 0.032	1.288HisArg: 1.288 ± 0.046	1.269HisSer: 1.269 ± 0.045	0.781HisThr: 0.781 ± 0.035	0.998HisVal: 0.998 ± 0.039	0.25HisTrp: 0.25 ± 0.018	0.644HisTyr: 0.644 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.258IleAla: 6.258 ± 0.112	0.706IleCys: 0.706 ± 0.033	4.547IleAsp: 4.547 ± 0.077	5.391IleGlu: 5.391 ± 0.095	2.795IlePhe: 2.795 ± 0.074	5.349IleGly: 5.349 ± 0.114	1.507IleHis: 1.507 ± 0.053	4.806IleIle: 4.806 ± 0.089	3.225IleLys: 3.225 ± 0.07	7.399IleLeu: 7.399 ± 0.121	1.229IleMet: 1.229 ± 0.043	2.751IleAsn: 2.751 ± 0.067	3.785IlePro: 3.785 ± 0.086	2.006IleGln: 2.006 ± 0.058	4.983IleArg: 4.983 ± 0.1	5.586IleSer: 5.586 ± 0.109	3.695IleThr: 3.695 ± 0.091	4.623IleVal: 4.623 ± 0.088	0.812IleTrp: 0.812 ± 0.039	2.047IleTyr: 2.047 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.01LysAla: 4.01 ± 0.096	0.363LysCys: 0.363 ± 0.026	2.498LysAsp: 2.498 ± 0.061	3.751LysGlu: 3.751 ± 0.087	1.823LysPhe: 1.823 ± 0.05	3.29LysGly: 3.29 ± 0.071	0.99LysHis: 0.99 ± 0.033	4.163LysIle: 4.163 ± 0.09	3.822LysLys: 3.822 ± 0.087	5.428LysLeu: 5.428 ± 0.097	1.421LysMet: 1.421 ± 0.049	2.598LysAsn: 2.598 ± 0.065	2.182LysPro: 2.182 ± 0.061	1.702LysGln: 1.702 ± 0.059	3.335LysArg: 3.335 ± 0.077	3.715LysSer: 3.715 ± 0.08	3.291LysThr: 3.291 ± 0.068	3.08LysVal: 3.08 ± 0.078	0.625LysTrp: 0.625 ± 0.03	1.547LysTyr: 1.547 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	8.572LeuAla: 8.572 ± 0.133	0.982LeuCys: 0.982 ± 0.048	5.735LeuAsp: 5.735 ± 0.096	7.31LeuGlu: 7.31 ± 0.126	4.332LeuPhe: 4.332 ± 0.099	7.312LeuGly: 7.312 ± 0.126	1.73LeuHis: 1.73 ± 0.055	7.251LeuIle: 7.251 ± 0.114	5.552LeuLys: 5.552 ± 0.113	10.186LeuLeu: 10.186 ± 0.153	2.464LeuMet: 2.464 ± 0.063	4.241LeuAsn: 4.241 ± 0.078	4.421LeuPro: 4.421 ± 0.087	2.601LeuGln: 2.601 ± 0.064	6.16LeuArg: 6.16 ± 0.104	8.024LeuSer: 8.024 ± 0.104	4.866LeuThr: 4.866 ± 0.084	6.41LeuVal: 6.41 ± 0.105	1.086LeuTrp: 1.086 ± 0.04	2.74LeuTyr: 2.74 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.152MetAla: 2.152 ± 0.063	0.155MetCys: 0.155 ± 0.015	1.316MetAsp: 1.316 ± 0.044	1.592MetGlu: 1.592 ± 0.052	0.708MetPhe: 0.708 ± 0.031	1.753MetGly: 1.753 ± 0.051	0.377MetHis: 0.377 ± 0.024	1.708MetIle: 1.708 ± 0.054	1.642MetLys: 1.642 ± 0.055	2.314MetLeu: 2.314 ± 0.059	0.658MetMet: 0.658 ± 0.034	1.203MetAsn: 1.203 ± 0.046	1.078MetPro: 1.078 ± 0.043	0.618MetGln: 0.618 ± 0.031	1.569MetArg: 1.569 ± 0.044	1.646MetSer: 1.646 ± 0.053	1.002MetThr: 1.002 ± 0.043	1.494MetVal: 1.494 ± 0.048	0.183MetTrp: 0.183 ± 0.016	0.481MetTyr: 0.481 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.874AsnAla: 2.874 ± 0.067	0.442AsnCys: 0.442 ± 0.029	1.811AsnAsp: 1.811 ± 0.049	2.553AsnGlu: 2.553 ± 0.066	1.771AsnPhe: 1.771 ± 0.055	2.871AsnGly: 2.871 ± 0.074	0.968AsnHis: 0.968 ± 0.038	2.734AsnIle: 2.734 ± 0.061	1.96AsnLys: 1.96 ± 0.058	5.014AsnLeu: 5.014 ± 0.097	0.9AsnMet: 0.9 ± 0.041	1.656AsnAsn: 1.656 ± 0.062	2.74AsnPro: 2.74 ± 0.063	1.42AsnGln: 1.42 ± 0.05	2.877AsnArg: 2.877 ± 0.075	3.082AsnSer: 3.082 ± 0.075	2.003AsnThr: 2.003 ± 0.057	2.283AsnVal: 2.283 ± 0.065	0.751AsnTrp: 0.751 ± 0.035	1.378AsnTyr: 1.378 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.962ProAla: 2.962 ± 0.07	0.31ProCys: 0.31 ± 0.023	2.526ProAsp: 2.526 ± 0.062	3.369ProGlu: 3.369 ± 0.074	1.699ProPhe: 1.699 ± 0.051	3.418ProGly: 3.418 ± 0.07	0.796ProHis: 0.796 ± 0.041	2.688ProIle: 2.688 ± 0.064	1.87ProLys: 1.87 ± 0.056	3.765ProLeu: 3.765 ± 0.085	0.976ProMet: 0.976 ± 0.039	1.552ProAsn: 1.552 ± 0.047	1.634ProPro: 1.634 ± 0.051	1.075ProGln: 1.075 ± 0.039	2.143ProArg: 2.143 ± 0.055	2.84ProSer: 2.84 ± 0.08	1.915ProThr: 1.915 ± 0.053	2.948ProVal: 2.948 ± 0.075	0.54ProTrp: 0.54 ± 0.028	1.186ProTyr: 1.186 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.225GlnAla: 2.225 ± 0.062	0.177GlnCys: 0.177 ± 0.016	1.289GlnAsp: 1.289 ± 0.049	1.921GlnGlu: 1.921 ± 0.066	1.311GlnPhe: 1.311 ± 0.05	1.843GlnGly: 1.843 ± 0.055	0.441GlnHis: 0.441 ± 0.028	2.312GlnIle: 2.312 ± 0.068	1.74GlnLys: 1.74 ± 0.053	2.737GlnLeu: 2.737 ± 0.064	0.746GlnMet: 0.746 ± 0.032	1.297GlnAsn: 1.297 ± 0.045	0.939GlnPro: 0.939 ± 0.043	0.869GlnGln: 0.869 ± 0.038	1.716GlnArg: 1.716 ± 0.054	1.895GlnSer: 1.895 ± 0.052	1.469GlnThr: 1.469 ± 0.043	1.82GlnVal: 1.82 ± 0.051	0.326GlnTrp: 0.326 ± 0.023	0.824GlnTyr: 0.824 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	4.196ArgAla: 4.196 ± 0.084	0.545ArgCys: 0.545 ± 0.03	3.294ArgAsp: 3.294 ± 0.086	4.543ArgGlu: 4.543 ± 0.1	2.757ArgPhe: 2.757 ± 0.065	4.419ArgGly: 4.419 ± 0.088	1.186ArgHis: 1.186 ± 0.047	5.385ArgIle: 5.385 ± 0.11	4.159ArgLys: 4.159 ± 0.083	6.283ArgLeu: 6.283 ± 0.107	1.674ArgMet: 1.674 ± 0.057	2.965ArgAsn: 2.965 ± 0.06	1.868ArgPro: 1.868 ± 0.065	1.912ArgGln: 1.912 ± 0.063	4.545ArgArg: 4.545 ± 0.098	3.808ArgSer: 3.808 ± 0.074	2.672ArgThr: 2.672 ± 0.065	3.833ArgVal: 3.833 ± 0.072	0.829ArgTrp: 0.829 ± 0.039	2.106ArgTyr: 2.106 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	5.026SerAla: 5.026 ± 0.092	0.714SerCys: 0.714 ± 0.037	3.923SerAsp: 3.923 ± 0.093	4.722SerGlu: 4.722 ± 0.11	3.305SerPhe: 3.305 ± 0.08	6.094SerGly: 6.094 ± 0.102	1.272SerHis: 1.272 ± 0.047	5.349SerIle: 5.349 ± 0.104	3.51SerLys: 3.51 ± 0.079	7.433SerLeu: 7.433 ± 0.117	1.674SerMet: 1.674 ± 0.048	2.818SerAsn: 2.818 ± 0.072	2.844SerPro: 2.844 ± 0.069	1.952SerGln: 1.952 ± 0.056	4.436SerArg: 4.436 ± 0.09	5.501SerSer: 5.501 ± 0.126	3.612SerThr: 3.612 ± 0.074	4.607SerVal: 4.607 ± 0.084	0.967SerTrp: 0.967 ± 0.043	2.211SerTyr: 2.211 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.927ThrAla: 3.927 ± 0.076	0.399ThrCys: 0.399 ± 0.026	2.579ThrAsp: 2.579 ± 0.072	3.117ThrGlu: 3.117 ± 0.073	1.82ThrPhe: 1.82 ± 0.061	4.211ThrGly: 4.211 ± 0.083	0.914ThrHis: 0.914 ± 0.04	3.513ThrIle: 3.513 ± 0.084	2.076ThrLys: 2.076 ± 0.058	5.394ThrLeu: 5.394 ± 0.093	1.145ThrMet: 1.145 ± 0.042	1.708ThrAsn: 1.708 ± 0.055	2.397ThrPro: 2.397 ± 0.065	1.353ThrGln: 1.353 ± 0.047	2.841ThrArg: 2.841 ± 0.069	3.268ThrSer: 3.268 ± 0.066	2.3ThrThr: 2.3 ± 0.072	3.567ThrVal: 3.567 ± 0.082	0.706ThrTrp: 0.706 ± 0.04	1.406ThrTyr: 1.406 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.09ValAla: 5.09 ± 0.104	0.613ValCys: 0.613 ± 0.038	4.033ValAsp: 4.033 ± 0.097	4.354ValGlu: 4.354 ± 0.092	3.175ValPhe: 3.175 ± 0.078	4.528ValGly: 4.528 ± 0.09	1.092ValHis: 1.092 ± 0.04	4.488ValIle: 4.488 ± 0.093	3.082ValLys: 3.082 ± 0.061	6.722ValLeu: 6.722 ± 0.117	1.438ValMet: 1.438 ± 0.055	2.702ValAsn: 2.702 ± 0.064	2.477ValPro: 2.477 ± 0.056	1.659ValGln: 1.659 ± 0.047	3.884ValArg: 3.884 ± 0.089	5.011ValSer: 5.011 ± 0.083	2.816ValThr: 2.816 ± 0.065	4.523ValVal: 4.523 ± 0.096	0.628ValTrp: 0.628 ± 0.033	2.039ValTyr: 2.039 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.796TrpAla: 0.796 ± 0.032	0.13TrpCys: 0.13 ± 0.014	0.663TrpAsp: 0.663 ± 0.041	0.916TrpGlu: 0.916 ± 0.04	0.568TrpPhe: 0.568 ± 0.034	0.813TrpGly: 0.813 ± 0.041	0.256TrpHis: 0.256 ± 0.02	0.953TrpIle: 0.953 ± 0.044	0.765TrpLys: 0.765 ± 0.043	1.303TrpLeu: 1.303 ± 0.044	0.365TrpMet: 0.365 ± 0.025	0.746TrpAsn: 0.746 ± 0.037	0.47TrpPro: 0.47 ± 0.028	0.462TrpGln: 0.462 ± 0.027	0.892TrpArg: 0.892 ± 0.037	0.704TrpSer: 0.704 ± 0.036	0.607TrpThr: 0.607 ± 0.031	0.695TrpVal: 0.695 ± 0.029	0.192TrpTrp: 0.192 ± 0.018	0.402TrpTyr: 0.402 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.092TyrAla: 2.092 ± 0.057	0.275TyrCys: 0.275 ± 0.019	1.694TyrAsp: 1.694 ± 0.051	1.932TyrGlu: 1.932 ± 0.062	1.333TyrPhe: 1.333 ± 0.051	2.39TyrGly: 2.39 ± 0.069	0.625TyrHis: 0.625 ± 0.032	1.84TyrIle: 1.84 ± 0.054	1.409TyrLys: 1.409 ± 0.045	3.266TyrLeu: 3.266 ± 0.072	0.656TyrMet: 0.656 ± 0.031	1.193TyrAsn: 1.193 ± 0.044	1.407TyrPro: 1.407 ± 0.052	1.046TyrGln: 1.046 ± 0.04	2.235TyrArg: 2.235 ± 0.064	2.345TyrSer: 2.345 ± 0.062	1.471TyrThr: 1.471 ± 0.055	1.912TyrVal: 1.912 ± 0.064	0.497TyrTrp: 0.497 ± 0.028	1.08TyrTyr: 1.08 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2385 proteins (644439 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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