Amino acid dipepetide frequency for Lactobacillus phage JNU_P10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.044AlaAla: 8.044 ± 1.116
0.234AlaCys: 0.234 ± 0.128
6.326AlaAsp: 6.326 ± 0.616
5.233AlaGlu: 5.233 ± 0.816
3.593AlaPhe: 3.593 ± 0.609
3.515AlaGly: 3.515 ± 0.76
1.64AlaHis: 1.64 ± 0.288
5.077AlaIle: 5.077 ± 1.017
6.17AlaLys: 6.17 ± 0.615
7.42AlaLeu: 7.42 ± 0.656
2.655AlaMet: 2.655 ± 0.643
4.296AlaAsn: 4.296 ± 0.647
1.562AlaPro: 1.562 ± 0.348
2.655AlaGln: 2.655 ± 0.585
3.124AlaArg: 3.124 ± 0.569
5.467AlaSer: 5.467 ± 0.603
6.56AlaThr: 6.56 ± 0.651
6.639AlaVal: 6.639 ± 1.133
1.25AlaTrp: 1.25 ± 0.502
2.734AlaTyr: 2.734 ± 0.609
0.0AlaXaa: 0.0 ± 0.0
Cys
0.547CysAla: 0.547 ± 0.236
0.156CysCys: 0.156 ± 0.097
0.469CysAsp: 0.469 ± 0.203
0.781CysGlu: 0.781 ± 0.249
0.234CysPhe: 0.234 ± 0.146
0.469CysGly: 0.469 ± 0.214
0.156CysHis: 0.156 ± 0.111
0.156CysIle: 0.156 ± 0.104
0.312CysLys: 0.312 ± 0.162
0.312CysLeu: 0.312 ± 0.189
0.0CysMet: 0.0 ± 0.0
0.156CysAsn: 0.156 ± 0.133
0.547CysPro: 0.547 ± 0.273
0.078CysGln: 0.078 ± 0.083
0.234CysArg: 0.234 ± 0.136
0.391CysSer: 0.391 ± 0.17
0.469CysThr: 0.469 ± 0.214
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.156CysTyr: 0.156 ± 0.117
0.0CysXaa: 0.0 ± 0.0
Asp
3.827AspAla: 3.827 ± 0.417
0.469AspCys: 0.469 ± 0.204
5.701AspAsp: 5.701 ± 0.8
4.92AspGlu: 4.92 ± 0.743
3.124AspPhe: 3.124 ± 0.486
5.701AspGly: 5.701 ± 0.688
1.25AspHis: 1.25 ± 0.235
4.764AspIle: 4.764 ± 0.738
4.374AspLys: 4.374 ± 0.496
5.389AspLeu: 5.389 ± 0.694
1.796AspMet: 1.796 ± 0.388
3.515AspAsn: 3.515 ± 0.617
3.358AspPro: 3.358 ± 0.737
2.812AspGln: 2.812 ± 0.487
2.109AspArg: 2.109 ± 0.357
4.92AspSer: 4.92 ± 0.565
2.734AspThr: 2.734 ± 0.523
3.905AspVal: 3.905 ± 0.703
1.093AspTrp: 1.093 ± 0.249
2.734AspTyr: 2.734 ± 0.63
0.0AspXaa: 0.0 ± 0.0
Glu
5.389GluAla: 5.389 ± 1.023
0.312GluCys: 0.312 ± 0.218
2.734GluAsp: 2.734 ± 0.497
3.515GluGlu: 3.515 ± 0.617
2.265GluPhe: 2.265 ± 0.373
2.89GluGly: 2.89 ± 0.487
0.781GluHis: 0.781 ± 0.225
3.827GluIle: 3.827 ± 0.629
4.139GluLys: 4.139 ± 0.645
5.701GluLeu: 5.701 ± 0.758
2.187GluMet: 2.187 ± 0.417
2.577GluAsn: 2.577 ± 0.458
1.718GluPro: 1.718 ± 0.472
2.265GluGln: 2.265 ± 0.386
3.28GluArg: 3.28 ± 0.5
3.593GluSer: 3.593 ± 0.612
3.28GluThr: 3.28 ± 0.496
3.515GluVal: 3.515 ± 0.565
0.547GluTrp: 0.547 ± 0.208
2.187GluTyr: 2.187 ± 0.526
0.0GluXaa: 0.0 ± 0.0
Phe
2.499PheAla: 2.499 ± 0.357
0.078PheCys: 0.078 ± 0.083
2.812PheAsp: 2.812 ± 0.44
2.031PheGlu: 2.031 ± 0.279
2.109PhePhe: 2.109 ± 0.639
2.734PheGly: 2.734 ± 0.381
0.937PheHis: 0.937 ± 0.319
1.953PheIle: 1.953 ± 0.379
3.202PheLys: 3.202 ± 0.5
3.046PheLeu: 3.046 ± 0.452
0.703PheMet: 0.703 ± 0.236
2.343PheAsn: 2.343 ± 0.369
1.25PhePro: 1.25 ± 0.42
1.406PheGln: 1.406 ± 0.31
0.781PheArg: 0.781 ± 0.295
3.593PheSer: 3.593 ± 0.819
3.202PheThr: 3.202 ± 0.514
2.499PheVal: 2.499 ± 0.464
0.703PheTrp: 0.703 ± 0.246
0.937PheTyr: 0.937 ± 0.249
0.0PheXaa: 0.0 ± 0.0
Gly
4.452GlyAla: 4.452 ± 1.164
0.0GlyCys: 0.0 ± 0.0
4.217GlyAsp: 4.217 ± 0.514
2.734GlyGlu: 2.734 ± 0.477
2.812GlyPhe: 2.812 ± 0.393
3.671GlyGly: 3.671 ± 0.581
0.937GlyHis: 0.937 ± 0.282
5.467GlyIle: 5.467 ± 1.213
4.686GlyLys: 4.686 ± 0.522
4.842GlyLeu: 4.842 ± 0.987
2.187GlyMet: 2.187 ± 0.46
3.827GlyAsn: 3.827 ± 0.654
1.718GlyPro: 1.718 ± 0.356
2.343GlyGln: 2.343 ± 0.354
1.953GlyArg: 1.953 ± 0.364
3.827GlySer: 3.827 ± 0.475
4.217GlyThr: 4.217 ± 0.633
4.686GlyVal: 4.686 ± 0.699
0.781GlyTrp: 0.781 ± 0.226
2.734GlyTyr: 2.734 ± 0.424
0.0GlyXaa: 0.0 ± 0.0
His
1.25HisAla: 1.25 ± 0.351
0.234HisCys: 0.234 ± 0.134
1.562HisAsp: 1.562 ± 0.351
1.015HisGlu: 1.015 ± 0.221
0.781HisPhe: 0.781 ± 0.236
1.25HisGly: 1.25 ± 0.313
0.547HisHis: 0.547 ± 0.239
0.859HisIle: 0.859 ± 0.238
1.25HisLys: 1.25 ± 0.273
1.015HisLeu: 1.015 ± 0.284
0.469HisMet: 0.469 ± 0.167
0.703HisAsn: 0.703 ± 0.312
0.625HisPro: 0.625 ± 0.216
0.625HisGln: 0.625 ± 0.227
0.781HisArg: 0.781 ± 0.23
1.484HisSer: 1.484 ± 0.419
0.781HisThr: 0.781 ± 0.212
1.328HisVal: 1.328 ± 0.333
0.234HisTrp: 0.234 ± 0.127
0.859HisTyr: 0.859 ± 0.259
0.0HisXaa: 0.0 ± 0.0
Ile
6.092IleAla: 6.092 ± 0.62
0.703IleCys: 0.703 ± 0.232
4.139IleAsp: 4.139 ± 0.638
3.515IleGlu: 3.515 ± 0.482
1.562IlePhe: 1.562 ± 0.293
3.749IleGly: 3.749 ± 0.58
1.015IleHis: 1.015 ± 0.307
3.749IleIle: 3.749 ± 0.581
4.374IleLys: 4.374 ± 0.601
3.593IleLeu: 3.593 ± 0.458
1.406IleMet: 1.406 ± 0.387
2.89IleAsn: 2.89 ± 0.603
1.874IlePro: 1.874 ± 0.378
2.655IleGln: 2.655 ± 0.561
2.812IleArg: 2.812 ± 0.541
5.467IleSer: 5.467 ± 0.573
3.671IleThr: 3.671 ± 0.676
3.827IleVal: 3.827 ± 0.649
1.015IleTrp: 1.015 ± 0.703
2.421IleTyr: 2.421 ± 0.456
0.0IleXaa: 0.0 ± 0.0
Lys
6.795LysAla: 6.795 ± 0.791
0.156LysCys: 0.156 ± 0.1
5.545LysAsp: 5.545 ± 0.742
4.139LysGlu: 4.139 ± 0.684
2.343LysPhe: 2.343 ± 0.463
3.593LysGly: 3.593 ± 0.576
1.172LysHis: 1.172 ± 0.308
2.89LysIle: 2.89 ± 0.492
4.608LysLys: 4.608 ± 0.77
6.717LysLeu: 6.717 ± 0.859
2.421LysMet: 2.421 ± 0.488
2.577LysAsn: 2.577 ± 0.35
3.124LysPro: 3.124 ± 0.541
4.53LysGln: 4.53 ± 0.658
4.061LysArg: 4.061 ± 0.63
4.139LysSer: 4.139 ± 0.478
4.608LysThr: 4.608 ± 0.445
4.061LysVal: 4.061 ± 0.494
1.015LysTrp: 1.015 ± 0.297
2.655LysTyr: 2.655 ± 0.519
0.0LysXaa: 0.0 ± 0.0
Leu
7.029LeuAla: 7.029 ± 0.729
0.469LeuCys: 0.469 ± 0.197
5.936LeuAsp: 5.936 ± 0.722
3.436LeuGlu: 3.436 ± 0.485
2.655LeuPhe: 2.655 ± 0.542
4.374LeuGly: 4.374 ± 0.623
1.64LeuHis: 1.64 ± 0.415
5.623LeuIle: 5.623 ± 0.574
6.092LeuLys: 6.092 ± 0.676
5.545LeuLeu: 5.545 ± 0.781
1.796LeuMet: 1.796 ± 0.302
4.452LeuAsn: 4.452 ± 0.596
2.734LeuPro: 2.734 ± 0.505
3.593LeuGln: 3.593 ± 0.58
3.436LeuArg: 3.436 ± 0.596
6.717LeuSer: 6.717 ± 0.719
5.545LeuThr: 5.545 ± 0.603
4.452LeuVal: 4.452 ± 0.549
1.328LeuTrp: 1.328 ± 0.524
2.577LeuTyr: 2.577 ± 0.529
0.0LeuXaa: 0.0 ± 0.0
Met
2.734MetAla: 2.734 ± 0.445
0.312MetCys: 0.312 ± 0.153
1.718MetAsp: 1.718 ± 0.414
1.484MetGlu: 1.484 ± 0.359
0.625MetPhe: 0.625 ± 0.208
1.484MetGly: 1.484 ± 0.362
0.312MetHis: 0.312 ± 0.194
1.172MetIle: 1.172 ± 0.253
2.031MetLys: 2.031 ± 0.488
2.031MetLeu: 2.031 ± 0.413
0.937MetMet: 0.937 ± 0.338
2.499MetAsn: 2.499 ± 0.484
1.093MetPro: 1.093 ± 0.293
1.328MetGln: 1.328 ± 0.306
1.484MetArg: 1.484 ± 0.285
1.796MetSer: 1.796 ± 0.331
1.718MetThr: 1.718 ± 0.378
1.328MetVal: 1.328 ± 0.301
0.234MetTrp: 0.234 ± 0.121
1.328MetTyr: 1.328 ± 0.338
0.0MetXaa: 0.0 ± 0.0
Asn
4.374AsnAla: 4.374 ± 0.513
0.078AsnCys: 0.078 ± 0.069
3.749AsnAsp: 3.749 ± 0.568
2.421AsnGlu: 2.421 ± 0.471
1.953AsnPhe: 1.953 ± 0.357
4.686AsnGly: 4.686 ± 0.7
0.703AsnHis: 0.703 ± 0.212
2.031AsnIle: 2.031 ± 0.465
2.89AsnLys: 2.89 ± 0.552
3.671AsnLeu: 3.671 ± 0.506
1.484AsnMet: 1.484 ± 0.331
1.64AsnAsn: 1.64 ± 0.324
3.124AsnPro: 3.124 ± 0.555
2.734AsnGln: 2.734 ± 0.448
2.734AsnArg: 2.734 ± 0.439
3.593AsnSer: 3.593 ± 0.571
2.655AsnThr: 2.655 ± 0.432
3.358AsnVal: 3.358 ± 0.476
0.859AsnTrp: 0.859 ± 0.272
1.406AsnTyr: 1.406 ± 0.366
0.0AsnXaa: 0.0 ± 0.0
Pro
2.734ProAla: 2.734 ± 0.416
0.0ProCys: 0.0 ± 0.0
2.655ProAsp: 2.655 ± 0.392
2.499ProGlu: 2.499 ± 0.497
1.25ProPhe: 1.25 ± 0.287
1.718ProGly: 1.718 ± 0.319
0.547ProHis: 0.547 ± 0.207
2.343ProIle: 2.343 ± 0.411
3.124ProLys: 3.124 ± 0.53
2.187ProLeu: 2.187 ± 0.423
1.093ProMet: 1.093 ± 0.28
2.109ProAsn: 2.109 ± 0.462
0.625ProPro: 0.625 ± 0.218
1.874ProGln: 1.874 ± 0.394
1.093ProArg: 1.093 ± 0.294
3.593ProSer: 3.593 ± 0.713
2.187ProThr: 2.187 ± 0.467
2.734ProVal: 2.734 ± 0.549
0.703ProTrp: 0.703 ± 0.238
1.328ProTyr: 1.328 ± 0.353
0.0ProXaa: 0.0 ± 0.0
Gln
4.686GlnAla: 4.686 ± 0.552
0.234GlnCys: 0.234 ± 0.122
2.031GlnAsp: 2.031 ± 0.366
1.796GlnGlu: 1.796 ± 0.325
1.796GlnPhe: 1.796 ± 0.467
3.28GlnGly: 3.28 ± 0.479
0.781GlnHis: 0.781 ± 0.26
1.953GlnIle: 1.953 ± 0.363
3.436GlnLys: 3.436 ± 0.47
4.452GlnLeu: 4.452 ± 0.665
1.25GlnMet: 1.25 ± 0.31
1.484GlnAsn: 1.484 ± 0.28
1.25GlnPro: 1.25 ± 0.302
2.655GlnGln: 2.655 ± 0.506
2.187GlnArg: 2.187 ± 0.403
2.812GlnSer: 2.812 ± 0.549
3.28GlnThr: 3.28 ± 0.627
2.734GlnVal: 2.734 ± 0.538
0.781GlnTrp: 0.781 ± 0.214
1.953GlnTyr: 1.953 ± 0.391
0.0GlnXaa: 0.0 ± 0.0
Arg
2.89ArgAla: 2.89 ± 0.412
0.703ArgCys: 0.703 ± 0.241
1.562ArgAsp: 1.562 ± 0.415
2.968ArgGlu: 2.968 ± 0.516
1.874ArgPhe: 1.874 ± 0.388
2.655ArgGly: 2.655 ± 0.441
0.781ArgHis: 0.781 ± 0.239
2.577ArgIle: 2.577 ± 0.583
2.89ArgLys: 2.89 ± 0.487
3.202ArgLeu: 3.202 ± 0.486
1.406ArgMet: 1.406 ± 0.315
1.64ArgAsn: 1.64 ± 0.313
1.64ArgPro: 1.64 ± 0.32
2.421ArgGln: 2.421 ± 0.597
1.796ArgArg: 1.796 ± 0.444
2.812ArgSer: 2.812 ± 0.408
2.577ArgThr: 2.577 ± 0.525
2.499ArgVal: 2.499 ± 0.36
0.312ArgTrp: 0.312 ± 0.195
2.577ArgTyr: 2.577 ± 0.587
0.0ArgXaa: 0.0 ± 0.0
Ser
5.701SerAla: 5.701 ± 0.891
0.312SerCys: 0.312 ± 0.151
4.452SerAsp: 4.452 ± 0.49
3.905SerGlu: 3.905 ± 0.73
3.358SerPhe: 3.358 ± 0.468
4.92SerGly: 4.92 ± 0.953
1.484SerHis: 1.484 ± 0.303
4.374SerIle: 4.374 ± 0.46
5.311SerLys: 5.311 ± 0.625
6.639SerLeu: 6.639 ± 0.742
2.031SerMet: 2.031 ± 0.354
3.202SerAsn: 3.202 ± 0.492
2.655SerPro: 2.655 ± 0.532
2.187SerGln: 2.187 ± 0.419
2.577SerArg: 2.577 ± 0.551
5.623SerSer: 5.623 ± 0.976
5.389SerThr: 5.389 ± 0.659
4.842SerVal: 4.842 ± 0.694
0.859SerTrp: 0.859 ± 0.204
3.046SerTyr: 3.046 ± 0.518
0.0SerXaa: 0.0 ± 0.0
Thr
5.389ThrAla: 5.389 ± 0.438
0.156ThrCys: 0.156 ± 0.1
5.389ThrAsp: 5.389 ± 0.677
3.28ThrGlu: 3.28 ± 0.485
2.031ThrPhe: 2.031 ± 0.352
3.827ThrGly: 3.827 ± 0.481
1.015ThrHis: 1.015 ± 0.323
4.296ThrIle: 4.296 ± 0.496
4.374ThrLys: 4.374 ± 0.566
5.389ThrLeu: 5.389 ± 0.546
1.25ThrMet: 1.25 ± 0.382
3.046ThrAsn: 3.046 ± 0.504
3.202ThrPro: 3.202 ± 0.512
3.046ThrGln: 3.046 ± 0.463
2.655ThrArg: 2.655 ± 0.358
4.139ThrSer: 4.139 ± 0.577
3.983ThrThr: 3.983 ± 0.552
5.467ThrVal: 5.467 ± 0.67
0.547ThrTrp: 0.547 ± 0.258
2.499ThrTyr: 2.499 ± 0.445
0.0ThrXaa: 0.0 ± 0.0
Val
6.014ValAla: 6.014 ± 0.716
0.234ValCys: 0.234 ± 0.115
4.374ValAsp: 4.374 ± 0.552
3.983ValGlu: 3.983 ± 0.598
2.109ValPhe: 2.109 ± 0.389
4.452ValGly: 4.452 ± 0.678
0.859ValHis: 0.859 ± 0.217
4.061ValIle: 4.061 ± 0.608
4.296ValLys: 4.296 ± 0.551
4.608ValLeu: 4.608 ± 0.57
1.64ValMet: 1.64 ± 0.295
3.358ValAsn: 3.358 ± 0.478
2.734ValPro: 2.734 ± 0.531
2.265ValGln: 2.265 ± 0.513
2.655ValArg: 2.655 ± 0.463
5.077ValSer: 5.077 ± 0.905
4.139ValThr: 4.139 ± 0.523
3.124ValVal: 3.124 ± 0.521
1.172ValTrp: 1.172 ± 0.475
2.031ValTyr: 2.031 ± 0.433
0.0ValXaa: 0.0 ± 0.0
Trp
0.781TrpAla: 0.781 ± 0.222
0.078TrpCys: 0.078 ± 0.079
0.391TrpAsp: 0.391 ± 0.145
0.781TrpGlu: 0.781 ± 0.226
0.625TrpPhe: 0.625 ± 0.204
0.859TrpGly: 0.859 ± 0.231
0.312TrpHis: 0.312 ± 0.135
1.093TrpIle: 1.093 ± 0.244
0.781TrpLys: 0.781 ± 0.283
1.093TrpLeu: 1.093 ± 0.255
0.312TrpMet: 0.312 ± 0.159
1.874TrpAsn: 1.874 ± 0.909
0.156TrpPro: 0.156 ± 0.108
0.703TrpGln: 0.703 ± 0.309
0.391TrpArg: 0.391 ± 0.179
1.328TrpSer: 1.328 ± 0.64
1.484TrpThr: 1.484 ± 0.267
0.703TrpVal: 0.703 ± 0.195
0.391TrpTrp: 0.391 ± 0.147
0.703TrpTyr: 0.703 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.968TyrAla: 2.968 ± 0.449
0.703TyrCys: 0.703 ± 0.312
2.734TyrAsp: 2.734 ± 0.498
2.265TyrGlu: 2.265 ± 0.558
1.796TyrPhe: 1.796 ± 0.305
2.265TyrGly: 2.265 ± 0.494
0.781TyrHis: 0.781 ± 0.277
2.265TyrIle: 2.265 ± 0.472
2.812TyrLys: 2.812 ± 0.519
2.577TyrLeu: 2.577 ± 0.411
0.547TyrMet: 0.547 ± 0.181
1.953TyrAsn: 1.953 ± 0.4
1.406TyrPro: 1.406 ± 0.287
2.655TyrGln: 2.655 ± 0.576
1.64TyrArg: 1.64 ± 0.303
2.499TyrSer: 2.499 ± 0.392
2.499TyrThr: 2.499 ± 0.467
1.484TyrVal: 1.484 ± 0.386
1.015TyrTrp: 1.015 ± 0.298
1.796TyrTyr: 1.796 ± 0.415
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (12805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski