Amino acid dipepetide frequency for Eubacterium sp. CAG:251

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.334AlaAla: 5.334 ± 0.139
1.226AlaCys: 1.226 ± 0.046
4.182AlaAsp: 4.182 ± 0.096
3.964AlaGlu: 3.964 ± 0.088
3.326AlaPhe: 3.326 ± 0.077
4.848AlaGly: 4.848 ± 0.102
1.055AlaHis: 1.055 ± 0.04
5.57AlaIle: 5.57 ± 0.099
6.361AlaLys: 6.361 ± 0.125
6.59AlaLeu: 6.59 ± 0.13
1.938AlaMet: 1.938 ± 0.066
3.359AlaAsn: 3.359 ± 0.087
1.997AlaPro: 1.997 ± 0.067
2.556AlaGln: 2.556 ± 0.077
2.395AlaArg: 2.395 ± 0.08
4.029AlaSer: 4.029 ± 0.086
3.672AlaThr: 3.672 ± 0.097
6.168AlaVal: 6.168 ± 0.133
0.502AlaTrp: 0.502 ± 0.033
2.721AlaTyr: 2.721 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.331CysAla: 1.331 ± 0.057
0.297CysCys: 0.297 ± 0.024
1.293CysAsp: 1.293 ± 0.059
1.127CysGlu: 1.127 ± 0.044
0.773CysPhe: 0.773 ± 0.039
1.536CysGly: 1.536 ± 0.062
0.288CysHis: 0.288 ± 0.025
1.165CysIle: 1.165 ± 0.051
1.217CysLys: 1.217 ± 0.055
1.082CysLeu: 1.082 ± 0.043
0.312CysMet: 0.312 ± 0.024
0.839CysAsn: 0.839 ± 0.043
0.692CysPro: 0.692 ± 0.041
0.418CysGln: 0.418 ± 0.029
0.564CysArg: 0.564 ± 0.029
1.129CysSer: 1.129 ± 0.048
0.893CysThr: 0.893 ± 0.052
1.153CysVal: 1.153 ± 0.048
0.124CysTrp: 0.124 ± 0.016
0.564CysTyr: 0.564 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.937AspAla: 3.937 ± 0.109
1.043AspCys: 1.043 ± 0.043
3.933AspAsp: 3.933 ± 0.107
5.457AspGlu: 5.457 ± 0.117
3.265AspPhe: 3.265 ± 0.089
4.605AspGly: 4.605 ± 0.097
0.616AspHis: 0.616 ± 0.034
5.57AspIle: 5.57 ± 0.099
5.547AspLys: 5.547 ± 0.109
4.369AspLeu: 4.369 ± 0.094
1.808AspMet: 1.808 ± 0.06
3.596AspAsn: 3.596 ± 0.098
1.3AspPro: 1.3 ± 0.05
0.706AspGln: 0.706 ± 0.036
1.871AspArg: 1.871 ± 0.065
3.436AspSer: 3.436 ± 0.093
3.355AspThr: 3.355 ± 0.08
4.153AspVal: 4.153 ± 0.09
0.486AspTrp: 0.486 ± 0.033
3.162AspTyr: 3.162 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.193GluAla: 4.193 ± 0.096
0.917GluCys: 0.917 ± 0.048
3.22GluAsp: 3.22 ± 0.098
4.668GluGlu: 4.668 ± 0.121
2.885GluPhe: 2.885 ± 0.078
3.135GluGly: 3.135 ± 0.082
1.072GluHis: 1.072 ± 0.049
5.947GluIle: 5.947 ± 0.119
6.627GluLys: 6.627 ± 0.154
5.958GluLeu: 5.958 ± 0.115
1.931GluMet: 1.931 ± 0.063
5.089GluAsn: 5.089 ± 0.098
1.516GluPro: 1.516 ± 0.053
2.024GluGln: 2.024 ± 0.063
2.496GluArg: 2.496 ± 0.08
3.242GluSer: 3.242 ± 0.082
2.874GluThr: 2.874 ± 0.072
3.596GluVal: 3.596 ± 0.093
0.463GluTrp: 0.463 ± 0.032
3.063GluTyr: 3.063 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
3.35PheAla: 3.35 ± 0.087
0.832PheCys: 0.832 ± 0.045
3.47PheAsp: 3.47 ± 0.1
3.099PheGlu: 3.099 ± 0.074
1.985PhePhe: 1.985 ± 0.078
3.377PheGly: 3.377 ± 0.082
0.582PheHis: 0.582 ± 0.034
3.454PheIle: 3.454 ± 0.094
3.366PheLys: 3.366 ± 0.08
3.425PheLeu: 3.425 ± 0.102
1.045PheMet: 1.045 ± 0.047
2.446PheAsn: 2.446 ± 0.064
1.207PhePro: 1.207 ± 0.045
0.863PheGln: 0.863 ± 0.042
1.198PheArg: 1.198 ± 0.044
3.281PheSer: 3.281 ± 0.087
2.451PheThr: 2.451 ± 0.073
3.278PheVal: 3.278 ± 0.087
0.348PheTrp: 0.348 ± 0.026
1.828PheTyr: 1.828 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.841GlyAla: 4.841 ± 0.125
1.18GlyCys: 1.18 ± 0.061
3.87GlyAsp: 3.87 ± 0.085
4.292GlyGlu: 4.292 ± 0.093
3.103GlyPhe: 3.103 ± 0.082
4.497GlyGly: 4.497 ± 0.109
1.059GlyHis: 1.059 ± 0.056
5.713GlyIle: 5.713 ± 0.11
5.994GlyLys: 5.994 ± 0.109
4.967GlyLeu: 4.967 ± 0.102
1.911GlyMet: 1.911 ± 0.063
3.364GlyAsn: 3.364 ± 0.093
1.122GlyPro: 1.122 ± 0.054
1.533GlyGln: 1.533 ± 0.056
2.303GlyArg: 2.303 ± 0.071
3.744GlySer: 3.744 ± 0.107
3.913GlyThr: 3.913 ± 0.094
5.122GlyVal: 5.122 ± 0.096
0.519GlyTrp: 0.519 ± 0.03
3.148GlyTyr: 3.148 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
0.805HisAla: 0.805 ± 0.036
0.29HisCys: 0.29 ± 0.026
0.758HisAsp: 0.758 ± 0.042
0.726HisGlu: 0.726 ± 0.033
0.823HisPhe: 0.823 ± 0.038
1.108HisGly: 1.108 ± 0.057
0.358HisHis: 0.358 ± 0.034
1.284HisIle: 1.284 ± 0.048
1.104HisLys: 1.104 ± 0.047
1.176HisLeu: 1.176 ± 0.042
0.281HisMet: 0.281 ± 0.023
0.882HisAsn: 0.882 ± 0.041
0.76HisPro: 0.76 ± 0.038
0.394HisGln: 0.394 ± 0.025
0.573HisArg: 0.573 ± 0.032
0.951HisSer: 0.951 ± 0.045
0.854HisThr: 0.854 ± 0.048
0.638HisVal: 0.638 ± 0.037
0.121HisTrp: 0.121 ± 0.015
0.636HisTyr: 0.636 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.994IleAla: 5.994 ± 0.121
1.583IleCys: 1.583 ± 0.052
5.477IleAsp: 5.477 ± 0.105
5.34IleGlu: 5.34 ± 0.121
3.251IlePhe: 3.251 ± 0.096
5.053IleGly: 5.053 ± 0.112
1.028IleHis: 1.028 ± 0.038
6.804IleIle: 6.804 ± 0.157
6.883IleLys: 6.883 ± 0.107
6.107IleLeu: 6.107 ± 0.131
2.001IleMet: 2.001 ± 0.069
4.801IleAsn: 4.801 ± 0.108
2.791IlePro: 2.791 ± 0.072
1.48IleGln: 1.48 ± 0.051
2.487IleArg: 2.487 ± 0.072
5.785IleSer: 5.785 ± 0.128
4.845IleThr: 4.845 ± 0.086
5.419IleVal: 5.419 ± 0.11
0.517IleTrp: 0.517 ± 0.03
2.959IleTyr: 2.959 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
6.518LysAla: 6.518 ± 0.125
1.135LysCys: 1.135 ± 0.051
4.673LysAsp: 4.673 ± 0.101
6.287LysGlu: 6.287 ± 0.108
2.889LysPhe: 2.889 ± 0.071
4.85LysGly: 4.85 ± 0.09
1.061LysHis: 1.061 ± 0.046
6.768LysIle: 6.768 ± 0.121
8.56LysLys: 8.56 ± 0.168
6.698LysLeu: 6.698 ± 0.106
2.525LysMet: 2.525 ± 0.063
5.788LysAsn: 5.788 ± 0.122
2.458LysPro: 2.458 ± 0.069
2.356LysGln: 2.356 ± 0.068
2.97LysArg: 2.97 ± 0.085
5.66LysSer: 5.66 ± 0.133
4.812LysThr: 4.812 ± 0.107
4.922LysVal: 4.922 ± 0.094
0.603LysTrp: 0.603 ± 0.032
4.088LysTyr: 4.088 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
6.026LeuAla: 6.026 ± 0.11
1.639LeuCys: 1.639 ± 0.057
5.5LeuAsp: 5.5 ± 0.11
5.066LeuGlu: 5.066 ± 0.106
3.784LeuPhe: 3.784 ± 0.112
5.597LeuGly: 5.597 ± 0.121
1.144LeuHis: 1.144 ± 0.047
6.347LeuIle: 6.347 ± 0.136
6.707LeuLys: 6.707 ± 0.114
6.734LeuLeu: 6.734 ± 0.154
2.154LeuMet: 2.154 ± 0.067
4.389LeuAsn: 4.389 ± 0.091
2.981LeuPro: 2.981 ± 0.075
1.92LeuGln: 1.92 ± 0.066
2.689LeuArg: 2.689 ± 0.065
6.109LeuSer: 6.109 ± 0.117
4.654LeuThr: 4.654 ± 0.103
5.026LeuVal: 5.026 ± 0.098
0.607LeuTrp: 0.607 ± 0.034
3.018LeuTyr: 3.018 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.066MetAla: 2.066 ± 0.063
0.371MetCys: 0.371 ± 0.025
1.378MetAsp: 1.378 ± 0.048
1.347MetGlu: 1.347 ± 0.05
1.001MetPhe: 1.001 ± 0.052
1.765MetGly: 1.765 ± 0.061
0.385MetHis: 0.385 ± 0.024
1.918MetIle: 1.918 ± 0.073
2.365MetLys: 2.365 ± 0.068
2.574MetLeu: 2.574 ± 0.062
0.713MetMet: 0.713 ± 0.035
1.506MetAsn: 1.506 ± 0.054
1.104MetPro: 1.104 ± 0.047
0.755MetGln: 0.755 ± 0.036
1.007MetArg: 1.007 ± 0.044
1.767MetSer: 1.767 ± 0.049
1.554MetThr: 1.554 ± 0.05
1.515MetVal: 1.515 ± 0.062
0.173MetTrp: 0.173 ± 0.016
0.843MetTyr: 0.843 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
4.126AsnAla: 4.126 ± 0.093
0.938AsnCys: 0.938 ± 0.048
3.881AsnAsp: 3.881 ± 0.102
4.104AsnGlu: 4.104 ± 0.093
2.226AsnPhe: 2.226 ± 0.07
4.369AsnGly: 4.369 ± 0.118
0.837AsnHis: 0.837 ± 0.045
4.81AsnIle: 4.81 ± 0.107
4.56AsnLys: 4.56 ± 0.112
4.202AsnLeu: 4.202 ± 0.102
1.509AsnMet: 1.509 ± 0.052
3.517AsnAsn: 3.517 ± 0.103
2.12AsnPro: 2.12 ± 0.065
1.428AsnGln: 1.428 ± 0.054
1.718AsnArg: 1.718 ± 0.056
3.587AsnSer: 3.587 ± 0.105
2.903AsnThr: 2.903 ± 0.075
4.065AsnVal: 4.065 ± 0.092
0.403AsnTrp: 0.403 ± 0.026
2.303AsnTyr: 2.303 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.941ProAla: 1.941 ± 0.069
0.515ProCys: 0.515 ± 0.032
1.97ProAsp: 1.97 ± 0.057
2.199ProGlu: 2.199 ± 0.073
1.567ProPhe: 1.567 ± 0.044
1.565ProGly: 1.565 ± 0.06
0.495ProHis: 0.495 ± 0.029
2.242ProIle: 2.242 ± 0.064
2.536ProLys: 2.536 ± 0.072
2.467ProLeu: 2.467 ± 0.071
0.746ProMet: 0.746 ± 0.037
1.752ProAsn: 1.752 ± 0.058
0.711ProPro: 0.711 ± 0.037
0.897ProGln: 0.897 ± 0.044
0.879ProArg: 0.879 ± 0.045
1.914ProSer: 1.914 ± 0.061
1.718ProThr: 1.718 ± 0.051
2.325ProVal: 2.325 ± 0.072
0.326ProTrp: 0.326 ± 0.025
1.371ProTyr: 1.371 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.866GlnAla: 1.866 ± 0.068
0.331GlnCys: 0.331 ± 0.026
1.05GlnAsp: 1.05 ± 0.043
1.407GlnGlu: 1.407 ± 0.057
0.989GlnPhe: 0.989 ± 0.043
1.633GlnGly: 1.633 ± 0.052
0.328GlnHis: 0.328 ± 0.023
2.235GlnIle: 2.235 ± 0.06
2.338GlnLys: 2.338 ± 0.062
2.122GlnLeu: 2.122 ± 0.067
0.827GlnMet: 0.827 ± 0.041
1.725GlnAsn: 1.725 ± 0.061
0.76GlnPro: 0.76 ± 0.041
0.742GlnGln: 0.742 ± 0.051
1.07GlnArg: 1.07 ± 0.046
1.675GlnSer: 1.675 ± 0.06
1.435GlnThr: 1.435 ± 0.051
1.434GlnVal: 1.434 ± 0.051
0.216GlnTrp: 0.216 ± 0.018
1.14GlnTyr: 1.14 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.219ArgAla: 2.219 ± 0.067
0.546ArgCys: 0.546 ± 0.034
1.88ArgAsp: 1.88 ± 0.058
2.473ArgGlu: 2.473 ± 0.083
1.57ArgPhe: 1.57 ± 0.058
2.028ArgGly: 2.028 ± 0.075
0.627ArgHis: 0.627 ± 0.033
2.588ArgIle: 2.588 ± 0.077
2.779ArgLys: 2.779 ± 0.079
3.186ArgLeu: 3.186 ± 0.087
0.931ArgMet: 0.931 ± 0.04
1.769ArgAsn: 1.769 ± 0.066
0.971ArgPro: 0.971 ± 0.052
1.156ArgGln: 1.156 ± 0.045
1.426ArgArg: 1.426 ± 0.056
1.662ArgSer: 1.662 ± 0.054
1.561ArgThr: 1.561 ± 0.066
2.183ArgVal: 2.183 ± 0.061
0.258ArgTrp: 0.258 ± 0.023
1.428ArgTyr: 1.428 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.807SerAla: 4.807 ± 0.1
0.891SerCys: 0.891 ± 0.04
3.976SerAsp: 3.976 ± 0.088
3.735SerGlu: 3.735 ± 0.086
3.337SerPhe: 3.337 ± 0.087
4.628SerGly: 4.628 ± 0.092
0.971SerHis: 0.971 ± 0.044
4.774SerIle: 4.774 ± 0.108
5.217SerLys: 5.217 ± 0.11
5.709SerLeu: 5.709 ± 0.126
1.495SerMet: 1.495 ± 0.051
3.445SerAsn: 3.445 ± 0.085
1.812SerPro: 1.812 ± 0.058
1.778SerGln: 1.778 ± 0.054
2.188SerArg: 2.188 ± 0.058
4.625SerSer: 4.625 ± 0.122
3.379SerThr: 3.379 ± 0.086
4.841SerVal: 4.841 ± 0.105
0.524SerTrp: 0.524 ± 0.034
2.559SerTyr: 2.559 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
4.398ThrAla: 4.398 ± 0.109
0.776ThrCys: 0.776 ± 0.048
3.551ThrAsp: 3.551 ± 0.082
2.667ThrGlu: 2.667 ± 0.069
2.492ThrPhe: 2.492 ± 0.08
4.011ThrGly: 4.011 ± 0.088
0.929ThrHis: 0.929 ± 0.046
3.872ThrIle: 3.872 ± 0.105
4.083ThrLys: 4.083 ± 0.101
4.942ThrLeu: 4.942 ± 0.099
1.169ThrMet: 1.169 ± 0.046
2.492ThrAsn: 2.492 ± 0.068
2.186ThrPro: 2.186 ± 0.059
1.572ThrGln: 1.572 ± 0.06
1.641ThrArg: 1.641 ± 0.055
3.487ThrSer: 3.487 ± 0.089
3.173ThrThr: 3.173 ± 0.115
5.028ThrVal: 5.028 ± 0.114
0.337ThrTrp: 0.337 ± 0.028
2.262ThrTyr: 2.262 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
4.938ValAla: 4.938 ± 0.107
1.372ValCys: 1.372 ± 0.055
4.439ValAsp: 4.439 ± 0.089
4.103ValGlu: 4.103 ± 0.096
3.162ValPhe: 3.162 ± 0.082
4.16ValGly: 4.16 ± 0.105
0.909ValHis: 0.909 ± 0.045
5.691ValIle: 5.691 ± 0.106
5.502ValLys: 5.502 ± 0.093
5.945ValLeu: 5.945 ± 0.114
1.767ValMet: 1.767 ± 0.052
3.735ValAsn: 3.735 ± 0.093
2.242ValPro: 2.242 ± 0.062
1.36ValGln: 1.36 ± 0.052
2.185ValArg: 2.185 ± 0.072
4.962ValSer: 4.962 ± 0.1
4.14ValThr: 4.14 ± 0.107
4.589ValVal: 4.589 ± 0.121
0.535ValTrp: 0.535 ± 0.032
2.728ValTyr: 2.728 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.036
0.182TrpCys: 0.182 ± 0.016
0.526TrpAsp: 0.526 ± 0.036
0.423TrpGlu: 0.423 ± 0.032
0.342TrpPhe: 0.342 ± 0.026
0.607TrpGly: 0.607 ± 0.038
0.16TrpHis: 0.16 ± 0.015
0.481TrpIle: 0.481 ± 0.031
0.515TrpLys: 0.515 ± 0.033
0.659TrpLeu: 0.659 ± 0.035
0.196TrpMet: 0.196 ± 0.02
0.427TrpAsn: 0.427 ± 0.03
0.09TrpPro: 0.09 ± 0.014
0.321TrpGln: 0.321 ± 0.026
0.285TrpArg: 0.285 ± 0.021
0.497TrpSer: 0.497 ± 0.034
0.353TrpThr: 0.353 ± 0.026
0.456TrpVal: 0.456 ± 0.032
0.106TrpTrp: 0.106 ± 0.018
0.346TrpTyr: 0.346 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.586TyrAla: 2.586 ± 0.07
0.733TyrCys: 0.733 ± 0.04
3.188TyrAsp: 3.188 ± 0.082
2.433TyrGlu: 2.433 ± 0.066
2.113TyrPhe: 2.113 ± 0.063
2.82TyrGly: 2.82 ± 0.07
0.616TyrHis: 0.616 ± 0.035
3.371TyrIle: 3.371 ± 0.089
3.362TyrLys: 3.362 ± 0.092
3.179TyrLeu: 3.179 ± 0.096
0.846TyrMet: 0.846 ± 0.043
2.685TyrAsn: 2.685 ± 0.087
1.316TyrPro: 1.316 ± 0.049
1.064TyrGln: 1.064 ± 0.049
1.297TyrArg: 1.297 ± 0.055
3.15TyrSer: 3.15 ± 0.088
2.529TyrThr: 2.529 ± 0.083
2.556TyrVal: 2.556 ± 0.078
0.324TyrTrp: 0.324 ± 0.023
2.067TyrTyr: 2.067 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1717 proteins (555267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski