Amino acid dipepetide frequency for Leucobacter sp. OH2974_COT-288

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.679AlaAla: 25.679 ± 0.435
0.725AlaCys: 0.725 ± 0.037
6.985AlaAsp: 6.985 ± 0.126
9.228AlaGlu: 9.228 ± 0.212
3.381AlaPhe: 3.381 ± 0.086
10.902AlaGly: 10.902 ± 0.176
2.341AlaHis: 2.341 ± 0.072
5.658AlaIle: 5.658 ± 0.109
4.684AlaLys: 4.684 ± 0.112
12.968AlaLeu: 12.968 ± 0.192
2.38AlaMet: 2.38 ± 0.078
3.336AlaAsn: 3.336 ± 0.089
5.494AlaPro: 5.494 ± 0.128
5.884AlaGln: 5.884 ± 0.158
6.139AlaArg: 6.139 ± 0.121
5.516AlaSer: 5.516 ± 0.102
8.059AlaThr: 8.059 ± 0.166
11.311AlaVal: 11.311 ± 0.191
1.292AlaTrp: 1.292 ± 0.044
2.467AlaTyr: 2.467 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.043
0.087CysCys: 0.087 ± 0.015
0.447CysAsp: 0.447 ± 0.032
0.467CysGlu: 0.467 ± 0.032
0.245CysPhe: 0.245 ± 0.02
0.773CysGly: 0.773 ± 0.039
0.135CysHis: 0.135 ± 0.018
0.233CysIle: 0.233 ± 0.022
0.16CysLys: 0.16 ± 0.017
0.559CysLeu: 0.559 ± 0.036
0.087CysMet: 0.087 ± 0.011
0.183CysAsn: 0.183 ± 0.019
0.253CysPro: 0.253 ± 0.023
0.214CysGln: 0.214 ± 0.02
0.299CysArg: 0.299 ± 0.024
0.378CysSer: 0.378 ± 0.026
0.422CysThr: 0.422 ± 0.034
0.54CysVal: 0.54 ± 0.034
0.087CysTrp: 0.087 ± 0.013
0.197CysTyr: 0.197 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
6.127AspAla: 6.127 ± 0.127
0.363AspCys: 0.363 ± 0.027
2.137AspAsp: 2.137 ± 0.077
2.995AspGlu: 2.995 ± 0.087
2.118AspPhe: 2.118 ± 0.068
3.766AspGly: 3.766 ± 0.099
0.808AspHis: 0.808 ± 0.04
2.482AspIle: 2.482 ± 0.074
1.695AspLys: 1.695 ± 0.063
4.654AspLeu: 4.654 ± 0.108
0.81AspMet: 0.81 ± 0.042
1.416AspAsn: 1.416 ± 0.066
3.375AspPro: 3.375 ± 0.086
1.252AspGln: 1.252 ± 0.046
2.55AspArg: 2.55 ± 0.076
2.854AspSer: 2.854 ± 0.078
3.032AspThr: 3.032 ± 0.089
3.693AspVal: 3.693 ± 0.087
0.642AspTrp: 0.642 ± 0.035
1.448AspTyr: 1.448 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
6.42GluAla: 6.42 ± 0.123
0.378GluCys: 0.378 ± 0.03
1.944GluAsp: 1.944 ± 0.077
2.777GluGlu: 2.777 ± 0.089
2.268GluPhe: 2.268 ± 0.082
3.134GluGly: 3.134 ± 0.091
1.5GluHis: 1.5 ± 0.062
4.125GluIle: 4.125 ± 0.109
2.492GluLys: 2.492 ± 0.084
8.167GluLeu: 8.167 ± 0.124
1.335GluMet: 1.335 ± 0.057
2.071GluAsn: 2.071 ± 0.072
2.528GluPro: 2.528 ± 0.087
3.379GluGln: 3.379 ± 0.1
4.009GluArg: 4.009 ± 0.111
2.58GluSer: 2.58 ± 0.079
3.724GluThr: 3.724 ± 0.098
5.024GluVal: 5.024 ± 0.116
0.654GluTrp: 0.654 ± 0.04
1.46GluTyr: 1.46 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
4.519PheAla: 4.519 ± 0.103
0.27PheCys: 0.27 ± 0.023
1.994PheAsp: 1.994 ± 0.066
2.216PheGlu: 2.216 ± 0.071
1.313PhePhe: 1.313 ± 0.051
3.311PheGly: 3.311 ± 0.095
0.523PheHis: 0.523 ± 0.033
1.516PheIle: 1.516 ± 0.06
1.236PheLys: 1.236 ± 0.06
2.899PheLeu: 2.899 ± 0.087
0.644PheMet: 0.644 ± 0.04
1.232PheAsn: 1.232 ± 0.055
1.217PhePro: 1.217 ± 0.054
0.841PheGln: 0.841 ± 0.041
1.396PheArg: 1.396 ± 0.066
2.104PheSer: 2.104 ± 0.065
2.478PheThr: 2.478 ± 0.074
2.793PheVal: 2.793 ± 0.084
0.498PheTrp: 0.498 ± 0.034
0.744PheTyr: 0.744 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
9.625GlyAla: 9.625 ± 0.176
0.667GlyCys: 0.667 ± 0.04
3.645GlyAsp: 3.645 ± 0.099
4.914GlyGlu: 4.914 ± 0.125
3.261GlyPhe: 3.261 ± 0.083
6.252GlyGly: 6.252 ± 0.13
1.446GlyHis: 1.446 ± 0.057
4.397GlyIle: 4.397 ± 0.112
3.795GlyLys: 3.795 ± 0.091
7.047GlyLeu: 7.047 ± 0.134
1.72GlyMet: 1.72 ± 0.063
2.16GlyAsn: 2.16 ± 0.071
2.453GlyPro: 2.453 ± 0.072
2.775GlyGln: 2.775 ± 0.076
4.009GlyArg: 4.009 ± 0.113
5.107GlySer: 5.107 ± 0.115
4.681GlyThr: 4.681 ± 0.117
7.091GlyVal: 7.091 ± 0.131
1.09GlyTrp: 1.09 ± 0.048
2.293GlyTyr: 2.293 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
2.131HisAla: 2.131 ± 0.069
0.147HisCys: 0.147 ± 0.017
1.109HisAsp: 1.109 ± 0.054
1.232HisGlu: 1.232 ± 0.051
0.617HisPhe: 0.617 ± 0.037
1.861HisGly: 1.861 ± 0.069
0.517HisHis: 0.517 ± 0.035
0.881HisIle: 0.881 ± 0.039
0.598HisLys: 0.598 ± 0.035
2.112HisLeu: 2.112 ± 0.067
0.339HisMet: 0.339 ± 0.031
0.702HisAsn: 0.702 ± 0.04
1.371HisPro: 1.371 ± 0.06
0.754HisGln: 0.754 ± 0.037
1.263HisArg: 1.263 ± 0.048
1.306HisSer: 1.306 ± 0.061
1.379HisThr: 1.379 ± 0.059
1.2HisVal: 1.2 ± 0.048
0.251HisTrp: 0.251 ± 0.025
0.511HisTyr: 0.511 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
7.3IleAla: 7.3 ± 0.135
0.386IleCys: 0.386 ± 0.031
2.818IleAsp: 2.818 ± 0.081
2.598IleGlu: 2.598 ± 0.087
1.747IlePhe: 1.747 ± 0.07
4.137IleGly: 4.137 ± 0.109
0.773IleHis: 0.773 ± 0.04
2.553IleIle: 2.553 ± 0.082
1.655IleLys: 1.655 ± 0.06
4.029IleLeu: 4.029 ± 0.108
0.831IleMet: 0.831 ± 0.041
1.508IleAsn: 1.508 ± 0.05
2.235IlePro: 2.235 ± 0.069
1.043IleGln: 1.043 ± 0.046
2.295IleArg: 2.295 ± 0.077
3.093IleSer: 3.093 ± 0.092
3.982IleThr: 3.982 ± 0.089
4.06IleVal: 4.06 ± 0.102
0.546IleTrp: 0.546 ± 0.035
1.049IleTyr: 1.049 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
3.608LysAla: 3.608 ± 0.112
0.168LysCys: 0.168 ± 0.023
1.452LysAsp: 1.452 ± 0.059
1.792LysGlu: 1.792 ± 0.08
1.13LysPhe: 1.13 ± 0.055
1.907LysGly: 1.907 ± 0.067
0.852LysHis: 0.852 ± 0.039
2.16LysIle: 2.16 ± 0.072
1.645LysLys: 1.645 ± 0.075
3.973LysLeu: 3.973 ± 0.094
0.783LysMet: 0.783 ± 0.046
1.188LysAsn: 1.188 ± 0.06
1.855LysPro: 1.855 ± 0.069
1.983LysGln: 1.983 ± 0.067
2.31LysArg: 2.31 ± 0.065
1.57LysSer: 1.57 ± 0.062
2.509LysThr: 2.509 ± 0.085
2.586LysVal: 2.586 ± 0.07
0.411LysTrp: 0.411 ± 0.027
0.862LysTyr: 0.862 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
14.127LeuAla: 14.127 ± 0.205
0.719LeuCys: 0.719 ± 0.039
5.043LeuAsp: 5.043 ± 0.111
5.946LeuGlu: 5.946 ± 0.132
3.059LeuPhe: 3.059 ± 0.096
8.227LeuGly: 8.227 ± 0.145
2.064LeuHis: 2.064 ± 0.065
4.505LeuIle: 4.505 ± 0.107
2.897LeuLys: 2.897 ± 0.085
12.626LeuLeu: 12.626 ± 0.261
1.678LeuMet: 1.678 ± 0.075
2.619LeuAsn: 2.619 ± 0.071
5.778LeuPro: 5.778 ± 0.131
5.51LeuGln: 5.51 ± 0.128
6.96LeuArg: 6.96 ± 0.142
5.84LeuSer: 5.84 ± 0.106
6.983LeuThr: 6.983 ± 0.129
8.158LeuVal: 8.158 ± 0.151
1.153LeuTrp: 1.153 ± 0.054
1.873LeuTyr: 1.873 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.981MetAla: 1.981 ± 0.061
0.11MetCys: 0.11 ± 0.015
0.598MetAsp: 0.598 ± 0.036
0.777MetGlu: 0.777 ± 0.04
0.652MetPhe: 0.652 ± 0.034
1.232MetGly: 1.232 ± 0.059
0.393MetHis: 0.393 ± 0.03
0.876MetIle: 0.876 ± 0.04
0.546MetLys: 0.546 ± 0.037
2.397MetLeu: 2.397 ± 0.073
0.314MetMet: 0.314 ± 0.027
0.586MetAsn: 0.586 ± 0.031
0.966MetPro: 0.966 ± 0.048
0.966MetGln: 0.966 ± 0.049
1.352MetArg: 1.352 ± 0.055
1.34MetSer: 1.34 ± 0.055
1.294MetThr: 1.294 ± 0.049
1.406MetVal: 1.406 ± 0.06
0.206MetTrp: 0.206 ± 0.022
0.33MetTyr: 0.33 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.117AsnAla: 3.117 ± 0.073
0.216AsnCys: 0.216 ± 0.021
1.225AsnAsp: 1.225 ± 0.057
1.475AsnGlu: 1.475 ± 0.06
1.08AsnPhe: 1.08 ± 0.05
2.307AsnGly: 2.307 ± 0.083
0.54AsnHis: 0.54 ± 0.035
1.458AsnIle: 1.458 ± 0.055
0.976AsnLys: 0.976 ± 0.048
2.86AsnLeu: 2.86 ± 0.082
0.588AsnMet: 0.588 ± 0.036
0.989AsnAsn: 0.989 ± 0.052
2.183AsnPro: 2.183 ± 0.067
1.088AsnGln: 1.088 ± 0.055
1.576AsnArg: 1.576 ± 0.054
1.861AsnSer: 1.861 ± 0.082
1.857AsnThr: 1.857 ± 0.064
1.967AsnVal: 1.967 ± 0.07
0.451AsnTrp: 0.451 ± 0.03
0.833AsnTyr: 0.833 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
6.345ProAla: 6.345 ± 0.152
0.21ProCys: 0.21 ± 0.025
2.474ProAsp: 2.474 ± 0.086
4.168ProGlu: 4.168 ± 0.111
1.458ProPhe: 1.458 ± 0.058
4.2ProGly: 4.2 ± 0.101
1.319ProHis: 1.319 ± 0.059
1.699ProIle: 1.699 ± 0.06
1.346ProLys: 1.346 ± 0.058
4.991ProLeu: 4.991 ± 0.112
0.525ProMet: 0.525 ± 0.029
1.329ProAsn: 1.329 ± 0.058
1.487ProPro: 1.487 ± 0.055
2.887ProGln: 2.887 ± 0.088
2.426ProArg: 2.426 ± 0.074
2.15ProSer: 2.15 ± 0.062
2.634ProThr: 2.634 ± 0.082
4.123ProVal: 4.123 ± 0.094
0.54ProTrp: 0.54 ± 0.034
1.065ProTyr: 1.065 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.69GlnAla: 4.69 ± 0.106
0.156GlnCys: 0.156 ± 0.02
1.533GlnAsp: 1.533 ± 0.059
2.457GlnGlu: 2.457 ± 0.079
1.115GlnPhe: 1.115 ± 0.044
2.411GlnGly: 2.411 ± 0.068
1.333GlnHis: 1.333 ± 0.062
2.177GlnIle: 2.177 ± 0.072
1.373GlnLys: 1.373 ± 0.052
6.561GlnLeu: 6.561 ± 0.152
0.895GlnMet: 0.895 ± 0.04
1.329GlnAsn: 1.329 ± 0.061
2.411GlnPro: 2.411 ± 0.082
4.114GlnGln: 4.114 ± 0.169
3.383GlnArg: 3.383 ± 0.116
1.691GlnSer: 1.691 ± 0.064
2.216GlnThr: 2.216 ± 0.071
3.277GlnVal: 3.277 ± 0.083
0.511GlnTrp: 0.511 ± 0.032
0.895GlnTyr: 0.895 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
6.264ArgAla: 6.264 ± 0.128
0.262ArgCys: 0.262 ± 0.022
3.115ArgAsp: 3.115 ± 0.103
4.127ArgGlu: 4.127 ± 0.104
2.083ArgPhe: 2.083 ± 0.066
4.401ArgGly: 4.401 ± 0.12
1.207ArgHis: 1.207 ± 0.052
3.007ArgIle: 3.007 ± 0.075
2.137ArgLys: 2.137 ± 0.072
5.857ArgLeu: 5.857 ± 0.125
1.209ArgMet: 1.209 ± 0.049
1.639ArgAsn: 1.639 ± 0.061
2.224ArgPro: 2.224 ± 0.072
2.561ArgGln: 2.561 ± 0.075
3.747ArgArg: 3.747 ± 0.131
2.887ArgSer: 2.887 ± 0.083
2.993ArgThr: 2.993 ± 0.09
4.694ArgVal: 4.694 ± 0.1
0.694ArgTrp: 0.694 ± 0.037
1.435ArgTyr: 1.435 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
6.513SerAla: 6.513 ± 0.13
0.463SerCys: 0.463 ± 0.029
2.845SerAsp: 2.845 ± 0.087
3.153SerGlu: 3.153 ± 0.085
1.996SerPhe: 1.996 ± 0.066
5.502SerGly: 5.502 ± 0.106
1.026SerHis: 1.026 ± 0.042
2.241SerIle: 2.241 ± 0.081
1.817SerLys: 1.817 ± 0.06
5.07SerLeu: 5.07 ± 0.112
0.984SerMet: 0.984 ± 0.046
1.456SerAsn: 1.456 ± 0.061
2.347SerPro: 2.347 ± 0.068
2.17SerGln: 2.17 ± 0.067
3.101SerArg: 3.101 ± 0.081
3.101SerSer: 3.101 ± 0.085
3.084SerThr: 3.084 ± 0.093
3.876SerVal: 3.876 ± 0.093
0.839SerTrp: 0.839 ± 0.041
1.551SerTyr: 1.551 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
10.295ThrAla: 10.295 ± 0.216
0.336ThrCys: 0.336 ± 0.027
2.86ThrAsp: 2.86 ± 0.087
3.537ThrGlu: 3.537 ± 0.09
1.853ThrPhe: 1.853 ± 0.06
5.483ThrGly: 5.483 ± 0.123
1.242ThrHis: 1.242 ± 0.052
2.754ThrIle: 2.754 ± 0.085
2.133ThrLys: 2.133 ± 0.074
6.04ThrLeu: 6.04 ± 0.108
1.024ThrMet: 1.024 ± 0.054
1.643ThrAsn: 1.643 ± 0.064
3.618ThrPro: 3.618 ± 0.096
2.199ThrGln: 2.199 ± 0.07
2.845ThrArg: 2.845 ± 0.075
3.103ThrSer: 3.103 ± 0.087
4.073ThrThr: 4.073 ± 0.103
6.704ThrVal: 6.704 ± 0.133
0.737ThrTrp: 0.737 ± 0.044
1.057ThrTyr: 1.057 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
11.004ValAla: 11.004 ± 0.17
0.646ValCys: 0.646 ± 0.045
4.1ValAsp: 4.1 ± 0.097
3.938ValGlu: 3.938 ± 0.09
2.987ValPhe: 2.987 ± 0.093
5.705ValGly: 5.705 ± 0.11
1.537ValHis: 1.537 ± 0.061
4.438ValIle: 4.438 ± 0.114
2.642ValLys: 2.642 ± 0.085
9.085ValLeu: 9.085 ± 0.181
1.61ValMet: 1.61 ± 0.059
2.287ValAsn: 2.287 ± 0.071
4.002ValPro: 4.002 ± 0.095
3.045ValGln: 3.045 ± 0.085
4.443ValArg: 4.443 ± 0.094
4.719ValSer: 4.719 ± 0.098
6.287ValThr: 6.287 ± 0.124
7.107ValVal: 7.107 ± 0.163
1.022ValTrp: 1.022 ± 0.042
1.664ValTyr: 1.664 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.263TrpAla: 1.263 ± 0.049
0.125TrpCys: 0.125 ± 0.016
0.598TrpAsp: 0.598 ± 0.035
0.729TrpGlu: 0.729 ± 0.042
0.528TrpPhe: 0.528 ± 0.033
0.872TrpGly: 0.872 ± 0.046
0.303TrpHis: 0.303 ± 0.028
0.65TrpIle: 0.65 ± 0.037
0.285TrpLys: 0.285 ± 0.025
1.452TrpLeu: 1.452 ± 0.06
0.245TrpMet: 0.245 ± 0.022
0.336TrpAsn: 0.336 ± 0.025
0.457TrpPro: 0.457 ± 0.032
0.895TrpGln: 0.895 ± 0.043
0.86TrpArg: 0.86 ± 0.044
0.671TrpSer: 0.671 ± 0.036
0.411TrpThr: 0.411 ± 0.031
0.968TrpVal: 0.968 ± 0.051
0.243TrpTrp: 0.243 ± 0.023
0.305TrpTyr: 0.305 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.544TyrAla: 2.544 ± 0.067
0.206TyrCys: 0.206 ± 0.019
1.296TyrAsp: 1.296 ± 0.056
1.441TyrGlu: 1.441 ± 0.067
0.854TyrPhe: 0.854 ± 0.044
2.044TyrGly: 2.044 ± 0.067
0.424TyrHis: 0.424 ± 0.026
0.829TyrIle: 0.829 ± 0.048
0.631TyrLys: 0.631 ± 0.04
2.42TyrLeu: 2.42 ± 0.069
0.318TyrMet: 0.318 ± 0.025
0.64TyrAsn: 0.64 ± 0.037
1.122TyrPro: 1.122 ± 0.053
0.968TyrGln: 0.968 ± 0.05
1.581TyrArg: 1.581 ± 0.058
1.267TyrSer: 1.267 ± 0.058
1.441TyrThr: 1.441 ± 0.055
1.689TyrVal: 1.689 ± 0.061
0.328TyrTrp: 0.328 ± 0.025
0.555TyrTyr: 0.555 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1426 proteins (481477 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski