Amino acid dipepetide frequency for Candidatus Campylobacter infans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.122AlaAla: 4.122 ± 0.107
1.432AlaCys: 1.432 ± 0.065
3.565AlaAsp: 3.565 ± 0.093
2.859AlaGlu: 2.859 ± 0.085
4.171AlaPhe: 4.171 ± 0.097
4.868AlaGly: 4.868 ± 0.113
1.551AlaHis: 1.551 ± 0.053
6.382AlaIle: 6.382 ± 0.113
8.543AlaLys: 8.543 ± 0.152
10.277AlaLeu: 10.277 ± 0.184
2.273AlaMet: 2.273 ± 0.075
5.334AlaAsn: 5.334 ± 0.123
2.289AlaPro: 2.289 ± 0.072
3.828AlaGln: 3.828 ± 0.091
3.616AlaArg: 3.616 ± 0.098
6.376AlaSer: 6.376 ± 0.117
3.399AlaThr: 3.399 ± 0.082
4.093AlaVal: 4.093 ± 0.095
0.614AlaTrp: 0.614 ± 0.039
2.91AlaTyr: 2.91 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
1.585CysAla: 1.585 ± 0.058
0.11CysCys: 0.11 ± 0.016
1.151CysAsp: 1.151 ± 0.058
1.198CysGlu: 1.198 ± 0.048
0.757CysPhe: 0.757 ± 0.046
1.122CysGly: 1.122 ± 0.051
0.271CysHis: 0.271 ± 0.029
0.745CysIle: 0.745 ± 0.037
0.902CysLys: 0.902 ± 0.043
1.088CysLeu: 1.088 ± 0.052
0.261CysMet: 0.261 ± 0.023
0.445CysAsn: 0.445 ± 0.033
0.331CysPro: 0.331 ± 0.028
0.416CysGln: 0.416 ± 0.032
0.255CysArg: 0.255 ± 0.024
0.657CysSer: 0.657 ± 0.033
0.396CysThr: 0.396 ± 0.032
1.161CysVal: 1.161 ± 0.05
0.069CysTrp: 0.069 ± 0.013
0.455CysTyr: 0.455 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.795AspAla: 3.795 ± 0.087
0.602AspCys: 0.602 ± 0.034
3.609AspAsp: 3.609 ± 0.092
6.284AspGlu: 6.284 ± 0.167
3.705AspPhe: 3.705 ± 0.091
3.561AspGly: 3.561 ± 0.115
0.492AspHis: 0.492 ± 0.036
4.948AspIle: 4.948 ± 0.101
4.544AspLys: 4.544 ± 0.091
5.531AspLeu: 5.531 ± 0.101
1.169AspMet: 1.169 ± 0.048
2.561AspAsn: 2.561 ± 0.081
1.251AspPro: 1.251 ± 0.054
0.786AspGln: 0.786 ± 0.04
1.228AspArg: 1.228 ± 0.053
2.82AspSer: 2.82 ± 0.075
2.22AspThr: 2.22 ± 0.101
2.593AspVal: 2.593 ± 0.082
0.229AspTrp: 0.229 ± 0.024
2.232AspTyr: 2.232 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
3.763GluAla: 3.763 ± 0.1
0.853GluCys: 0.853 ± 0.042
1.851GluAsp: 1.851 ± 0.068
2.216GluGlu: 2.216 ± 0.085
3.56GluPhe: 3.56 ± 0.101
2.171GluGly: 2.171 ± 0.072
1.183GluHis: 1.183 ± 0.051
6.578GluIle: 6.578 ± 0.12
4.775GluLys: 4.775 ± 0.102
8.349GluLeu: 8.349 ± 0.147
1.287GluMet: 1.287 ± 0.053
5.06GluAsn: 5.06 ± 0.11
1.742GluPro: 1.742 ± 0.07
2.979GluGln: 2.979 ± 0.081
2.771GluArg: 2.771 ± 0.096
3.018GluSer: 3.018 ± 0.085
1.51GluThr: 1.51 ± 0.052
2.834GluVal: 2.834 ± 0.083
0.382GluTrp: 0.382 ± 0.026
2.287GluTyr: 2.287 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
4.079PheAla: 4.079 ± 0.1
1.053PheCys: 1.053 ± 0.05
3.281PheAsp: 3.281 ± 0.084
3.073PheGlu: 3.073 ± 0.085
2.701PhePhe: 2.701 ± 0.091
4.081PheGly: 4.081 ± 0.117
0.581PheHis: 0.581 ± 0.035
4.36PheIle: 4.36 ± 0.129
4.364PheLys: 4.364 ± 0.094
5.354PheLeu: 5.354 ± 0.143
1.492PheMet: 1.492 ± 0.058
3.252PheAsn: 3.252 ± 0.089
0.759PhePro: 0.759 ± 0.047
0.83PheGln: 0.83 ± 0.04
1.416PheArg: 1.416 ± 0.054
4.626PheSer: 4.626 ± 0.101
2.208PheThr: 2.208 ± 0.065
3.208PheVal: 3.208 ± 0.097
0.51PheTrp: 0.51 ± 0.032
2.24PheTyr: 2.24 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
5.733GlyAla: 5.733 ± 0.149
0.765GlyCys: 0.765 ± 0.044
3.63GlyAsp: 3.63 ± 0.109
3.581GlyGlu: 3.581 ± 0.087
3.865GlyPhe: 3.865 ± 0.11
4.275GlyGly: 4.275 ± 0.13
1.026GlyHis: 1.026 ± 0.044
5.097GlyIle: 5.097 ± 0.113
4.379GlyLys: 4.379 ± 0.089
6.121GlyLeu: 6.121 ± 0.125
1.216GlyMet: 1.216 ± 0.051
2.157GlyAsn: 2.157 ± 0.113
0.812GlyPro: 0.812 ± 0.038
1.867GlyGln: 1.867 ± 0.062
2.226GlyArg: 2.226 ± 0.069
3.475GlySer: 3.475 ± 0.178
2.614GlyThr: 2.614 ± 0.124
4.734GlyVal: 4.734 ± 0.11
0.426GlyTrp: 0.426 ± 0.03
2.328GlyTyr: 2.328 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.132HisAla: 1.132 ± 0.047
0.21HisCys: 0.21 ± 0.018
0.592HisAsp: 0.592 ± 0.037
0.9HisGlu: 0.9 ± 0.042
1.114HisPhe: 1.114 ± 0.049
0.971HisGly: 0.971 ± 0.043
0.261HisHis: 0.261 ± 0.022
1.383HisIle: 1.383 ± 0.056
1.298HisLys: 1.298 ± 0.054
1.634HisLeu: 1.634 ± 0.063
0.263HisMet: 0.263 ± 0.022
0.822HisAsn: 0.822 ± 0.042
0.582HisPro: 0.582 ± 0.037
0.459HisGln: 0.459 ± 0.03
0.479HisArg: 0.479 ± 0.035
1.108HisSer: 1.108 ± 0.045
0.804HisThr: 0.804 ± 0.039
0.404HisVal: 0.404 ± 0.034
0.116HisTrp: 0.116 ± 0.016
0.643HisTyr: 0.643 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
7.19IleAla: 7.19 ± 0.123
1.412IleCys: 1.412 ± 0.053
4.893IleAsp: 4.893 ± 0.115
4.489IleGlu: 4.489 ± 0.118
4.709IlePhe: 4.709 ± 0.129
4.613IleGly: 4.613 ± 0.119
0.969IleHis: 0.969 ± 0.047
7.211IleIle: 7.211 ± 0.165
8.031IleLys: 8.031 ± 0.129
8.839IleLeu: 8.839 ± 0.146
1.64IleMet: 1.64 ± 0.055
5.581IleAsn: 5.581 ± 0.13
1.996IlePro: 1.996 ± 0.062
2.349IleGln: 2.349 ± 0.073
2.349IleArg: 2.349 ± 0.075
7.466IleSer: 7.466 ± 0.14
4.152IleThr: 4.152 ± 0.12
3.922IleVal: 3.922 ± 0.1
0.563IleTrp: 0.563 ± 0.038
2.957IleTyr: 2.957 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
7.198LysAla: 7.198 ± 0.135
0.855LysCys: 0.855 ± 0.048
5.293LysAsp: 5.293 ± 0.107
5.791LysGlu: 5.791 ± 0.116
3.546LysPhe: 3.546 ± 0.08
4.003LysGly: 4.003 ± 0.107
1.334LysHis: 1.334 ± 0.057
9.119LysIle: 9.119 ± 0.152
6.78LysLys: 6.78 ± 0.149
7.333LysLeu: 7.333 ± 0.135
2.438LysMet: 2.438 ± 0.073
7.268LysAsn: 7.268 ± 0.14
2.304LysPro: 2.304 ± 0.068
3.35LysGln: 3.35 ± 0.095
2.989LysArg: 2.989 ± 0.094
5.884LysSer: 5.884 ± 0.109
3.95LysThr: 3.95 ± 0.098
3.261LysVal: 3.261 ± 0.096
0.473LysTrp: 0.473 ± 0.03
2.767LysTyr: 2.767 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
9.131LeuAla: 9.131 ± 0.148
1.759LeuCys: 1.759 ± 0.066
5.576LeuAsp: 5.576 ± 0.112
6.39LeuGlu: 6.39 ± 0.118
4.832LeuPhe: 4.832 ± 0.139
6.905LeuGly: 6.905 ± 0.139
1.487LeuHis: 1.487 ± 0.062
7.79LeuIle: 7.79 ± 0.14
10.235LeuLys: 10.235 ± 0.156
9.104LeuLeu: 9.104 ± 0.17
2.155LeuMet: 2.155 ± 0.069
7.956LeuAsn: 7.956 ± 0.156
3.25LeuPro: 3.25 ± 0.092
2.906LeuGln: 2.906 ± 0.083
3.738LeuArg: 3.738 ± 0.09
8.725LeuSer: 8.725 ± 0.151
3.548LeuThr: 3.548 ± 0.084
4.65LeuVal: 4.65 ± 0.103
0.682LeuTrp: 0.682 ± 0.039
3.397LeuTyr: 3.397 ± 0.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.891MetAla: 1.891 ± 0.065
0.243MetCys: 0.243 ± 0.022
1.088MetAsp: 1.088 ± 0.047
0.849MetGlu: 0.849 ± 0.038
0.792MetPhe: 0.792 ± 0.04
1.375MetGly: 1.375 ± 0.057
0.355MetHis: 0.355 ± 0.028
1.724MetIle: 1.724 ± 0.052
1.84MetLys: 1.84 ± 0.066
2.746MetLeu: 2.746 ± 0.073
0.5MetMet: 0.5 ± 0.029
1.179MetAsn: 1.179 ± 0.05
1.088MetPro: 1.088 ± 0.048
1.279MetGln: 1.279 ± 0.053
1.147MetArg: 1.147 ± 0.054
1.536MetSer: 1.536 ± 0.05
0.686MetThr: 0.686 ± 0.038
1.065MetVal: 1.065 ± 0.044
0.147MetTrp: 0.147 ± 0.017
0.475MetTyr: 0.475 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
6.807AsnAla: 6.807 ± 0.151
0.543AsnCys: 0.543 ± 0.035
3.689AsnAsp: 3.689 ± 0.093
5.252AsnGlu: 5.252 ± 0.098
3.822AsnPhe: 3.822 ± 0.103
3.922AsnGly: 3.922 ± 0.127
0.792AsnHis: 0.792 ± 0.038
5.44AsnIle: 5.44 ± 0.139
4.803AsnLys: 4.803 ± 0.11
6.395AsnLeu: 6.395 ± 0.129
1.065AsnMet: 1.065 ± 0.044
3.318AsnAsn: 3.318 ± 0.116
2.265AsnPro: 2.265 ± 0.072
2.034AsnGln: 2.034 ± 0.074
1.467AsnArg: 1.467 ± 0.057
4.046AsnSer: 4.046 ± 0.101
3.022AsnThr: 3.022 ± 0.084
2.614AsnVal: 2.614 ± 0.086
0.263AsnTrp: 0.263 ± 0.027
2.246AsnTyr: 2.246 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.94ProAla: 1.94 ± 0.071
0.375ProCys: 0.375 ± 0.027
1.212ProAsp: 1.212 ± 0.052
1.312ProGlu: 1.312 ± 0.054
1.681ProPhe: 1.681 ± 0.064
1.251ProGly: 1.251 ± 0.048
0.52ProHis: 0.52 ± 0.033
1.822ProIle: 1.822 ± 0.061
2.744ProLys: 2.744 ± 0.085
2.901ProLeu: 2.901 ± 0.08
0.5ProMet: 0.5 ± 0.029
2.046ProAsn: 2.046 ± 0.062
0.714ProPro: 0.714 ± 0.043
1.338ProGln: 1.338 ± 0.059
1.053ProArg: 1.053 ± 0.046
2.165ProSer: 2.165 ± 0.065
1.251ProThr: 1.251 ± 0.057
1.567ProVal: 1.567 ± 0.053
0.224ProTrp: 0.224 ± 0.02
1.09ProTyr: 1.09 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.056GlnAla: 3.056 ± 0.095
0.282GlnCys: 0.282 ± 0.022
1.614GlnAsp: 1.614 ± 0.053
1.949GlnGlu: 1.949 ± 0.065
0.973GlnPhe: 0.973 ± 0.045
1.665GlnGly: 1.665 ± 0.06
0.367GlnHis: 0.367 ± 0.028
4.171GlnIle: 4.171 ± 0.095
3.86GlnLys: 3.86 ± 0.103
2.142GlnLeu: 2.142 ± 0.064
1.002GlnMet: 1.002 ± 0.04
4.417GlnAsn: 4.417 ± 0.107
0.62GlnPro: 0.62 ± 0.035
0.824GlnGln: 0.824 ± 0.048
1.071GlnArg: 1.071 ± 0.047
2.461GlnSer: 2.461 ± 0.066
1.726GlnThr: 1.726 ± 0.066
1.381GlnVal: 1.381 ± 0.051
0.178GlnTrp: 0.178 ± 0.018
0.877GlnTyr: 0.877 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.577ArgAla: 3.577 ± 0.1
0.292ArgCys: 0.292 ± 0.023
1.979ArgAsp: 1.979 ± 0.066
2.165ArgGlu: 2.165 ± 0.065
2.069ArgPhe: 2.069 ± 0.062
1.995ArgGly: 1.995 ± 0.071
0.592ArgHis: 0.592 ± 0.036
2.803ArgIle: 2.803 ± 0.078
2.332ArgLys: 2.332 ± 0.073
3.709ArgLeu: 3.709 ± 0.091
0.669ArgMet: 0.669 ± 0.038
1.541ArgAsn: 1.541 ± 0.051
1.041ArgPro: 1.041 ± 0.048
1.287ArgGln: 1.287 ± 0.057
1.328ArgArg: 1.328 ± 0.056
1.798ArgSer: 1.798 ± 0.061
1.404ArgThr: 1.404 ± 0.057
2.363ArgVal: 2.363 ± 0.074
0.233ArgTrp: 0.233 ± 0.022
1.359ArgTyr: 1.359 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.223SerAla: 6.223 ± 0.123
0.749SerCys: 0.749 ± 0.039
3.881SerAsp: 3.881 ± 0.103
3.487SerGlu: 3.487 ± 0.092
4.02SerPhe: 4.02 ± 0.088
4.911SerGly: 4.911 ± 0.218
1.12SerHis: 1.12 ± 0.046
5.189SerIle: 5.189 ± 0.103
5.864SerLys: 5.864 ± 0.111
7.376SerLeu: 7.376 ± 0.124
1.234SerMet: 1.234 ± 0.05
3.285SerAsn: 3.285 ± 0.097
1.879SerPro: 1.879 ± 0.071
3.163SerGln: 3.163 ± 0.088
2.022SerArg: 2.022 ± 0.066
4.558SerSer: 4.558 ± 0.11
3.393SerThr: 3.393 ± 0.105
4.436SerVal: 4.436 ± 0.098
0.559SerTrp: 0.559 ± 0.031
2.361SerTyr: 2.361 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.242ThrAla: 3.242 ± 0.085
0.424ThrCys: 0.424 ± 0.027
1.781ThrAsp: 1.781 ± 0.06
1.32ThrGlu: 1.32 ± 0.056
1.726ThrPhe: 1.726 ± 0.06
2.718ThrGly: 2.718 ± 0.115
0.892ThrHis: 0.892 ± 0.045
3.369ThrIle: 3.369 ± 0.187
3.734ThrLys: 3.734 ± 0.095
4.807ThrLeu: 4.807 ± 0.124
0.884ThrMet: 0.884 ± 0.04
2.944ThrAsn: 2.944 ± 0.081
1.985ThrPro: 1.985 ± 0.064
2.281ThrGln: 2.281 ± 0.074
1.724ThrArg: 1.724 ± 0.062
3.085ThrSer: 3.085 ± 0.093
2.212ThrThr: 2.212 ± 0.116
1.098ThrVal: 1.098 ± 0.065
0.265ThrTrp: 0.265 ± 0.023
1.294ThrTyr: 1.294 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.391ValAla: 4.391 ± 0.097
0.837ValCys: 0.837 ± 0.043
2.753ValAsp: 2.753 ± 0.078
2.753ValGlu: 2.753 ± 0.084
2.81ValPhe: 2.81 ± 0.081
3.238ValGly: 3.238 ± 0.101
0.596ValHis: 0.596 ± 0.031
4.185ValIle: 4.185 ± 0.094
3.561ValLys: 3.561 ± 0.094
6.184ValLeu: 6.184 ± 0.124
1.179ValMet: 1.179 ± 0.05
2.567ValAsn: 2.567 ± 0.078
1.549ValPro: 1.549 ± 0.064
1.163ValGln: 1.163 ± 0.053
2.212ValArg: 2.212 ± 0.071
3.483ValSer: 3.483 ± 0.088
1.536ValThr: 1.536 ± 0.067
3.279ValVal: 3.279 ± 0.092
0.394ValTrp: 0.394 ± 0.029
1.663ValTyr: 1.663 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.59TrpAla: 0.59 ± 0.035
0.127TrpCys: 0.127 ± 0.016
0.379TrpAsp: 0.379 ± 0.028
0.337TrpGlu: 0.337 ± 0.025
0.333TrpPhe: 0.333 ± 0.027
0.512TrpGly: 0.512 ± 0.036
0.214TrpHis: 0.214 ± 0.02
0.518TrpIle: 0.518 ± 0.037
0.194TrpLys: 0.194 ± 0.023
0.912TrpLeu: 0.912 ± 0.045
0.175TrpMet: 0.175 ± 0.021
0.214TrpAsn: 0.214 ± 0.02
0.114TrpPro: 0.114 ± 0.016
0.428TrpGln: 0.428 ± 0.03
0.363TrpArg: 0.363 ± 0.027
0.341TrpSer: 0.341 ± 0.028
0.167TrpThr: 0.167 ± 0.02
0.394TrpVal: 0.394 ± 0.029
0.106TrpTrp: 0.106 ± 0.018
0.229TrpTyr: 0.229 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.059TyrAla: 3.059 ± 0.081
0.451TyrCys: 0.451 ± 0.031
2.342TyrAsp: 2.342 ± 0.08
2.961TyrGlu: 2.961 ± 0.079
2.283TyrPhe: 2.283 ± 0.081
2.171TyrGly: 2.171 ± 0.07
0.573TyrHis: 0.573 ± 0.036
2.499TyrIle: 2.499 ± 0.072
3.152TyrLys: 3.152 ± 0.081
3.418TyrLeu: 3.418 ± 0.091
0.602TyrMet: 0.602 ± 0.033
1.859TyrAsn: 1.859 ± 0.065
1.132TyrPro: 1.132 ± 0.044
1.069TyrGln: 1.069 ± 0.049
1.083TyrArg: 1.083 ± 0.05
2.081TyrSer: 2.081 ± 0.069
1.587TyrThr: 1.587 ± 0.055
1.277TyrVal: 1.277 ± 0.054
0.214TyrTrp: 0.214 ± 0.022
1.369TyrTyr: 1.369 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1672 proteins (509900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski