Amino acid dipepetide frequency for Marinosulfonomonas sp. PRT-SC04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.149AlaAla: 14.149 ± 0.233
1.1AlaCys: 1.1 ± 0.063
6.834AlaAsp: 6.834 ± 0.158
6.87AlaGlu: 6.87 ± 0.137
4.054AlaPhe: 4.054 ± 0.105
9.365AlaGly: 9.365 ± 0.183
2.016AlaHis: 2.016 ± 0.077
6.437AlaIle: 6.437 ± 0.136
5.415AlaLys: 5.415 ± 0.12
12.06AlaLeu: 12.06 ± 0.209
3.638AlaMet: 3.638 ± 0.103
3.259AlaAsn: 3.259 ± 0.096
4.885AlaPro: 4.885 ± 0.12
3.955AlaGln: 3.955 ± 0.098
6.527AlaArg: 6.527 ± 0.133
5.57AlaSer: 5.57 ± 0.127
5.681AlaThr: 5.681 ± 0.119
7.89AlaVal: 7.89 ± 0.144
1.288AlaTrp: 1.288 ± 0.064
2.78AlaTyr: 2.78 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
1.008CysAla: 1.008 ± 0.052
0.133CysCys: 0.133 ± 0.018
0.711CysAsp: 0.711 ± 0.044
0.525CysGlu: 0.525 ± 0.034
0.372CysPhe: 0.372 ± 0.03
0.909CysGly: 0.909 ± 0.044
0.309CysHis: 0.309 ± 0.025
0.491CysIle: 0.491 ± 0.036
0.346CysLys: 0.346 ± 0.027
0.89CysLeu: 0.89 ± 0.049
0.189CysMet: 0.189 ± 0.023
0.29CysAsn: 0.29 ± 0.026
0.481CysPro: 0.481 ± 0.035
0.266CysGln: 0.266 ± 0.024
0.525CysArg: 0.525 ± 0.036
0.525CysSer: 0.525 ± 0.036
0.483CysThr: 0.483 ± 0.037
0.674CysVal: 0.674 ± 0.048
0.123CysTrp: 0.123 ± 0.016
0.266CysTyr: 0.266 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
7.044AspAla: 7.044 ± 0.162
0.568AspCys: 0.568 ± 0.038
3.336AspAsp: 3.336 ± 0.094
3.454AspGlu: 3.454 ± 0.088
2.458AspPhe: 2.458 ± 0.074
5.197AspGly: 5.197 ± 0.113
1.24AspHis: 1.24 ± 0.066
3.575AspIle: 3.575 ± 0.083
2.212AspLys: 2.212 ± 0.068
5.993AspLeu: 5.993 ± 0.127
1.915AspMet: 1.915 ± 0.074
1.525AspAsn: 1.525 ± 0.068
3.036AspPro: 3.036 ± 0.089
2.047AspGln: 2.047 ± 0.079
3.227AspArg: 3.227 ± 0.09
2.347AspSer: 2.347 ± 0.075
3.0AspThr: 3.0 ± 0.082
4.617AspVal: 4.617 ± 0.109
1.03AspTrp: 1.03 ± 0.052
1.588AspTyr: 1.588 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
7.068GluAla: 7.068 ± 0.161
0.447GluCys: 0.447 ± 0.033
2.998GluAsp: 2.998 ± 0.095
2.976GluGlu: 2.976 ± 0.093
2.026GluPhe: 2.026 ± 0.069
4.204GluGly: 4.204 ± 0.104
1.235GluHis: 1.235 ± 0.06
4.16GluIle: 4.16 ± 0.095
2.642GluLys: 2.642 ± 0.092
4.946GluLeu: 4.946 ± 0.121
2.057GluMet: 2.057 ± 0.067
2.229GluAsn: 2.229 ± 0.072
2.127GluPro: 2.127 ± 0.07
2.002GluGln: 2.002 ± 0.069
3.696GluArg: 3.696 ± 0.098
2.193GluSer: 2.193 ± 0.07
3.619GluThr: 3.619 ± 0.098
4.421GluVal: 4.421 ± 0.106
0.716GluTrp: 0.716 ± 0.04
1.315GluTyr: 1.315 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
4.037PheAla: 4.037 ± 0.113
0.469PheCys: 0.469 ± 0.034
2.635PheAsp: 2.635 ± 0.092
2.364PheGlu: 2.364 ± 0.075
1.53PhePhe: 1.53 ± 0.069
3.848PheGly: 3.848 ± 0.111
0.783PheHis: 0.783 ± 0.042
2.135PheIle: 2.135 ± 0.068
1.462PheLys: 1.462 ± 0.069
3.329PheLeu: 3.329 ± 0.088
1.032PheMet: 1.032 ± 0.046
1.291PheAsn: 1.291 ± 0.06
1.518PhePro: 1.518 ± 0.063
1.165PheGln: 1.165 ± 0.055
1.883PheArg: 1.883 ± 0.086
2.516PheSer: 2.516 ± 0.084
2.193PheThr: 2.193 ± 0.063
2.562PheVal: 2.562 ± 0.087
0.609PheTrp: 0.609 ± 0.039
0.984PheTyr: 0.984 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
9.005GlyAla: 9.005 ± 0.165
0.977GlyCys: 0.977 ± 0.056
4.516GlyAsp: 4.516 ± 0.105
4.443GlyGlu: 4.443 ± 0.108
3.778GlyPhe: 3.778 ± 0.1
6.904GlyGly: 6.904 ± 0.182
1.902GlyHis: 1.902 ± 0.062
4.745GlyIle: 4.745 ± 0.11
4.073GlyLys: 4.073 ± 0.118
8.33GlyLeu: 8.33 ± 0.162
2.78GlyMet: 2.78 ± 0.077
2.287GlyAsn: 2.287 ± 0.083
3.01GlyPro: 3.01 ± 0.076
3.046GlyGln: 3.046 ± 0.091
4.728GlyArg: 4.728 ± 0.121
3.952GlySer: 3.952 ± 0.1
4.197GlyThr: 4.197 ± 0.104
6.561GlyVal: 6.561 ± 0.132
1.359GlyTrp: 1.359 ± 0.064
2.451GlyTyr: 2.451 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
2.103HisAla: 2.103 ± 0.071
0.203HisCys: 0.203 ± 0.023
1.255HisAsp: 1.255 ± 0.058
1.054HisGlu: 1.054 ± 0.05
0.873HisPhe: 0.873 ± 0.04
1.907HisGly: 1.907 ± 0.074
0.532HisHis: 0.532 ± 0.038
1.218HisIle: 1.218 ± 0.053
0.829HisLys: 0.829 ± 0.046
2.072HisLeu: 2.072 ± 0.083
0.67HisMet: 0.67 ± 0.045
0.66HisAsn: 0.66 ± 0.042
1.255HisPro: 1.255 ± 0.063
0.696HisGln: 0.696 ± 0.041
1.148HisArg: 1.148 ± 0.052
0.96HisSer: 0.96 ± 0.046
0.923HisThr: 0.923 ± 0.052
1.465HisVal: 1.465 ± 0.06
0.363HisTrp: 0.363 ± 0.029
0.573HisTyr: 0.573 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
7.344IleAla: 7.344 ± 0.165
0.764IleCys: 0.764 ± 0.046
3.935IleAsp: 3.935 ± 0.09
4.233IleGlu: 4.233 ± 0.105
2.101IlePhe: 2.101 ± 0.079
5.495IleGly: 5.495 ± 0.124
1.117IleHis: 1.117 ± 0.053
3.225IleIle: 3.225 ± 0.09
2.632IleLys: 2.632 ± 0.084
5.188IleLeu: 5.188 ± 0.117
1.433IleMet: 1.433 ± 0.071
1.963IleAsn: 1.963 ± 0.077
2.48IlePro: 2.48 ± 0.077
1.523IleGln: 1.523 ± 0.056
3.266IleArg: 3.266 ± 0.092
3.945IleSer: 3.945 ± 0.094
3.655IleThr: 3.655 ± 0.096
3.8IleVal: 3.8 ± 0.104
0.781IleTrp: 0.781 ± 0.047
1.438IleTyr: 1.438 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.086LysAla: 5.086 ± 0.132
0.322LysCys: 0.322 ± 0.028
2.325LysAsp: 2.325 ± 0.08
2.086LysGlu: 2.086 ± 0.08
1.39LysPhe: 1.39 ± 0.066
3.379LysGly: 3.379 ± 0.09
1.003LysHis: 1.003 ± 0.053
3.002LysIle: 3.002 ± 0.091
2.154LysLys: 2.154 ± 0.091
4.066LysLeu: 4.066 ± 0.098
1.448LysMet: 1.448 ± 0.056
1.518LysAsn: 1.518 ± 0.065
2.246LysPro: 2.246 ± 0.087
1.433LysGln: 1.433 ± 0.064
3.14LysArg: 3.14 ± 0.103
2.678LysSer: 2.678 ± 0.087
3.082LysThr: 3.082 ± 0.079
2.92LysVal: 2.92 ± 0.116
0.541LysTrp: 0.541 ± 0.035
0.969LysTyr: 0.969 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
11.231LeuAla: 11.231 ± 0.17
0.844LeuCys: 0.844 ± 0.036
5.521LeuAsp: 5.521 ± 0.124
5.458LeuGlu: 5.458 ± 0.124
3.481LeuPhe: 3.481 ± 0.112
8.05LeuGly: 8.05 ± 0.14
1.876LeuHis: 1.876 ± 0.074
5.722LeuIle: 5.722 ± 0.137
4.487LeuLys: 4.487 ± 0.091
8.499LeuLeu: 8.499 ± 0.201
2.891LeuMet: 2.891 ± 0.082
3.162LeuAsn: 3.162 ± 0.087
4.694LeuPro: 4.694 ± 0.123
2.898LeuGln: 2.898 ± 0.09
5.906LeuArg: 5.906 ± 0.128
6.084LeuSer: 6.084 ± 0.12
5.811LeuThr: 5.811 ± 0.135
6.145LeuVal: 6.145 ± 0.123
1.073LeuTrp: 1.073 ± 0.047
1.968LeuTyr: 1.968 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
3.79MetAla: 3.79 ± 0.087
0.227MetCys: 0.227 ± 0.023
1.542MetAsp: 1.542 ± 0.063
1.332MetGlu: 1.332 ± 0.059
0.991MetPhe: 0.991 ± 0.057
2.413MetGly: 2.413 ± 0.079
0.5MetHis: 0.5 ± 0.039
1.927MetIle: 1.927 ± 0.073
1.438MetLys: 1.438 ± 0.057
2.906MetLeu: 2.906 ± 0.082
0.996MetMet: 0.996 ± 0.052
1.141MetAsn: 1.141 ± 0.045
1.641MetPro: 1.641 ± 0.058
1.257MetGln: 1.257 ± 0.047
1.973MetArg: 1.973 ± 0.069
2.055MetSer: 2.055 ± 0.074
1.97MetThr: 1.97 ± 0.073
2.168MetVal: 2.168 ± 0.071
0.234MetTrp: 0.234 ± 0.024
0.396MetTyr: 0.396 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.638AsnAla: 3.638 ± 0.095
0.317AsnCys: 0.317 ± 0.027
1.76AsnAsp: 1.76 ± 0.076
1.535AsnGlu: 1.535 ± 0.066
1.201AsnPhe: 1.201 ± 0.052
2.913AsnGly: 2.913 ± 0.086
0.636AsnHis: 0.636 ± 0.039
2.043AsnIle: 2.043 ± 0.075
1.262AsnLys: 1.262 ± 0.056
2.927AsnLeu: 2.927 ± 0.087
1.003AsnMet: 1.003 ± 0.053
0.974AsnAsn: 0.974 ± 0.058
2.084AsnPro: 2.084 ± 0.071
0.863AsnGln: 0.863 ± 0.043
1.946AsnArg: 1.946 ± 0.082
1.535AsnSer: 1.535 ± 0.065
1.711AsnThr: 1.711 ± 0.08
2.171AsnVal: 2.171 ± 0.074
0.491AsnTrp: 0.491 ± 0.037
0.73AsnTyr: 0.73 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.765ProAla: 4.765 ± 0.126
0.399ProCys: 0.399 ± 0.033
3.481ProAsp: 3.481 ± 0.097
3.534ProGlu: 3.534 ± 0.089
1.762ProPhe: 1.762 ± 0.063
2.797ProGly: 2.797 ± 0.085
0.991ProHis: 0.991 ± 0.054
2.637ProIle: 2.637 ± 0.08
2.318ProLys: 2.318 ± 0.092
4.189ProLeu: 4.189 ± 0.113
1.291ProMet: 1.291 ± 0.054
1.639ProAsn: 1.639 ± 0.062
1.796ProPro: 1.796 ± 0.077
1.397ProGln: 1.397 ± 0.058
2.183ProArg: 2.183 ± 0.083
2.4ProSer: 2.4 ± 0.07
2.42ProThr: 2.42 ± 0.072
3.67ProVal: 3.67 ± 0.097
0.498ProTrp: 0.498 ± 0.037
1.141ProTyr: 1.141 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
3.89GlnAla: 3.89 ± 0.1
0.205GlnCys: 0.205 ± 0.021
1.574GlnAsp: 1.574 ± 0.06
1.462GlnGlu: 1.462 ± 0.068
1.262GlnPhe: 1.262 ± 0.057
2.565GlnGly: 2.565 ± 0.082
0.687GlnHis: 0.687 ± 0.046
2.313GlnIle: 2.313 ± 0.08
1.489GlnLys: 1.489 ± 0.06
2.828GlnLeu: 2.828 ± 0.09
1.097GlnMet: 1.097 ± 0.052
1.185GlnAsn: 1.185 ± 0.053
1.404GlnPro: 1.404 ± 0.057
1.139GlnGln: 1.139 ± 0.058
1.999GlnArg: 1.999 ± 0.082
1.97GlnSer: 1.97 ± 0.071
1.915GlnThr: 1.915 ± 0.074
2.359GlnVal: 2.359 ± 0.064
0.409GlnTrp: 0.409 ± 0.036
0.696GlnTyr: 0.696 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
6.36ArgAla: 6.36 ± 0.128
0.498ArgCys: 0.498 ± 0.035
3.723ArgAsp: 3.723 ± 0.113
3.377ArgGlu: 3.377 ± 0.09
2.224ArgPhe: 2.224 ± 0.075
4.054ArgGly: 4.054 ± 0.113
1.351ArgHis: 1.351 ± 0.062
3.699ArgIle: 3.699 ± 0.099
2.816ArgLys: 2.816 ± 0.094
6.188ArgLeu: 6.188 ± 0.129
1.849ArgMet: 1.849 ± 0.072
1.808ArgAsn: 1.808 ± 0.066
2.427ArgPro: 2.427 ± 0.09
1.934ArgGln: 1.934 ± 0.07
4.059ArgArg: 4.059 ± 0.116
2.93ArgSer: 2.93 ± 0.081
2.674ArgThr: 2.674 ± 0.079
4.049ArgVal: 4.049 ± 0.096
0.774ArgTrp: 0.774 ± 0.046
1.595ArgTyr: 1.595 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
5.582SerAla: 5.582 ± 0.13
0.481SerCys: 0.481 ± 0.037
3.508SerAsp: 3.508 ± 0.101
3.0SerGlu: 3.0 ± 0.086
2.386SerPhe: 2.386 ± 0.083
5.478SerGly: 5.478 ± 0.104
1.218SerHis: 1.218 ± 0.06
3.099SerIle: 3.099 ± 0.083
2.398SerLys: 2.398 ± 0.081
4.844SerLeu: 4.844 ± 0.132
1.593SerMet: 1.593 ± 0.064
1.699SerAsn: 1.699 ± 0.068
2.321SerPro: 2.321 ± 0.078
1.823SerGln: 1.823 ± 0.07
2.894SerArg: 2.894 ± 0.09
2.703SerSer: 2.703 ± 0.086
2.831SerThr: 2.831 ± 0.079
3.827SerVal: 3.827 ± 0.097
0.694SerTrp: 0.694 ± 0.044
1.409SerTyr: 1.409 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
5.944ThrAla: 5.944 ± 0.153
0.515ThrCys: 0.515 ± 0.035
3.237ThrAsp: 3.237 ± 0.09
2.956ThrGlu: 2.956 ± 0.081
1.917ThrPhe: 1.917 ± 0.073
5.178ThrGly: 5.178 ± 0.117
1.245ThrHis: 1.245 ± 0.052
3.174ThrIle: 3.174 ± 0.096
2.27ThrLys: 2.27 ± 0.074
5.84ThrLeu: 5.84 ± 0.11
1.494ThrMet: 1.494 ± 0.056
1.617ThrAsn: 1.617 ± 0.056
3.225ThrPro: 3.225 ± 0.098
1.608ThrGln: 1.608 ± 0.062
3.111ThrArg: 3.111 ± 0.08
2.927ThrSer: 2.927 ± 0.086
3.268ThrThr: 3.268 ± 0.097
4.093ThrVal: 4.093 ± 0.098
0.699ThrTrp: 0.699 ± 0.042
1.472ThrTyr: 1.472 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
8.026ValAla: 8.026 ± 0.13
0.629ValCys: 0.629 ± 0.04
4.105ValAsp: 4.105 ± 0.096
4.414ValGlu: 4.414 ± 0.12
2.935ValPhe: 2.935 ± 0.096
5.246ValGly: 5.246 ± 0.116
1.264ValHis: 1.264 ± 0.06
4.656ValIle: 4.656 ± 0.13
3.027ValLys: 3.027 ± 0.095
7.034ValLeu: 7.034 ± 0.131
2.497ValMet: 2.497 ± 0.088
2.151ValAsn: 2.151 ± 0.076
3.116ValPro: 3.116 ± 0.087
2.016ValGln: 2.016 ± 0.076
3.764ValArg: 3.764 ± 0.088
4.327ValSer: 4.327 ± 0.112
4.349ValThr: 4.349 ± 0.102
5.666ValVal: 5.666 ± 0.146
0.882ValTrp: 0.882 ± 0.044
1.441ValTyr: 1.441 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
1.291TrpAla: 1.291 ± 0.063
0.169TrpCys: 0.169 ± 0.021
0.798TrpAsp: 0.798 ± 0.045
0.631TrpGlu: 0.631 ± 0.041
0.602TrpPhe: 0.602 ± 0.04
0.928TrpGly: 0.928 ± 0.053
0.285TrpHis: 0.285 ± 0.028
0.73TrpIle: 0.73 ± 0.048
0.539TrpLys: 0.539 ± 0.033
1.441TrpLeu: 1.441 ± 0.062
0.423TrpMet: 0.423 ± 0.03
0.471TrpAsn: 0.471 ± 0.04
0.549TrpPro: 0.549 ± 0.04
0.561TrpGln: 0.561 ± 0.036
0.923TrpArg: 0.923 ± 0.049
0.72TrpSer: 0.72 ± 0.05
0.648TrpThr: 0.648 ± 0.051
0.948TrpVal: 0.948 ± 0.05
0.213TrpTrp: 0.213 ± 0.024
0.259TrpTyr: 0.259 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.413TyrAla: 2.413 ± 0.081
0.249TyrCys: 0.249 ± 0.022
1.62TyrAsp: 1.62 ± 0.068
1.371TyrGlu: 1.371 ± 0.061
1.003TyrPhe: 1.003 ± 0.042
2.217TyrGly: 2.217 ± 0.07
0.566TyrHis: 0.566 ± 0.034
1.33TyrIle: 1.33 ± 0.051
0.981TyrLys: 0.981 ± 0.051
2.231TyrLeu: 2.231 ± 0.082
0.6TyrMet: 0.6 ± 0.035
0.87TyrAsn: 0.87 ± 0.049
1.013TyrPro: 1.013 ± 0.049
0.819TyrGln: 0.819 ± 0.042
1.492TyrArg: 1.492 ± 0.057
1.448TyrSer: 1.448 ± 0.059
1.361TyrThr: 1.361 ± 0.059
1.537TyrVal: 1.537 ± 0.063
0.353TyrTrp: 0.353 ± 0.03
0.662TyrTyr: 0.662 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1568 proteins (413677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski