Amino acid dipepetide frequency for Limimonas halophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.101AlaAla: 19.101 ± 0.243
1.186AlaCys: 1.186 ± 0.039
8.606AlaAsp: 8.606 ± 0.123
9.118AlaGlu: 9.118 ± 0.122
4.13AlaPhe: 4.13 ± 0.081
12.473AlaGly: 12.473 ± 0.158
2.838AlaHis: 2.838 ± 0.059
4.905AlaIle: 4.905 ± 0.068
3.01AlaLys: 3.01 ± 0.079
13.369AlaLeu: 13.369 ± 0.18
3.292AlaMet: 3.292 ± 0.068
3.047AlaAsn: 3.047 ± 0.067
6.074AlaPro: 6.074 ± 0.107
4.07AlaGln: 4.07 ± 0.065
10.723AlaArg: 10.723 ± 0.159
5.573AlaSer: 5.573 ± 0.099
6.239AlaThr: 6.239 ± 0.1
10.656AlaVal: 10.656 ± 0.136
1.822AlaTrp: 1.822 ± 0.048
2.642AlaTyr: 2.642 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.97CysAla: 0.97 ± 0.033
0.102CysCys: 0.102 ± 0.012
0.492CysAsp: 0.492 ± 0.024
0.456CysGlu: 0.456 ± 0.021
0.273CysPhe: 0.273 ± 0.019
0.884CysGly: 0.884 ± 0.033
0.245CysHis: 0.245 ± 0.017
0.301CysIle: 0.301 ± 0.018
0.182CysLys: 0.182 ± 0.015
0.652CysLeu: 0.652 ± 0.027
0.144CysMet: 0.144 ± 0.013
0.179CysAsn: 0.179 ± 0.013
0.479CysPro: 0.479 ± 0.023
0.2CysGln: 0.2 ± 0.015
0.649CysArg: 0.649 ± 0.029
0.379CysSer: 0.379 ± 0.022
0.474CysThr: 0.474 ± 0.025
0.6CysVal: 0.6 ± 0.026
0.1CysTrp: 0.1 ± 0.01
0.197CysTyr: 0.197 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.867AspAla: 8.867 ± 0.144
0.398AspCys: 0.398 ± 0.023
3.838AspAsp: 3.838 ± 0.09
3.846AspGlu: 3.846 ± 0.083
1.783AspPhe: 1.783 ± 0.053
6.412AspGly: 6.412 ± 0.137
1.466AspHis: 1.466 ± 0.043
2.528AspIle: 2.528 ± 0.059
1.442AspLys: 1.442 ± 0.043
5.802AspLeu: 5.802 ± 0.098
1.076AspMet: 1.076 ± 0.036
1.24AspAsn: 1.24 ± 0.037
4.027AspPro: 4.027 ± 0.076
1.835AspGln: 1.835 ± 0.041
5.003AspArg: 5.003 ± 0.08
2.699AspSer: 2.699 ± 0.059
3.655AspThr: 3.655 ± 0.071
4.667AspVal: 4.667 ± 0.068
0.879AspTrp: 0.879 ± 0.037
1.144AspTyr: 1.144 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.105GluAla: 8.105 ± 0.113
0.282GluCys: 0.282 ± 0.018
2.969GluAsp: 2.969 ± 0.072
3.283GluGlu: 3.283 ± 0.082
1.21GluPhe: 1.21 ± 0.043
4.55GluGly: 4.55 ± 0.076
1.608GluHis: 1.608 ± 0.049
3.005GluIle: 3.005 ± 0.066
1.798GluLys: 1.798 ± 0.058
6.352GluLeu: 6.352 ± 0.102
1.595GluMet: 1.595 ± 0.045
1.604GluAsn: 1.604 ± 0.047
3.502GluPro: 3.502 ± 0.074
2.659GluGln: 2.659 ± 0.067
6.559GluArg: 6.559 ± 0.097
2.786GluSer: 2.786 ± 0.057
4.288GluThr: 4.288 ± 0.076
4.583GluVal: 4.583 ± 0.068
0.539GluTrp: 0.539 ± 0.024
0.799GluTyr: 0.799 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.953PheAla: 3.953 ± 0.079
0.344PheCys: 0.344 ± 0.022
2.363PheAsp: 2.363 ± 0.062
1.852PheGlu: 1.852 ± 0.051
1.093PhePhe: 1.093 ± 0.04
2.915PheGly: 2.915 ± 0.061
0.717PheHis: 0.717 ± 0.029
1.086PheIle: 1.086 ± 0.042
0.733PheLys: 0.733 ± 0.03
2.776PheLeu: 2.776 ± 0.065
0.615PheMet: 0.615 ± 0.026
0.861PheAsn: 0.861 ± 0.033
1.36PhePro: 1.36 ± 0.04
1.019PheGln: 1.019 ± 0.033
1.998PheArg: 1.998 ± 0.054
1.508PheSer: 1.508 ± 0.046
1.993PheThr: 1.993 ± 0.048
2.425PheVal: 2.425 ± 0.057
0.43PheTrp: 0.43 ± 0.021
0.759PheTyr: 0.759 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.945GlyAla: 9.945 ± 0.143
0.82GlyCys: 0.82 ± 0.032
5.238GlyAsp: 5.238 ± 0.115
6.494GlyGlu: 6.494 ± 0.094
3.182GlyPhe: 3.182 ± 0.066
8.574GlyGly: 8.574 ± 0.136
2.183GlyHis: 2.183 ± 0.047
3.772GlyIle: 3.772 ± 0.066
2.478GlyLys: 2.478 ± 0.053
8.518GlyLeu: 8.518 ± 0.11
2.579GlyMet: 2.579 ± 0.058
2.106GlyAsn: 2.106 ± 0.065
3.794GlyPro: 3.794 ± 0.069
2.969GlyGln: 2.969 ± 0.066
6.694GlyArg: 6.694 ± 0.103
4.111GlySer: 4.111 ± 0.085
5.329GlyThr: 5.329 ± 0.088
6.926GlyVal: 6.926 ± 0.1
1.323GlyTrp: 1.323 ± 0.047
2.269GlyTyr: 2.269 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
3.155HisAla: 3.155 ± 0.062
0.24HisCys: 0.24 ± 0.016
1.412HisAsp: 1.412 ± 0.038
1.393HisGlu: 1.393 ± 0.04
0.716HisPhe: 0.716 ± 0.031
2.417HisGly: 2.417 ± 0.058
0.653HisHis: 0.653 ± 0.031
0.873HisIle: 0.873 ± 0.032
0.483HisLys: 0.483 ± 0.025
2.366HisLeu: 2.366 ± 0.048
0.444HisMet: 0.444 ± 0.021
0.527HisAsn: 0.527 ± 0.026
1.527HisPro: 1.527 ± 0.04
0.652HisGln: 0.652 ± 0.026
1.788HisArg: 1.788 ± 0.052
0.844HisSer: 0.844 ± 0.03
1.263HisThr: 1.263 ± 0.042
1.855HisVal: 1.855 ± 0.048
0.35HisTrp: 0.35 ± 0.021
0.549HisTyr: 0.549 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.675IleAla: 5.675 ± 0.088
0.372IleCys: 0.372 ± 0.022
2.793IleAsp: 2.793 ± 0.059
2.743IleGlu: 2.743 ± 0.064
1.279IlePhe: 1.279 ± 0.045
3.671IleGly: 3.671 ± 0.074
0.922IleHis: 0.922 ± 0.032
1.212IleIle: 1.212 ± 0.042
0.963IleLys: 0.963 ± 0.038
3.245IleLeu: 3.245 ± 0.07
0.717IleMet: 0.717 ± 0.029
1.075IleAsn: 1.075 ± 0.038
2.055IlePro: 2.055 ± 0.047
1.309IleGln: 1.309 ± 0.046
2.746IleArg: 2.746 ± 0.051
1.966IleSer: 1.966 ± 0.052
2.236IleThr: 2.236 ± 0.056
3.309IleVal: 3.309 ± 0.061
0.435IleTrp: 0.435 ± 0.021
0.916IleTyr: 0.916 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.128LysAla: 3.128 ± 0.069
0.123LysCys: 0.123 ± 0.012
1.311LysAsp: 1.311 ± 0.044
1.162LysGlu: 1.162 ± 0.047
0.581LysPhe: 0.581 ± 0.026
1.949LysGly: 1.949 ± 0.053
0.6LysHis: 0.6 ± 0.026
1.059LysIle: 1.059 ± 0.039
0.981LysLys: 0.981 ± 0.041
2.766LysLeu: 2.766 ± 0.056
0.522LysMet: 0.522 ± 0.024
0.615LysAsn: 0.615 ± 0.029
1.499LysPro: 1.499 ± 0.046
1.184LysGln: 1.184 ± 0.038
2.3LysArg: 2.3 ± 0.054
1.17LysSer: 1.17 ± 0.038
1.486LysThr: 1.486 ± 0.038
1.743LysVal: 1.743 ± 0.049
0.211LysTrp: 0.211 ± 0.015
0.505LysTyr: 0.505 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
14.408LeuAla: 14.408 ± 0.182
0.742LeuCys: 0.742 ± 0.031
7.122LeuAsp: 7.122 ± 0.091
5.283LeuGlu: 5.283 ± 0.093
2.727LeuPhe: 2.727 ± 0.066
8.315LeuGly: 8.315 ± 0.106
2.199LeuHis: 2.199 ± 0.058
3.706LeuIle: 3.706 ± 0.067
2.546LeuLys: 2.546 ± 0.058
8.427LeuLeu: 8.427 ± 0.137
2.024LeuMet: 2.024 ± 0.052
2.533LeuAsn: 2.533 ± 0.063
5.205LeuPro: 5.205 ± 0.085
2.868LeuGln: 2.868 ± 0.056
7.821LeuArg: 7.821 ± 0.102
5.047LeuSer: 5.047 ± 0.081
5.971LeuThr: 5.971 ± 0.101
7.353LeuVal: 7.353 ± 0.102
1.067LeuTrp: 1.067 ± 0.041
1.824LeuTyr: 1.824 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
3.252MetAla: 3.252 ± 0.071
0.129MetCys: 0.129 ± 0.013
1.171MetAsp: 1.171 ± 0.036
1.019MetGlu: 1.019 ± 0.039
0.527MetPhe: 0.527 ± 0.024
1.752MetGly: 1.752 ± 0.052
0.481MetHis: 0.481 ± 0.025
0.84MetIle: 0.84 ± 0.032
0.708MetLys: 0.708 ± 0.029
2.138MetLeu: 2.138 ± 0.053
0.547MetMet: 0.547 ± 0.037
0.556MetAsn: 0.556 ± 0.027
1.444MetPro: 1.444 ± 0.042
0.836MetGln: 0.836 ± 0.027
1.893MetArg: 1.893 ± 0.049
1.358MetSer: 1.358 ± 0.03
1.799MetThr: 1.799 ± 0.044
1.52MetVal: 1.52 ± 0.041
0.18MetTrp: 0.18 ± 0.013
0.315MetTyr: 0.315 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.341AsnAla: 3.341 ± 0.068
0.202AsnCys: 0.202 ± 0.016
1.306AsnAsp: 1.306 ± 0.044
1.231AsnGlu: 1.231 ± 0.043
0.733AsnPhe: 0.733 ± 0.031
2.269AsnGly: 2.269 ± 0.059
0.517AsnHis: 0.517 ± 0.022
1.016AsnIle: 1.016 ± 0.045
0.611AsnLys: 0.611 ± 0.028
2.408AsnLeu: 2.408 ± 0.056
0.502AsnMet: 0.502 ± 0.027
0.668AsnAsn: 0.668 ± 0.037
1.608AsnPro: 1.608 ± 0.049
0.863AsnGln: 0.863 ± 0.035
1.855AsnArg: 1.855 ± 0.041
0.889AsnSer: 0.889 ± 0.036
1.333AsnThr: 1.333 ± 0.05
1.968AsnVal: 1.968 ± 0.061
0.265AsnTrp: 0.265 ± 0.019
0.488AsnTyr: 0.488 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.143ProAla: 7.143 ± 0.125
0.352ProCys: 0.352 ± 0.022
4.462ProAsp: 4.462 ± 0.075
4.312ProGlu: 4.312 ± 0.08
1.69ProPhe: 1.69 ± 0.043
5.079ProGly: 5.079 ± 0.079
1.201ProHis: 1.201 ± 0.033
1.774ProIle: 1.774 ± 0.044
1.249ProLys: 1.249 ± 0.042
4.468ProLeu: 4.468 ± 0.075
1.069ProMet: 1.069 ± 0.035
1.233ProAsn: 1.233 ± 0.038
2.806ProPro: 2.806 ± 0.071
1.589ProGln: 1.589 ± 0.043
3.481ProArg: 3.481 ± 0.059
2.297ProSer: 2.297 ± 0.056
2.611ProThr: 2.611 ± 0.057
4.529ProVal: 4.529 ± 0.076
0.743ProTrp: 0.743 ± 0.031
1.194ProTyr: 1.194 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.633GlnAla: 4.633 ± 0.08
0.201GlnCys: 0.201 ± 0.016
1.783GlnAsp: 1.783 ± 0.05
1.816GlnGlu: 1.816 ± 0.055
0.891GlnPhe: 0.891 ± 0.034
2.758GlnGly: 2.758 ± 0.065
0.922GlnHis: 0.922 ± 0.032
1.345GlnIle: 1.345 ± 0.042
0.829GlnLys: 0.829 ± 0.031
3.172GlnLeu: 3.172 ± 0.064
0.793GlnMet: 0.793 ± 0.028
0.767GlnAsn: 0.767 ± 0.034
2.141GlnPro: 2.141 ± 0.047
1.702GlnGln: 1.702 ± 0.061
3.295GlnArg: 3.295 ± 0.067
1.407GlnSer: 1.407 ± 0.046
1.971GlnThr: 1.971 ± 0.054
2.521GlnVal: 2.521 ± 0.051
0.37GlnTrp: 0.37 ± 0.021
0.617GlnTyr: 0.617 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
10.221ArgAla: 10.221 ± 0.127
0.607ArgCys: 0.607 ± 0.029
5.022ArgAsp: 5.022 ± 0.084
5.808ArgGlu: 5.808 ± 0.1
2.763ArgPhe: 2.763 ± 0.059
5.653ArgGly: 5.653 ± 0.086
2.071ArgHis: 2.071 ± 0.045
3.555ArgIle: 3.555 ± 0.057
1.993ArgLys: 1.993 ± 0.049
8.616ArgLeu: 8.616 ± 0.123
1.989ArgMet: 1.989 ± 0.043
1.734ArgAsn: 1.734 ± 0.046
3.772ArgPro: 3.772 ± 0.071
2.995ArgGln: 2.995 ± 0.063
7.072ArgArg: 7.072 ± 0.1
3.181ArgSer: 3.181 ± 0.061
4.19ArgThr: 4.19 ± 0.078
6.579ArgVal: 6.579 ± 0.088
1.06ArgTrp: 1.06 ± 0.036
1.758ArgTyr: 1.758 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.628SerAla: 5.628 ± 0.09
0.338SerCys: 0.338 ± 0.019
2.621SerAsp: 2.621 ± 0.063
2.746SerGlu: 2.746 ± 0.061
1.728SerPhe: 1.728 ± 0.049
4.959SerGly: 4.959 ± 0.093
0.949SerHis: 0.949 ± 0.029
1.789SerIle: 1.789 ± 0.05
1.09SerLys: 1.09 ± 0.039
4.263SerLeu: 4.263 ± 0.073
1.089SerMet: 1.089 ± 0.036
1.139SerAsn: 1.139 ± 0.046
2.346SerPro: 2.346 ± 0.054
1.681SerGln: 1.681 ± 0.051
3.271SerArg: 3.271 ± 0.071
2.121SerSer: 2.121 ± 0.062
2.361SerThr: 2.361 ± 0.056
3.612SerVal: 3.612 ± 0.065
0.597SerTrp: 0.597 ± 0.028
1.056SerTyr: 1.056 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
7.401ThrAla: 7.401 ± 0.103
0.451ThrCys: 0.451 ± 0.025
3.252ThrAsp: 3.252 ± 0.062
3.055ThrGlu: 3.055 ± 0.06
1.917ThrPhe: 1.917 ± 0.052
5.884ThrGly: 5.884 ± 0.094
1.18ThrHis: 1.18 ± 0.044
2.432ThrIle: 2.432 ± 0.054
1.092ThrLys: 1.092 ± 0.038
6.097ThrLeu: 6.097 ± 0.091
1.042ThrMet: 1.042 ± 0.033
1.369ThrAsn: 1.369 ± 0.045
3.617ThrPro: 3.617 ± 0.061
1.741ThrGln: 1.741 ± 0.048
4.02ThrArg: 4.02 ± 0.073
2.494ThrSer: 2.494 ± 0.06
3.071ThrThr: 3.071 ± 0.073
5.196ThrVal: 5.196 ± 0.09
0.731ThrTrp: 0.731 ± 0.024
1.231ThrTyr: 1.231 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
10.183ValAla: 10.183 ± 0.113
0.75ValCys: 0.75 ± 0.029
4.812ValAsp: 4.812 ± 0.075
4.804ValGlu: 4.804 ± 0.079
2.519ValPhe: 2.519 ± 0.058
5.966ValGly: 5.966 ± 0.087
1.86ValHis: 1.86 ± 0.05
3.198ValIle: 3.198 ± 0.073
1.816ValLys: 1.816 ± 0.048
7.927ValLeu: 7.927 ± 0.115
1.727ValMet: 1.727 ± 0.051
2.012ValAsn: 2.012 ± 0.053
4.248ValPro: 4.248 ± 0.069
2.586ValGln: 2.586 ± 0.055
6.416ValArg: 6.416 ± 0.092
4.051ValSer: 4.051 ± 0.069
5.022ValThr: 5.022 ± 0.09
6.494ValVal: 6.494 ± 0.102
0.899ValTrp: 0.899 ± 0.033
1.618ValTyr: 1.618 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.306TrpAla: 1.306 ± 0.045
0.113TrpCys: 0.113 ± 0.013
0.681TrpAsp: 0.681 ± 0.03
0.517TrpGlu: 0.517 ± 0.025
0.425TrpPhe: 0.425 ± 0.024
0.877TrpGly: 0.877 ± 0.033
0.347TrpHis: 0.347 ± 0.02
0.457TrpIle: 0.457 ± 0.026
0.336TrpLys: 0.336 ± 0.021
1.702TrpLeu: 1.702 ± 0.055
0.293TrpMet: 0.293 ± 0.017
0.284TrpAsn: 0.284 ± 0.02
0.77TrpPro: 0.77 ± 0.036
0.497TrpGln: 0.497 ± 0.024
1.263TrpArg: 1.263 ± 0.038
0.611TrpSer: 0.611 ± 0.028
0.721TrpThr: 0.721 ± 0.034
0.833TrpVal: 0.833 ± 0.034
0.212TrpTrp: 0.212 ± 0.016
0.268TrpTyr: 0.268 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.456TyrAla: 2.456 ± 0.062
0.206TyrCys: 0.206 ± 0.014
1.353TyrAsp: 1.353 ± 0.044
1.138TyrGlu: 1.138 ± 0.037
0.634TyrPhe: 0.634 ± 0.03
1.949TyrGly: 1.949 ± 0.056
0.551TyrHis: 0.551 ± 0.024
0.786TyrIle: 0.786 ± 0.032
0.555TyrLys: 0.555 ± 0.029
2.12TyrLeu: 2.12 ± 0.048
0.403TyrMet: 0.403 ± 0.021
0.525TyrAsn: 0.525 ± 0.026
1.007TyrPro: 1.007 ± 0.031
0.68TyrGln: 0.68 ± 0.029
1.791TyrArg: 1.791 ± 0.049
0.891TyrSer: 0.891 ± 0.038
1.26TyrThr: 1.26 ± 0.037
1.542TyrVal: 1.542 ± 0.043
0.301TyrTrp: 0.301 ± 0.02
0.52TyrTyr: 0.52 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2820 proteins (886467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski