Amino acid dipepetide frequency for Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.03AlaAla: 10.03 ± 0.158
1.083AlaCys: 1.083 ± 0.04
5.076AlaAsp: 5.076 ± 0.084
5.815AlaGlu: 5.815 ± 0.103
3.329AlaPhe: 3.329 ± 0.072
8.035AlaGly: 8.035 ± 0.122
2.144AlaHis: 2.144 ± 0.056
5.845AlaIle: 5.845 ± 0.095
3.118AlaLys: 3.118 ± 0.083
10.239AlaLeu: 10.239 ± 0.132
2.393AlaMet: 2.393 ± 0.06
2.861AlaAsn: 2.861 ± 0.063
3.098AlaPro: 3.098 ± 0.071
3.743AlaGln: 3.743 ± 0.076
6.291AlaArg: 6.291 ± 0.106
5.11AlaSer: 5.11 ± 0.101
4.506AlaThr: 4.506 ± 0.106
6.56AlaVal: 6.56 ± 0.099
1.222AlaTrp: 1.222 ± 0.044
2.307AlaTyr: 2.307 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.832CysAla: 0.832 ± 0.036
0.121CysCys: 0.121 ± 0.014
0.511CysAsp: 0.511 ± 0.025
0.496CysGlu: 0.496 ± 0.026
0.417CysPhe: 0.417 ± 0.022
0.847CysGly: 0.847 ± 0.038
0.386CysHis: 0.386 ± 0.025
0.526CysIle: 0.526 ± 0.026
0.348CysLys: 0.348 ± 0.022
0.946CysLeu: 0.946 ± 0.034
0.206CysMet: 0.206 ± 0.017
0.321CysAsn: 0.321 ± 0.021
0.467CysPro: 0.467 ± 0.026
0.364CysGln: 0.364 ± 0.025
0.666CysArg: 0.666 ± 0.028
0.58CysSer: 0.58 ± 0.028
0.521CysThr: 0.521 ± 0.026
0.634CysVal: 0.634 ± 0.031
0.14CysTrp: 0.14 ± 0.014
0.261CysTyr: 0.261 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
4.541AspAla: 4.541 ± 0.076
0.536AspCys: 0.536 ± 0.027
2.756AspAsp: 2.756 ± 0.079
3.521AspGlu: 3.521 ± 0.077
2.406AspPhe: 2.406 ± 0.066
3.574AspGly: 3.574 ± 0.082
1.344AspHis: 1.344 ± 0.048
3.626AspIle: 3.626 ± 0.063
2.374AspLys: 2.374 ± 0.063
5.509AspLeu: 5.509 ± 0.085
1.231AspMet: 1.231 ± 0.038
1.844AspAsn: 1.844 ± 0.053
2.748AspPro: 2.748 ± 0.069
2.196AspGln: 2.196 ± 0.05
3.34AspArg: 3.34 ± 0.064
2.992AspSer: 2.992 ± 0.073
3.043AspThr: 3.043 ± 0.072
3.277AspVal: 3.277 ± 0.069
0.873AspTrp: 0.873 ± 0.036
1.814AspTyr: 1.814 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.595GluAla: 5.595 ± 0.096
0.427GluCys: 0.427 ± 0.02
2.612GluAsp: 2.612 ± 0.064
3.514GluGlu: 3.514 ± 0.085
2.158GluPhe: 2.158 ± 0.055
3.475GluGly: 3.475 ± 0.08
1.521GluHis: 1.521 ± 0.045
4.686GluIle: 4.686 ± 0.082
3.237GluLys: 3.237 ± 0.072
6.208GluLeu: 6.208 ± 0.093
1.58GluMet: 1.58 ± 0.043
2.527GluAsn: 2.527 ± 0.059
2.258GluPro: 2.258 ± 0.057
3.35GluGln: 3.35 ± 0.078
3.975GluArg: 3.975 ± 0.076
3.354GluSer: 3.354 ± 0.062
3.459GluThr: 3.459 ± 0.075
3.763GluVal: 3.763 ± 0.079
0.819GluTrp: 0.819 ± 0.033
1.525GluTyr: 1.525 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.338PheAla: 3.338 ± 0.07
0.471PheCys: 0.471 ± 0.028
2.63PheAsp: 2.63 ± 0.051
2.121PheGlu: 2.121 ± 0.049
1.766PhePhe: 1.766 ± 0.054
2.889PheGly: 2.889 ± 0.077
0.935PheHis: 0.935 ± 0.036
2.432PheIle: 2.432 ± 0.052
1.262PheLys: 1.262 ± 0.048
3.745PheLeu: 3.745 ± 0.089
0.95PheMet: 0.95 ± 0.036
1.593PheAsn: 1.593 ± 0.049
1.74PhePro: 1.74 ± 0.047
1.348PheGln: 1.348 ± 0.037
2.229PheArg: 2.229 ± 0.057
3.103PheSer: 3.103 ± 0.065
2.333PheThr: 2.333 ± 0.052
2.565PheVal: 2.565 ± 0.059
0.549PheTrp: 0.549 ± 0.031
1.283PheTyr: 1.283 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.383GlyAla: 5.383 ± 0.098
0.808GlyCys: 0.808 ± 0.036
3.45GlyAsp: 3.45 ± 0.068
4.398GlyGlu: 4.398 ± 0.073
3.131GlyPhe: 3.131 ± 0.067
5.068GlyGly: 5.068 ± 0.106
1.766GlyHis: 1.766 ± 0.046
5.27GlyIle: 5.27 ± 0.089
4.125GlyLys: 4.125 ± 0.082
7.389GlyLeu: 7.389 ± 0.104
2.221GlyMet: 2.221 ± 0.065
2.843GlyAsn: 2.843 ± 0.073
1.965GlyPro: 1.965 ± 0.048
2.848GlyGln: 2.848 ± 0.064
4.292GlyArg: 4.292 ± 0.083
4.542GlySer: 4.542 ± 0.087
3.947GlyThr: 3.947 ± 0.093
4.983GlyVal: 4.983 ± 0.092
1.126GlyTrp: 1.126 ± 0.042
2.499GlyTyr: 2.499 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.334HisAla: 2.334 ± 0.062
0.32HisCys: 0.32 ± 0.022
1.326HisAsp: 1.326 ± 0.043
1.355HisGlu: 1.355 ± 0.04
1.052HisPhe: 1.052 ± 0.038
1.874HisGly: 1.874 ± 0.05
0.856HisHis: 0.856 ± 0.033
1.488HisIle: 1.488 ± 0.041
0.874HisLys: 0.874 ± 0.033
2.499HisLeu: 2.499 ± 0.058
0.482HisMet: 0.482 ± 0.021
0.817HisAsn: 0.817 ± 0.031
1.634HisPro: 1.634 ± 0.046
1.025HisGln: 1.025 ± 0.037
1.521HisArg: 1.521 ± 0.048
1.438HisSer: 1.438 ± 0.039
1.404HisThr: 1.404 ± 0.047
1.395HisVal: 1.395 ± 0.037
0.364HisTrp: 0.364 ± 0.02
0.886HisTyr: 0.886 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.306IleAla: 6.306 ± 0.095
0.603IleCys: 0.603 ± 0.026
4.015IleAsp: 4.015 ± 0.062
4.34IleGlu: 4.34 ± 0.078
2.302IlePhe: 2.302 ± 0.053
4.677IleGly: 4.677 ± 0.087
1.472IleHis: 1.472 ± 0.049
3.77IleIle: 3.77 ± 0.095
2.463IleLys: 2.463 ± 0.068
6.111IleLeu: 6.111 ± 0.109
1.34IleMet: 1.34 ± 0.042
2.375IleAsn: 2.375 ± 0.063
3.403IlePro: 3.403 ± 0.064
2.293IleGln: 2.293 ± 0.052
4.31IleArg: 4.31 ± 0.066
4.215IleSer: 4.215 ± 0.074
3.748IleThr: 3.748 ± 0.073
4.114IleVal: 4.114 ± 0.084
0.678IleTrp: 0.678 ± 0.032
1.634IleTyr: 1.634 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
3.467LysAla: 3.467 ± 0.075
0.258LysCys: 0.258 ± 0.016
1.865LysAsp: 1.865 ± 0.056
2.184LysGlu: 2.184 ± 0.058
1.319LysPhe: 1.319 ± 0.047
2.441LysGly: 2.441 ± 0.064
0.953LysHis: 0.953 ± 0.032
2.902LysIle: 2.902 ± 0.064
2.025LysLys: 2.025 ± 0.074
4.485LysLeu: 4.485 ± 0.083
1.062LysMet: 1.062 ± 0.039
1.708LysAsn: 1.708 ± 0.047
2.072LysPro: 2.072 ± 0.052
2.05LysGln: 2.05 ± 0.06
2.745LysArg: 2.745 ± 0.059
2.379LysSer: 2.379 ± 0.061
2.517LysThr: 2.517 ± 0.053
2.581LysVal: 2.581 ± 0.063
0.527LysTrp: 0.527 ± 0.025
1.053LysTyr: 1.053 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
11.009LeuAla: 11.009 ± 0.151
0.957LeuCys: 0.957 ± 0.038
5.864LeuAsp: 5.864 ± 0.097
6.16LeuGlu: 6.16 ± 0.1
4.011LeuPhe: 4.011 ± 0.084
7.112LeuGly: 7.112 ± 0.116
2.495LeuHis: 2.495 ± 0.054
6.427LeuIle: 6.427 ± 0.109
4.426LeuLys: 4.426 ± 0.083
11.788LeuLeu: 11.788 ± 0.18
2.357LeuMet: 2.357 ± 0.056
3.757LeuAsn: 3.757 ± 0.081
5.855LeuPro: 5.855 ± 0.105
4.577LeuGln: 4.577 ± 0.084
6.623LeuArg: 6.623 ± 0.105
7.035LeuSer: 7.035 ± 0.098
6.12LeuThr: 6.12 ± 0.088
6.63LeuVal: 6.63 ± 0.094
1.211LeuTrp: 1.211 ± 0.044
2.646LeuTyr: 2.646 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.394MetAla: 2.394 ± 0.058
0.193MetCys: 0.193 ± 0.015
1.205MetAsp: 1.205 ± 0.037
1.384MetGlu: 1.384 ± 0.041
0.772MetPhe: 0.772 ± 0.032
1.551MetGly: 1.551 ± 0.053
0.57MetHis: 0.57 ± 0.028
1.505MetIle: 1.505 ± 0.046
1.22MetLys: 1.22 ± 0.041
2.776MetLeu: 2.776 ± 0.063
0.608MetMet: 0.608 ± 0.026
1.081MetAsn: 1.081 ± 0.039
1.249MetPro: 1.249 ± 0.04
1.2MetGln: 1.2 ± 0.042
1.551MetArg: 1.551 ± 0.05
1.425MetSer: 1.425 ± 0.045
1.555MetThr: 1.555 ± 0.05
1.622MetVal: 1.622 ± 0.049
0.181MetTrp: 0.181 ± 0.016
0.402MetTyr: 0.402 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.003AsnAla: 3.003 ± 0.07
0.291AsnCys: 0.291 ± 0.021
1.766AsnAsp: 1.766 ± 0.063
1.892AsnGlu: 1.892 ± 0.054
1.476AsnPhe: 1.476 ± 0.042
2.645AsnGly: 2.645 ± 0.076
0.958AsnHis: 0.958 ± 0.037
2.268AsnIle: 2.268 ± 0.05
1.386AsnLys: 1.386 ± 0.048
3.904AsnLeu: 3.904 ± 0.072
0.832AsnMet: 0.832 ± 0.033
1.262AsnAsn: 1.262 ± 0.053
2.203AsnPro: 2.203 ± 0.057
1.547AsnGln: 1.547 ± 0.044
2.412AsnArg: 2.412 ± 0.06
1.901AsnSer: 1.901 ± 0.058
2.025AsnThr: 2.025 ± 0.067
2.301AsnVal: 2.301 ± 0.072
0.527AsnTrp: 0.527 ± 0.027
1.002AsnTyr: 1.002 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.746ProAla: 4.746 ± 0.095
0.365ProCys: 0.365 ± 0.02
3.445ProAsp: 3.445 ± 0.072
3.631ProGlu: 3.631 ± 0.074
1.832ProPhe: 1.832 ± 0.051
4.007ProGly: 4.007 ± 0.08
1.052ProHis: 1.052 ± 0.044
2.265ProIle: 2.265 ± 0.057
1.409ProLys: 1.409 ± 0.046
4.479ProLeu: 4.479 ± 0.076
1.012ProMet: 1.012 ± 0.033
1.395ProAsn: 1.395 ± 0.038
2.009ProPro: 2.009 ± 0.058
1.732ProGln: 1.732 ± 0.052
2.199ProArg: 2.199 ± 0.062
2.289ProSer: 2.289 ± 0.056
1.848ProThr: 1.848 ± 0.059
4.286ProVal: 4.286 ± 0.099
0.63ProTrp: 0.63 ± 0.031
1.301ProTyr: 1.301 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.548GlnAla: 4.548 ± 0.089
0.363GlnCys: 0.363 ± 0.02
1.939GlnAsp: 1.939 ± 0.06
2.468GlnGlu: 2.468 ± 0.07
1.541GlnPhe: 1.541 ± 0.045
2.688GlnGly: 2.688 ± 0.062
1.215GlnHis: 1.215 ± 0.047
2.861GlnIle: 2.861 ± 0.063
1.796GlnLys: 1.796 ± 0.048
4.499GlnLeu: 4.499 ± 0.096
0.975GlnMet: 0.975 ± 0.037
1.492GlnAsn: 1.492 ± 0.041
2.185GlnPro: 2.185 ± 0.054
2.545GlnGln: 2.545 ± 0.068
2.715GlnArg: 2.715 ± 0.064
2.509GlnSer: 2.509 ± 0.046
2.195GlnThr: 2.195 ± 0.058
2.829GlnVal: 2.829 ± 0.071
0.607GlnTrp: 0.607 ± 0.026
1.105GlnTyr: 1.105 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
5.043ArgAla: 5.043 ± 0.083
0.557ArgCys: 0.557 ± 0.027
3.184ArgAsp: 3.184 ± 0.07
4.183ArgGlu: 4.183 ± 0.072
2.855ArgPhe: 2.855 ± 0.068
3.611ArgGly: 3.611 ± 0.065
1.796ArgHis: 1.796 ± 0.056
4.618ArgIle: 4.618 ± 0.076
2.916ArgLys: 2.916 ± 0.06
7.236ArgLeu: 7.236 ± 0.094
1.75ArgMet: 1.75 ± 0.049
2.625ArgAsn: 2.625 ± 0.062
2.461ArgPro: 2.461 ± 0.053
3.266ArgGln: 3.266 ± 0.065
3.808ArgArg: 3.808 ± 0.076
3.472ArgSer: 3.472 ± 0.063
3.166ArgThr: 3.166 ± 0.066
3.899ArgVal: 3.899 ± 0.083
0.871ArgTrp: 0.871 ± 0.034
2.32ArgTyr: 2.32 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.418SerAla: 5.418 ± 0.082
0.593SerCys: 0.593 ± 0.027
3.113SerAsp: 3.113 ± 0.064
3.31SerGlu: 3.31 ± 0.065
2.383SerPhe: 2.383 ± 0.056
5.653SerGly: 5.653 ± 0.096
1.461SerHis: 1.461 ± 0.043
3.723SerIle: 3.723 ± 0.069
2.063SerLys: 2.063 ± 0.057
6.391SerLeu: 6.391 ± 0.099
1.611SerMet: 1.611 ± 0.048
1.943SerAsn: 1.943 ± 0.052
2.635SerPro: 2.635 ± 0.063
2.257SerGln: 2.257 ± 0.058
3.938SerArg: 3.938 ± 0.077
3.904SerSer: 3.904 ± 0.076
3.116SerThr: 3.116 ± 0.082
4.128SerVal: 4.128 ± 0.086
0.787SerTrp: 0.787 ± 0.034
1.703SerTyr: 1.703 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
5.194ThrAla: 5.194 ± 0.098
0.511ThrCys: 0.511 ± 0.025
3.061ThrAsp: 3.061 ± 0.081
2.994ThrGlu: 2.994 ± 0.065
2.032ThrPhe: 2.032 ± 0.061
5.023ThrGly: 5.023 ± 0.076
1.363ThrHis: 1.363 ± 0.043
3.165ThrIle: 3.165 ± 0.068
1.469ThrLys: 1.469 ± 0.048
6.435ThrLeu: 6.435 ± 0.102
1.08ThrMet: 1.08 ± 0.036
1.494ThrAsn: 1.494 ± 0.046
3.001ThrPro: 3.001 ± 0.081
1.969ThrGln: 1.969 ± 0.057
3.675ThrArg: 3.675 ± 0.065
3.111ThrSer: 3.111 ± 0.067
2.848ThrThr: 2.848 ± 0.085
4.178ThrVal: 4.178 ± 0.118
0.652ThrTrp: 0.652 ± 0.032
1.353ThrTyr: 1.353 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.278ValAla: 6.278 ± 0.099
0.661ValCys: 0.661 ± 0.029
3.597ValAsp: 3.597 ± 0.065
4.218ValGlu: 4.218 ± 0.083
2.645ValPhe: 2.645 ± 0.054
3.962ValGly: 3.962 ± 0.074
1.462ValHis: 1.462 ± 0.046
4.613ValIle: 4.613 ± 0.094
2.591ValLys: 2.591 ± 0.065
7.266ValLeu: 7.266 ± 0.107
1.856ValMet: 1.856 ± 0.056
2.343ValAsn: 2.343 ± 0.081
3.014ValPro: 3.014 ± 0.066
2.382ValGln: 2.382 ± 0.061
4.178ValArg: 4.178 ± 0.077
4.391ValSer: 4.391 ± 0.082
4.259ValThr: 4.259 ± 0.127
4.871ValVal: 4.871 ± 0.101
0.773ValTrp: 0.773 ± 0.03
1.777ValTyr: 1.777 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.851TrpAla: 0.851 ± 0.036
0.153TrpCys: 0.153 ± 0.014
0.562TrpAsp: 0.562 ± 0.027
0.664TrpGlu: 0.664 ± 0.027
0.561TrpPhe: 0.561 ± 0.028
0.792TrpGly: 0.792 ± 0.033
0.405TrpHis: 0.405 ± 0.023
0.8TrpIle: 0.8 ± 0.035
0.545TrpLys: 0.545 ± 0.026
1.962TrpLeu: 1.962 ± 0.057
0.355TrpMet: 0.355 ± 0.02
0.485TrpAsn: 0.485 ± 0.029
0.548TrpPro: 0.548 ± 0.03
0.928TrpGln: 0.928 ± 0.039
0.962TrpArg: 0.962 ± 0.032
0.684TrpSer: 0.684 ± 0.03
0.535TrpThr: 0.535 ± 0.03
0.835TrpVal: 0.835 ± 0.035
0.24TrpTrp: 0.24 ± 0.021
0.363TrpTyr: 0.363 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.492TyrAla: 2.492 ± 0.05
0.321TyrCys: 0.321 ± 0.024
1.57TyrAsp: 1.57 ± 0.053
1.397TyrGlu: 1.397 ± 0.048
1.294TyrPhe: 1.294 ± 0.043
2.131TyrGly: 2.131 ± 0.054
0.791TyrHis: 0.791 ± 0.033
1.381TyrIle: 1.381 ± 0.042
0.944TyrLys: 0.944 ± 0.036
3.193TyrLeu: 3.193 ± 0.062
0.54TyrMet: 0.54 ± 0.029
0.833TyrAsn: 0.833 ± 0.039
1.391TyrPro: 1.391 ± 0.048
1.454TyrGln: 1.454 ± 0.049
2.208TyrArg: 2.208 ± 0.062
1.694TyrSer: 1.694 ± 0.052
1.462TyrThr: 1.462 ± 0.049
1.687TyrVal: 1.687 ± 0.048
0.451TyrTrp: 0.451 ± 0.023
0.898TyrTyr: 0.898 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2375 proteins (777646 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski