Amino acid dipepetide frequency for Clostridium phage slur17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.428AlaCys: 0.428 ± 0.184
3.251AlaAsp: 3.251 ± 0.507
4.706AlaGlu: 4.706 ± 0.486
2.396AlaPhe: 2.396 ± 0.52
4.363AlaGly: 4.363 ± 0.905
0.342AlaHis: 0.342 ± 0.217
6.331AlaIle: 6.331 ± 0.718
4.877AlaLys: 4.877 ± 0.76
4.791AlaLeu: 4.791 ± 1.012
2.396AlaMet: 2.396 ± 0.681
3.85AlaAsn: 3.85 ± 0.574
1.027AlaPro: 1.027 ± 0.288
1.882AlaGln: 1.882 ± 0.439
3.166AlaArg: 3.166 ± 0.637
3.166AlaSer: 3.166 ± 0.513
4.278AlaThr: 4.278 ± 0.53
3.251AlaVal: 3.251 ± 0.806
0.428AlaTrp: 0.428 ± 0.15
1.882AlaTyr: 1.882 ± 0.417
0.0AlaXaa: 0.0 ± 0.0
Cys
0.599CysAla: 0.599 ± 0.268
0.428CysCys: 0.428 ± 0.277
0.513CysAsp: 0.513 ± 0.198
1.198CysGlu: 1.198 ± 0.323
0.342CysPhe: 0.342 ± 0.166
0.684CysGly: 0.684 ± 0.237
0.086CysHis: 0.086 ± 0.086
0.428CysIle: 0.428 ± 0.195
0.77CysLys: 0.77 ± 0.235
1.027CysLeu: 1.027 ± 0.298
0.171CysMet: 0.171 ± 0.138
0.428CysAsn: 0.428 ± 0.184
0.257CysPro: 0.257 ± 0.156
0.257CysGln: 0.257 ± 0.159
0.086CysArg: 0.086 ± 0.096
1.112CysSer: 1.112 ± 0.365
0.257CysThr: 0.257 ± 0.145
0.342CysVal: 0.342 ± 0.147
0.086CysTrp: 0.086 ± 0.07
0.428CysTyr: 0.428 ± 0.185
0.0CysXaa: 0.0 ± 0.0
Asp
3.765AspAla: 3.765 ± 0.513
0.77AspCys: 0.77 ± 0.281
2.225AspAsp: 2.225 ± 0.38
3.936AspGlu: 3.936 ± 0.58
2.652AspPhe: 2.652 ± 0.551
3.679AspGly: 3.679 ± 0.657
0.257AspHis: 0.257 ± 0.169
7.101AspIle: 7.101 ± 0.973
5.305AspLys: 5.305 ± 0.73
5.647AspLeu: 5.647 ± 0.65
1.711AspMet: 1.711 ± 0.426
4.278AspAsn: 4.278 ± 0.583
0.941AspPro: 0.941 ± 0.305
0.599AspGln: 0.599 ± 0.172
2.053AspArg: 2.053 ± 0.343
4.278AspSer: 4.278 ± 0.581
2.225AspThr: 2.225 ± 0.403
3.422AspVal: 3.422 ± 0.452
0.342AspTrp: 0.342 ± 0.183
3.422AspTyr: 3.422 ± 0.585
0.0AspXaa: 0.0 ± 0.0
Glu
4.791GluAla: 4.791 ± 0.927
0.684GluCys: 0.684 ± 0.222
3.166GluAsp: 3.166 ± 0.54
8.299GluGlu: 8.299 ± 0.847
3.593GluPhe: 3.593 ± 0.607
4.962GluGly: 4.962 ± 0.686
0.77GluHis: 0.77 ± 0.299
7.7GluIle: 7.7 ± 1.118
9.069GluLys: 9.069 ± 0.94
8.812GluLeu: 8.812 ± 0.95
3.08GluMet: 3.08 ± 0.589
6.588GluAsn: 6.588 ± 0.844
0.428GluPro: 0.428 ± 0.208
3.337GluGln: 3.337 ± 0.493
3.08GluArg: 3.08 ± 0.618
4.962GluSer: 4.962 ± 0.784
5.39GluThr: 5.39 ± 0.658
4.449GluVal: 4.449 ± 0.722
0.941GluTrp: 0.941 ± 0.476
4.449GluTyr: 4.449 ± 0.738
0.0GluXaa: 0.0 ± 0.0
Phe
2.823PheAla: 2.823 ± 0.558
0.342PheCys: 0.342 ± 0.17
2.053PheAsp: 2.053 ± 0.383
2.823PheGlu: 2.823 ± 0.411
2.481PhePhe: 2.481 ± 0.868
2.481PheGly: 2.481 ± 0.867
0.257PheHis: 0.257 ± 0.166
3.08PheIle: 3.08 ± 0.463
4.192PheLys: 4.192 ± 0.592
2.481PheLeu: 2.481 ± 0.395
0.77PheMet: 0.77 ± 0.326
4.449PheAsn: 4.449 ± 0.635
0.599PhePro: 0.599 ± 0.221
0.599PheGln: 0.599 ± 0.262
2.225PheArg: 2.225 ± 0.364
3.593PheSer: 3.593 ± 0.509
2.652PheThr: 2.652 ± 0.29
2.31PheVal: 2.31 ± 0.567
0.086PheTrp: 0.086 ± 0.086
1.711PheTyr: 1.711 ± 0.488
0.0PheXaa: 0.0 ± 0.0
Gly
4.791GlyAla: 4.791 ± 0.65
0.171GlyCys: 0.171 ± 0.128
4.62GlyAsp: 4.62 ± 0.666
4.62GlyGlu: 4.62 ± 0.688
3.679GlyPhe: 3.679 ± 1.287
3.85GlyGly: 3.85 ± 0.848
0.599GlyHis: 0.599 ± 0.233
6.331GlyIle: 6.331 ± 0.899
5.476GlyLys: 5.476 ± 0.679
4.877GlyLeu: 4.877 ± 0.971
1.112GlyMet: 1.112 ± 0.241
3.337GlyAsn: 3.337 ± 0.664
0.086GlyPro: 0.086 ± 0.069
2.053GlyGln: 2.053 ± 0.566
1.626GlyArg: 1.626 ± 0.294
4.449GlySer: 4.449 ± 0.744
2.567GlyThr: 2.567 ± 0.527
3.251GlyVal: 3.251 ± 0.582
0.77GlyTrp: 0.77 ± 0.328
2.31GlyTyr: 2.31 ± 0.582
0.0GlyXaa: 0.0 ± 0.0
His
0.513HisAla: 0.513 ± 0.287
0.086HisCys: 0.086 ± 0.082
0.428HisAsp: 0.428 ± 0.228
0.941HisGlu: 0.941 ± 0.364
0.342HisPhe: 0.342 ± 0.163
0.599HisGly: 0.599 ± 0.204
0.086HisHis: 0.086 ± 0.086
0.342HisIle: 0.342 ± 0.19
1.027HisLys: 1.027 ± 0.335
0.599HisLeu: 0.599 ± 0.195
0.086HisMet: 0.086 ± 0.081
0.428HisAsn: 0.428 ± 0.211
0.086HisPro: 0.086 ± 0.083
0.428HisGln: 0.428 ± 0.197
0.171HisArg: 0.171 ± 0.113
1.112HisSer: 1.112 ± 0.27
0.684HisThr: 0.684 ± 0.427
0.599HisVal: 0.599 ± 0.225
0.257HisTrp: 0.257 ± 0.137
0.428HisTyr: 0.428 ± 0.212
0.0HisXaa: 0.0 ± 0.0
Ile
4.877IleAla: 4.877 ± 0.676
0.684IleCys: 0.684 ± 0.231
6.674IleAsp: 6.674 ± 0.649
9.754IleGlu: 9.754 ± 1.204
3.337IlePhe: 3.337 ± 0.593
5.305IleGly: 5.305 ± 1.477
1.112IleHis: 1.112 ± 0.303
5.647IleIle: 5.647 ± 0.66
10.096IleLys: 10.096 ± 1.024
5.989IleLeu: 5.989 ± 1.26
2.31IleMet: 2.31 ± 0.414
6.845IleAsn: 6.845 ± 0.887
2.139IlePro: 2.139 ± 0.409
3.166IleGln: 3.166 ± 0.563
3.593IleArg: 3.593 ± 0.631
5.561IleSer: 5.561 ± 0.835
3.508IleThr: 3.508 ± 0.493
4.62IleVal: 4.62 ± 0.495
0.77IleTrp: 0.77 ± 0.275
3.166IleTyr: 3.166 ± 0.504
0.0IleXaa: 0.0 ± 0.0
Lys
5.818LysAla: 5.818 ± 0.81
1.027LysCys: 1.027 ± 0.363
5.732LysAsp: 5.732 ± 0.742
11.721LysGlu: 11.721 ± 1.456
4.278LysPhe: 4.278 ± 0.541
5.048LysGly: 5.048 ± 0.876
0.599LysHis: 0.599 ± 0.278
8.984LysIle: 8.984 ± 0.9
9.582LysLys: 9.582 ± 1.136
7.7LysLeu: 7.7 ± 1.075
2.139LysMet: 2.139 ± 0.465
8.042LysAsn: 8.042 ± 0.806
1.027LysPro: 1.027 ± 0.3
2.909LysGln: 2.909 ± 0.509
2.652LysArg: 2.652 ± 0.584
6.674LysSer: 6.674 ± 0.713
4.62LysThr: 4.62 ± 0.643
5.818LysVal: 5.818 ± 0.516
1.027LysTrp: 1.027 ± 0.329
4.363LysTyr: 4.363 ± 0.665
0.0LysXaa: 0.0 ± 0.0
Leu
4.107LeuAla: 4.107 ± 0.572
0.684LeuCys: 0.684 ± 0.278
5.133LeuAsp: 5.133 ± 0.626
7.7LeuGlu: 7.7 ± 0.894
2.995LeuPhe: 2.995 ± 0.342
5.219LeuGly: 5.219 ± 0.651
0.342LeuHis: 0.342 ± 0.17
7.101LeuIle: 7.101 ± 0.773
9.24LeuLys: 9.24 ± 0.811
5.561LeuLeu: 5.561 ± 0.83
1.797LeuMet: 1.797 ± 0.455
6.93LeuAsn: 6.93 ± 0.905
2.396LeuPro: 2.396 ± 0.57
2.225LeuGln: 2.225 ± 0.499
2.396LeuArg: 2.396 ± 0.381
4.449LeuSer: 4.449 ± 0.595
3.85LeuThr: 3.85 ± 0.568
3.422LeuVal: 3.422 ± 0.61
0.684LeuTrp: 0.684 ± 0.307
3.166LeuTyr: 3.166 ± 0.585
0.0LeuXaa: 0.0 ± 0.0
Met
1.198MetAla: 1.198 ± 0.308
0.086MetCys: 0.086 ± 0.087
1.112MetAsp: 1.112 ± 0.358
2.053MetGlu: 2.053 ± 0.397
1.027MetPhe: 1.027 ± 0.302
1.454MetGly: 1.454 ± 0.362
0.171MetHis: 0.171 ± 0.114
1.198MetIle: 1.198 ± 0.335
2.139MetLys: 2.139 ± 0.403
2.567MetLeu: 2.567 ± 0.527
0.428MetMet: 0.428 ± 0.208
1.626MetAsn: 1.626 ± 0.434
0.513MetPro: 0.513 ± 0.174
0.856MetGln: 0.856 ± 0.207
0.941MetArg: 0.941 ± 0.237
1.968MetSer: 1.968 ± 0.36
1.454MetThr: 1.454 ± 0.448
1.027MetVal: 1.027 ± 0.365
0.171MetTrp: 0.171 ± 0.11
1.027MetTyr: 1.027 ± 0.309
0.0MetXaa: 0.0 ± 0.0
Asn
4.021AsnAla: 4.021 ± 0.829
0.856AsnCys: 0.856 ± 0.257
4.021AsnAsp: 4.021 ± 0.7
4.62AsnGlu: 4.62 ± 0.653
3.337AsnPhe: 3.337 ± 0.584
4.021AsnGly: 4.021 ± 0.607
0.599AsnHis: 0.599 ± 0.267
7.615AsnIle: 7.615 ± 1.142
7.101AsnLys: 7.101 ± 0.897
6.246AsnLeu: 6.246 ± 0.71
1.112AsnMet: 1.112 ± 0.263
5.219AsnAsn: 5.219 ± 0.973
1.54AsnPro: 1.54 ± 0.282
2.225AsnGln: 2.225 ± 0.455
2.139AsnArg: 2.139 ± 0.415
5.561AsnSer: 5.561 ± 1.263
4.535AsnThr: 4.535 ± 0.675
4.877AsnVal: 4.877 ± 0.629
1.626AsnTrp: 1.626 ± 0.501
2.225AsnTyr: 2.225 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
1.797ProAla: 1.797 ± 0.392
0.086ProCys: 0.086 ± 0.068
0.599ProAsp: 0.599 ± 0.239
0.856ProGlu: 0.856 ± 0.255
0.941ProPhe: 0.941 ± 0.271
1.369ProGly: 1.369 ± 0.3
0.428ProHis: 0.428 ± 0.185
1.626ProIle: 1.626 ± 0.28
1.626ProLys: 1.626 ± 0.332
0.856ProLeu: 0.856 ± 0.195
0.086ProMet: 0.086 ± 0.079
1.369ProAsn: 1.369 ± 0.352
0.257ProPro: 0.257 ± 0.158
0.599ProGln: 0.599 ± 0.175
0.599ProArg: 0.599 ± 0.219
1.198ProSer: 1.198 ± 0.291
0.941ProThr: 0.941 ± 0.381
1.369ProVal: 1.369 ± 0.327
0.086ProTrp: 0.086 ± 0.076
0.941ProTyr: 0.941 ± 0.338
0.0ProXaa: 0.0 ± 0.0
Gln
1.797GlnAla: 1.797 ± 0.357
0.257GlnCys: 0.257 ± 0.163
1.283GlnAsp: 1.283 ± 0.274
2.823GlnGlu: 2.823 ± 0.488
1.454GlnPhe: 1.454 ± 0.462
1.626GlnGly: 1.626 ± 0.383
0.342GlnHis: 0.342 ± 0.136
2.995GlnIle: 2.995 ± 0.578
3.85GlnLys: 3.85 ± 0.747
2.225GlnLeu: 2.225 ± 0.428
1.027GlnMet: 1.027 ± 0.38
1.882GlnAsn: 1.882 ± 0.403
0.171GlnPro: 0.171 ± 0.128
1.027GlnGln: 1.027 ± 0.364
1.112GlnArg: 1.112 ± 0.308
1.626GlnSer: 1.626 ± 0.285
1.882GlnThr: 1.882 ± 0.486
1.797GlnVal: 1.797 ± 0.348
0.0GlnTrp: 0.0 ± 0.0
1.54GlnTyr: 1.54 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
2.139ArgAla: 2.139 ± 0.5
0.257ArgCys: 0.257 ± 0.183
2.738ArgAsp: 2.738 ± 0.328
3.422ArgGlu: 3.422 ± 0.714
1.027ArgPhe: 1.027 ± 0.345
2.738ArgGly: 2.738 ± 0.591
0.684ArgHis: 0.684 ± 0.26
3.337ArgIle: 3.337 ± 0.521
2.652ArgLys: 2.652 ± 0.613
2.823ArgLeu: 2.823 ± 0.582
0.941ArgMet: 0.941 ± 0.297
2.139ArgAsn: 2.139 ± 0.342
0.684ArgPro: 0.684 ± 0.311
1.626ArgGln: 1.626 ± 0.361
1.198ArgArg: 1.198 ± 0.28
0.428ArgSer: 0.428 ± 0.236
1.797ArgThr: 1.797 ± 0.468
2.139ArgVal: 2.139 ± 0.561
0.342ArgTrp: 0.342 ± 0.213
1.027ArgTyr: 1.027 ± 0.339
0.0ArgXaa: 0.0 ± 0.0
Ser
4.363SerAla: 4.363 ± 0.731
1.027SerCys: 1.027 ± 0.358
3.85SerAsp: 3.85 ± 0.623
5.219SerGlu: 5.219 ± 0.665
1.882SerPhe: 1.882 ± 0.495
4.021SerGly: 4.021 ± 0.623
0.599SerHis: 0.599 ± 0.238
5.647SerIle: 5.647 ± 0.769
6.246SerLys: 6.246 ± 0.708
5.133SerLeu: 5.133 ± 0.599
1.027SerMet: 1.027 ± 0.271
4.278SerAsn: 4.278 ± 0.758
1.54SerPro: 1.54 ± 0.438
1.882SerGln: 1.882 ± 0.287
1.369SerArg: 1.369 ± 0.429
4.021SerSer: 4.021 ± 0.676
4.278SerThr: 4.278 ± 0.851
4.021SerVal: 4.021 ± 0.705
0.77SerTrp: 0.77 ± 0.205
2.823SerTyr: 2.823 ± 0.54
0.0SerXaa: 0.0 ± 0.0
Thr
3.765ThrAla: 3.765 ± 0.698
0.428ThrCys: 0.428 ± 0.202
3.422ThrAsp: 3.422 ± 0.414
4.192ThrGlu: 4.192 ± 0.528
2.31ThrPhe: 2.31 ± 0.409
3.936ThrGly: 3.936 ± 0.606
0.513ThrHis: 0.513 ± 0.227
5.39ThrIle: 5.39 ± 0.932
5.219ThrLys: 5.219 ± 0.624
4.706ThrLeu: 4.706 ± 0.693
1.198ThrMet: 1.198 ± 0.259
2.823ThrAsn: 2.823 ± 0.453
1.454ThrPro: 1.454 ± 0.349
1.882ThrGln: 1.882 ± 0.419
1.968ThrArg: 1.968 ± 0.479
2.652ThrSer: 2.652 ± 0.457
4.021ThrThr: 4.021 ± 0.848
3.593ThrVal: 3.593 ± 0.555
0.856ThrTrp: 0.856 ± 0.263
2.396ThrTyr: 2.396 ± 0.569
0.0ThrXaa: 0.0 ± 0.0
Val
3.08ValAla: 3.08 ± 0.567
0.428ValCys: 0.428 ± 0.215
4.192ValAsp: 4.192 ± 0.59
4.962ValGlu: 4.962 ± 0.699
1.283ValPhe: 1.283 ± 0.367
3.337ValGly: 3.337 ± 0.516
0.856ValHis: 0.856 ± 0.259
3.422ValIle: 3.422 ± 0.615
5.732ValLys: 5.732 ± 0.579
3.936ValLeu: 3.936 ± 0.508
1.027ValMet: 1.027 ± 0.262
4.706ValAsn: 4.706 ± 0.659
1.797ValPro: 1.797 ± 0.381
1.369ValGln: 1.369 ± 0.351
1.797ValArg: 1.797 ± 0.448
4.192ValSer: 4.192 ± 0.534
4.192ValThr: 4.192 ± 0.573
2.481ValVal: 2.481 ± 0.443
0.342ValTrp: 0.342 ± 0.15
1.968ValTyr: 1.968 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
0.684TrpAla: 0.684 ± 0.232
0.171TrpCys: 0.171 ± 0.123
1.626TrpAsp: 1.626 ± 0.463
1.112TrpGlu: 1.112 ± 0.302
0.77TrpPhe: 0.77 ± 0.32
0.856TrpGly: 0.856 ± 0.302
0.086TrpHis: 0.086 ± 0.081
0.599TrpIle: 0.599 ± 0.227
0.77TrpLys: 0.77 ± 0.28
1.027TrpLeu: 1.027 ± 0.303
0.086TrpMet: 0.086 ± 0.076
0.684TrpAsn: 0.684 ± 0.249
0.0TrpPro: 0.0 ± 0.0
0.428TrpGln: 0.428 ± 0.287
0.086TrpArg: 0.086 ± 0.083
0.171TrpSer: 0.171 ± 0.123
0.171TrpThr: 0.171 ± 0.112
0.171TrpVal: 0.171 ± 0.101
0.171TrpTrp: 0.171 ± 0.111
0.428TrpTyr: 0.428 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.882TyrAla: 1.882 ± 0.408
0.599TyrCys: 0.599 ± 0.203
1.968TyrAsp: 1.968 ± 0.476
3.593TyrGlu: 3.593 ± 0.524
1.882TyrPhe: 1.882 ± 0.392
1.027TyrGly: 1.027 ± 0.331
0.513TyrHis: 0.513 ± 0.195
4.278TyrIle: 4.278 ± 0.744
4.791TyrLys: 4.791 ± 0.809
2.396TyrLeu: 2.396 ± 0.458
0.428TyrMet: 0.428 ± 0.166
3.593TyrAsn: 3.593 ± 0.561
0.684TyrPro: 0.684 ± 0.216
1.369TyrGln: 1.369 ± 0.283
1.968TyrArg: 1.968 ± 0.512
2.823TyrSer: 2.823 ± 0.668
3.422TyrThr: 3.422 ± 0.912
2.139TyrVal: 2.139 ± 0.451
0.342TyrTrp: 0.342 ± 0.164
1.797TyrTyr: 1.797 ± 0.435
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (11689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski