Amino acid dipepetide frequency for Balneola sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.401AlaAla: 4.401 ± 0.08	0.51AlaCys: 0.51 ± 0.025	3.464AlaAsp: 3.464 ± 0.064	4.379AlaGlu: 4.379 ± 0.069	3.422AlaPhe: 3.422 ± 0.064	4.757AlaGly: 4.757 ± 0.076	1.19AlaHis: 1.19 ± 0.033	4.937AlaIle: 4.937 ± 0.074	3.526AlaLys: 3.526 ± 0.061	6.582AlaLeu: 6.582 ± 0.092	1.506AlaMet: 1.506 ± 0.04	3.084AlaAsn: 3.084 ± 0.064	2.148AlaPro: 2.148 ± 0.051	2.589AlaGln: 2.589 ± 0.055	2.68AlaArg: 2.68 ± 0.056	4.729AlaSer: 4.729 ± 0.069	3.606AlaThr: 3.606 ± 0.07	4.136AlaVal: 4.136 ± 0.069	0.766AlaTrp: 0.766 ± 0.025	2.304AlaTyr: 2.304 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.396CysAla: 0.396 ± 0.02	0.083CysCys: 0.083 ± 0.009	0.307CysAsp: 0.307 ± 0.019	0.389CysGlu: 0.389 ± 0.018	0.362CysPhe: 0.362 ± 0.02	0.46CysGly: 0.46 ± 0.025	0.143CysHis: 0.143 ± 0.013	0.428CysIle: 0.428 ± 0.019	0.271CysLys: 0.271 ± 0.016	0.491CysLeu: 0.491 ± 0.022	0.128CysMet: 0.128 ± 0.012	0.227CysAsn: 0.227 ± 0.015	0.241CysPro: 0.241 ± 0.019	0.145CysGln: 0.145 ± 0.012	0.183CysArg: 0.183 ± 0.014	0.52CysSer: 0.52 ± 0.023	0.365CysThr: 0.365 ± 0.023	0.341CysVal: 0.341 ± 0.018	0.059CysTrp: 0.059 ± 0.008	0.214CysTyr: 0.214 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.761AspAla: 3.761 ± 0.066	0.28AspCys: 0.28 ± 0.016	3.247AspAsp: 3.247 ± 0.063	4.6AspGlu: 4.6 ± 0.076	3.441AspPhe: 3.441 ± 0.056	4.585AspGly: 4.585 ± 0.091	1.139AspHis: 1.139 ± 0.033	4.375AspIle: 4.375 ± 0.074	2.715AspLys: 2.715 ± 0.059	5.511AspLeu: 5.511 ± 0.084	1.209AspMet: 1.209 ± 0.029	2.545AspAsn: 2.545 ± 0.057	2.63AspPro: 2.63 ± 0.058	2.252AspGln: 2.252 ± 0.049	2.567AspArg: 2.567 ± 0.055	4.132AspSer: 4.132 ± 0.08	2.856AspThr: 2.856 ± 0.062	3.673AspVal: 3.673 ± 0.067	0.894AspTrp: 0.894 ± 0.027	2.479AspTyr: 2.479 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.238GluAla: 5.238 ± 0.08	0.326GluCys: 0.326 ± 0.016	4.073GluAsp: 4.073 ± 0.063	6.731GluGlu: 6.731 ± 0.12	3.589GluPhe: 3.589 ± 0.056	4.735GluGly: 4.735 ± 0.071	1.373GluHis: 1.373 ± 0.043	5.593GluIle: 5.593 ± 0.073	4.587GluLys: 4.587 ± 0.082	7.678GluLeu: 7.678 ± 0.103	1.74GluMet: 1.74 ± 0.049	3.83GluAsn: 3.83 ± 0.063	2.082GluPro: 2.082 ± 0.048	2.866GluGln: 2.866 ± 0.05	3.235GluArg: 3.235 ± 0.056	4.34GluSer: 4.34 ± 0.066	3.704GluThr: 3.704 ± 0.061	5.33GluVal: 5.33 ± 0.079	0.907GluTrp: 0.907 ± 0.029	2.826GluTyr: 2.826 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.083PheAla: 3.083 ± 0.053	0.327PheCys: 0.327 ± 0.018	3.559PheAsp: 3.559 ± 0.071	4.051PheGlu: 4.051 ± 0.063	2.855PhePhe: 2.855 ± 0.062	4.078PheGly: 4.078 ± 0.071	0.822PheHis: 0.822 ± 0.027	3.676PheIle: 3.676 ± 0.062	2.47PheLys: 2.47 ± 0.046	4.781PheLeu: 4.781 ± 0.075	1.097PheMet: 1.097 ± 0.034	2.787PheAsn: 2.787 ± 0.049	1.802PhePro: 1.802 ± 0.035	1.563PheGln: 1.563 ± 0.04	2.102PheArg: 2.102 ± 0.051	4.402PheSer: 4.402 ± 0.074	3.065PheThr: 3.065 ± 0.057	3.071PheVal: 3.071 ± 0.051	0.734PheTrp: 0.734 ± 0.028	2.018PheTyr: 2.018 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.746GlyAla: 4.746 ± 0.083	0.506GlyCys: 0.506 ± 0.023	4.109GlyAsp: 4.109 ± 0.082	4.736GlyGlu: 4.736 ± 0.072	4.128GlyPhe: 4.128 ± 0.066	5.083GlyGly: 5.083 ± 0.101	1.164GlyHis: 1.164 ± 0.042	5.924GlyIle: 5.924 ± 0.075	3.854GlyLys: 3.854 ± 0.078	6.576GlyLeu: 6.576 ± 0.084	1.753GlyMet: 1.753 ± 0.045	3.569GlyAsn: 3.569 ± 0.06	1.579GlyPro: 1.579 ± 0.038	2.064GlyGln: 2.064 ± 0.046	2.762GlyArg: 2.762 ± 0.053	5.012GlySer: 5.012 ± 0.088	4.57GlyThr: 4.57 ± 0.082	4.951GlyVal: 4.951 ± 0.072	1.009GlyTrp: 1.009 ± 0.032	2.986GlyTyr: 2.986 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.035HisAla: 1.035 ± 0.036	0.141HisCys: 0.141 ± 0.011	0.862HisAsp: 0.862 ± 0.032	1.12HisGlu: 1.12 ± 0.035	1.096HisPhe: 1.096 ± 0.035	1.175HisGly: 1.175 ± 0.039	0.542HisHis: 0.542 ± 0.043	1.354HisIle: 1.354 ± 0.039	0.886HisLys: 0.886 ± 0.028	1.756HisLeu: 1.756 ± 0.042	0.357HisMet: 0.357 ± 0.02	0.781HisAsn: 0.781 ± 0.024	1.02HisPro: 1.02 ± 0.031	0.652HisGln: 0.652 ± 0.022	0.758HisArg: 0.758 ± 0.025	1.278HisSer: 1.278 ± 0.037	0.972HisThr: 0.972 ± 0.032	1.026HisVal: 1.026 ± 0.031	0.257HisTrp: 0.257 ± 0.013	0.734HisTyr: 0.734 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.234IleAla: 5.234 ± 0.076	0.477IleCys: 0.477 ± 0.023	4.819IleAsp: 4.819 ± 0.071	5.784IleGlu: 5.784 ± 0.077	3.304IlePhe: 3.304 ± 0.058	5.327IleGly: 5.327 ± 0.073	1.418IleHis: 1.418 ± 0.04	5.233IleIle: 5.233 ± 0.074	3.971IleLys: 3.971 ± 0.064	6.458IleLeu: 6.458 ± 0.101	1.296IleMet: 1.296 ± 0.037	3.83IleAsn: 3.83 ± 0.055	3.393IlePro: 3.393 ± 0.049	2.698IleGln: 2.698 ± 0.048	3.092IleArg: 3.092 ± 0.058	6.048IleSer: 6.048 ± 0.078	4.591IleThr: 4.591 ± 0.093	4.332IleVal: 4.332 ± 0.07	0.825IleTrp: 0.825 ± 0.029	2.517IleTyr: 2.517 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	3.969LysAla: 3.969 ± 0.07	0.208LysCys: 0.208 ± 0.014	3.058LysAsp: 3.058 ± 0.053	5.167LysGlu: 5.167 ± 0.089	2.028LysPhe: 2.028 ± 0.041	3.53LysGly: 3.53 ± 0.068	0.955LysHis: 0.955 ± 0.031	3.642LysIle: 3.642 ± 0.069	4.433LysLys: 4.433 ± 0.081	4.87LysLeu: 4.87 ± 0.073	1.399LysMet: 1.399 ± 0.038	2.834LysAsn: 2.834 ± 0.052	1.957LysPro: 1.957 ± 0.042	1.805LysGln: 1.805 ± 0.037	2.574LysArg: 2.574 ± 0.057	3.42LysSer: 3.42 ± 0.057	3.06LysThr: 3.06 ± 0.056	3.693LysVal: 3.693 ± 0.07	0.609LysTrp: 0.609 ± 0.021	2.03LysTyr: 2.03 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	6.176LeuAla: 6.176 ± 0.085	0.54LeuCys: 0.54 ± 0.025	5.652LeuAsp: 5.652 ± 0.078	6.813LeuGlu: 6.813 ± 0.092	5.014LeuPhe: 5.014 ± 0.075	6.516LeuGly: 6.516 ± 0.096	1.489LeuHis: 1.489 ± 0.039	7.101LeuIle: 7.101 ± 0.099	5.558LeuLys: 5.558 ± 0.083	8.753LeuLeu: 8.753 ± 0.122	2.017LeuMet: 2.017 ± 0.044	4.928LeuAsn: 4.928 ± 0.082	3.737LeuPro: 3.737 ± 0.06	2.853LeuGln: 2.853 ± 0.051	3.942LeuArg: 3.942 ± 0.066	7.71LeuSer: 7.71 ± 0.087	5.261LeuThr: 5.261 ± 0.076	6.055LeuVal: 6.055 ± 0.09	0.894LeuTrp: 0.894 ± 0.029	2.955LeuTyr: 2.955 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.579MetAla: 1.579 ± 0.039	0.104MetCys: 0.104 ± 0.009	1.297MetAsp: 1.297 ± 0.038	1.486MetGlu: 1.486 ± 0.037	0.873MetPhe: 0.873 ± 0.033	1.587MetGly: 1.587 ± 0.039	0.389MetHis: 0.389 ± 0.018	1.597MetIle: 1.597 ± 0.042	1.622MetLys: 1.622 ± 0.033	1.949MetLeu: 1.949 ± 0.045	0.564MetMet: 0.564 ± 0.025	1.272MetAsn: 1.272 ± 0.035	0.909MetPro: 0.909 ± 0.028	0.683MetGln: 0.683 ± 0.026	0.985MetArg: 0.985 ± 0.028	1.492MetSer: 1.492 ± 0.038	0.999MetThr: 0.999 ± 0.033	1.342MetVal: 1.342 ± 0.036	0.172MetTrp: 0.172 ± 0.013	0.668MetTyr: 0.668 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.051AsnAla: 3.051 ± 0.052	0.278AsnCys: 0.278 ± 0.018	2.847AsnAsp: 2.847 ± 0.064	3.622AsnGlu: 3.622 ± 0.058	2.374AsnPhe: 2.374 ± 0.055	3.773AsnGly: 3.773 ± 0.087	0.921AsnHis: 0.921 ± 0.027	3.475AsnIle: 3.475 ± 0.06	2.411AsnLys: 2.411 ± 0.051	4.561AsnLeu: 4.561 ± 0.067	1.138AsnMet: 1.138 ± 0.032	2.507AsnAsn: 2.507 ± 0.064	2.954AsnPro: 2.954 ± 0.052	1.95AsnGln: 1.95 ± 0.042	2.309AsnArg: 2.309 ± 0.049	3.693AsnSer: 3.693 ± 0.063	3.067AsnThr: 3.067 ± 0.061	2.845AsnVal: 2.845 ± 0.053	0.749AsnTrp: 0.749 ± 0.025	2.187AsnTyr: 2.187 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.186ProAla: 2.186 ± 0.046	0.177ProCys: 0.177 ± 0.012	2.784ProAsp: 2.784 ± 0.055	3.435ProGlu: 3.435 ± 0.065	2.185ProPhe: 2.185 ± 0.043	2.794ProGly: 2.794 ± 0.055	0.655ProHis: 0.655 ± 0.025	2.802ProIle: 2.802 ± 0.052	1.883ProLys: 1.883 ± 0.046	3.171ProLeu: 3.171 ± 0.053	0.69ProMet: 0.69 ± 0.025	2.127ProAsn: 2.127 ± 0.044	1.126ProPro: 1.126 ± 0.04	1.141ProGln: 1.141 ± 0.031	1.22ProArg: 1.22 ± 0.036	2.632ProSer: 2.632 ± 0.055	2.112ProThr: 2.112 ± 0.048	2.781ProVal: 2.781 ± 0.05	0.433ProTrp: 0.433 ± 0.022	1.381ProTyr: 1.381 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.315GlnAla: 2.315 ± 0.044	0.128GlnCys: 0.128 ± 0.011	1.692GlnAsp: 1.692 ± 0.038	2.602GlnGlu: 2.602 ± 0.055	1.622GlnPhe: 1.622 ± 0.044	2.074GlnGly: 2.074 ± 0.045	0.573GlnHis: 0.573 ± 0.02	2.541GlnIle: 2.541 ± 0.05	2.199GlnLys: 2.199 ± 0.047	3.459GlnLeu: 3.459 ± 0.061	0.721GlnMet: 0.721 ± 0.028	1.86GlnAsn: 1.86 ± 0.045	1.164GlnPro: 1.164 ± 0.034	1.51GlnGln: 1.51 ± 0.048	1.563GlnArg: 1.563 ± 0.04	2.233GlnSer: 2.233 ± 0.046	1.949GlnThr: 1.949 ± 0.042	2.325GlnVal: 2.325 ± 0.044	0.379GlnTrp: 0.379 ± 0.017	1.236GlnTyr: 1.236 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.564ArgAla: 2.564 ± 0.058	0.194ArgCys: 0.194 ± 0.014	2.344ArgAsp: 2.344 ± 0.048	2.99ArgGlu: 2.99 ± 0.057	2.528ArgPhe: 2.528 ± 0.049	2.488ArgGly: 2.488 ± 0.054	0.687ArgHis: 0.687 ± 0.024	3.437ArgIle: 3.437 ± 0.056	2.566ArgLys: 2.566 ± 0.051	3.946ArgLeu: 3.946 ± 0.068	1.024ArgMet: 1.024 ± 0.031	2.301ArgAsn: 2.301 ± 0.05	1.42ArgPro: 1.42 ± 0.041	1.291ArgGln: 1.291 ± 0.036	1.99ArgArg: 1.99 ± 0.051	2.812ArgSer: 2.812 ± 0.062	2.304ArgThr: 2.304 ± 0.046	2.856ArgVal: 2.856 ± 0.057	0.506ArgTrp: 0.506 ± 0.021	1.798ArgTyr: 1.798 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.138SerAla: 4.138 ± 0.059	0.429SerCys: 0.429 ± 0.019	4.244SerAsp: 4.244 ± 0.072	5.19SerGlu: 5.19 ± 0.069	4.342SerPhe: 4.342 ± 0.069	5.955SerGly: 5.955 ± 0.09	1.106SerHis: 1.106 ± 0.031	5.898SerIle: 5.898 ± 0.092	3.837SerLys: 3.837 ± 0.069	6.866SerLeu: 6.866 ± 0.083	1.523SerMet: 1.523 ± 0.039	3.619SerAsn: 3.619 ± 0.065	2.621SerPro: 2.621 ± 0.057	2.182SerGln: 2.182 ± 0.044	2.923SerArg: 2.923 ± 0.056	5.811SerSer: 5.811 ± 0.106	4.405SerThr: 4.405 ± 0.07	4.547SerVal: 4.547 ± 0.067	0.894SerTrp: 0.894 ± 0.028	2.865SerTyr: 2.865 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.6ThrAla: 3.6 ± 0.064	0.291ThrCys: 0.291 ± 0.016	3.322ThrAsp: 3.322 ± 0.062	3.678ThrGlu: 3.678 ± 0.057	2.971ThrPhe: 2.971 ± 0.063	4.466ThrGly: 4.466 ± 0.082	1.029ThrHis: 1.029 ± 0.035	4.575ThrIle: 4.575 ± 0.075	2.701ThrLys: 2.701 ± 0.055	5.541ThrLeu: 5.541 ± 0.08	1.029ThrMet: 1.029 ± 0.029	2.782ThrAsn: 2.782 ± 0.06	2.533ThrPro: 2.533 ± 0.048	1.848ThrGln: 1.848 ± 0.037	2.208ThrArg: 2.208 ± 0.046	4.333ThrSer: 4.333 ± 0.073	3.443ThrThr: 3.443 ± 0.078	3.702ThrVal: 3.702 ± 0.075	0.724ThrTrp: 0.724 ± 0.032	2.124ThrTyr: 2.124 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.288ValAla: 4.288 ± 0.07	0.459ValCys: 0.459 ± 0.022	4.0ValAsp: 4.0 ± 0.069	4.482ValGlu: 4.482 ± 0.07	3.488ValPhe: 3.488 ± 0.056	4.26ValGly: 4.26 ± 0.069	1.13ValHis: 1.13 ± 0.039	4.835ValIle: 4.835 ± 0.063	3.197ValLys: 3.197 ± 0.056	6.278ValLeu: 6.278 ± 0.078	1.289ValMet: 1.289 ± 0.035	3.276ValAsn: 3.276 ± 0.056	2.473ValPro: 2.473 ± 0.045	2.208ValGln: 2.208 ± 0.047	2.559ValArg: 2.559 ± 0.046	4.965ValSer: 4.965 ± 0.074	3.748ValThr: 3.748 ± 0.061	4.317ValVal: 4.317 ± 0.076	0.723ValTrp: 0.723 ± 0.029	2.337ValTyr: 2.337 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.755TrpAla: 0.755 ± 0.027	0.07TrpCys: 0.07 ± 0.008	0.789TrpAsp: 0.789 ± 0.029	0.903TrpGlu: 0.903 ± 0.031	0.639TrpPhe: 0.639 ± 0.024	0.869TrpGly: 0.869 ± 0.029	0.271TrpHis: 0.271 ± 0.016	0.872TrpIle: 0.872 ± 0.026	0.678TrpLys: 0.678 ± 0.028	1.115TrpLeu: 1.115 ± 0.034	0.355TrpMet: 0.355 ± 0.02	0.667TrpAsn: 0.667 ± 0.026	0.314TrpPro: 0.314 ± 0.021	0.371TrpGln: 0.371 ± 0.018	0.512TrpArg: 0.512 ± 0.02	0.813TrpSer: 0.813 ± 0.03	0.674TrpThr: 0.674 ± 0.027	0.879TrpVal: 0.879 ± 0.03	0.188TrpTrp: 0.188 ± 0.013	0.501TrpTyr: 0.501 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.202TyrAla: 2.202 ± 0.047	0.224TyrCys: 0.224 ± 0.015	2.423TyrAsp: 2.423 ± 0.066	2.623TyrGlu: 2.623 ± 0.05	2.083TyrPhe: 2.083 ± 0.047	2.571TyrGly: 2.571 ± 0.051	0.805TyrHis: 0.805 ± 0.026	2.353TyrIle: 2.353 ± 0.049	1.876TyrLys: 1.876 ± 0.046	3.621TyrLeu: 3.621 ± 0.074	0.733TyrMet: 0.733 ± 0.029	1.886TyrAsn: 1.886 ± 0.048	1.611TyrPro: 1.611 ± 0.035	1.476TyrGln: 1.476 ± 0.041	1.878TyrArg: 1.878 ± 0.044	3.02TyrSer: 3.02 ± 0.061	2.149TyrThr: 2.149 ± 0.048	2.114TyrVal: 2.114 ± 0.046	0.511TyrTrp: 0.511 ± 0.023	1.585TyrTyr: 1.585 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3130 proteins (1114347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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