Amino acid dipepetide frequency for Shimia abyssi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.688AlaAla: 13.688 ± 0.157
1.085AlaCys: 1.085 ± 0.03
6.449AlaAsp: 6.449 ± 0.065
7.289AlaGlu: 7.289 ± 0.08
4.31AlaPhe: 4.31 ± 0.062
9.194AlaGly: 9.194 ± 0.083
2.255AlaHis: 2.255 ± 0.037
6.061AlaIle: 6.061 ± 0.075
3.992AlaLys: 3.992 ± 0.063
12.318AlaLeu: 12.318 ± 0.123
3.645AlaMet: 3.645 ± 0.052
3.138AlaAsn: 3.138 ± 0.05
5.022AlaPro: 5.022 ± 0.064
4.29AlaGln: 4.29 ± 0.059
7.439AlaArg: 7.439 ± 0.077
5.686AlaSer: 5.686 ± 0.059
5.783AlaThr: 5.783 ± 0.062
7.769AlaVal: 7.769 ± 0.074
1.364AlaTrp: 1.364 ± 0.033
2.505AlaTyr: 2.505 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.073CysAla: 1.073 ± 0.028
0.126CysCys: 0.126 ± 0.009
0.648CysAsp: 0.648 ± 0.021
0.499CysGlu: 0.499 ± 0.02
0.379CysPhe: 0.379 ± 0.016
0.983CysGly: 0.983 ± 0.032
0.309CysHis: 0.309 ± 0.018
0.452CysIle: 0.452 ± 0.018
0.259CysLys: 0.259 ± 0.014
0.884CysLeu: 0.884 ± 0.024
0.201CysMet: 0.201 ± 0.012
0.268CysAsn: 0.268 ± 0.014
0.48CysPro: 0.48 ± 0.018
0.284CysGln: 0.284 ± 0.016
0.524CysArg: 0.524 ± 0.017
0.514CysSer: 0.514 ± 0.02
0.481CysThr: 0.481 ± 0.02
0.677CysVal: 0.677 ± 0.023
0.124CysTrp: 0.124 ± 0.008
0.221CysTyr: 0.221 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.046AspAla: 7.046 ± 0.083
0.559AspCys: 0.559 ± 0.021
3.443AspAsp: 3.443 ± 0.081
3.626AspGlu: 3.626 ± 0.06
2.429AspPhe: 2.429 ± 0.044
5.627AspGly: 5.627 ± 0.101
1.402AspHis: 1.402 ± 0.036
3.481AspIle: 3.481 ± 0.053
1.919AspLys: 1.919 ± 0.037
6.199AspLeu: 6.199 ± 0.081
1.808AspMet: 1.808 ± 0.036
1.578AspAsn: 1.578 ± 0.037
3.313AspPro: 3.313 ± 0.047
2.12AspGln: 2.12 ± 0.04
3.709AspArg: 3.709 ± 0.052
2.315AspSer: 2.315 ± 0.049
3.309AspThr: 3.309 ± 0.062
4.789AspVal: 4.789 ± 0.066
1.178AspTrp: 1.178 ± 0.03
1.602AspTyr: 1.602 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.341GluAla: 7.341 ± 0.083
0.457GluCys: 0.457 ± 0.019
3.314GluAsp: 3.314 ± 0.054
3.533GluGlu: 3.533 ± 0.064
2.041GluPhe: 2.041 ± 0.035
4.44GluGly: 4.44 ± 0.07
1.319GluHis: 1.319 ± 0.035
3.769GluIle: 3.769 ± 0.059
2.39GluLys: 2.39 ± 0.041
5.485GluLeu: 5.485 ± 0.069
1.923GluMet: 1.923 ± 0.037
2.169GluAsn: 2.169 ± 0.038
2.455GluPro: 2.455 ± 0.054
2.143GluGln: 2.143 ± 0.038
4.071GluArg: 4.071 ± 0.061
2.39GluSer: 2.39 ± 0.039
3.934GluThr: 3.934 ± 0.061
4.252GluVal: 4.252 ± 0.052
0.763GluTrp: 0.763 ± 0.024
1.226GluTyr: 1.226 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.414PheAla: 4.414 ± 0.063
0.474PheCys: 0.474 ± 0.018
3.077PheAsp: 3.077 ± 0.05
2.544PheGlu: 2.544 ± 0.046
1.618PhePhe: 1.618 ± 0.042
3.976PheGly: 3.976 ± 0.052
0.811PheHis: 0.811 ± 0.025
1.671PheIle: 1.671 ± 0.039
1.074PheLys: 1.074 ± 0.029
3.725PheLeu: 3.725 ± 0.062
0.971PheMet: 0.971 ± 0.029
1.159PheAsn: 1.159 ± 0.029
1.627PhePro: 1.627 ± 0.035
1.193PheGln: 1.193 ± 0.031
2.129PheArg: 2.129 ± 0.031
2.488PheSer: 2.488 ± 0.045
2.061PheThr: 2.061 ± 0.037
2.957PheVal: 2.957 ± 0.056
0.643PheTrp: 0.643 ± 0.023
1.031PheTyr: 1.031 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.239GlyAla: 9.239 ± 0.089
0.882GlyCys: 0.882 ± 0.025
4.889GlyAsp: 4.889 ± 0.097
4.756GlyGlu: 4.756 ± 0.063
3.789GlyPhe: 3.789 ± 0.05
7.231GlyGly: 7.231 ± 0.115
1.988GlyHis: 1.988 ± 0.044
4.528GlyIle: 4.528 ± 0.055
3.258GlyLys: 3.258 ± 0.056
8.655GlyLeu: 8.655 ± 0.081
2.556GlyMet: 2.556 ± 0.046
2.434GlyAsn: 2.434 ± 0.076
3.437GlyPro: 3.437 ± 0.047
3.058GlyGln: 3.058 ± 0.046
5.052GlyArg: 5.052 ± 0.062
4.253GlySer: 4.253 ± 0.07
4.748GlyThr: 4.748 ± 0.104
6.661GlyVal: 6.661 ± 0.078
1.439GlyTrp: 1.439 ± 0.033
2.368GlyTyr: 2.368 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.235HisAla: 2.235 ± 0.049
0.275HisCys: 0.275 ± 0.014
1.328HisAsp: 1.328 ± 0.035
1.125HisGlu: 1.125 ± 0.028
0.908HisPhe: 0.908 ± 0.024
1.911HisGly: 1.911 ± 0.039
0.606HisHis: 0.606 ± 0.022
1.112HisIle: 1.112 ± 0.03
0.65HisLys: 0.65 ± 0.023
2.191HisLeu: 2.191 ± 0.048
0.632HisMet: 0.632 ± 0.024
0.575HisAsn: 0.575 ± 0.023
1.345HisPro: 1.345 ± 0.034
0.621HisGln: 0.621 ± 0.023
1.246HisArg: 1.246 ± 0.027
1.111HisSer: 1.111 ± 0.031
0.946HisThr: 0.946 ± 0.026
1.646HisVal: 1.646 ± 0.031
0.375HisTrp: 0.375 ± 0.018
0.6HisTyr: 0.6 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.707IleAla: 6.707 ± 0.071
0.663IleCys: 0.663 ± 0.021
3.677IleAsp: 3.677 ± 0.063
3.674IleGlu: 3.674 ± 0.053
1.895IlePhe: 1.895 ± 0.04
4.967IleGly: 4.967 ± 0.068
0.932IleHis: 0.932 ± 0.026
2.388IleIle: 2.388 ± 0.051
1.672IleLys: 1.672 ± 0.036
4.94IleLeu: 4.94 ± 0.071
1.185IleMet: 1.185 ± 0.028
1.63IleAsn: 1.63 ± 0.042
2.489IlePro: 2.489 ± 0.045
1.347IleGln: 1.347 ± 0.03
3.006IleArg: 3.006 ± 0.05
3.36IleSer: 3.36 ± 0.051
2.994IleThr: 2.994 ± 0.044
4.037IleVal: 4.037 ± 0.057
0.782IleTrp: 0.782 ± 0.026
1.22IleTyr: 1.22 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.915LysAla: 3.915 ± 0.062
0.207LysCys: 0.207 ± 0.012
1.987LysAsp: 1.987 ± 0.038
1.777LysGlu: 1.777 ± 0.042
1.14LysPhe: 1.14 ± 0.03
2.913LysGly: 2.913 ± 0.059
0.729LysHis: 0.729 ± 0.022
1.874LysIle: 1.874 ± 0.041
1.332LysLys: 1.332 ± 0.033
3.269LysLeu: 3.269 ± 0.05
0.954LysMet: 0.954 ± 0.028
1.057LysAsn: 1.057 ± 0.028
1.945LysPro: 1.945 ± 0.043
1.084LysGln: 1.084 ± 0.027
2.448LysArg: 2.448 ± 0.043
2.18LysSer: 2.18 ± 0.042
2.168LysThr: 2.168 ± 0.042
2.527LysVal: 2.527 ± 0.044
0.45LysTrp: 0.45 ± 0.019
0.78LysTyr: 0.78 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
11.425LeuAla: 11.425 ± 0.105
0.959LeuCys: 0.959 ± 0.029
5.923LeuAsp: 5.923 ± 0.072
5.548LeuGlu: 5.548 ± 0.063
3.773LeuPhe: 3.773 ± 0.067
8.167LeuGly: 8.167 ± 0.082
1.855LeuHis: 1.855 ± 0.041
5.308LeuIle: 5.308 ± 0.069
3.596LeuLys: 3.596 ± 0.052
8.393LeuLeu: 8.393 ± 0.114
2.777LeuMet: 2.777 ± 0.048
3.143LeuAsn: 3.143 ± 0.049
5.186LeuPro: 5.186 ± 0.065
2.796LeuGln: 2.796 ± 0.047
6.311LeuArg: 6.311 ± 0.083
6.988LeuSer: 6.988 ± 0.079
5.752LeuThr: 5.752 ± 0.075
6.776LeuVal: 6.776 ± 0.08
1.256LeuTrp: 1.256 ± 0.034
1.902LeuTyr: 1.902 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.398MetAla: 3.398 ± 0.057
0.216MetCys: 0.216 ± 0.01
1.528MetAsp: 1.528 ± 0.029
1.287MetGlu: 1.287 ± 0.031
0.959MetPhe: 0.959 ± 0.031
2.324MetGly: 2.324 ± 0.038
0.541MetHis: 0.541 ± 0.022
1.66MetIle: 1.66 ± 0.039
1.149MetLys: 1.149 ± 0.032
2.615MetLeu: 2.615 ± 0.047
0.81MetMet: 0.81 ± 0.024
0.94MetAsn: 0.94 ± 0.03
1.501MetPro: 1.501 ± 0.033
1.011MetGln: 1.011 ± 0.025
1.952MetArg: 1.952 ± 0.037
1.996MetSer: 1.996 ± 0.042
2.022MetThr: 2.022 ± 0.037
2.005MetVal: 2.005 ± 0.043
0.269MetTrp: 0.269 ± 0.014
0.411MetTyr: 0.411 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.549AsnAla: 3.549 ± 0.049
0.283AsnCys: 0.283 ± 0.013
1.824AsnAsp: 1.824 ± 0.06
1.49AsnGlu: 1.49 ± 0.034
1.138AsnPhe: 1.138 ± 0.033
2.87AsnGly: 2.87 ± 0.065
0.638AsnHis: 0.638 ± 0.02
1.597AsnIle: 1.597 ± 0.034
0.851AsnLys: 0.851 ± 0.026
2.814AsnLeu: 2.814 ± 0.049
0.802AsnMet: 0.802 ± 0.024
0.876AsnAsn: 0.876 ± 0.031
1.962AsnPro: 1.962 ± 0.039
0.903AsnGln: 0.903 ± 0.024
1.867AsnArg: 1.867 ± 0.038
1.488AsnSer: 1.488 ± 0.032
1.731AsnThr: 1.731 ± 0.038
2.24AsnVal: 2.24 ± 0.044
0.563AsnTrp: 0.563 ± 0.02
0.765AsnTyr: 0.765 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
4.648ProAla: 4.648 ± 0.061
0.355ProCys: 0.355 ± 0.015
3.704ProAsp: 3.704 ± 0.051
3.969ProGlu: 3.969 ± 0.061
1.998ProPhe: 1.998 ± 0.041
3.927ProGly: 3.927 ± 0.061
1.054ProHis: 1.054 ± 0.032
2.431ProIle: 2.431 ± 0.039
1.876ProLys: 1.876 ± 0.041
4.365ProLeu: 4.365 ± 0.051
1.324ProMet: 1.324 ± 0.035
1.619ProAsn: 1.619 ± 0.037
1.957ProPro: 1.957 ± 0.041
1.495ProGln: 1.495 ± 0.033
2.417ProArg: 2.417 ± 0.042
2.655ProSer: 2.655 ± 0.042
2.581ProThr: 2.581 ± 0.041
4.001ProVal: 4.001 ± 0.053
0.662ProTrp: 0.662 ± 0.022
1.146ProTyr: 1.146 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.733GlnAla: 3.733 ± 0.053
0.259GlnCys: 0.259 ± 0.014
1.816GlnAsp: 1.816 ± 0.034
1.73GlnGlu: 1.73 ± 0.037
1.256GlnPhe: 1.256 ± 0.03
2.624GlnGly: 2.624 ± 0.046
0.65GlnHis: 0.65 ± 0.022
1.999GlnIle: 1.999 ± 0.035
1.241GlnLys: 1.241 ± 0.03
2.92GlnLeu: 2.92 ± 0.048
1.119GlnMet: 1.119 ± 0.029
1.126GlnAsn: 1.126 ± 0.029
1.513GlnPro: 1.513 ± 0.034
1.066GlnGln: 1.066 ± 0.03
2.144GlnArg: 2.144 ± 0.042
2.158GlnSer: 2.158 ± 0.043
1.909GlnThr: 1.909 ± 0.038
2.432GlnVal: 2.432 ± 0.043
0.432GlnTrp: 0.432 ± 0.02
0.665GlnTyr: 0.665 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.96ArgAla: 6.96 ± 0.077
0.48ArgCys: 0.48 ± 0.022
4.111ArgAsp: 4.111 ± 0.052
3.674ArgGlu: 3.674 ± 0.058
2.625ArgPhe: 2.625 ± 0.049
4.205ArgGly: 4.205 ± 0.061
1.459ArgHis: 1.459 ± 0.033
3.484ArgIle: 3.484 ± 0.048
2.351ArgLys: 2.351 ± 0.047
6.455ArgLeu: 6.455 ± 0.079
1.842ArgMet: 1.842 ± 0.041
1.919ArgAsn: 1.919 ± 0.037
2.809ArgPro: 2.809 ± 0.051
2.15ArgGln: 2.15 ± 0.041
4.219ArgArg: 4.219 ± 0.074
3.143ArgSer: 3.143 ± 0.047
2.885ArgThr: 2.885 ± 0.049
4.435ArgVal: 4.435 ± 0.055
0.916ArgTrp: 0.916 ± 0.028
1.502ArgTyr: 1.502 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.866SerAla: 5.866 ± 0.066
0.457SerCys: 0.457 ± 0.017
3.674SerAsp: 3.674 ± 0.061
3.333SerGlu: 3.333 ± 0.051
2.496SerPhe: 2.496 ± 0.05
5.785SerGly: 5.785 ± 0.101
1.209SerHis: 1.209 ± 0.029
2.772SerIle: 2.772 ± 0.043
1.854SerLys: 1.854 ± 0.037
5.254SerLeu: 5.254 ± 0.06
1.548SerMet: 1.548 ± 0.029
1.673SerAsn: 1.673 ± 0.033
2.512SerPro: 2.512 ± 0.047
1.825SerGln: 1.825 ± 0.037
3.166SerArg: 3.166 ± 0.051
2.905SerSer: 2.905 ± 0.05
2.776SerThr: 2.776 ± 0.047
4.274SerVal: 4.274 ± 0.063
0.765SerTrp: 0.765 ± 0.027
1.362SerTyr: 1.362 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
5.883ThrAla: 5.883 ± 0.068
0.537ThrCys: 0.537 ± 0.023
3.221ThrAsp: 3.221 ± 0.056
2.901ThrGlu: 2.901 ± 0.05
2.101ThrPhe: 2.101 ± 0.04
5.204ThrGly: 5.204 ± 0.081
1.28ThrHis: 1.28 ± 0.029
2.91ThrIle: 2.91 ± 0.055
1.817ThrLys: 1.817 ± 0.058
5.983ThrLeu: 5.983 ± 0.078
1.38ThrMet: 1.38 ± 0.032
1.572ThrAsn: 1.572 ± 0.034
3.336ThrPro: 3.336 ± 0.05
1.775ThrGln: 1.775 ± 0.037
3.22ThrArg: 3.22 ± 0.055
3.049ThrSer: 3.049 ± 0.048
2.948ThrThr: 2.948 ± 0.055
4.272ThrVal: 4.272 ± 0.069
0.697ThrTrp: 0.697 ± 0.025
1.347ThrTyr: 1.347 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.344ValAla: 8.344 ± 0.077
0.687ValCys: 0.687 ± 0.02
4.368ValAsp: 4.368 ± 0.068
4.603ValGlu: 4.603 ± 0.058
3.187ValPhe: 3.187 ± 0.048
5.663ValGly: 5.663 ± 0.063
1.453ValHis: 1.453 ± 0.032
4.3ValIle: 4.3 ± 0.062
2.316ValLys: 2.316 ± 0.048
7.488ValLeu: 7.488 ± 0.101
2.175ValMet: 2.175 ± 0.047
2.223ValAsn: 2.223 ± 0.051
3.493ValPro: 3.493 ± 0.045
2.264ValGln: 2.264 ± 0.042
4.15ValArg: 4.15 ± 0.055
4.672ValSer: 4.672 ± 0.059
4.483ValThr: 4.483 ± 0.06
5.834ValVal: 5.834 ± 0.076
0.989ValTrp: 0.989 ± 0.028
1.543ValTyr: 1.543 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.39TrpAla: 1.39 ± 0.032
0.142TrpCys: 0.142 ± 0.01
0.806TrpAsp: 0.806 ± 0.022
0.677TrpGlu: 0.677 ± 0.023
0.608TrpPhe: 0.608 ± 0.019
1.074TrpGly: 1.074 ± 0.031
0.375TrpHis: 0.375 ± 0.018
0.765TrpIle: 0.765 ± 0.023
0.491TrpLys: 0.491 ± 0.018
1.563TrpLeu: 1.563 ± 0.037
0.442TrpMet: 0.442 ± 0.018
0.492TrpAsn: 0.492 ± 0.019
0.695TrpPro: 0.695 ± 0.025
0.612TrpGln: 0.612 ± 0.023
1.036TrpArg: 1.036 ± 0.029
0.849TrpSer: 0.849 ± 0.023
0.74TrpThr: 0.74 ± 0.025
1.003TrpVal: 1.003 ± 0.031
0.212TrpTrp: 0.212 ± 0.014
0.308TrpTyr: 0.308 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.429TyrAla: 2.429 ± 0.044
0.284TyrCys: 0.284 ± 0.014
1.663TyrAsp: 1.663 ± 0.033
1.38TyrGlu: 1.38 ± 0.034
0.997TyrPhe: 0.997 ± 0.025
2.138TyrGly: 2.138 ± 0.041
0.576TyrHis: 0.576 ± 0.022
1.003TyrIle: 1.003 ± 0.028
0.646TyrLys: 0.646 ± 0.021
2.317TyrLeu: 2.317 ± 0.045
0.501TyrMet: 0.501 ± 0.02
0.659TyrAsn: 0.659 ± 0.023
1.105TyrPro: 1.105 ± 0.031
0.756TyrGln: 0.756 ± 0.02
1.517TyrArg: 1.517 ± 0.032
1.308TyrSer: 1.308 ± 0.035
1.179TyrThr: 1.179 ± 0.037
1.646TyrVal: 1.646 ± 0.039
0.404TyrTrp: 0.404 ± 0.018
0.63TyrTyr: 0.63 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4539 proteins (1417739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski