Amino acid dipepetide frequency for Variovorax gossypii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.478AlaAla: 18.478 ± 0.172	1.262AlaCys: 1.262 ± 0.025	6.527AlaAsp: 6.527 ± 0.067	6.646AlaGlu: 6.646 ± 0.065	4.26AlaPhe: 4.26 ± 0.048	11.323AlaGly: 11.323 ± 0.106	2.497AlaHis: 2.497 ± 0.037	5.262AlaIle: 5.262 ± 0.061	3.967AlaLys: 3.967 ± 0.065	14.822AlaLeu: 14.822 ± 0.116	3.618AlaMet: 3.618 ± 0.048	3.046AlaAsn: 3.046 ± 0.046	6.539AlaPro: 6.539 ± 0.082	5.558AlaGln: 5.558 ± 0.059	9.157AlaArg: 9.157 ± 0.094	7.562AlaSer: 7.562 ± 0.081	6.474AlaThr: 6.474 ± 0.075	9.377AlaVal: 9.377 ± 0.085	1.898AlaTrp: 1.898 ± 0.035	2.471AlaTyr: 2.471 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.136CysAla: 1.136 ± 0.024	0.117CysCys: 0.117 ± 0.008	0.496CysAsp: 0.496 ± 0.017	0.494CysGlu: 0.494 ± 0.018	0.279CysPhe: 0.279 ± 0.012	0.936CysGly: 0.936 ± 0.022	0.23CysHis: 0.23 ± 0.011	0.409CysIle: 0.409 ± 0.016	0.205CysLys: 0.205 ± 0.01	0.768CysLeu: 0.768 ± 0.02	0.215CysMet: 0.215 ± 0.01	0.214CysAsn: 0.214 ± 0.011	0.386CysPro: 0.386 ± 0.016	0.207CysGln: 0.207 ± 0.009	0.564CysArg: 0.564 ± 0.018	0.498CysSer: 0.498 ± 0.017	0.511CysThr: 0.511 ± 0.018	0.692CysVal: 0.692 ± 0.02	0.129CysTrp: 0.129 ± 0.009	0.18CysTyr: 0.18 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.416AspAla: 7.416 ± 0.087	0.425AspCys: 0.425 ± 0.016	2.698AspAsp: 2.698 ± 0.05	3.178AspGlu: 3.178 ± 0.039	2.13AspPhe: 2.13 ± 0.033	4.712AspGly: 4.712 ± 0.069	1.026AspHis: 1.026 ± 0.021	2.381AspIle: 2.381 ± 0.041	1.543AspLys: 1.543 ± 0.032	5.01AspLeu: 5.01 ± 0.045	1.172AspMet: 1.172 ± 0.025	1.253AspAsn: 1.253 ± 0.028	2.778AspPro: 2.778 ± 0.043	1.398AspGln: 1.398 ± 0.03	3.428AspArg: 3.428 ± 0.048	2.423AspSer: 2.423 ± 0.039	2.578AspThr: 2.578 ± 0.046	3.882AspVal: 3.882 ± 0.053	0.884AspTrp: 0.884 ± 0.021	1.339AspTyr: 1.339 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.124GluAla: 7.124 ± 0.071	0.364GluCys: 0.364 ± 0.015	2.182GluAsp: 2.182 ± 0.033	2.65GluGlu: 2.65 ± 0.041	1.717GluPhe: 1.717 ± 0.03	3.999GluGly: 3.999 ± 0.047	1.229GluHis: 1.229 ± 0.026	2.586GluIle: 2.586 ± 0.042	1.88GluLys: 1.88 ± 0.036	5.81GluLeu: 5.81 ± 0.07	1.177GluMet: 1.177 ± 0.024	1.233GluAsn: 1.233 ± 0.026	2.657GluPro: 2.657 ± 0.041	2.342GluGln: 2.342 ± 0.037	4.638GluArg: 4.638 ± 0.064	2.649GluSer: 2.649 ± 0.035	2.46GluThr: 2.46 ± 0.039	3.897GluVal: 3.897 ± 0.049	0.743GluTrp: 0.743 ± 0.021	0.997GluTyr: 0.997 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.411PheAla: 4.411 ± 0.041	0.338PheCys: 0.338 ± 0.016	2.559PheAsp: 2.559 ± 0.043	2.139PheGlu: 2.139 ± 0.035	1.388PhePhe: 1.388 ± 0.037	3.541PheGly: 3.541 ± 0.041	0.72PheHis: 0.72 ± 0.021	1.481PheIle: 1.481 ± 0.031	1.126PheLys: 1.126 ± 0.026	2.966PheLeu: 2.966 ± 0.041	0.803PheMet: 0.803 ± 0.023	1.118PheAsn: 1.118 ± 0.028	1.555PhePro: 1.555 ± 0.026	1.012PheGln: 1.012 ± 0.023	2.0PheArg: 2.0 ± 0.035	2.252PheSer: 2.252 ± 0.036	1.885PheThr: 1.885 ± 0.031	2.862PheVal: 2.862 ± 0.038	0.544PheTrp: 0.544 ± 0.018	0.819PheTyr: 0.819 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.914GlyAla: 9.914 ± 0.076	0.875GlyCys: 0.875 ± 0.019	4.055GlyAsp: 4.055 ± 0.071	4.503GlyGlu: 4.503 ± 0.055	3.46GlyPhe: 3.46 ± 0.046	7.608GlyGly: 7.608 ± 0.126	1.852GlyHis: 1.852 ± 0.037	4.151GlyIle: 4.151 ± 0.048	3.278GlyLys: 3.278 ± 0.05	8.852GlyLeu: 8.852 ± 0.094	2.263GlyMet: 2.263 ± 0.04	2.454GlyAsn: 2.454 ± 0.064	3.275GlyPro: 3.275 ± 0.042	3.14GlyGln: 3.14 ± 0.047	5.743GlyArg: 5.743 ± 0.062	5.153GlySer: 5.153 ± 0.069	5.082GlyThr: 5.082 ± 0.071	6.609GlyVal: 6.609 ± 0.06	1.472GlyTrp: 1.472 ± 0.032	2.353GlyTyr: 2.353 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.854HisAla: 2.854 ± 0.038	0.237HisCys: 0.237 ± 0.011	1.164HisAsp: 1.164 ± 0.027	1.15HisGlu: 1.15 ± 0.024	0.848HisPhe: 0.848 ± 0.024	2.075HisGly: 2.075 ± 0.04	0.6HisHis: 0.6 ± 0.022	0.859HisIle: 0.859 ± 0.021	0.512HisLys: 0.512 ± 0.017	1.993HisLeu: 1.993 ± 0.031	0.486HisMet: 0.486 ± 0.016	0.468HisAsn: 0.468 ± 0.016	1.373HisPro: 1.373 ± 0.026	0.632HisGln: 0.632 ± 0.019	1.514HisArg: 1.514 ± 0.029	1.033HisSer: 1.033 ± 0.023	0.991HisThr: 0.991 ± 0.022	1.548HisVal: 1.548 ± 0.026	0.378HisTrp: 0.378 ± 0.013	0.554HisTyr: 0.554 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.524IleAla: 6.524 ± 0.065	0.389IleCys: 0.389 ± 0.012	3.21IleAsp: 3.21 ± 0.045	3.052IleGlu: 3.052 ± 0.047	1.229IlePhe: 1.229 ± 0.026	4.487IleGly: 4.487 ± 0.054	0.78IleHis: 0.78 ± 0.02	1.223IleIle: 1.223 ± 0.034	1.297IleLys: 1.297 ± 0.028	2.948IleLeu: 2.948 ± 0.048	0.636IleMet: 0.636 ± 0.021	1.268IleAsn: 1.268 ± 0.031	1.976IlePro: 1.976 ± 0.033	1.17IleGln: 1.17 ± 0.022	2.538IleArg: 2.538 ± 0.037	2.375IleSer: 2.375 ± 0.041	2.235IleThr: 2.235 ± 0.038	3.804IleVal: 3.804 ± 0.048	0.471IleTrp: 0.471 ± 0.017	0.959IleTyr: 0.959 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.14LysAla: 4.14 ± 0.062	0.136LysCys: 0.136 ± 0.01	1.643LysAsp: 1.643 ± 0.034	1.519LysGlu: 1.519 ± 0.031	0.936LysPhe: 0.936 ± 0.022	2.395LysGly: 2.395 ± 0.045	0.607LysHis: 0.607 ± 0.017	1.367LysIle: 1.367 ± 0.035	1.417LysLys: 1.417 ± 0.038	3.569LysLeu: 3.569 ± 0.052	0.699LysMet: 0.699 ± 0.021	0.885LysAsn: 0.885 ± 0.022	2.14LysPro: 2.14 ± 0.041	1.182LysGln: 1.182 ± 0.025	2.161LysArg: 2.161 ± 0.036	1.814LysSer: 1.814 ± 0.033	1.944LysThr: 1.944 ± 0.03	2.482LysVal: 2.482 ± 0.043	0.385LysTrp: 0.385 ± 0.014	0.622LysTyr: 0.622 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.644LeuAla: 14.644 ± 0.118	0.976LeuCys: 0.976 ± 0.024	5.712LeuAsp: 5.712 ± 0.061	5.035LeuGlu: 5.035 ± 0.059	3.474LeuPhe: 3.474 ± 0.052	8.839LeuGly: 8.839 ± 0.099	2.244LeuHis: 2.244 ± 0.04	4.133LeuIle: 4.133 ± 0.053	3.409LeuLys: 3.409 ± 0.049	11.046LeuLeu: 11.046 ± 0.126	2.417LeuMet: 2.417 ± 0.041	2.504LeuAsn: 2.504 ± 0.04	6.123LeuPro: 6.123 ± 0.064	3.895LeuGln: 3.895 ± 0.048	7.786LeuArg: 7.786 ± 0.069	6.435LeuSer: 6.435 ± 0.109	5.053LeuThr: 5.053 ± 0.065	7.991LeuVal: 7.991 ± 0.076	1.287LeuTrp: 1.287 ± 0.029	1.961LeuTyr: 1.961 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.895MetAla: 2.895 ± 0.043	0.183MetCys: 0.183 ± 0.009	1.003MetAsp: 1.003 ± 0.025	0.991MetGlu: 0.991 ± 0.019	0.717MetPhe: 0.717 ± 0.018	1.784MetGly: 1.784 ± 0.036	0.543MetHis: 0.543 ± 0.019	0.898MetIle: 0.898 ± 0.024	1.026MetLys: 1.026 ± 0.026	2.646MetLeu: 2.646 ± 0.047	0.515MetMet: 0.515 ± 0.018	0.843MetAsn: 0.843 ± 0.019	1.535MetPro: 1.535 ± 0.03	1.065MetGln: 1.065 ± 0.024	1.796MetArg: 1.796 ± 0.029	1.639MetSer: 1.639 ± 0.026	1.582MetThr: 1.582 ± 0.031	1.629MetVal: 1.629 ± 0.031	0.207MetTrp: 0.207 ± 0.01	0.377MetTyr: 0.377 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.429AsnAla: 3.429 ± 0.049	0.243AsnCys: 0.243 ± 0.011	1.335AsnAsp: 1.335 ± 0.037	1.217AsnGlu: 1.217 ± 0.025	0.949AsnPhe: 0.949 ± 0.021	2.438AsnGly: 2.438 ± 0.044	0.477AsnHis: 0.477 ± 0.015	1.195AsnIle: 1.195 ± 0.025	0.785AsnLys: 0.785 ± 0.021	2.526AsnLeu: 2.526 ± 0.038	0.533AsnMet: 0.533 ± 0.015	0.828AsnAsn: 0.828 ± 0.031	1.767AsnPro: 1.767 ± 0.035	0.816AsnGln: 0.816 ± 0.022	1.586AsnArg: 1.586 ± 0.03	1.386AsnSer: 1.386 ± 0.047	1.496AsnThr: 1.496 ± 0.039	2.048AsnVal: 2.048 ± 0.044	0.422AsnTrp: 0.422 ± 0.014	0.695AsnTyr: 0.695 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.361ProAla: 7.361 ± 0.077	0.345ProCys: 0.345 ± 0.013	3.069ProAsp: 3.069 ± 0.04	3.301ProGlu: 3.301 ± 0.044	1.841ProPhe: 1.841 ± 0.031	4.771ProGly: 4.771 ± 0.05	1.147ProHis: 1.147 ± 0.027	1.865ProIle: 1.865 ± 0.031	1.633ProLys: 1.633 ± 0.033	5.197ProLeu: 5.197 ± 0.069	1.302ProMet: 1.302 ± 0.025	1.304ProAsn: 1.304 ± 0.027	2.861ProPro: 2.861 ± 0.06	2.047ProGln: 2.047 ± 0.033	3.09ProArg: 3.09 ± 0.044	3.177ProSer: 3.177 ± 0.047	2.678ProThr: 2.678 ± 0.039	4.45ProVal: 4.45 ± 0.049	0.807ProTrp: 0.807 ± 0.018	1.191ProTyr: 1.191 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.146GlnAla: 5.146 ± 0.061	0.271GlnCys: 0.271 ± 0.013	1.403GlnAsp: 1.403 ± 0.031	1.537GlnGlu: 1.537 ± 0.027	1.169GlnPhe: 1.169 ± 0.025	2.901GlnGly: 2.901 ± 0.04	0.817GlnHis: 0.817 ± 0.021	1.664GlnIle: 1.664 ± 0.034	1.138GlnLys: 1.138 ± 0.028	4.013GlnLeu: 4.013 ± 0.049	0.898GlnMet: 0.898 ± 0.024	0.829GlnAsn: 0.829 ± 0.023	2.249GlnPro: 2.249 ± 0.036	1.992GlnGln: 1.992 ± 0.062	3.25GlnArg: 3.25 ± 0.05	2.005GlnSer: 2.005 ± 0.035	1.781GlnThr: 1.781 ± 0.029	2.777GlnVal: 2.777 ± 0.043	0.624GlnTrp: 0.624 ± 0.017	0.753GlnTyr: 0.753 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.079ArgAla: 8.079 ± 0.071	0.609ArgCys: 0.609 ± 0.019	3.59ArgAsp: 3.59 ± 0.044	4.234ArgGlu: 4.234 ± 0.057	2.838ArgPhe: 2.838 ± 0.04	4.82ArgGly: 4.82 ± 0.051	1.833ArgHis: 1.833 ± 0.032	3.616ArgIle: 3.616 ± 0.049	2.211ArgLys: 2.211 ± 0.037	7.634ArgLeu: 7.634 ± 0.088	1.949ArgMet: 1.949 ± 0.031	1.865ArgAsn: 1.865 ± 0.034	3.233ArgPro: 3.233 ± 0.052	2.693ArgGln: 2.693 ± 0.039	5.221ArgArg: 5.221 ± 0.07	3.737ArgSer: 3.737 ± 0.049	3.557ArgThr: 3.557 ± 0.046	5.1ArgVal: 5.1 ± 0.066	1.183ArgTrp: 1.183 ± 0.029	1.77ArgTyr: 1.77 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.872SerAla: 6.872 ± 0.075	0.451SerCys: 0.451 ± 0.015	2.645SerAsp: 2.645 ± 0.039	2.505SerGlu: 2.505 ± 0.04	2.289SerPhe: 2.289 ± 0.036	5.694SerGly: 5.694 ± 0.077	1.234SerHis: 1.234 ± 0.029	2.49SerIle: 2.49 ± 0.04	1.65SerLys: 1.65 ± 0.031	6.059SerLeu: 6.059 ± 0.077	1.417SerMet: 1.417 ± 0.028	1.513SerAsn: 1.513 ± 0.035	3.235SerPro: 3.235 ± 0.049	1.996SerGln: 1.996 ± 0.035	3.73SerArg: 3.73 ± 0.046	3.709SerSer: 3.709 ± 0.084	3.391SerThr: 3.391 ± 0.134	4.294SerVal: 4.294 ± 0.055	0.775SerTrp: 0.775 ± 0.021	1.347SerTyr: 1.347 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.465ThrAla: 6.465 ± 0.068	0.37ThrCys: 0.37 ± 0.015	2.501ThrAsp: 2.501 ± 0.039	2.326ThrGlu: 2.326 ± 0.037	1.697ThrPhe: 1.697 ± 0.03	5.03ThrGly: 5.03 ± 0.078	1.105ThrHis: 1.105 ± 0.024	2.171ThrIle: 2.171 ± 0.04	1.273ThrLys: 1.273 ± 0.028	6.284ThrLeu: 6.284 ± 0.056	1.133ThrMet: 1.133 ± 0.023	1.348ThrAsn: 1.348 ± 0.041	3.581ThrPro: 3.581 ± 0.051	1.932ThrGln: 1.932 ± 0.032	3.349ThrArg: 3.349 ± 0.044	2.958ThrSer: 2.958 ± 0.077	3.081ThrThr: 3.081 ± 0.059	4.515ThrVal: 4.515 ± 0.059	0.678ThrTrp: 0.678 ± 0.019	1.106ThrTyr: 1.106 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.86ValAla: 9.86 ± 0.085	0.713ValCys: 0.713 ± 0.021	3.995ValAsp: 3.995 ± 0.051	4.099ValGlu: 4.099 ± 0.051	2.791ValPhe: 2.791 ± 0.043	5.732ValGly: 5.732 ± 0.058	1.557ValHis: 1.557 ± 0.032	3.358ValIle: 3.358 ± 0.052	2.479ValLys: 2.479 ± 0.043	8.575ValLeu: 8.575 ± 0.086	1.799ValMet: 1.799 ± 0.034	2.132ValAsn: 2.132 ± 0.042	4.321ValPro: 4.321 ± 0.042	2.719ValGln: 2.719 ± 0.042	5.306ValArg: 5.306 ± 0.058	4.447ValSer: 4.447 ± 0.05	4.162ValThr: 4.162 ± 0.055	6.485ValVal: 6.485 ± 0.073	0.951ValTrp: 0.951 ± 0.025	1.572ValTyr: 1.572 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.348TrpAla: 1.348 ± 0.03	0.146TrpCys: 0.146 ± 0.008	0.605TrpAsp: 0.605 ± 0.018	0.559TrpGlu: 0.559 ± 0.016	0.57TrpPhe: 0.57 ± 0.017	0.987TrpGly: 0.987 ± 0.022	0.379TrpHis: 0.379 ± 0.016	0.686TrpIle: 0.686 ± 0.021	0.511TrpLys: 0.511 ± 0.017	1.977TrpLeu: 1.977 ± 0.039	0.409TrpMet: 0.409 ± 0.013	0.464TrpAsn: 0.464 ± 0.017	0.737TrpPro: 0.737 ± 0.02	0.71TrpGln: 0.71 ± 0.023	1.254TrpArg: 1.254 ± 0.031	0.861TrpSer: 0.861 ± 0.024	0.762TrpThr: 0.762 ± 0.02	0.974TrpVal: 0.974 ± 0.023	0.258TrpTrp: 0.258 ± 0.013	0.298TrpTyr: 0.298 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.65TyrAla: 2.65 ± 0.04	0.218TyrCys: 0.218 ± 0.01	1.262TyrAsp: 1.262 ± 0.033	1.197TyrGlu: 1.197 ± 0.025	0.939TyrPhe: 0.939 ± 0.024	2.021TyrGly: 2.021 ± 0.035	0.392TyrHis: 0.392 ± 0.013	0.773TyrIle: 0.773 ± 0.023	0.703TyrLys: 0.703 ± 0.022	2.267TyrLeu: 2.267 ± 0.037	0.432TyrMet: 0.432 ± 0.016	0.605TyrAsn: 0.605 ± 0.021	1.113TyrPro: 1.113 ± 0.029	0.708TyrGln: 0.708 ± 0.018	1.658TyrArg: 1.658 ± 0.03	1.184TyrSer: 1.184 ± 0.025	1.202TyrThr: 1.202 ± 0.025	1.639TyrVal: 1.639 ± 0.032	0.397TyrTrp: 0.397 ± 0.014	0.565TyrTyr: 0.565 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5720 proteins (1918561 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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