Amino acid dipepetide frequency for Mesoplasma syrphidae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.495AlaAla: 4.495 ± 0.246
0.43AlaCys: 0.43 ± 0.036
2.846AlaAsp: 2.846 ± 0.1
3.572AlaGlu: 3.572 ± 0.121
2.746AlaPhe: 2.746 ± 0.099
3.558AlaGly: 3.558 ± 0.156
0.967AlaHis: 0.967 ± 0.059
6.519AlaIle: 6.519 ± 0.175
6.122AlaLys: 6.122 ± 0.2
5.763AlaLeu: 5.763 ± 0.154
1.608AlaMet: 1.608 ± 0.083
4.243AlaAsn: 4.243 ± 0.137
1.334AlaPro: 1.334 ± 0.078
2.09AlaGln: 2.09 ± 0.086
2.005AlaArg: 2.005 ± 0.087
3.684AlaSer: 3.684 ± 0.117
3.58AlaThr: 3.58 ± 0.124
3.799AlaVal: 3.799 ± 0.117
0.567AlaTrp: 0.567 ± 0.048
2.22AlaTyr: 2.22 ± 0.099
0.0AlaXaa: 0.0 ± 0.0
Cys
0.319CysAla: 0.319 ± 0.033
0.059CysCys: 0.059 ± 0.014
0.319CysAsp: 0.319 ± 0.029
0.419CysGlu: 0.419 ± 0.043
0.352CysPhe: 0.352 ± 0.039
0.46CysGly: 0.46 ± 0.047
0.119CysHis: 0.119 ± 0.024
0.467CysIle: 0.467 ± 0.039
0.385CysLys: 0.385 ± 0.038
0.548CysLeu: 0.548 ± 0.039
0.137CysMet: 0.137 ± 0.024
0.304CysAsn: 0.304 ± 0.035
0.167CysPro: 0.167 ± 0.024
0.233CysGln: 0.233 ± 0.026
0.119CysArg: 0.119 ± 0.022
0.456CysSer: 0.456 ± 0.04
0.308CysThr: 0.308 ± 0.035
0.293CysVal: 0.293 ± 0.033
0.085CysTrp: 0.085 ± 0.018
0.219CysTyr: 0.219 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
2.835AspAla: 2.835 ± 0.108
0.248AspCys: 0.248 ± 0.032
2.483AspAsp: 2.483 ± 0.098
3.899AspGlu: 3.899 ± 0.168
3.228AspPhe: 3.228 ± 0.109
2.702AspGly: 2.702 ± 0.108
0.786AspHis: 0.786 ± 0.056
4.588AspIle: 4.588 ± 0.155
4.477AspLys: 4.477 ± 0.158
5.525AspLeu: 5.525 ± 0.164
1.141AspMet: 1.141 ± 0.062
2.92AspAsn: 2.92 ± 0.112
1.442AspPro: 1.442 ± 0.07
2.224AspGln: 2.224 ± 0.085
1.382AspArg: 1.382 ± 0.076
3.154AspSer: 3.154 ± 0.109
2.161AspThr: 2.161 ± 0.084
2.98AspVal: 2.98 ± 0.09
0.541AspTrp: 0.541 ± 0.044
2.401AspTyr: 2.401 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
4.025GluAla: 4.025 ± 0.151
0.289GluCys: 0.289 ± 0.03
2.831GluAsp: 2.831 ± 0.11
4.799GluGlu: 4.799 ± 0.15
3.506GluPhe: 3.506 ± 0.125
2.909GluGly: 2.909 ± 0.115
0.871GluHis: 0.871 ± 0.052
7.86GluIle: 7.86 ± 0.222
6.834GluLys: 6.834 ± 0.185
6.578GluLeu: 6.578 ± 0.174
1.723GluMet: 1.723 ± 0.084
5.055GluAsn: 5.055 ± 0.146
1.486GluPro: 1.486 ± 0.068
2.791GluGln: 2.791 ± 0.126
2.005GluArg: 2.005 ± 0.087
3.48GluSer: 3.48 ± 0.133
3.628GluThr: 3.628 ± 0.135
4.336GluVal: 4.336 ± 0.151
0.7GluTrp: 0.7 ± 0.05
2.753GluTyr: 2.753 ± 0.112
0.0GluXaa: 0.0 ± 0.0
Phe
3.517PheAla: 3.517 ± 0.129
0.308PheCys: 0.308 ± 0.035
3.28PheAsp: 3.28 ± 0.116
3.598PheGlu: 3.598 ± 0.125
2.535PhePhe: 2.535 ± 0.11
3.254PheGly: 3.254 ± 0.127
0.397PheHis: 0.397 ± 0.039
4.473PheIle: 4.473 ± 0.15
4.773PheLys: 4.773 ± 0.146
4.773PheLeu: 4.773 ± 0.168
1.108PheMet: 1.108 ± 0.064
3.391PheAsn: 3.391 ± 0.107
1.09PhePro: 1.09 ± 0.065
1.319PheGln: 1.319 ± 0.07
1.353PheArg: 1.353 ± 0.065
3.535PheSer: 3.535 ± 0.133
2.676PheThr: 2.676 ± 0.102
3.513PheVal: 3.513 ± 0.13
0.611PheTrp: 0.611 ± 0.057
1.942PheTyr: 1.942 ± 0.088
0.0PheXaa: 0.0 ± 0.0
Gly
3.554GlyAla: 3.554 ± 0.142
0.289GlyCys: 0.289 ± 0.034
2.513GlyAsp: 2.513 ± 0.12
3.157GlyGlu: 3.157 ± 0.113
3.035GlyPhe: 3.035 ± 0.114
3.113GlyGly: 3.113 ± 0.13
0.834GlyHis: 0.834 ± 0.055
5.9GlyIle: 5.9 ± 0.167
4.621GlyLys: 4.621 ± 0.115
5.14GlyLeu: 5.14 ± 0.141
1.56GlyMet: 1.56 ± 0.072
3.08GlyAsn: 3.08 ± 0.112
1.29GlyPro: 1.29 ± 0.076
1.801GlyGln: 1.801 ± 0.082
1.857GlyArg: 1.857 ± 0.095
3.298GlySer: 3.298 ± 0.131
3.532GlyThr: 3.532 ± 0.129
3.713GlyVal: 3.713 ± 0.139
0.686GlyTrp: 0.686 ± 0.06
2.298GlyTyr: 2.298 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
0.834HisAla: 0.834 ± 0.06
0.1HisCys: 0.1 ± 0.02
0.723HisAsp: 0.723 ± 0.05
0.893HisGlu: 0.893 ± 0.048
0.682HisPhe: 0.682 ± 0.052
0.841HisGly: 0.841 ± 0.057
0.285HisHis: 0.285 ± 0.035
1.067HisIle: 1.067 ± 0.067
1.008HisLys: 1.008 ± 0.063
1.212HisLeu: 1.212 ± 0.072
0.289HisMet: 0.289 ± 0.036
0.856HisAsn: 0.856 ± 0.054
0.452HisPro: 0.452 ± 0.045
0.6HisGln: 0.6 ± 0.052
0.508HisArg: 0.508 ± 0.045
0.73HisSer: 0.73 ± 0.052
0.563HisThr: 0.563 ± 0.045
0.708HisVal: 0.708 ± 0.05
0.133HisTrp: 0.133 ± 0.021
0.552HisTyr: 0.552 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
6.641IleAla: 6.641 ± 0.185
0.812IleCys: 0.812 ± 0.057
5.548IleAsp: 5.548 ± 0.136
6.611IleGlu: 6.611 ± 0.187
5.303IlePhe: 5.303 ± 0.171
5.303IleGly: 5.303 ± 0.166
1.071IleHis: 1.071 ± 0.075
8.85IleIle: 8.85 ± 0.219
8.538IleLys: 8.538 ± 0.219
8.864IleLeu: 8.864 ± 0.222
1.82IleMet: 1.82 ± 0.072
6.426IleAsn: 6.426 ± 0.177
2.865IlePro: 2.865 ± 0.113
2.731IleGln: 2.731 ± 0.103
2.676IleArg: 2.676 ± 0.096
6.804IleSer: 6.804 ± 0.176
5.185IleThr: 5.185 ± 0.136
6.067IleVal: 6.067 ± 0.169
0.852IleTrp: 0.852 ± 0.058
3.391IleTyr: 3.391 ± 0.109
0.0IleXaa: 0.0 ± 0.0
Lys
5.27LysAla: 5.27 ± 0.144
0.408LysCys: 0.408 ± 0.044
4.695LysAsp: 4.695 ± 0.162
7.167LysGlu: 7.167 ± 0.189
3.873LysPhe: 3.873 ± 0.117
3.85LysGly: 3.85 ± 0.146
1.112LysHis: 1.112 ± 0.065
9.124LysIle: 9.124 ± 0.222
8.097LysLys: 8.097 ± 0.201
7.378LysLeu: 7.378 ± 0.202
2.787LysMet: 2.787 ± 0.095
6.926LysAsn: 6.926 ± 0.187
2.324LysPro: 2.324 ± 0.098
3.754LysGln: 3.754 ± 0.125
2.95LysArg: 2.95 ± 0.119
5.047LysSer: 5.047 ± 0.149
5.711LysThr: 5.711 ± 0.145
5.752LysVal: 5.752 ± 0.155
0.982LysTrp: 0.982 ± 0.061
3.906LysTyr: 3.906 ± 0.131
0.0LysXaa: 0.0 ± 0.0
Leu
6.148LeuAla: 6.148 ± 0.169
0.582LeuCys: 0.582 ± 0.042
4.847LeuAsp: 4.847 ± 0.135
6.545LeuGlu: 6.545 ± 0.184
4.555LeuPhe: 4.555 ± 0.201
5.444LeuGly: 5.444 ± 0.167
1.03LeuHis: 1.03 ± 0.064
8.257LeuIle: 8.257 ± 0.231
8.887LeuLys: 8.887 ± 0.204
7.945LeuLeu: 7.945 ± 0.219
2.172LeuMet: 2.172 ± 0.095
6.433LeuAsn: 6.433 ± 0.156
2.472LeuPro: 2.472 ± 0.096
2.894LeuGln: 2.894 ± 0.115
2.935LeuArg: 2.935 ± 0.106
6.089LeuSer: 6.089 ± 0.17
5.466LeuThr: 5.466 ± 0.135
6.011LeuVal: 6.011 ± 0.157
0.93LeuTrp: 0.93 ± 0.065
2.716LeuTyr: 2.716 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.579MetAla: 1.579 ± 0.079
0.119MetCys: 0.119 ± 0.019
1.015MetAsp: 1.015 ± 0.064
1.078MetGlu: 1.078 ± 0.066
1.249MetPhe: 1.249 ± 0.066
1.43MetGly: 1.43 ± 0.066
0.345MetHis: 0.345 ± 0.04
2.472MetIle: 2.472 ± 0.104
2.146MetLys: 2.146 ± 0.084
2.149MetLeu: 2.149 ± 0.088
0.523MetMet: 0.523 ± 0.048
1.556MetAsn: 1.556 ± 0.077
0.83MetPro: 0.83 ± 0.065
0.704MetGln: 0.704 ± 0.054
0.782MetArg: 0.782 ± 0.055
1.501MetSer: 1.501 ± 0.078
1.367MetThr: 1.367 ± 0.073
1.379MetVal: 1.379 ± 0.081
0.233MetTrp: 0.233 ± 0.031
0.726MetTyr: 0.726 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
3.424AsnAla: 3.424 ± 0.12
0.341AsnCys: 0.341 ± 0.034
3.828AsnAsp: 3.828 ± 0.132
4.662AsnGlu: 4.662 ± 0.143
3.906AsnPhe: 3.906 ± 0.147
3.476AsnGly: 3.476 ± 0.119
1.034AsnHis: 1.034 ± 0.072
6.204AsnIle: 6.204 ± 0.175
6.126AsnLys: 6.126 ± 0.153
6.519AsnLeu: 6.519 ± 0.181
1.216AsnMet: 1.216 ± 0.059
4.718AsnAsn: 4.718 ± 0.172
2.131AsnPro: 2.131 ± 0.093
2.98AsnGln: 2.98 ± 0.119
1.983AsnArg: 1.983 ± 0.08
4.669AsnSer: 4.669 ± 0.168
2.702AsnThr: 2.702 ± 0.096
3.572AsnVal: 3.572 ± 0.113
0.867AsnTrp: 0.867 ± 0.058
2.942AsnTyr: 2.942 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
1.367ProAla: 1.367 ± 0.072
0.107ProCys: 0.107 ± 0.019
1.264ProAsp: 1.264 ± 0.067
2.112ProGlu: 2.112 ± 0.09
1.43ProPhe: 1.43 ± 0.074
1.619ProGly: 1.619 ± 0.089
0.404ProHis: 0.404 ± 0.041
2.553ProIle: 2.553 ± 0.109
2.161ProLys: 2.161 ± 0.089
2.39ProLeu: 2.39 ± 0.094
0.586ProMet: 0.586 ± 0.052
1.812ProAsn: 1.812 ± 0.082
0.463ProPro: 0.463 ± 0.041
0.901ProGln: 0.901 ± 0.058
0.63ProArg: 0.63 ± 0.057
1.657ProSer: 1.657 ± 0.084
1.653ProThr: 1.653 ± 0.075
1.612ProVal: 1.612 ± 0.087
0.348ProTrp: 0.348 ± 0.04
1.012ProTyr: 1.012 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.261GlnAla: 2.261 ± 0.095
0.145GlnCys: 0.145 ± 0.021
1.479GlnAsp: 1.479 ± 0.07
2.609GlnGlu: 2.609 ± 0.106
1.531GlnPhe: 1.531 ± 0.072
1.949GlnGly: 1.949 ± 0.094
0.493GlnHis: 0.493 ± 0.049
3.824GlnIle: 3.824 ± 0.133
3.728GlnLys: 3.728 ± 0.144
2.98GlnLeu: 2.98 ± 0.11
0.808GlnMet: 0.808 ± 0.053
2.487GlnAsn: 2.487 ± 0.101
0.763GlnPro: 0.763 ± 0.054
1.586GlnGln: 1.586 ± 0.086
1.249GlnArg: 1.249 ± 0.082
1.923GlnSer: 1.923 ± 0.087
2.272GlnThr: 2.272 ± 0.087
1.875GlnVal: 1.875 ± 0.089
0.411GlnTrp: 0.411 ± 0.042
1.412GlnTyr: 1.412 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
1.731ArgAla: 1.731 ± 0.08
0.156ArgCys: 0.156 ± 0.025
1.631ArgAsp: 1.631 ± 0.089
2.12ArgGlu: 2.12 ± 0.091
1.486ArgPhe: 1.486 ± 0.086
1.594ArgGly: 1.594 ± 0.086
0.4ArgHis: 0.4 ± 0.038
2.894ArgIle: 2.894 ± 0.103
2.865ArgLys: 2.865 ± 0.1
2.835ArgLeu: 2.835 ± 0.104
0.863ArgMet: 0.863 ± 0.062
2.29ArgAsn: 2.29 ± 0.092
0.856ArgPro: 0.856 ± 0.052
1.201ArgGln: 1.201 ± 0.069
1.279ArgArg: 1.279 ± 0.074
1.682ArgSer: 1.682 ± 0.094
1.597ArgThr: 1.597 ± 0.071
1.871ArgVal: 1.871 ± 0.081
0.319ArgTrp: 0.319 ± 0.034
1.275ArgTyr: 1.275 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.472SerAla: 3.472 ± 0.121
0.363SerCys: 0.363 ± 0.035
2.905SerAsp: 2.905 ± 0.125
4.451SerGlu: 4.451 ± 0.156
3.358SerPhe: 3.358 ± 0.118
3.81SerGly: 3.81 ± 0.109
0.83SerHis: 0.83 ± 0.049
5.585SerIle: 5.585 ± 0.156
5.84SerLys: 5.84 ± 0.17
6.089SerLeu: 6.089 ± 0.196
1.253SerMet: 1.253 ± 0.063
4.128SerAsn: 4.128 ± 0.161
1.508SerPro: 1.508 ± 0.073
2.546SerGln: 2.546 ± 0.094
2.038SerArg: 2.038 ± 0.095
4.321SerSer: 4.321 ± 0.172
3.587SerThr: 3.587 ± 0.128
3.676SerVal: 3.676 ± 0.119
0.86SerTrp: 0.86 ± 0.054
2.572SerTyr: 2.572 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
3.309ThrAla: 3.309 ± 0.122
0.285ThrCys: 0.285 ± 0.031
2.735ThrAsp: 2.735 ± 0.116
3.206ThrGlu: 3.206 ± 0.123
2.965ThrPhe: 2.965 ± 0.11
3.635ThrGly: 3.635 ± 0.119
0.649ThrHis: 0.649 ± 0.051
5.455ThrIle: 5.455 ± 0.149
5.066ThrLys: 5.066 ± 0.122
5.155ThrLeu: 5.155 ± 0.151
1.093ThrMet: 1.093 ± 0.059
3.635ThrAsn: 3.635 ± 0.124
1.831ThrPro: 1.831 ± 0.085
1.594ThrGln: 1.594 ± 0.072
1.768ThrArg: 1.768 ± 0.087
3.532ThrSer: 3.532 ± 0.105
3.658ThrThr: 3.658 ± 0.131
3.487ThrVal: 3.487 ± 0.125
0.545ThrTrp: 0.545 ± 0.039
1.894ThrTyr: 1.894 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
4.555ValAla: 4.555 ± 0.153
0.415ValCys: 0.415 ± 0.047
3.361ValAsp: 3.361 ± 0.129
4.247ValGlu: 4.247 ± 0.134
2.902ValPhe: 2.902 ± 0.124
3.584ValGly: 3.584 ± 0.131
0.726ValHis: 0.726 ± 0.049
6.041ValIle: 6.041 ± 0.159
5.114ValLys: 5.114 ± 0.163
5.648ValLeu: 5.648 ± 0.162
1.371ValMet: 1.371 ± 0.079
3.673ValAsn: 3.673 ± 0.12
1.753ValPro: 1.753 ± 0.083
1.668ValGln: 1.668 ± 0.09
1.842ValArg: 1.842 ± 0.089
4.251ValSer: 4.251 ± 0.127
3.498ValThr: 3.498 ± 0.117
4.154ValVal: 4.154 ± 0.157
0.56ValTrp: 0.56 ± 0.046
2.224ValTyr: 2.224 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.608TrpAla: 0.608 ± 0.048
0.056TrpCys: 0.056 ± 0.014
0.548TrpAsp: 0.548 ± 0.05
0.73TrpGlu: 0.73 ± 0.051
0.66TrpPhe: 0.66 ± 0.046
0.6TrpGly: 0.6 ± 0.053
0.137TrpHis: 0.137 ± 0.023
1.067TrpIle: 1.067 ± 0.065
0.975TrpLys: 0.975 ± 0.061
0.975TrpLeu: 0.975 ± 0.071
0.304TrpMet: 0.304 ± 0.031
0.8TrpAsn: 0.8 ± 0.053
0.2TrpPro: 0.2 ± 0.028
0.315TrpGln: 0.315 ± 0.038
0.322TrpArg: 0.322 ± 0.031
0.671TrpSer: 0.671 ± 0.051
0.615TrpThr: 0.615 ± 0.045
0.697TrpVal: 0.697 ± 0.053
0.23TrpTrp: 0.23 ± 0.03
0.471TrpTyr: 0.471 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.205TyrAla: 2.205 ± 0.099
0.256TyrCys: 0.256 ± 0.029
2.264TyrAsp: 2.264 ± 0.103
2.583TyrGlu: 2.583 ± 0.11
2.146TyrPhe: 2.146 ± 0.101
2.138TyrGly: 2.138 ± 0.082
0.548TyrHis: 0.548 ± 0.044
3.157TyrIle: 3.157 ± 0.11
3.354TyrLys: 3.354 ± 0.132
3.891TyrLeu: 3.891 ± 0.136
0.819TyrMet: 0.819 ± 0.053
2.564TyrAsn: 2.564 ± 0.107
0.826TyrPro: 0.826 ± 0.061
1.853TyrGln: 1.853 ± 0.086
1.264TyrArg: 1.264 ± 0.071
2.709TyrSer: 2.709 ± 0.112
1.738TyrThr: 1.738 ± 0.084
2.09TyrVal: 2.09 ± 0.098
0.519TyrTrp: 0.519 ± 0.047
1.46TyrTyr: 1.46 ± 0.081
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 740 proteins (269842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski