Amino acid dipepetide frequency for Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.846AlaAla: 11.846 ± 0.157	1.368AlaCys: 1.368 ± 0.042	5.245AlaAsp: 5.245 ± 0.065	6.439AlaGlu: 6.439 ± 0.087	3.433AlaPhe: 3.433 ± 0.058	8.154AlaGly: 8.154 ± 0.108	1.664AlaHis: 1.664 ± 0.039	5.363AlaIle: 5.363 ± 0.077	3.963AlaLys: 3.963 ± 0.071	10.474AlaLeu: 10.474 ± 0.112	2.558AlaMet: 2.558 ± 0.051	2.658AlaAsn: 2.658 ± 0.055	3.649AlaPro: 3.649 ± 0.061	3.322AlaGln: 3.322 ± 0.06	5.432AlaArg: 5.432 ± 0.081	5.027AlaSer: 5.027 ± 0.086	5.341AlaThr: 5.341 ± 0.077	7.447AlaVal: 7.447 ± 0.089	1.065AlaTrp: 1.065 ± 0.032	2.181AlaTyr: 2.181 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.024CysAla: 1.024 ± 0.034	0.314CysCys: 0.314 ± 0.019	0.623CysAsp: 0.623 ± 0.026	0.624CysGlu: 0.624 ± 0.026	0.515CysPhe: 0.515 ± 0.018	1.312CysGly: 1.312 ± 0.039	0.623CysHis: 0.623 ± 0.043	0.717CysIle: 0.717 ± 0.026	0.492CysLys: 0.492 ± 0.02	1.347CysLeu: 1.347 ± 0.037	0.303CysMet: 0.303 ± 0.016	0.433CysAsn: 0.433 ± 0.021	0.78CysPro: 0.78 ± 0.031	0.433CysGln: 0.433 ± 0.024	0.93CysArg: 0.93 ± 0.032	1.05CysSer: 1.05 ± 0.037	0.629CysThr: 0.629 ± 0.024	0.758CysVal: 0.758 ± 0.027	0.163CysTrp: 0.163 ± 0.012	0.401CysTyr: 0.401 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.525AspAla: 4.525 ± 0.066	0.768AspCys: 0.768 ± 0.027	2.614AspAsp: 2.614 ± 0.057	3.436AspGlu: 3.436 ± 0.064	2.053AspPhe: 2.053 ± 0.044	3.921AspGly: 3.921 ± 0.06	1.05AspHis: 1.05 ± 0.03	3.194AspIle: 3.194 ± 0.058	2.292AspLys: 2.292 ± 0.05	5.889AspLeu: 5.889 ± 0.084	1.027AspMet: 1.027 ± 0.035	1.657AspAsn: 1.657 ± 0.042	2.646AspPro: 2.646 ± 0.042	2.118AspGln: 2.118 ± 0.04	3.208AspArg: 3.208 ± 0.065	2.785AspSer: 2.785 ± 0.048	2.603AspThr: 2.603 ± 0.045	2.899AspVal: 2.899 ± 0.046	0.689AspTrp: 0.689 ± 0.026	1.651AspTyr: 1.651 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.933GluAla: 5.933 ± 0.086	0.502GluCys: 0.502 ± 0.021	2.369GluAsp: 2.369 ± 0.046	4.218GluGlu: 4.218 ± 0.085	2.052GluPhe: 2.052 ± 0.042	3.79GluGly: 3.79 ± 0.066	1.319GluHis: 1.319 ± 0.04	3.946GluIle: 3.946 ± 0.073	3.55GluLys: 3.55 ± 0.062	7.824GluLeu: 7.824 ± 0.083	1.74GluMet: 1.74 ± 0.041	1.871GluAsn: 1.871 ± 0.04	2.232GluPro: 2.232 ± 0.053	3.952GluGln: 3.952 ± 0.075	4.425GluArg: 4.425 ± 0.073	2.915GluSer: 2.915 ± 0.049	3.156GluThr: 3.156 ± 0.049	3.907GluVal: 3.907 ± 0.064	0.586GluTrp: 0.586 ± 0.023	1.646GluTyr: 1.646 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.154PheAla: 3.154 ± 0.052	0.652PheCys: 0.652 ± 0.022	2.234PheAsp: 2.234 ± 0.043	2.243PheGlu: 2.243 ± 0.045	1.676PhePhe: 1.676 ± 0.038	3.175PheGly: 3.175 ± 0.058	0.764PheHis: 0.764 ± 0.025	2.141PheIle: 2.141 ± 0.044	1.755PheLys: 1.755 ± 0.046	3.658PheLeu: 3.658 ± 0.061	0.986PheMet: 0.986 ± 0.027	1.476PheAsn: 1.476 ± 0.036	1.6PhePro: 1.6 ± 0.041	1.172PheGln: 1.172 ± 0.035	2.109PheArg: 2.109 ± 0.041	3.075PheSer: 3.075 ± 0.056	2.219PheThr: 2.219 ± 0.048	2.5PheVal: 2.5 ± 0.045	0.457PheTrp: 0.457 ± 0.021	1.132PheTyr: 1.132 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.027GlyAla: 6.027 ± 0.084	1.362GlyCys: 1.362 ± 0.042	3.679GlyAsp: 3.679 ± 0.062	4.166GlyGlu: 4.166 ± 0.068	3.173GlyPhe: 3.173 ± 0.059	5.762GlyGly: 5.762 ± 0.095	1.591GlyHis: 1.591 ± 0.037	5.209GlyIle: 5.209 ± 0.075	4.11GlyLys: 4.11 ± 0.064	7.79GlyLeu: 7.79 ± 0.078	2.337GlyMet: 2.337 ± 0.049	2.511GlyAsn: 2.511 ± 0.048	2.144GlyPro: 2.144 ± 0.047	2.747GlyGln: 2.747 ± 0.048	4.516GlyArg: 4.516 ± 0.058	4.795GlySer: 4.795 ± 0.074	4.534GlyThr: 4.534 ± 0.073	5.515GlyVal: 5.515 ± 0.062	1.009GlyTrp: 1.009 ± 0.031	2.661GlyTyr: 2.661 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.936HisAla: 1.936 ± 0.039	0.364HisCys: 0.364 ± 0.017	1.227HisAsp: 1.227 ± 0.036	1.261HisGlu: 1.261 ± 0.034	0.854HisPhe: 0.854 ± 0.025	1.705HisGly: 1.705 ± 0.042	0.657HisHis: 0.657 ± 0.026	1.064HisIle: 1.064 ± 0.029	0.829HisLys: 0.829 ± 0.029	2.307HisLeu: 2.307 ± 0.042	0.356HisMet: 0.356 ± 0.019	0.699HisAsn: 0.699 ± 0.023	1.276HisPro: 1.276 ± 0.035	0.926HisGln: 0.926 ± 0.03	1.31HisArg: 1.31 ± 0.038	1.124HisSer: 1.124 ± 0.033	1.102HisThr: 1.102 ± 0.033	1.03HisVal: 1.03 ± 0.028	0.241HisTrp: 0.241 ± 0.013	0.659HisTyr: 0.659 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.735IleAla: 5.735 ± 0.076	0.861IleCys: 0.861 ± 0.023	3.164IleAsp: 3.164 ± 0.055	3.642IleGlu: 3.642 ± 0.06	2.045IlePhe: 2.045 ± 0.05	4.454IleGly: 4.454 ± 0.068	1.211IleHis: 1.211 ± 0.031	3.486IleIle: 3.486 ± 0.058	2.825IleLys: 2.825 ± 0.05	5.287IleLeu: 5.287 ± 0.07	1.35IleMet: 1.35 ± 0.038	2.253IleAsn: 2.253 ± 0.047	3.007IlePro: 3.007 ± 0.043	1.837IleGln: 1.837 ± 0.038	3.677IleArg: 3.677 ± 0.061	4.061IleSer: 4.061 ± 0.062	3.732IleThr: 3.732 ± 0.059	3.751IleVal: 3.751 ± 0.072	0.537IleTrp: 0.537 ± 0.022	1.433IleTyr: 1.433 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.511LysAla: 4.511 ± 0.075	0.431LysCys: 0.431 ± 0.022	2.381LysAsp: 2.381 ± 0.054	3.293LysGlu: 3.293 ± 0.057	1.229LysPhe: 1.229 ± 0.035	3.58LysGly: 3.58 ± 0.069	0.852LysHis: 0.852 ± 0.028	2.77LysIle: 2.77 ± 0.055	2.994LysLys: 2.994 ± 0.072	4.639LysLeu: 4.639 ± 0.078	1.245LysMet: 1.245 ± 0.035	1.813LysAsn: 1.813 ± 0.044	2.321LysPro: 2.321 ± 0.043	2.302LysGln: 2.302 ± 0.044	2.88LysArg: 2.88 ± 0.051	2.526LysSer: 2.526 ± 0.054	2.656LysThr: 2.656 ± 0.047	3.188LysVal: 3.188 ± 0.062	0.354LysTrp: 0.354 ± 0.017	1.144LysTyr: 1.144 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.539LeuAla: 11.539 ± 0.125	1.273LeuCys: 1.273 ± 0.034	5.674LeuAsp: 5.674 ± 0.071	6.868LeuGlu: 6.868 ± 0.091	4.4LeuPhe: 4.4 ± 0.074	7.259LeuGly: 7.259 ± 0.095	2.253LeuHis: 2.253 ± 0.044	5.684LeuIle: 5.684 ± 0.065	5.652LeuLys: 5.652 ± 0.075	13.384LeuLeu: 13.384 ± 0.187	2.472LeuMet: 2.472 ± 0.042	3.438LeuAsn: 3.438 ± 0.052	5.414LeuPro: 5.414 ± 0.074	4.957LeuGln: 4.957 ± 0.075	5.994LeuArg: 5.994 ± 0.091	6.54LeuSer: 6.54 ± 0.079	6.196LeuThr: 6.196 ± 0.079	7.547LeuVal: 7.547 ± 0.088	0.927LeuTrp: 0.927 ± 0.03	2.72LeuTyr: 2.72 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.608MetAla: 2.608 ± 0.046	0.167MetCys: 0.167 ± 0.011	1.165MetAsp: 1.165 ± 0.033	1.41MetGlu: 1.41 ± 0.031	0.692MetPhe: 0.692 ± 0.027	1.764MetGly: 1.764 ± 0.036	0.475MetHis: 0.475 ± 0.02	1.428MetIle: 1.428 ± 0.037	1.462MetLys: 1.462 ± 0.037	2.761MetLeu: 2.761 ± 0.045	0.535MetMet: 0.535 ± 0.024	0.963MetAsn: 0.963 ± 0.025	1.329MetPro: 1.329 ± 0.031	1.17MetGln: 1.17 ± 0.032	1.259MetArg: 1.259 ± 0.034	1.435MetSer: 1.435 ± 0.033	1.57MetThr: 1.57 ± 0.041	1.803MetVal: 1.803 ± 0.046	0.133MetTrp: 0.133 ± 0.01	0.475MetTyr: 0.475 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.733AsnAla: 2.733 ± 0.053	0.456AsnCys: 0.456 ± 0.022	1.587AsnAsp: 1.587 ± 0.031	1.644AsnGlu: 1.644 ± 0.038	1.116AsnPhe: 1.116 ± 0.031	2.733AsnGly: 2.733 ± 0.056	0.705AsnHis: 0.705 ± 0.025	1.934AsnIle: 1.934 ± 0.044	1.337AsnLys: 1.337 ± 0.033	3.783AsnLeu: 3.783 ± 0.062	0.732AsnMet: 0.732 ± 0.023	1.249AsnAsn: 1.249 ± 0.044	1.981AsnPro: 1.981 ± 0.047	1.33AsnGln: 1.33 ± 0.031	2.334AsnArg: 2.334 ± 0.039	1.992AsnSer: 1.992 ± 0.051	1.549AsnThr: 1.549 ± 0.039	1.945AsnVal: 1.945 ± 0.053	0.385AsnTrp: 0.385 ± 0.016	0.976AsnTyr: 0.976 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.846ProAla: 4.846 ± 0.077	0.498ProCys: 0.498 ± 0.022	3.061ProAsp: 3.061 ± 0.056	3.54ProGlu: 3.54 ± 0.061	1.982ProPhe: 1.982 ± 0.043	3.475ProGly: 3.475 ± 0.052	0.953ProHis: 0.953 ± 0.028	1.93ProIle: 1.93 ± 0.04	1.788ProLys: 1.788 ± 0.044	4.931ProLeu: 4.931 ± 0.077	0.976ProMet: 0.976 ± 0.028	1.182ProAsn: 1.182 ± 0.032	2.098ProPro: 2.098 ± 0.047	1.776ProGln: 1.776 ± 0.044	2.033ProArg: 2.033 ± 0.045	2.286ProSer: 2.286 ± 0.042	2.103ProThr: 2.103 ± 0.046	4.0ProVal: 4.0 ± 0.063	0.542ProTrp: 0.542 ± 0.023	1.268ProTyr: 1.268 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.268GlnAla: 4.268 ± 0.073	0.394GlnCys: 0.394 ± 0.022	1.735GlnAsp: 1.735 ± 0.042	2.777GlnGlu: 2.777 ± 0.055	1.327GlnPhe: 1.327 ± 0.034	3.029GlnGly: 3.029 ± 0.051	0.981GlnHis: 0.981 ± 0.028	2.366GlnIle: 2.366 ± 0.048	1.952GlnLys: 1.952 ± 0.046	4.725GlnLeu: 4.725 ± 0.077	1.09GlnMet: 1.09 ± 0.031	1.152GlnAsn: 1.152 ± 0.035	1.97GlnPro: 1.97 ± 0.051	2.857GlnGln: 2.857 ± 0.06	2.693GlnArg: 2.693 ± 0.054	2.025GlnSer: 2.025 ± 0.04	2.116GlnThr: 2.116 ± 0.042	3.028GlnVal: 3.028 ± 0.052	0.409GlnTrp: 0.409 ± 0.017	1.04GlnTyr: 1.04 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.319ArgAla: 4.319 ± 0.074	0.776ArgCys: 0.776 ± 0.032	2.932ArgAsp: 2.932 ± 0.058	4.142ArgGlu: 4.142 ± 0.071	2.843ArgPhe: 2.843 ± 0.052	3.354ArgGly: 3.354 ± 0.052	1.512ArgHis: 1.512 ± 0.039	4.189ArgIle: 4.189 ± 0.071	2.897ArgLys: 2.897 ± 0.055	7.232ArgLeu: 7.232 ± 0.105	1.771ArgMet: 1.771 ± 0.047	2.058ArgAsn: 2.058 ± 0.04	2.364ArgPro: 2.364 ± 0.049	3.001ArgGln: 3.001 ± 0.05	3.77ArgArg: 3.77 ± 0.071	3.48ArgSer: 3.48 ± 0.053	2.896ArgThr: 2.896 ± 0.053	3.761ArgVal: 3.761 ± 0.068	0.695ArgTrp: 0.695 ± 0.025	2.014ArgTyr: 2.014 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.27SerAla: 5.27 ± 0.085	0.983SerCys: 0.983 ± 0.033	3.003SerAsp: 3.003 ± 0.054	3.04SerGlu: 3.04 ± 0.055	2.718SerPhe: 2.718 ± 0.055	5.438SerGly: 5.438 ± 0.085	1.222SerHis: 1.222 ± 0.033	3.421SerIle: 3.421 ± 0.056	2.264SerLys: 2.264 ± 0.053	6.5SerLeu: 6.5 ± 0.076	1.383SerMet: 1.383 ± 0.031	1.877SerAsn: 1.877 ± 0.045	2.601SerPro: 2.601 ± 0.052	2.06SerGln: 2.06 ± 0.037	3.675SerArg: 3.675 ± 0.058	4.214SerSer: 4.214 ± 0.1	3.134SerThr: 3.134 ± 0.067	3.893SerVal: 3.893 ± 0.067	0.735SerTrp: 0.735 ± 0.026	1.828SerTyr: 1.828 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.998ThrAla: 5.998 ± 0.084	0.7ThrCys: 0.7 ± 0.025	2.676ThrAsp: 2.676 ± 0.05	2.873ThrGlu: 2.873 ± 0.052	2.075ThrPhe: 2.075 ± 0.046	5.115ThrGly: 5.115 ± 0.063	0.949ThrHis: 0.949 ± 0.03	3.474ThrIle: 3.474 ± 0.051	2.048ThrLys: 2.048 ± 0.046	5.882ThrLeu: 5.882 ± 0.075	1.182ThrMet: 1.182 ± 0.035	1.624ThrAsn: 1.624 ± 0.044	3.031ThrPro: 3.031 ± 0.05	1.439ThrGln: 1.439 ± 0.039	2.988ThrArg: 2.988 ± 0.059	3.162ThrSer: 3.162 ± 0.064	3.427ThrThr: 3.427 ± 0.073	4.702ThrVal: 4.702 ± 0.067	0.595ThrTrp: 0.595 ± 0.024	1.308ThrTyr: 1.308 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.267ValAla: 7.267 ± 0.096	1.005ValCys: 1.005 ± 0.035	3.539ValAsp: 3.539 ± 0.052	4.366ValGlu: 4.366 ± 0.068	2.381ValPhe: 2.381 ± 0.048	4.664ValGly: 4.664 ± 0.066	1.199ValHis: 1.199 ± 0.033	4.221ValIle: 4.221 ± 0.068	3.296ValLys: 3.296 ± 0.066	7.022ValLeu: 7.022 ± 0.077	1.82ValMet: 1.82 ± 0.04	2.219ValAsn: 2.219 ± 0.045	2.968ValPro: 2.968 ± 0.049	2.535ValGln: 2.535 ± 0.056	4.037ValArg: 4.037 ± 0.07	4.421ValSer: 4.421 ± 0.065	4.394ValThr: 4.394 ± 0.07	5.607ValVal: 5.607 ± 0.082	0.728ValTrp: 0.728 ± 0.028	1.704ValTyr: 1.704 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.733TrpAla: 0.733 ± 0.028	0.152TrpCys: 0.152 ± 0.01	0.546TrpAsp: 0.546 ± 0.021	0.596TrpGlu: 0.596 ± 0.026	0.482TrpPhe: 0.482 ± 0.021	0.756TrpGly: 0.756 ± 0.029	0.29TrpHis: 0.29 ± 0.017	0.574TrpIle: 0.574 ± 0.024	0.512TrpLys: 0.512 ± 0.021	1.402TrpLeu: 1.402 ± 0.04	0.262TrpMet: 0.262 ± 0.014	0.385TrpAsn: 0.385 ± 0.019	0.426TrpPro: 0.426 ± 0.019	0.688TrpGln: 0.688 ± 0.026	0.678TrpArg: 0.678 ± 0.025	0.698TrpSer: 0.698 ± 0.025	0.451TrpThr: 0.451 ± 0.02	0.633TrpVal: 0.633 ± 0.024	0.158TrpTrp: 0.158 ± 0.012	0.363TrpTyr: 0.363 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.357TyrAla: 2.357 ± 0.05	0.443TyrCys: 0.443 ± 0.019	1.571TyrAsp: 1.571 ± 0.038	1.357TyrGlu: 1.357 ± 0.033	1.133TyrPhe: 1.133 ± 0.031	2.199TyrGly: 2.199 ± 0.039	0.659TyrHis: 0.659 ± 0.023	1.238TyrIle: 1.238 ± 0.033	1.09TyrLys: 1.09 ± 0.035	3.354TyrLeu: 3.354 ± 0.053	0.477TyrMet: 0.477 ± 0.021	0.983TyrAsn: 0.983 ± 0.037	1.431TyrPro: 1.431 ± 0.039	1.313TyrGln: 1.313 ± 0.038	2.058TyrArg: 2.058 ± 0.04	1.648TyrSer: 1.648 ± 0.04	1.438TyrThr: 1.438 ± 0.044	1.476TyrVal: 1.476 ± 0.039	0.377TyrTrp: 0.377 ± 0.018	0.958TyrTyr: 0.958 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3644 proteins (1204365 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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