Amino acid dipepetide frequency for Salmonella enterica subsp. enterica serovar Newport str. S09097

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.252AlaAla: 10.252 ± 0.258
1.446AlaCys: 1.446 ± 0.097
5.156AlaAsp: 5.156 ± 0.163
5.75AlaGlu: 5.75 ± 0.194
3.177AlaPhe: 3.177 ± 0.141
7.481AlaGly: 7.481 ± 0.209
1.939AlaHis: 1.939 ± 0.086
5.943AlaIle: 5.943 ± 0.166
3.974AlaLys: 3.974 ± 0.156
11.363AlaLeu: 11.363 ± 0.277
3.187AlaMet: 3.187 ± 0.131
3.187AlaAsn: 3.187 ± 0.126
3.903AlaPro: 3.903 ± 0.148
4.618AlaGln: 4.618 ± 0.172
5.73AlaArg: 5.73 ± 0.172
5.441AlaSer: 5.441 ± 0.183
4.715AlaThr: 4.715 ± 0.167
6.877AlaVal: 6.877 ± 0.199
1.573AlaTrp: 1.573 ± 0.089
2.02AlaTyr: 2.02 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
1.32CysAla: 1.32 ± 0.086
0.365CysCys: 0.365 ± 0.05
0.66CysAsp: 0.66 ± 0.064
0.858CysGlu: 0.858 ± 0.067
0.482CysPhe: 0.482 ± 0.053
1.264CysGly: 1.264 ± 0.081
0.396CysHis: 0.396 ± 0.05
0.726CysIle: 0.726 ± 0.061
0.411CysLys: 0.411 ± 0.05
1.147CysLeu: 1.147 ± 0.078
0.33CysMet: 0.33 ± 0.038
0.376CysAsn: 0.376 ± 0.049
0.609CysPro: 0.609 ± 0.058
0.548CysGln: 0.548 ± 0.055
1.071CysArg: 1.071 ± 0.075
0.797CysSer: 0.797 ± 0.062
0.675CysThr: 0.675 ± 0.056
0.868CysVal: 0.868 ± 0.067
0.249CysTrp: 0.249 ± 0.035
0.442CysTyr: 0.442 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
5.349AspAla: 5.349 ± 0.178
0.604AspCys: 0.604 ± 0.055
3.035AspAsp: 3.035 ± 0.149
3.598AspGlu: 3.598 ± 0.137
1.929AspPhe: 1.929 ± 0.108
4.157AspGly: 4.157 ± 0.147
1.02AspHis: 1.02 ± 0.073
3.395AspIle: 3.395 ± 0.118
2.527AspLys: 2.527 ± 0.097
4.476AspLeu: 4.476 ± 0.139
1.365AspMet: 1.365 ± 0.085
2.198AspAsn: 2.198 ± 0.109
2.01AspPro: 2.01 ± 0.112
1.512AspGln: 1.512 ± 0.091
2.527AspArg: 2.527 ± 0.117
2.857AspSer: 2.857 ± 0.117
2.593AspThr: 2.593 ± 0.114
3.679AspVal: 3.679 ± 0.14
0.705AspTrp: 0.705 ± 0.053
1.71AspTyr: 1.71 ± 0.095
0.0AspXaa: 0.0 ± 0.0
Glu
5.583GluAla: 5.583 ± 0.162
0.609GluCys: 0.609 ± 0.057
2.426GluAsp: 2.426 ± 0.093
3.319GluGlu: 3.319 ± 0.158
1.7GluPhe: 1.7 ± 0.095
3.7GluGly: 3.7 ± 0.134
1.37GluHis: 1.37 ± 0.08
3.324GluIle: 3.324 ± 0.137
3.243GluLys: 3.243 ± 0.13
5.562GluLeu: 5.562 ± 0.167
1.918GluMet: 1.918 ± 0.096
2.37GluAsn: 2.37 ± 0.115
1.949GluPro: 1.949 ± 0.1
3.334GluGln: 3.334 ± 0.148
3.928GluArg: 3.928 ± 0.174
3.136GluSer: 3.136 ± 0.132
3.273GluThr: 3.273 ± 0.145
3.476GluVal: 3.476 ± 0.164
0.837GluTrp: 0.837 ± 0.066
1.482GluTyr: 1.482 ± 0.089
0.0GluXaa: 0.0 ± 0.0
Phe
3.537PheAla: 3.537 ± 0.128
0.573PheCys: 0.573 ± 0.057
2.02PheAsp: 2.02 ± 0.104
1.619PheGlu: 1.619 ± 0.092
1.594PhePhe: 1.594 ± 0.105
2.512PheGly: 2.512 ± 0.12
0.716PheHis: 0.716 ± 0.056
2.406PheIle: 2.406 ± 0.113
1.269PheLys: 1.269 ± 0.069
2.832PheLeu: 2.832 ± 0.113
1.117PheMet: 1.117 ± 0.069
1.517PheAsn: 1.517 ± 0.094
1.604PhePro: 1.604 ± 0.095
0.99PheGln: 0.99 ± 0.065
1.939PheArg: 1.939 ± 0.097
2.822PheSer: 2.822 ± 0.135
2.431PheThr: 2.431 ± 0.121
2.34PheVal: 2.34 ± 0.109
0.624PheTrp: 0.624 ± 0.06
1.045PheTyr: 1.045 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
6.202GlyAla: 6.202 ± 0.161
1.233GlyCys: 1.233 ± 0.077
3.882GlyAsp: 3.882 ± 0.154
4.7GlyGlu: 4.7 ± 0.16
2.842GlyPhe: 2.842 ± 0.101
5.446GlyGly: 5.446 ± 0.207
1.695GlyHis: 1.695 ± 0.1
4.923GlyIle: 4.923 ± 0.157
4.096GlyLys: 4.096 ± 0.152
6.785GlyLeu: 6.785 ± 0.203
2.329GlyMet: 2.329 ± 0.094
2.893GlyAsn: 2.893 ± 0.126
1.863GlyPro: 1.863 ± 0.089
2.949GlyGln: 2.949 ± 0.128
3.801GlyArg: 3.801 ± 0.13
4.136GlySer: 4.136 ± 0.14
3.745GlyThr: 3.745 ± 0.161
5.77GlyVal: 5.77 ± 0.177
1.274GlyTrp: 1.274 ± 0.085
2.507GlyTyr: 2.507 ± 0.113
0.0GlyXaa: 0.0 ± 0.0
His
1.929HisAla: 1.929 ± 0.089
0.431HisCys: 0.431 ± 0.041
1.162HisAsp: 1.162 ± 0.06
1.056HisGlu: 1.056 ± 0.079
0.893HisPhe: 0.893 ± 0.073
1.685HisGly: 1.685 ± 0.088
0.776HisHis: 0.776 ± 0.072
1.517HisIle: 1.517 ± 0.093
0.782HisLys: 0.782 ± 0.064
2.248HisLeu: 2.248 ± 0.102
0.568HisMet: 0.568 ± 0.051
0.761HisAsn: 0.761 ± 0.06
1.441HisPro: 1.441 ± 0.086
1.304HisGln: 1.304 ± 0.083
1.396HisArg: 1.396 ± 0.071
1.172HisSer: 1.172 ± 0.069
1.228HisThr: 1.228 ± 0.078
1.396HisVal: 1.396 ± 0.085
0.34HisTrp: 0.34 ± 0.038
0.822HisTyr: 0.822 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
6.435IleAla: 6.435 ± 0.2
0.746IleCys: 0.746 ± 0.064
3.314IleAsp: 3.314 ± 0.125
3.355IleGlu: 3.355 ± 0.125
1.741IlePhe: 1.741 ± 0.094
4.177IleGly: 4.177 ± 0.147
1.38IleHis: 1.38 ± 0.092
3.466IleIle: 3.466 ± 0.133
2.68IleLys: 2.68 ± 0.136
5.085IleLeu: 5.085 ± 0.17
1.37IleMet: 1.37 ± 0.085
2.781IleAsn: 2.781 ± 0.126
2.624IlePro: 2.624 ± 0.113
1.903IleGln: 1.903 ± 0.105
3.289IleArg: 3.289 ± 0.129
3.877IleSer: 3.877 ± 0.138
3.903IleThr: 3.903 ± 0.164
3.781IleVal: 3.781 ± 0.129
0.853IleTrp: 0.853 ± 0.064
1.685IleTyr: 1.685 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
4.202LysAla: 4.202 ± 0.161
0.35LysCys: 0.35 ± 0.043
1.873LysAsp: 1.873 ± 0.096
2.517LysGlu: 2.517 ± 0.117
1.142LysPhe: 1.142 ± 0.073
2.903LysGly: 2.903 ± 0.128
0.883LysHis: 0.883 ± 0.062
2.558LysIle: 2.558 ± 0.124
2.482LysLys: 2.482 ± 0.13
4.162LysLeu: 4.162 ± 0.152
1.365LysMet: 1.365 ± 0.081
1.954LysAsn: 1.954 ± 0.097
2.126LysPro: 2.126 ± 0.104
1.923LysGln: 1.923 ± 0.106
3.055LysArg: 3.055 ± 0.138
2.502LysSer: 2.502 ± 0.105
2.578LysThr: 2.578 ± 0.124
2.822LysVal: 2.822 ± 0.115
0.396LysTrp: 0.396 ± 0.05
1.269LysTyr: 1.269 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
10.937LeuAla: 10.937 ± 0.25
1.294LeuCys: 1.294 ± 0.083
5.182LeuAsp: 5.182 ± 0.173
5.141LeuGlu: 5.141 ± 0.173
3.837LeuPhe: 3.837 ± 0.169
6.582LeuGly: 6.582 ± 0.172
2.172LeuHis: 2.172 ± 0.095
5.877LeuIle: 5.877 ± 0.184
4.522LeuLys: 4.522 ± 0.168
11.358LeuLeu: 11.358 ± 0.318
3.045LeuMet: 3.045 ± 0.134
4.091LeuAsn: 4.091 ± 0.146
5.593LeuPro: 5.593 ± 0.177
3.948LeuGln: 3.948 ± 0.142
6.405LeuArg: 6.405 ± 0.192
7.171LeuSer: 7.171 ± 0.212
6.501LeuThr: 6.501 ± 0.234
6.735LeuVal: 6.735 ± 0.199
1.462LeuTrp: 1.462 ± 0.09
2.664LeuTyr: 2.664 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
3.131MetAla: 3.131 ± 0.12
0.279MetCys: 0.279 ± 0.035
1.304MetAsp: 1.304 ± 0.079
1.223MetGlu: 1.223 ± 0.075
0.853MetPhe: 0.853 ± 0.063
1.863MetGly: 1.863 ± 0.113
0.548MetHis: 0.548 ± 0.048
1.634MetIle: 1.634 ± 0.095
1.614MetLys: 1.614 ± 0.085
3.187MetLeu: 3.187 ± 0.108
0.878MetMet: 0.878 ± 0.07
1.188MetAsn: 1.188 ± 0.076
1.421MetPro: 1.421 ± 0.078
1.299MetGln: 1.299 ± 0.091
1.69MetArg: 1.69 ± 0.091
1.913MetSer: 1.913 ± 0.089
1.873MetThr: 1.873 ± 0.097
2.066MetVal: 2.066 ± 0.107
0.325MetTrp: 0.325 ± 0.042
0.533MetTyr: 0.533 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.771AsnAla: 3.771 ± 0.159
0.497AsnCys: 0.497 ± 0.048
2.071AsnAsp: 2.071 ± 0.1
1.898AsnGlu: 1.898 ± 0.106
1.198AsnPhe: 1.198 ± 0.076
3.253AsnGly: 3.253 ± 0.139
0.787AsnHis: 0.787 ± 0.062
2.269AsnIle: 2.269 ± 0.138
1.482AsnLys: 1.482 ± 0.082
3.446AsnLeu: 3.446 ± 0.137
1.051AsnMet: 1.051 ± 0.072
1.639AsnAsn: 1.639 ± 0.101
1.964AsnPro: 1.964 ± 0.096
1.589AsnGln: 1.589 ± 0.093
2.157AsnArg: 2.157 ± 0.098
2.005AsnSer: 2.005 ± 0.11
2.05AsnThr: 2.05 ± 0.114
2.609AsnVal: 2.609 ± 0.122
0.568AsnTrp: 0.568 ± 0.043
1.391AsnTyr: 1.391 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
4.248ProAla: 4.248 ± 0.149
0.487ProCys: 0.487 ± 0.063
2.746ProAsp: 2.746 ± 0.124
3.324ProGlu: 3.324 ± 0.135
1.827ProPhe: 1.827 ± 0.087
3.537ProGly: 3.537 ± 0.128
1.056ProHis: 1.056 ± 0.06
1.654ProIle: 1.654 ± 0.094
1.411ProLys: 1.411 ± 0.088
5.009ProLeu: 5.009 ± 0.174
1.188ProMet: 1.188 ± 0.082
1.218ProAsn: 1.218 ± 0.078
1.893ProPro: 1.893 ± 0.105
2.309ProGln: 2.309 ± 0.1
2.076ProArg: 2.076 ± 0.102
2.086ProSer: 2.086 ± 0.118
2.076ProThr: 2.076 ± 0.096
4.106ProVal: 4.106 ± 0.162
0.65ProTrp: 0.65 ± 0.056
1.071ProTyr: 1.071 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
4.415GlnAla: 4.415 ± 0.158
0.523GlnCys: 0.523 ± 0.052
1.705GlnAsp: 1.705 ± 0.086
2.619GlnGlu: 2.619 ± 0.124
1.533GlnPhe: 1.533 ± 0.084
3.025GlnGly: 3.025 ± 0.137
1.218GlnHis: 1.218 ± 0.092
2.416GlnIle: 2.416 ± 0.11
1.923GlnLys: 1.923 ± 0.102
4.598GlnLeu: 4.598 ± 0.154
1.218GlnMet: 1.218 ± 0.073
1.446GlnAsn: 1.446 ± 0.086
2.187GlnPro: 2.187 ± 0.108
3.248GlnGln: 3.248 ± 0.16
3.273GlnArg: 3.273 ± 0.122
2.461GlnSer: 2.461 ± 0.101
2.264GlnThr: 2.264 ± 0.103
2.918GlnVal: 2.918 ± 0.133
0.756GlnTrp: 0.756 ± 0.066
1.335GlnTyr: 1.335 ± 0.078
0.0GlnXaa: 0.0 ± 0.0
Arg
4.578ArgAla: 4.578 ± 0.137
0.883ArgCys: 0.883 ± 0.067
3.096ArgAsp: 3.096 ± 0.126
4.03ArgGlu: 4.03 ± 0.119
2.395ArgPhe: 2.395 ± 0.116
3.659ArgGly: 3.659 ± 0.163
1.893ArgHis: 1.893 ± 0.104
3.822ArgIle: 3.822 ± 0.151
2.522ArgLys: 2.522 ± 0.096
6.867ArgLeu: 6.867 ± 0.212
1.883ArgMet: 1.883 ± 0.088
2.061ArgAsn: 2.061 ± 0.086
2.111ArgPro: 2.111 ± 0.126
3.537ArgGln: 3.537 ± 0.149
4.4ArgArg: 4.4 ± 0.156
2.918ArgSer: 2.918 ± 0.138
2.649ArgThr: 2.649 ± 0.114
3.745ArgVal: 3.745 ± 0.136
0.985ArgTrp: 0.985 ± 0.073
2.446ArgTyr: 2.446 ± 0.117
0.0ArgXaa: 0.0 ± 0.0
Ser
6.232SerAla: 6.232 ± 0.18
0.883SerCys: 0.883 ± 0.074
2.898SerAsp: 2.898 ± 0.126
3.025SerGlu: 3.025 ± 0.127
2.147SerPhe: 2.147 ± 0.089
5.435SerGly: 5.435 ± 0.16
1.32SerHis: 1.32 ± 0.081
3.096SerIle: 3.096 ± 0.138
1.923SerLys: 1.923 ± 0.105
6.75SerLeu: 6.75 ± 0.203
1.482SerMet: 1.482 ± 0.088
1.619SerAsn: 1.619 ± 0.102
2.614SerPro: 2.614 ± 0.116
2.751SerGln: 2.751 ± 0.133
3.619SerArg: 3.619 ± 0.128
3.573SerSer: 3.573 ± 0.172
2.817SerThr: 2.817 ± 0.125
4.385SerVal: 4.385 ± 0.136
0.964SerTrp: 0.964 ± 0.072
1.533SerTyr: 1.533 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
5.212ThrAla: 5.212 ± 0.159
0.665ThrCys: 0.665 ± 0.057
2.857ThrAsp: 2.857 ± 0.121
2.695ThrGlu: 2.695 ± 0.116
1.934ThrPhe: 1.934 ± 0.096
4.72ThrGly: 4.72 ± 0.17
1.36ThrHis: 1.36 ± 0.087
2.974ThrIle: 2.974 ± 0.13
1.72ThrLys: 1.72 ± 0.091
7.43ThrLeu: 7.43 ± 0.22
1.279ThrMet: 1.279 ± 0.08
1.736ThrAsn: 1.736 ± 0.105
3.41ThrPro: 3.41 ± 0.159
2.314ThrGln: 2.314 ± 0.102
2.994ThrArg: 2.994 ± 0.111
2.827ThrSer: 2.827 ± 0.126
3.02ThrThr: 3.02 ± 0.126
4.162ThrVal: 4.162 ± 0.139
0.695ThrTrp: 0.695 ± 0.057
1.127ThrTyr: 1.127 ± 0.093
0.0ThrXaa: 0.0 ± 0.0
Val
6.912ValAla: 6.912 ± 0.211
0.883ValCys: 0.883 ± 0.065
3.796ValAsp: 3.796 ± 0.131
3.989ValGlu: 3.989 ± 0.143
2.477ValPhe: 2.477 ± 0.128
4.623ValGly: 4.623 ± 0.152
1.238ValHis: 1.238 ± 0.078
4.512ValIle: 4.512 ± 0.154
3.116ValLys: 3.116 ± 0.129
6.77ValLeu: 6.77 ± 0.181
2.258ValMet: 2.258 ± 0.122
3.01ValAsn: 3.01 ± 0.113
2.659ValPro: 2.659 ± 0.128
2.238ValGln: 2.238 ± 0.105
3.73ValArg: 3.73 ± 0.142
4.75ValSer: 4.75 ± 0.144
4.527ValThr: 4.527 ± 0.179
5.583ValVal: 5.583 ± 0.197
1.172ValTrp: 1.172 ± 0.082
1.654ValTyr: 1.654 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
1.061TrpAla: 1.061 ± 0.068
0.289TrpCys: 0.289 ± 0.042
0.573TrpAsp: 0.573 ± 0.057
0.614TrpGlu: 0.614 ± 0.057
0.624TrpPhe: 0.624 ± 0.061
0.746TrpGly: 0.746 ± 0.073
0.442TrpHis: 0.442 ± 0.045
0.67TrpIle: 0.67 ± 0.047
0.447TrpLys: 0.447 ± 0.052
2.548TrpLeu: 2.548 ± 0.131
0.426TrpMet: 0.426 ± 0.041
0.497TrpAsn: 0.497 ± 0.039
0.65TrpPro: 0.65 ± 0.056
1.248TrpGln: 1.248 ± 0.076
1.223TrpArg: 1.223 ± 0.087
0.848TrpSer: 0.848 ± 0.069
0.609TrpThr: 0.609 ± 0.053
0.99TrpVal: 0.99 ± 0.078
0.233TrpTrp: 0.233 ± 0.035
0.401TrpTyr: 0.401 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.421TyrAla: 2.421 ± 0.119
0.548TyrCys: 0.548 ± 0.056
1.492TyrAsp: 1.492 ± 0.086
1.213TyrGlu: 1.213 ± 0.075
1.183TyrPhe: 1.183 ± 0.078
2.304TyrGly: 2.304 ± 0.108
0.7TyrHis: 0.7 ± 0.066
1.264TyrIle: 1.264 ± 0.08
0.919TyrLys: 0.919 ± 0.077
2.893TyrLeu: 2.893 ± 0.115
0.563TyrMet: 0.563 ± 0.054
1.152TyrAsn: 1.152 ± 0.074
1.34TyrPro: 1.34 ± 0.094
1.517TyrGln: 1.517 ± 0.096
2.177TyrArg: 2.177 ± 0.105
1.771TyrSer: 1.771 ± 0.092
1.604TyrThr: 1.604 ± 0.098
1.594TyrVal: 1.594 ± 0.096
0.477TyrTrp: 0.477 ± 0.047
0.959TyrTyr: 0.959 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1663 proteins (197040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski