Amino acid dipepetide frequency for Herbert virus strain F23/CI/2004

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.862AlaCys: 0.862 ± 1.394
1.15AlaAsp: 1.15 ± 0.207
1.725AlaGlu: 1.725 ± 0.342
1.725AlaPhe: 1.725 ± 0.342
2.012AlaGly: 2.012 ± 0.948
0.862AlaHis: 0.862 ± 0.614
3.162AlaIle: 3.162 ± 1.97
4.312AlaLys: 4.312 ± 1.27
2.874AlaLeu: 2.874 ± 1.305
0.862AlaMet: 0.862 ± 0.453
2.587AlaAsn: 2.587 ± 1.02
0.862AlaPro: 0.862 ± 0.171
0.862AlaGln: 0.862 ± 0.171
1.437AlaArg: 1.437 ± 0.397
1.437AlaSer: 1.437 ± 0.529
1.725AlaThr: 1.725 ± 0.671
0.575AlaVal: 0.575 ± 0.247
0.575AlaTrp: 0.575 ± 0.302
1.437AlaTyr: 1.437 ± 1.249
0.0AlaXaa: 0.0 ± 0.0
Cys
1.15CysAla: 1.15 ± 1.447
0.575CysCys: 0.575 ± 0.302
1.437CysAsp: 1.437 ± 0.859
0.575CysGlu: 0.575 ± 0.745
1.437CysPhe: 1.437 ± 0.397
2.012CysGly: 2.012 ± 2.101
0.862CysHis: 0.862 ± 0.614
1.725CysIle: 1.725 ± 0.468
1.725CysLys: 1.725 ± 1.228
0.862CysLeu: 0.862 ± 0.614
0.287CysMet: 0.287 ± 0.151
1.437CysAsn: 1.437 ± 1.357
0.862CysPro: 0.862 ± 0.453
0.287CysGln: 0.287 ± 0.151
1.725CysArg: 1.725 ± 0.342
1.437CysSer: 1.437 ± 0.319
0.575CysThr: 0.575 ± 0.247
1.15CysVal: 1.15 ± 0.495
0.287CysTrp: 0.287 ± 0.151
1.15CysTyr: 1.15 ± 0.985
0.0CysXaa: 0.0 ± 0.0
Asp
2.3AspAla: 2.3 ± 0.989
0.862AspCys: 0.862 ± 1.118
4.024AspAsp: 4.024 ± 0.162
2.012AspGlu: 2.012 ± 1.351
3.737AspPhe: 3.737 ± 0.673
0.575AspGly: 0.575 ± 0.745
0.287AspHis: 0.287 ± 0.151
6.899AspIle: 6.899 ± 1.143
4.024AspLys: 4.024 ± 0.696
8.911AspLeu: 8.911 ± 0.763
4.024AspMet: 4.024 ± 1.639
3.737AspAsn: 3.737 ± 1.511
2.012AspPro: 2.012 ± 1.057
2.3AspGln: 2.3 ± 0.743
1.725AspArg: 1.725 ± 0.455
3.737AspSer: 3.737 ± 1.489
3.449AspThr: 3.449 ± 0.683
5.461AspVal: 5.461 ± 2.264
0.862AspTrp: 0.862 ± 0.171
2.874AspTyr: 2.874 ± 0.638
0.0AspXaa: 0.0 ± 0.0
Glu
2.012GluAla: 2.012 ± 0.348
0.575GluCys: 0.575 ± 0.247
2.874GluAsp: 2.874 ± 0.638
1.15GluGlu: 1.15 ± 0.604
6.899GluPhe: 6.899 ± 1.629
1.437GluGly: 1.437 ± 1.588
0.0GluHis: 0.0 ± 0.0
6.899GluIle: 6.899 ± 1.143
4.886GluLys: 4.886 ± 1.634
3.449GluLeu: 3.449 ± 0.219
2.874GluMet: 2.874 ± 0.638
3.162GluAsn: 3.162 ± 1.97
2.012GluPro: 2.012 ± 1.057
3.162GluGln: 3.162 ± 0.771
1.15GluArg: 1.15 ± 0.604
4.024GluSer: 4.024 ± 0.162
4.886GluThr: 4.886 ± 0.731
2.012GluVal: 2.012 ± 0.597
0.287GluTrp: 0.287 ± 0.151
3.162GluTyr: 3.162 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
1.15PheAla: 1.15 ± 0.207
2.3PheCys: 2.3 ± 0.414
4.599PheAsp: 4.599 ± 1.487
4.024PheGlu: 4.024 ± 0.851
3.162PhePhe: 3.162 ± 0.771
1.725PheGly: 1.725 ± 0.342
0.575PheHis: 0.575 ± 0.302
3.162PheIle: 3.162 ± 0.771
7.473PheLys: 7.473 ± 0.616
6.324PheLeu: 6.324 ± 0.42
1.725PheMet: 1.725 ± 0.461
2.587PheAsn: 2.587 ± 0.323
1.15PhePro: 1.15 ± 0.604
2.874PheGln: 2.874 ± 1.04
2.3PheArg: 2.3 ± 1.242
4.886PheSer: 4.886 ± 1.451
2.587PheThr: 2.587 ± 0.323
2.587PheVal: 2.587 ± 1.359
0.287PheTrp: 0.287 ± 0.151
2.874PheTyr: 2.874 ± 1.472
0.0PheXaa: 0.0 ± 0.0
Gly
0.862GlyAla: 0.862 ± 0.453
2.012GlyCys: 2.012 ± 0.64
4.312GlyAsp: 4.312 ± 1.192
4.024GlyGlu: 4.024 ± 2.38
2.874GlyPhe: 2.874 ± 0.283
0.862GlyGly: 0.862 ± 1.394
0.862GlyHis: 0.862 ± 0.614
4.886GlyIle: 4.886 ± 1.032
2.587GlyLys: 2.587 ± 2.126
3.162GlyLeu: 3.162 ± 0.726
1.437GlyMet: 1.437 ± 0.529
1.437GlyAsn: 1.437 ± 0.859
1.725GlyPro: 1.725 ± 1.466
0.862GlyGln: 0.862 ± 1.118
1.15GlyArg: 1.15 ± 0.207
3.737GlySer: 3.737 ± 2.047
2.3GlyThr: 2.3 ± 0.56
1.437GlyVal: 1.437 ± 1.283
0.287GlyTrp: 0.287 ± 0.151
2.587GlyTyr: 2.587 ± 0.557
0.0GlyXaa: 0.0 ± 0.0
His
0.287HisAla: 0.287 ± 0.373
0.287HisCys: 0.287 ± 0.373
0.862HisAsp: 0.862 ± 0.453
1.437HisGlu: 1.437 ± 0.811
0.575HisPhe: 0.575 ± 0.302
0.287HisGly: 0.287 ± 0.151
0.575HisHis: 0.575 ± 0.302
1.15HisIle: 1.15 ± 0.495
0.575HisLys: 0.575 ± 0.247
1.437HisLeu: 1.437 ± 0.811
0.287HisMet: 0.287 ± 0.151
0.862HisAsn: 0.862 ± 0.171
0.287HisPro: 0.287 ± 0.373
0.287HisGln: 0.287 ± 0.151
0.287HisArg: 0.287 ± 0.151
1.437HisSer: 1.437 ± 0.755
0.287HisThr: 0.287 ± 0.151
0.287HisVal: 0.287 ± 0.735
0.0HisTrp: 0.0 ± 0.0
0.575HisTyr: 0.575 ± 0.745
0.0HisXaa: 0.0 ± 0.0
Ile
2.587IleAla: 2.587 ± 1.265
2.587IleCys: 2.587 ± 0.885
6.899IleAsp: 6.899 ± 0.427
6.899IleGlu: 6.899 ± 1.629
3.737IlePhe: 3.737 ± 1.051
4.024IleGly: 4.024 ± 0.372
0.575IleHis: 0.575 ± 0.302
5.174IleIle: 5.174 ± 0.242
8.911IleLys: 8.911 ± 1.618
8.048IleLeu: 8.048 ± 0.631
3.162IleMet: 3.162 ± 1.131
6.036IleAsn: 6.036 ± 0.302
2.012IlePro: 2.012 ± 0.597
4.024IleGln: 4.024 ± 1.391
3.737IleArg: 3.737 ± 0.529
7.473IleSer: 7.473 ± 1.911
4.024IleThr: 4.024 ± 0.162
3.449IleVal: 3.449 ± 2.197
1.437IleTrp: 1.437 ± 0.529
4.599IleTyr: 4.599 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
2.874LysAla: 2.874 ± 1.621
1.725LysCys: 1.725 ± 0.342
4.886LysAsp: 4.886 ± 1.6
6.324LysGlu: 6.324 ± 1.938
4.312LysPhe: 4.312 ± 0.749
6.036LysGly: 6.036 ± 1.252
0.575LysHis: 0.575 ± 0.302
7.761LysIle: 7.761 ± 2.926
7.761LysLys: 7.761 ± 0.739
10.348LysLeu: 10.348 ± 1.785
2.012LysMet: 2.012 ± 1.057
4.024LysAsn: 4.024 ± 0.162
1.725LysPro: 1.725 ± 0.455
1.725LysGln: 1.725 ± 0.671
3.162LysArg: 3.162 ± 0.318
7.761LysSer: 7.761 ± 0.408
8.336LysThr: 8.336 ± 1.54
5.174LysVal: 5.174 ± 0.646
1.15LysTrp: 1.15 ± 0.954
4.886LysTyr: 4.886 ± 0.58
0.0LysXaa: 0.0 ± 0.0
Leu
2.3LeuAla: 2.3 ± 0.417
1.15LeuCys: 1.15 ± 0.495
7.186LeuAsp: 7.186 ± 0.508
7.761LeuGlu: 7.761 ± 1.549
5.174LeuPhe: 5.174 ± 0.728
4.599LeuGly: 4.599 ± 0.085
0.862LeuHis: 0.862 ± 0.171
9.485LeuIle: 9.485 ± 2.964
8.336LeuLys: 8.336 ± 0.595
9.485LeuLeu: 9.485 ± 2.313
2.587LeuMet: 2.587 ± 0.512
6.899LeuAsn: 6.899 ± 1.629
3.162LeuPro: 3.162 ± 1.66
3.162LeuGln: 3.162 ± 0.318
2.3LeuArg: 2.3 ± 0.904
6.611LeuSer: 6.611 ± 0.992
5.174LeuThr: 5.174 ± 0.828
4.886LeuVal: 4.886 ± 0.1
0.287LeuTrp: 0.287 ± 0.373
3.737LeuTyr: 3.737 ± 1.544
0.0LeuXaa: 0.0 ± 0.0
Met
0.862MetAla: 0.862 ± 0.626
0.575MetCys: 0.575 ± 0.857
1.437MetAsp: 1.437 ± 0.755
1.725MetGlu: 1.725 ± 0.906
1.15MetPhe: 1.15 ± 0.495
1.15MetGly: 1.15 ± 0.207
0.575MetHis: 0.575 ± 0.247
2.874MetIle: 2.874 ± 0.638
3.449MetLys: 3.449 ± 0.219
3.162MetLeu: 3.162 ± 0.774
1.437MetMet: 1.437 ± 0.397
2.3MetAsn: 2.3 ± 0.484
0.575MetPro: 0.575 ± 0.247
1.15MetGln: 1.15 ± 0.207
1.437MetArg: 1.437 ± 0.397
3.162MetSer: 3.162 ± 1.189
2.3MetThr: 2.3 ± 0.414
2.3MetVal: 2.3 ± 0.56
0.0MetTrp: 0.0 ± 0.0
0.287MetTyr: 0.287 ± 0.373
0.0MetXaa: 0.0 ± 0.0
Asn
2.3AsnAla: 2.3 ± 0.414
1.725AsnCys: 1.725 ± 0.742
5.749AsnAsp: 5.749 ± 0.565
3.449AsnGlu: 3.449 ± 0.909
3.737AsnPhe: 3.737 ± 0.529
2.587AsnGly: 2.587 ± 1.621
0.0AsnHis: 0.0 ± 0.0
5.461AsnIle: 5.461 ± 1.383
7.186AsnLys: 7.186 ± 1.426
6.899AsnLeu: 6.899 ± 1.629
1.437AsnMet: 1.437 ± 0.755
5.174AsnAsn: 5.174 ± 0.892
1.437AsnPro: 1.437 ± 0.319
1.725AsnGln: 1.725 ± 0.906
2.012AsnArg: 2.012 ± 0.348
4.312AsnSer: 4.312 ± 1.313
3.449AsnThr: 3.449 ± 1.747
3.449AsnVal: 3.449 ± 1.174
0.575AsnTrp: 0.575 ± 0.302
4.024AsnTyr: 4.024 ± 1.195
0.0AsnXaa: 0.0 ± 0.0
Pro
0.575ProAla: 0.575 ± 0.302
0.287ProCys: 0.287 ± 0.151
2.012ProAsp: 2.012 ± 1.238
1.437ProGlu: 1.437 ± 0.319
2.3ProPhe: 2.3 ± 0.414
1.725ProGly: 1.725 ± 0.468
0.575ProHis: 0.575 ± 0.302
3.737ProIle: 3.737 ± 0.12
2.012ProLys: 2.012 ± 0.64
1.15ProLeu: 1.15 ± 0.604
0.862ProMet: 0.862 ± 0.733
2.3ProAsn: 2.3 ± 0.743
0.575ProPro: 0.575 ± 0.302
0.287ProGln: 0.287 ± 0.735
0.575ProArg: 0.575 ± 0.247
2.874ProSer: 2.874 ± 1.51
1.15ProThr: 1.15 ± 0.207
2.012ProVal: 2.012 ± 0.64
0.0ProTrp: 0.0 ± 0.0
0.575ProTyr: 0.575 ± 0.302
0.0ProXaa: 0.0 ± 0.0
Gln
1.437GlnAla: 1.437 ± 0.529
0.287GlnCys: 0.287 ± 0.373
1.437GlnAsp: 1.437 ± 0.859
2.012GlnGlu: 2.012 ± 0.597
1.725GlnPhe: 1.725 ± 0.906
2.587GlnGly: 2.587 ± 0.557
0.862GlnHis: 0.862 ± 0.614
2.3GlnIle: 2.3 ± 1.208
2.012GlnLys: 2.012 ± 0.64
3.162GlnLeu: 3.162 ± 0.318
0.575GlnMet: 0.575 ± 0.486
2.874GlnAsn: 2.874 ± 0.638
0.575GlnPro: 0.575 ± 0.745
0.0GlnGln: 0.0 ± 0.0
2.012GlnArg: 2.012 ± 0.801
2.587GlnSer: 2.587 ± 1.092
2.012GlnThr: 2.012 ± 0.597
3.162GlnVal: 3.162 ± 0.726
0.0GlnTrp: 0.0 ± 0.0
1.15GlnTyr: 1.15 ± 0.207
0.0GlnXaa: 0.0 ± 0.0
Arg
0.862ArgAla: 0.862 ± 0.626
0.575ArgCys: 0.575 ± 0.745
2.874ArgAsp: 2.874 ± 1.072
1.437ArgGlu: 1.437 ± 0.319
1.437ArgPhe: 1.437 ± 0.652
1.437ArgGly: 1.437 ± 0.529
0.575ArgHis: 0.575 ± 0.302
1.725ArgIle: 1.725 ± 0.906
2.3ArgLys: 2.3 ± 0.56
4.886ArgLeu: 4.886 ± 1.089
0.575ArgMet: 0.575 ± 0.745
2.874ArgAsn: 2.874 ± 1.04
0.862ArgPro: 0.862 ± 0.171
1.15ArgGln: 1.15 ± 0.604
0.287ArgArg: 0.287 ± 0.151
3.737ArgSer: 3.737 ± 1.883
1.437ArgThr: 1.437 ± 0.319
1.15ArgVal: 1.15 ± 0.985
0.0ArgTrp: 0.0 ± 0.0
2.587ArgTyr: 2.587 ± 0.891
0.0ArgXaa: 0.0 ± 0.0
Ser
3.162SerAla: 3.162 ± 0.356
2.012SerCys: 2.012 ± 1.105
3.449SerAsp: 3.449 ± 0.41
0.862SerGlu: 0.862 ± 0.171
5.749SerPhe: 5.749 ± 0.565
4.024SerGly: 4.024 ± 0.162
2.012SerHis: 2.012 ± 1.999
7.761SerIle: 7.761 ± 1.133
6.611SerLys: 6.611 ± 2.084
8.336SerLeu: 8.336 ± 2.877
2.587SerMet: 2.587 ± 0.891
6.611SerAsn: 6.611 ± 1.349
1.725SerPro: 1.725 ± 0.455
2.3SerGln: 2.3 ± 0.743
2.874SerArg: 2.874 ± 1.797
6.899SerSer: 6.899 ± 2.188
3.162SerThr: 3.162 ± 0.318
4.024SerVal: 4.024 ± 0.88
0.287SerTrp: 0.287 ± 0.151
4.599SerTyr: 4.599 ± 0.593
0.0SerXaa: 0.0 ± 0.0
Thr
2.587ThrAla: 2.587 ± 0.891
0.862ThrCys: 0.862 ± 0.614
3.449ThrAsp: 3.449 ± 1.484
3.162ThrGlu: 3.162 ± 0.771
3.162ThrPhe: 3.162 ± 1.792
3.162ThrGly: 3.162 ± 1.15
0.575ThrHis: 0.575 ± 0.745
4.312ThrIle: 4.312 ± 0.224
5.461ThrLys: 5.461 ± 0.878
4.886ThrLeu: 4.886 ± 0.964
1.725ThrMet: 1.725 ± 0.742
4.024ThrAsn: 4.024 ± 1.391
2.587ThrPro: 2.587 ± 0.323
1.725ThrGln: 1.725 ± 0.455
0.575ThrArg: 0.575 ± 0.302
3.449ThrSer: 3.449 ± 0.41
3.737ThrThr: 3.737 ± 0.522
3.162ThrVal: 3.162 ± 0.318
0.287ThrTrp: 0.287 ± 0.151
3.737ThrTyr: 3.737 ± 0.673
0.0ThrXaa: 0.0 ± 0.0
Val
1.437ValAla: 1.437 ± 1.283
1.725ValCys: 1.725 ± 1.228
2.3ValAsp: 2.3 ± 0.799
2.874ValGlu: 2.874 ± 1.04
2.874ValPhe: 2.874 ± 1.861
2.012ValGly: 2.012 ± 0.64
0.575ValHis: 0.575 ± 0.302
5.461ValIle: 5.461 ± 2.118
5.749ValLys: 5.749 ± 0.633
4.024ValLeu: 4.024 ± 1.279
0.862ValMet: 0.862 ± 0.708
3.449ValAsn: 3.449 ± 0.672
1.15ValPro: 1.15 ± 0.207
2.3ValGln: 2.3 ± 1.242
1.725ValArg: 1.725 ± 0.342
3.449ValSer: 3.449 ± 0.909
3.162ValThr: 3.162 ± 1.131
2.012ValVal: 2.012 ± 1.105
0.287ValTrp: 0.287 ± 0.373
3.449ValTyr: 3.449 ± 1.747
0.0ValXaa: 0.0 ± 0.0
Trp
0.287TrpAla: 0.287 ± 0.151
0.0TrpCys: 0.0 ± 0.0
0.575TrpAsp: 0.575 ± 0.302
0.287TrpGlu: 0.287 ± 0.735
0.575TrpPhe: 0.575 ± 0.302
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.575TrpIle: 0.575 ± 0.302
0.287TrpLys: 0.287 ± 0.151
0.287TrpLeu: 0.287 ± 0.151
0.287TrpMet: 0.287 ± 0.373
0.575TrpAsn: 0.575 ± 0.247
0.575TrpPro: 0.575 ± 1.47
0.0TrpGln: 0.0 ± 0.0
0.575TrpArg: 0.575 ± 0.247
1.15TrpSer: 1.15 ± 0.207
0.575TrpThr: 0.575 ± 0.247
0.575TrpVal: 0.575 ± 0.247
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.012TyrAla: 2.012 ± 0.948
0.575TyrCys: 0.575 ± 0.247
2.3TyrAsp: 2.3 ± 0.414
3.737TyrGlu: 3.737 ± 0.12
2.3TyrPhe: 2.3 ± 0.56
1.15TyrGly: 1.15 ± 0.985
0.287TyrHis: 0.287 ± 0.151
4.886TyrIle: 4.886 ± 0.854
6.899TyrLys: 6.899 ± 0.694
3.449TyrLeu: 3.449 ± 1.683
2.012TyrMet: 2.012 ± 0.597
3.737TyrAsn: 3.737 ± 1.489
1.15TyrPro: 1.15 ± 0.954
2.587TyrGln: 2.587 ± 0.323
1.725TyrArg: 1.725 ± 0.906
4.886TyrSer: 4.886 ± 0.923
2.3TyrThr: 2.3 ± 1.922
2.012TyrVal: 2.012 ± 0.64
0.287TyrTrp: 0.287 ± 0.735
2.587TyrTyr: 2.587 ± 0.516
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski