Amino acid dipepetide frequency for Haloactinospora alba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.057AlaAla: 18.057 ± 0.192
1.002AlaCys: 1.002 ± 0.025
7.564AlaAsp: 7.564 ± 0.089
9.214AlaGlu: 9.214 ± 0.104
3.299AlaPhe: 3.299 ± 0.057
11.551AlaGly: 11.551 ± 0.109
2.765AlaHis: 2.765 ± 0.051
3.409AlaIle: 3.409 ± 0.058
1.936AlaLys: 1.936 ± 0.045
12.934AlaLeu: 12.934 ± 0.14
2.49AlaMet: 2.49 ± 0.039
2.139AlaAsn: 2.139 ± 0.038
6.308AlaPro: 6.308 ± 0.079
3.545AlaGln: 3.545 ± 0.055
9.503AlaArg: 9.503 ± 0.096
6.398AlaSer: 6.398 ± 0.074
6.881AlaThr: 6.881 ± 0.074
11.089AlaVal: 11.089 ± 0.121
1.722AlaTrp: 1.722 ± 0.039
2.21AlaTyr: 2.21 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.994CysAla: 0.994 ± 0.026
0.108CysCys: 0.108 ± 0.01
0.531CysAsp: 0.531 ± 0.021
0.449CysGlu: 0.449 ± 0.02
0.259CysPhe: 0.259 ± 0.014
1.019CysGly: 1.019 ± 0.032
0.198CysHis: 0.198 ± 0.013
0.159CysIle: 0.159 ± 0.011
0.085CysLys: 0.085 ± 0.008
0.679CysLeu: 0.679 ± 0.024
0.135CysMet: 0.135 ± 0.009
0.124CysAsn: 0.124 ± 0.01
0.54CysPro: 0.54 ± 0.024
0.205CysGln: 0.205 ± 0.012
0.624CysArg: 0.624 ± 0.021
0.512CysSer: 0.512 ± 0.02
0.425CysThr: 0.425 ± 0.019
0.705CysVal: 0.705 ± 0.025
0.111CysTrp: 0.111 ± 0.009
0.194CysTyr: 0.194 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.024AspAla: 7.024 ± 0.089
0.37AspCys: 0.37 ± 0.016
3.714AspAsp: 3.714 ± 0.067
4.175AspGlu: 4.175 ± 0.062
1.451AspPhe: 1.451 ± 0.037
5.924AspGly: 5.924 ± 0.078
1.473AspHis: 1.473 ± 0.036
2.17AspIle: 2.17 ± 0.046
0.892AspLys: 0.892 ± 0.033
5.664AspLeu: 5.664 ± 0.066
1.055AspMet: 1.055 ± 0.028
1.3AspAsn: 1.3 ± 0.037
4.72AspPro: 4.72 ± 0.062
1.686AspGln: 1.686 ± 0.042
4.672AspArg: 4.672 ± 0.066
3.487AspSer: 3.487 ± 0.058
4.35AspThr: 4.35 ± 0.056
4.869AspVal: 4.869 ± 0.062
0.832AspTrp: 0.832 ± 0.028
1.331AspTyr: 1.331 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.281GluAla: 7.281 ± 0.092
0.449GluCys: 0.449 ± 0.016
3.472GluAsp: 3.472 ± 0.062
5.314GluGlu: 5.314 ± 0.079
1.761GluPhe: 1.761 ± 0.037
4.786GluGly: 4.786 ± 0.06
2.009GluHis: 2.009 ± 0.04
2.361GluIle: 2.361 ± 0.054
1.293GluLys: 1.293 ± 0.038
7.627GluLeu: 7.627 ± 0.089
1.257GluMet: 1.257 ± 0.033
1.519GluAsn: 1.519 ± 0.033
3.852GluPro: 3.852 ± 0.067
2.686GluGln: 2.686 ± 0.045
6.447GluArg: 6.447 ± 0.082
3.411GluSer: 3.411 ± 0.051
3.651GluThr: 3.651 ± 0.06
5.005GluVal: 5.005 ± 0.065
0.958GluTrp: 0.958 ± 0.031
1.356GluTyr: 1.356 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.346PheAla: 3.346 ± 0.051
0.272PheCys: 0.272 ± 0.013
1.942PheAsp: 1.942 ± 0.04
1.302PheGlu: 1.302 ± 0.036
0.815PhePhe: 0.815 ± 0.029
2.936PheGly: 2.936 ± 0.057
0.697PheHis: 0.697 ± 0.026
0.685PheIle: 0.685 ± 0.022
0.34PheLys: 0.34 ± 0.017
2.797PheLeu: 2.797 ± 0.05
0.381PheMet: 0.381 ± 0.018
0.548PheAsn: 0.548 ± 0.021
1.471PhePro: 1.471 ± 0.029
0.636PheGln: 0.636 ± 0.023
1.704PheArg: 1.704 ± 0.033
1.671PheSer: 1.671 ± 0.034
2.024PheThr: 2.024 ± 0.037
2.284PheVal: 2.284 ± 0.049
0.425PheTrp: 0.425 ± 0.017
0.601PheTyr: 0.601 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.202GlyAla: 10.202 ± 0.098
0.82GlyCys: 0.82 ± 0.026
5.399GlyAsp: 5.399 ± 0.072
6.142GlyGlu: 6.142 ± 0.078
2.706GlyPhe: 2.706 ± 0.047
8.556GlyGly: 8.556 ± 0.103
2.138GlyHis: 2.138 ± 0.045
3.609GlyIle: 3.609 ± 0.062
2.067GlyLys: 2.067 ± 0.049
7.928GlyLeu: 7.928 ± 0.079
2.374GlyMet: 2.374 ± 0.046
2.097GlyAsn: 2.097 ± 0.046
4.404GlyPro: 4.404 ± 0.063
2.838GlyGln: 2.838 ± 0.055
6.698GlyArg: 6.698 ± 0.079
5.718GlySer: 5.718 ± 0.069
6.299GlyThr: 6.299 ± 0.084
7.602GlyVal: 7.602 ± 0.081
1.594GlyTrp: 1.594 ± 0.037
2.332GlyTyr: 2.332 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.768HisAla: 2.768 ± 0.055
0.195HisCys: 0.195 ± 0.011
1.434HisAsp: 1.434 ± 0.034
1.381HisGlu: 1.381 ± 0.033
0.521HisPhe: 0.521 ± 0.018
2.43HisGly: 2.43 ± 0.04
0.83HisHis: 0.83 ± 0.03
0.73HisIle: 0.73 ± 0.021
0.329HisLys: 0.329 ± 0.015
2.315HisLeu: 2.315 ± 0.044
0.403HisMet: 0.403 ± 0.017
0.465HisAsn: 0.465 ± 0.017
1.856HisPro: 1.856 ± 0.038
0.753HisGln: 0.753 ± 0.021
2.125HisArg: 2.125 ± 0.045
1.205HisSer: 1.205 ± 0.032
1.621HisThr: 1.621 ± 0.037
1.844HisVal: 1.844 ± 0.038
0.363HisTrp: 0.363 ± 0.018
0.502HisTyr: 0.502 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.473IleAla: 4.473 ± 0.063
0.275IleCys: 0.275 ± 0.015
2.298IleAsp: 2.298 ± 0.052
1.853IleGlu: 1.853 ± 0.039
0.667IlePhe: 0.667 ± 0.027
3.09IleGly: 3.09 ± 0.047
0.641IleHis: 0.641 ± 0.021
1.022IleIle: 1.022 ± 0.033
0.54IleLys: 0.54 ± 0.025
2.53IleLeu: 2.53 ± 0.048
0.482IleMet: 0.482 ± 0.02
0.754IleAsn: 0.754 ± 0.026
1.848IlePro: 1.848 ± 0.036
0.736IleGln: 0.736 ± 0.025
2.239IleArg: 2.239 ± 0.042
1.874IleSer: 1.874 ± 0.038
2.364IleThr: 2.364 ± 0.047
2.65IleVal: 2.65 ± 0.051
0.328IleTrp: 0.328 ± 0.015
0.573IleTyr: 0.573 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.841LysAla: 1.841 ± 0.048
0.1LysCys: 0.1 ± 0.009
0.886LysAsp: 0.886 ± 0.029
1.049LysGlu: 1.049 ± 0.039
0.36LysPhe: 0.36 ± 0.018
1.261LysGly: 1.261 ± 0.038
0.413LysHis: 0.413 ± 0.014
0.623LysIle: 0.623 ± 0.027
0.58LysLys: 0.58 ± 0.03
1.662LysLeu: 1.662 ± 0.046
0.271LysMet: 0.271 ± 0.014
0.471LysAsn: 0.471 ± 0.023
0.976LysPro: 0.976 ± 0.032
0.617LysGln: 0.617 ± 0.024
1.54LysArg: 1.54 ± 0.037
1.04LysSer: 1.04 ± 0.039
0.984LysThr: 0.984 ± 0.028
1.245LysVal: 1.245 ± 0.036
0.194LysTrp: 0.194 ± 0.011
0.341LysTyr: 0.341 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
13.958LeuAla: 13.958 ± 0.131
0.812LeuCys: 0.812 ± 0.026
6.395LeuAsp: 6.395 ± 0.084
5.4LeuGlu: 5.4 ± 0.077
2.629LeuPhe: 2.629 ± 0.048
8.891LeuGly: 8.891 ± 0.094
2.186LeuHis: 2.186 ± 0.044
2.707LeuIle: 2.707 ± 0.052
1.24LeuLys: 1.24 ± 0.04
10.621LeuLeu: 10.621 ± 0.126
1.561LeuMet: 1.561 ± 0.036
1.776LeuAsn: 1.776 ± 0.041
6.0LeuPro: 6.0 ± 0.07
2.144LeuGln: 2.144 ± 0.046
8.781LeuArg: 8.781 ± 0.086
6.01LeuSer: 6.01 ± 0.065
6.227LeuThr: 6.227 ± 0.07
8.809LeuVal: 8.809 ± 0.092
1.323LeuTrp: 1.323 ± 0.033
1.709LeuTyr: 1.709 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.356MetAla: 2.356 ± 0.047
0.164MetCys: 0.164 ± 0.012
0.967MetAsp: 0.967 ± 0.026
0.961MetGlu: 0.961 ± 0.026
0.536MetPhe: 0.536 ± 0.021
1.42MetGly: 1.42 ± 0.037
0.365MetHis: 0.365 ± 0.018
0.567MetIle: 0.567 ± 0.02
0.32MetLys: 0.32 ± 0.017
1.938MetLeu: 1.938 ± 0.04
0.318MetMet: 0.318 ± 0.017
0.45MetAsn: 0.45 ± 0.017
1.159MetPro: 1.159 ± 0.029
0.472MetGln: 0.472 ± 0.018
1.707MetArg: 1.707 ± 0.04
1.511MetSer: 1.511 ± 0.034
1.443MetThr: 1.443 ± 0.032
1.668MetVal: 1.668 ± 0.03
0.238MetTrp: 0.238 ± 0.013
0.311MetTyr: 0.311 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.431AsnAla: 2.431 ± 0.045
0.15AsnCys: 0.15 ± 0.011
1.134AsnAsp: 1.134 ± 0.033
1.167AsnGlu: 1.167 ± 0.033
0.483AsnPhe: 0.483 ± 0.022
2.095AsnGly: 2.095 ± 0.042
0.473AsnHis: 0.473 ± 0.02
0.736AsnIle: 0.736 ± 0.025
0.391AsnLys: 0.391 ± 0.017
1.819AsnLeu: 1.819 ± 0.043
0.369AsnMet: 0.369 ± 0.016
0.506AsnAsn: 0.506 ± 0.026
1.507AsnPro: 1.507 ± 0.039
0.696AsnGln: 0.696 ± 0.024
1.605AsnArg: 1.605 ± 0.033
1.105AsnSer: 1.105 ± 0.034
1.374AsnThr: 1.374 ± 0.033
1.608AsnVal: 1.608 ± 0.037
0.312AsnTrp: 0.312 ± 0.018
0.46AsnTyr: 0.46 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.997ProAla: 6.997 ± 0.089
0.384ProCys: 0.384 ± 0.017
4.676ProAsp: 4.676 ± 0.072
5.433ProGlu: 5.433 ± 0.071
1.467ProPhe: 1.467 ± 0.034
5.803ProGly: 5.803 ± 0.083
1.585ProHis: 1.585 ± 0.035
1.282ProIle: 1.282 ± 0.029
0.854ProLys: 0.854 ± 0.03
4.954ProLeu: 4.954 ± 0.067
0.999ProMet: 0.999 ± 0.026
1.101ProAsn: 1.101 ± 0.029
3.949ProPro: 3.949 ± 0.105
1.956ProGln: 1.956 ± 0.043
4.148ProArg: 4.148 ± 0.06
3.484ProSer: 3.484 ± 0.055
3.167ProThr: 3.167 ± 0.052
5.139ProVal: 5.139 ± 0.072
0.871ProTrp: 0.871 ± 0.025
1.193ProTyr: 1.193 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.373GlnAla: 3.373 ± 0.052
0.235GlnCys: 0.235 ± 0.014
1.419GlnAsp: 1.419 ± 0.035
2.033GlnGlu: 2.033 ± 0.043
0.667GlnPhe: 0.667 ± 0.022
2.248GlnGly: 2.248 ± 0.047
0.864GlnHis: 0.864 ± 0.025
0.936GlnIle: 0.936 ± 0.026
0.518GlnLys: 0.518 ± 0.021
3.139GlnLeu: 3.139 ± 0.052
0.545GlnMet: 0.545 ± 0.019
0.628GlnAsn: 0.628 ± 0.024
1.822GlnPro: 1.822 ± 0.038
1.517GlnGln: 1.517 ± 0.042
3.433GlnArg: 3.433 ± 0.052
1.368GlnSer: 1.368 ± 0.038
1.38GlnThr: 1.38 ± 0.035
2.153GlnVal: 2.153 ± 0.046
0.507GlnTrp: 0.507 ± 0.018
0.587GlnTyr: 0.587 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
8.977ArgAla: 8.977 ± 0.094
0.653ArgCys: 0.653 ± 0.024
4.814ArgAsp: 4.814 ± 0.064
5.78ArgGlu: 5.78 ± 0.08
2.502ArgPhe: 2.502 ± 0.043
5.972ArgGly: 5.972 ± 0.077
2.036ArgHis: 2.036 ± 0.043
3.111ArgIle: 3.111 ± 0.049
1.527ArgLys: 1.527 ± 0.036
8.208ArgLeu: 8.208 ± 0.088
1.988ArgMet: 1.988 ± 0.036
1.76ArgAsn: 1.76 ± 0.039
4.347ArgPro: 4.347 ± 0.062
2.435ArgGln: 2.435 ± 0.038
7.612ArgArg: 7.612 ± 0.105
5.014ArgSer: 5.014 ± 0.059
4.995ArgThr: 4.995 ± 0.057
6.681ArgVal: 6.681 ± 0.076
1.401ArgTrp: 1.401 ± 0.036
1.866ArgTyr: 1.866 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
7.187SerAla: 7.187 ± 0.076
0.474SerCys: 0.474 ± 0.019
3.557SerAsp: 3.557 ± 0.058
3.71SerGlu: 3.71 ± 0.06
1.547SerPhe: 1.547 ± 0.031
7.247SerGly: 7.247 ± 0.093
1.228SerHis: 1.228 ± 0.029
1.558SerIle: 1.558 ± 0.039
0.872SerLys: 0.872 ± 0.03
5.061SerLeu: 5.061 ± 0.065
1.108SerMet: 1.108 ± 0.025
1.002SerAsn: 1.002 ± 0.027
3.612SerPro: 3.612 ± 0.059
1.677SerGln: 1.677 ± 0.033
4.351SerArg: 4.351 ± 0.063
3.671SerSer: 3.671 ± 0.05
3.414SerThr: 3.414 ± 0.051
4.604SerVal: 4.604 ± 0.056
0.967SerTrp: 0.967 ± 0.027
1.407SerTyr: 1.407 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
8.243ThrAla: 8.243 ± 0.091
0.466ThrCys: 0.466 ± 0.018
3.821ThrAsp: 3.821 ± 0.06
3.913ThrGlu: 3.913 ± 0.057
1.625ThrPhe: 1.625 ± 0.033
6.523ThrGly: 6.523 ± 0.071
1.365ThrHis: 1.365 ± 0.033
1.836ThrIle: 1.836 ± 0.035
0.928ThrLys: 0.928 ± 0.03
5.801ThrLeu: 5.801 ± 0.075
1.133ThrMet: 1.133 ± 0.03
1.148ThrAsn: 1.148 ± 0.035
4.101ThrPro: 4.101 ± 0.065
1.55ThrGln: 1.55 ± 0.037
4.29ThrArg: 4.29 ± 0.065
3.499ThrSer: 3.499 ± 0.047
4.077ThrThr: 4.077 ± 0.069
6.256ThrVal: 6.256 ± 0.084
0.914ThrTrp: 0.914 ± 0.027
1.213ThrTyr: 1.213 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
10.711ValAla: 10.711 ± 0.114
0.764ValCys: 0.764 ± 0.025
5.046ValAsp: 5.046 ± 0.071
5.063ValGlu: 5.063 ± 0.066
2.498ValPhe: 2.498 ± 0.05
6.715ValGly: 6.715 ± 0.081
1.94ValHis: 1.94 ± 0.037
2.645ValIle: 2.645 ± 0.047
1.154ValLys: 1.154 ± 0.032
9.475ValLeu: 9.475 ± 0.09
1.41ValMet: 1.41 ± 0.034
1.792ValAsn: 1.792 ± 0.037
4.972ValPro: 4.972 ± 0.068
1.965ValGln: 1.965 ± 0.036
6.951ValArg: 6.951 ± 0.075
5.188ValSer: 5.188 ± 0.063
5.831ValThr: 5.831 ± 0.079
7.789ValVal: 7.789 ± 0.096
1.236ValTrp: 1.236 ± 0.036
1.547ValTyr: 1.547 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.413TrpAla: 1.413 ± 0.034
0.172TrpCys: 0.172 ± 0.012
0.764TrpAsp: 0.764 ± 0.023
0.871TrpGlu: 0.871 ± 0.027
0.515TrpPhe: 0.515 ± 0.021
1.02TrpGly: 1.02 ± 0.03
0.417TrpHis: 0.417 ± 0.018
0.536TrpIle: 0.536 ± 0.021
0.301TrpLys: 0.301 ± 0.016
1.81TrpLeu: 1.81 ± 0.038
0.295TrpMet: 0.295 ± 0.015
0.414TrpAsn: 0.414 ± 0.016
0.837TrpPro: 0.837 ± 0.027
0.598TrpGln: 0.598 ± 0.02
1.428TrpArg: 1.428 ± 0.036
0.967TrpSer: 0.967 ± 0.028
0.86TrpThr: 0.86 ± 0.03
1.102TrpVal: 1.102 ± 0.029
0.388TrpTrp: 0.388 ± 0.02
0.287TrpTyr: 0.287 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.383TyrAla: 2.383 ± 0.038
0.189TyrCys: 0.189 ± 0.011
1.33TyrAsp: 1.33 ± 0.04
1.286TyrGlu: 1.286 ± 0.031
0.568TyrPhe: 0.568 ± 0.024
2.034TyrGly: 2.034 ± 0.038
0.447TyrHis: 0.447 ± 0.018
0.556TyrIle: 0.556 ± 0.025
0.287TyrLys: 0.287 ± 0.016
2.218TyrLeu: 2.218 ± 0.042
0.298TyrMet: 0.298 ± 0.014
0.426TyrAsn: 0.426 ± 0.02
1.162TyrPro: 1.162 ± 0.031
0.657TyrGln: 0.657 ± 0.022
1.822TyrArg: 1.822 ± 0.041
1.121TyrSer: 1.121 ± 0.033
1.333TyrThr: 1.333 ± 0.035
1.588TyrVal: 1.588 ± 0.035
0.313TyrTrp: 0.313 ± 0.018
0.491TyrTyr: 0.491 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4398 proteins (1363651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski