Amino acid dipepetide frequency for Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.65AlaAla: 8.65 ± 0.057	1.186AlaCys: 1.186 ± 0.016	4.164AlaAsp: 4.164 ± 0.034	4.878AlaGlu: 4.878 ± 0.035	3.172AlaPhe: 3.172 ± 0.024	5.755AlaGly: 5.755 ± 0.04	1.822AlaHis: 1.822 ± 0.017	4.336AlaIle: 4.336 ± 0.03	3.536AlaLys: 3.536 ± 0.029	7.963AlaLeu: 7.963 ± 0.049	2.01AlaMet: 2.01 ± 0.018	2.742AlaAsn: 2.742 ± 0.024	4.63AlaPro: 4.63 ± 0.036	3.332AlaGln: 3.332 ± 0.029	4.936AlaArg: 4.936 ± 0.031	7.145AlaSer: 7.145 ± 0.044	5.299AlaThr: 5.299 ± 0.038	5.517AlaVal: 5.517 ± 0.042	1.23AlaTrp: 1.23 ± 0.016	2.278AlaTyr: 2.278 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.013	0.287CysCys: 0.287 ± 0.009	0.729CysAsp: 0.729 ± 0.012	0.632CysGlu: 0.632 ± 0.01	0.593CysPhe: 0.593 ± 0.008	0.963CysGly: 0.963 ± 0.015	0.389CysHis: 0.389 ± 0.009	0.771CysIle: 0.771 ± 0.012	0.474CysLys: 0.474 ± 0.009	1.463CysLeu: 1.463 ± 0.019	0.313CysMet: 0.313 ± 0.007	0.46CysAsn: 0.46 ± 0.01	0.702CysPro: 0.702 ± 0.012	0.496CysGln: 0.496 ± 0.011	0.884CysArg: 0.884 ± 0.013	1.033CysSer: 1.033 ± 0.015	0.753CysThr: 0.753 ± 0.012	0.875CysVal: 0.875 ± 0.012	0.226CysTrp: 0.226 ± 0.006	0.393CysTyr: 0.393 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.562AspAla: 4.562 ± 0.033	0.654AspCys: 0.654 ± 0.01	3.891AspAsp: 3.891 ± 0.04	4.158AspGlu: 4.158 ± 0.033	2.117AspPhe: 2.117 ± 0.021	4.026AspGly: 4.026 ± 0.03	1.313AspHis: 1.313 ± 0.016	3.043AspIle: 3.043 ± 0.024	2.065AspLys: 2.065 ± 0.022	5.249AspLeu: 5.249 ± 0.036	1.272AspMet: 1.272 ± 0.015	1.771AspAsn: 1.771 ± 0.017	3.469AspPro: 3.469 ± 0.027	1.96AspGln: 1.96 ± 0.019	3.22AspArg: 3.22 ± 0.032	4.026AspSer: 4.026 ± 0.029	2.982AspThr: 2.982 ± 0.021	3.621AspVal: 3.621 ± 0.026	0.926AspTrp: 0.926 ± 0.014	1.671AspTyr: 1.671 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.15GluAla: 5.15 ± 0.036	0.665GluCys: 0.665 ± 0.011	3.936GluAsp: 3.936 ± 0.035	5.297GluGlu: 5.297 ± 0.059	1.929GluPhe: 1.929 ± 0.018	3.811GluGly: 3.811 ± 0.028	1.358GluHis: 1.358 ± 0.015	2.953GluIle: 2.953 ± 0.022	3.293GluLys: 3.293 ± 0.034	5.03GluLeu: 5.03 ± 0.036	1.493GluMet: 1.493 ± 0.017	2.139GluAsn: 2.139 ± 0.022	2.798GluPro: 2.798 ± 0.041	2.409GluGln: 2.409 ± 0.023	3.854GluArg: 3.854 ± 0.033	4.245GluSer: 4.245 ± 0.032	3.518GluThr: 3.518 ± 0.027	3.541GluVal: 3.541 ± 0.03	0.919GluTrp: 0.919 ± 0.014	1.738GluTyr: 1.738 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.998PheAla: 2.998 ± 0.023	0.616PheCys: 0.616 ± 0.009	2.244PheAsp: 2.244 ± 0.019	2.048PheGlu: 2.048 ± 0.021	1.712PhePhe: 1.712 ± 0.021	2.811PheGly: 2.811 ± 0.026	1.008PheHis: 1.008 ± 0.013	1.86PheIle: 1.86 ± 0.02	1.305PheLys: 1.305 ± 0.016	3.76PheLeu: 3.76 ± 0.03	0.786PheMet: 0.786 ± 0.01	1.377PheAsn: 1.377 ± 0.015	2.11PhePro: 2.11 ± 0.021	1.472PheGln: 1.472 ± 0.017	2.062PheArg: 2.062 ± 0.017	3.079PheSer: 3.079 ± 0.022	2.207PheThr: 2.207 ± 0.019	2.422PheVal: 2.422 ± 0.025	0.668PheTrp: 0.668 ± 0.012	1.186PheTyr: 1.186 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.22GlyAla: 5.22 ± 0.037	0.997GlyCys: 0.997 ± 0.013	3.655GlyAsp: 3.655 ± 0.031	3.707GlyGlu: 3.707 ± 0.029	2.854GlyPhe: 2.854 ± 0.026	5.528GlyGly: 5.528 ± 0.047	1.714GlyHis: 1.714 ± 0.019	3.584GlyIle: 3.584 ± 0.029	3.092GlyLys: 3.092 ± 0.024	6.411GlyLeu: 6.411 ± 0.04	1.651GlyMet: 1.651 ± 0.017	2.39GlyAsn: 2.39 ± 0.024	3.464GlyPro: 3.464 ± 0.029	2.615GlyGln: 2.615 ± 0.025	4.159GlyArg: 4.159 ± 0.03	5.706GlySer: 5.706 ± 0.037	4.003GlyThr: 4.003 ± 0.03	4.634GlyVal: 4.634 ± 0.028	1.259GlyTrp: 1.259 ± 0.016	2.251GlyTyr: 2.251 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.949HisAla: 1.949 ± 0.019	0.381HisCys: 0.381 ± 0.008	1.351HisAsp: 1.351 ± 0.018	1.328HisGlu: 1.328 ± 0.018	0.937HisPhe: 0.937 ± 0.013	1.777HisGly: 1.777 ± 0.02	0.954HisHis: 0.954 ± 0.019	1.27HisIle: 1.27 ± 0.014	0.791HisLys: 0.791 ± 0.011	2.477HisLeu: 2.477 ± 0.022	0.534HisMet: 0.534 ± 0.011	0.826HisAsn: 0.826 ± 0.013	1.901HisPro: 1.901 ± 0.022	1.032HisGln: 1.032 ± 0.014	1.65HisArg: 1.65 ± 0.018	1.866HisSer: 1.866 ± 0.018	1.358HisThr: 1.358 ± 0.017	1.486HisVal: 1.486 ± 0.016	0.384HisTrp: 0.384 ± 0.009	0.727HisTyr: 0.727 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.136IleAla: 4.136 ± 0.026	0.836IleCys: 0.836 ± 0.013	2.78IleAsp: 2.78 ± 0.024	2.702IleGlu: 2.702 ± 0.023	2.071IlePhe: 2.071 ± 0.019	3.246IleGly: 3.246 ± 0.026	1.336IleHis: 1.336 ± 0.016	2.571IleIle: 2.571 ± 0.024	1.888IleLys: 1.888 ± 0.021	4.824IleLeu: 4.824 ± 0.035	1.025IleMet: 1.025 ± 0.014	1.735IleAsn: 1.735 ± 0.015	3.265IlePro: 3.265 ± 0.026	1.998IleGln: 1.998 ± 0.021	2.881IleArg: 2.881 ± 0.023	3.837IleSer: 3.837 ± 0.026	2.897IleThr: 2.897 ± 0.023	3.165IleVal: 3.165 ± 0.025	0.759IleTrp: 0.759 ± 0.013	1.513IleTyr: 1.513 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.701LysAla: 3.701 ± 0.031	0.492LysCys: 0.492 ± 0.009	2.416LysAsp: 2.416 ± 0.021	2.974LysGlu: 2.974 ± 0.029	1.247LysPhe: 1.247 ± 0.015	2.7LysGly: 2.7 ± 0.025	1.017LysHis: 1.017 ± 0.013	2.023LysIle: 2.023 ± 0.022	2.658LysLys: 2.658 ± 0.036	3.62LysLeu: 3.62 ± 0.026	0.899LysMet: 0.899 ± 0.013	1.482LysAsn: 1.482 ± 0.016	2.449LysPro: 2.449 ± 0.025	1.668LysGln: 1.668 ± 0.018	3.053LysArg: 3.053 ± 0.029	3.052LysSer: 3.052 ± 0.027	2.467LysThr: 2.467 ± 0.022	2.583LysVal: 2.583 ± 0.023	0.615LysTrp: 0.615 ± 0.011	1.276LysTyr: 1.276 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.063LeuAla: 8.063 ± 0.045	1.32LeuCys: 1.32 ± 0.015	5.316LeuAsp: 5.316 ± 0.035	5.523LeuGlu: 5.523 ± 0.041	3.566LeuPhe: 3.566 ± 0.027	6.307LeuGly: 6.307 ± 0.035	2.448LeuHis: 2.448 ± 0.025	4.157LeuIle: 4.157 ± 0.033	3.76LeuLys: 3.76 ± 0.031	9.002LeuLeu: 9.002 ± 0.051	1.829LeuMet: 1.829 ± 0.018	3.11LeuAsn: 3.11 ± 0.024	5.733LeuPro: 5.733 ± 0.036	4.003LeuGln: 4.003 ± 0.032	6.003LeuArg: 6.003 ± 0.037	7.657LeuSer: 7.657 ± 0.035	5.105LeuThr: 5.105 ± 0.031	5.8LeuVal: 5.8 ± 0.034	1.285LeuTrp: 1.285 ± 0.017	2.565LeuTyr: 2.565 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.239MetAla: 2.239 ± 0.019	0.255MetCys: 0.255 ± 0.007	1.267MetAsp: 1.267 ± 0.015	1.333MetGlu: 1.333 ± 0.016	0.773MetPhe: 0.773 ± 0.012	1.545MetGly: 1.545 ± 0.019	0.518MetHis: 0.518 ± 0.01	1.046MetIle: 1.046 ± 0.014	0.925MetLys: 0.925 ± 0.014	1.905MetLeu: 1.905 ± 0.021	0.588MetMet: 0.588 ± 0.011	0.788MetAsn: 0.788 ± 0.012	1.256MetPro: 1.256 ± 0.015	0.871MetGln: 0.871 ± 0.013	1.259MetArg: 1.259 ± 0.015	1.89MetSer: 1.89 ± 0.018	1.339MetThr: 1.339 ± 0.015	1.415MetVal: 1.415 ± 0.016	0.268MetTrp: 0.268 ± 0.007	0.55MetTyr: 0.55 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.937AsnAla: 2.937 ± 0.023	0.459AsnCys: 0.459 ± 0.009	1.791AsnAsp: 1.791 ± 0.017	1.886AsnGlu: 1.886 ± 0.02	1.269AsnPhe: 1.269 ± 0.015	2.733AsnGly: 2.733 ± 0.026	0.853AsnHis: 0.853 ± 0.013	1.933AsnIle: 1.933 ± 0.021	1.318AsnLys: 1.318 ± 0.017	3.176AsnLeu: 3.176 ± 0.023	0.804AsnMet: 0.804 ± 0.013	1.349AsnAsn: 1.349 ± 0.019	2.534AsnPro: 2.534 ± 0.022	1.294AsnGln: 1.294 ± 0.017	1.935AsnArg: 1.935 ± 0.018	2.508AsnSer: 2.508 ± 0.024	2.1AsnThr: 2.1 ± 0.023	2.227AsnVal: 2.227 ± 0.021	0.566AsnTrp: 0.566 ± 0.01	1.065AsnTyr: 1.065 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.244ProAla: 5.244 ± 0.043	0.611ProCys: 0.611 ± 0.012	3.386ProAsp: 3.386 ± 0.022	3.923ProGlu: 3.923 ± 0.042	2.172ProPhe: 2.172 ± 0.02	4.02ProGly: 4.02 ± 0.031	1.422ProHis: 1.422 ± 0.018	2.62ProIle: 2.62 ± 0.021	2.344ProLys: 2.344 ± 0.027	4.935ProLeu: 4.935 ± 0.034	1.106ProMet: 1.106 ± 0.014	2.124ProAsn: 2.124 ± 0.024	4.964ProPro: 4.964 ± 0.055	2.462ProGln: 2.462 ± 0.027	3.525ProArg: 3.525 ± 0.029	6.21ProSer: 6.21 ± 0.043	4.1ProThr: 4.1 ± 0.029	3.798ProVal: 3.798 ± 0.028	0.84ProTrp: 0.84 ± 0.013	1.595ProTyr: 1.595 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.442GlnAla: 3.442 ± 0.033	0.5GlnCys: 0.5 ± 0.01	2.061GlnAsp: 2.061 ± 0.018	2.419GlnGlu: 2.419 ± 0.023	1.301GlnPhe: 1.301 ± 0.015	2.479GlnGly: 2.479 ± 0.02	1.065GlnHis: 1.065 ± 0.014	1.907GlnIle: 1.907 ± 0.018	1.827GlnLys: 1.827 ± 0.019	3.589GlnLeu: 3.589 ± 0.029	0.894GlnMet: 0.894 ± 0.015	1.45GlnAsn: 1.45 ± 0.018	2.628GlnPro: 2.628 ± 0.029	2.209GlnGln: 2.209 ± 0.038	2.644GlnArg: 2.644 ± 0.024	3.19GlnSer: 3.19 ± 0.025	2.423GlnThr: 2.423 ± 0.027	2.245GlnVal: 2.245 ± 0.02	0.62GlnTrp: 0.62 ± 0.01	1.187GlnTyr: 1.187 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.692ArgAla: 4.692 ± 0.029	0.808ArgCys: 0.808 ± 0.014	3.378ArgAsp: 3.378 ± 0.032	3.791ArgGlu: 3.791 ± 0.031	2.271ArgPhe: 2.271 ± 0.019	3.826ArgGly: 3.826 ± 0.03	1.62ArgHis: 1.62 ± 0.018	2.897ArgIle: 2.897 ± 0.023	3.16ArgLys: 3.16 ± 0.028	5.828ArgLeu: 5.828 ± 0.045	1.371ArgMet: 1.371 ± 0.017	2.166ArgAsn: 2.166 ± 0.02	3.578ArgPro: 3.578 ± 0.03	2.67ArgGln: 2.67 ± 0.025	5.037ArgArg: 5.037 ± 0.044	4.754ArgSer: 4.754 ± 0.04	3.325ArgThr: 3.325 ± 0.028	3.664ArgVal: 3.664 ± 0.024	1.002ArgTrp: 1.002 ± 0.014	1.778ArgTyr: 1.778 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.568SerAla: 6.568 ± 0.037	0.972SerCys: 0.972 ± 0.015	4.235SerAsp: 4.235 ± 0.034	4.05SerGlu: 4.05 ± 0.031	3.095SerPhe: 3.095 ± 0.026	5.581SerGly: 5.581 ± 0.038	2.071SerHis: 2.071 ± 0.019	3.986SerIle: 3.986 ± 0.025	3.26SerLys: 3.26 ± 0.027	7.584SerLeu: 7.584 ± 0.04	1.727SerMet: 1.727 ± 0.018	2.821SerAsn: 2.821 ± 0.025	5.565SerPro: 5.565 ± 0.046	3.276SerGln: 3.276 ± 0.027	4.99SerArg: 4.99 ± 0.039	8.691SerSer: 8.691 ± 0.077	5.65SerThr: 5.65 ± 0.038	4.732SerVal: 4.732 ± 0.028	1.21SerTrp: 1.21 ± 0.016	2.155SerTyr: 2.155 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.249ThrAla: 5.249 ± 0.036	0.81ThrCys: 0.81 ± 0.013	2.973ThrAsp: 2.973 ± 0.02	3.105ThrGlu: 3.105 ± 0.026	2.261ThrPhe: 2.261 ± 0.022	4.376ThrGly: 4.376 ± 0.036	1.379ThrHis: 1.379 ± 0.015	3.138ThrIle: 3.138 ± 0.026	2.296ThrLys: 2.296 ± 0.023	5.515ThrLeu: 5.515 ± 0.034	1.251ThrMet: 1.251 ± 0.014	2.044ThrAsn: 2.044 ± 0.023	4.323ThrPro: 4.323 ± 0.033	2.121ThrGln: 2.121 ± 0.021	3.174ThrArg: 3.174 ± 0.027	5.267ThrSer: 5.267 ± 0.039	4.567ThrThr: 4.567 ± 0.048	3.945ThrVal: 3.945 ± 0.027	0.925ThrTrp: 0.925 ± 0.014	1.748ThrTyr: 1.748 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.328ValAla: 5.328 ± 0.036	0.925ValCys: 0.925 ± 0.015	3.791ValAsp: 3.791 ± 0.027	3.87ValGlu: 3.87 ± 0.038	2.577ValPhe: 2.577 ± 0.026	4.225ValGly: 4.225 ± 0.032	1.477ValHis: 1.477 ± 0.014	3.057ValIle: 3.057 ± 0.024	2.613ValLys: 2.613 ± 0.024	5.924ValLeu: 5.924 ± 0.037	1.395ValMet: 1.395 ± 0.014	2.183ValAsn: 2.183 ± 0.019	3.714ValPro: 3.714 ± 0.025	2.461ValGln: 2.461 ± 0.022	3.583ValArg: 3.583 ± 0.024	4.838ValSer: 4.838 ± 0.032	3.614ValThr: 3.614 ± 0.027	4.495ValVal: 4.495 ± 0.037	0.925ValTrp: 0.925 ± 0.012	1.879ValTyr: 1.879 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.187TrpAla: 1.187 ± 0.015	0.211TrpCys: 0.211 ± 0.007	0.937TrpAsp: 0.937 ± 0.013	0.895TrpGlu: 0.895 ± 0.014	0.587TrpPhe: 0.587 ± 0.011	0.991TrpGly: 0.991 ± 0.015	0.383TrpHis: 0.383 ± 0.009	0.804TrpIle: 0.804 ± 0.014	0.794TrpLys: 0.794 ± 0.012	1.436TrpLeu: 1.436 ± 0.017	0.418TrpMet: 0.418 ± 0.009	0.655TrpAsn: 0.655 ± 0.013	0.658TrpPro: 0.658 ± 0.013	0.586TrpGln: 0.586 ± 0.01	1.019TrpArg: 1.019 ± 0.014	1.116TrpSer: 1.116 ± 0.014	1.005TrpThr: 1.005 ± 0.013	0.979TrpVal: 0.979 ± 0.014	0.304TrpTrp: 0.304 ± 0.008	0.459TrpTyr: 0.459 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.02	0.45TyrCys: 0.45 ± 0.009	1.694TyrAsp: 1.694 ± 0.019	1.559TyrGlu: 1.559 ± 0.017	1.227TyrPhe: 1.227 ± 0.016	2.195TyrGly: 2.195 ± 0.023	0.834TyrHis: 0.834 ± 0.012	1.51TyrIle: 1.51 ± 0.018	0.989TyrLys: 0.989 ± 0.016	2.863TyrLeu: 2.863 ± 0.023	0.665TyrMet: 0.665 ± 0.01	1.124TyrAsn: 1.124 ± 0.015	1.66TyrPro: 1.66 ± 0.02	1.146TyrGln: 1.146 ± 0.013	1.748TyrArg: 1.748 ± 0.018	2.109TyrSer: 2.109 ± 0.023	1.753TyrThr: 1.753 ± 0.02	1.728TyrVal: 1.728 ± 0.018	0.493TyrTrp: 0.493 ± 0.01	1.023TyrTyr: 1.023 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.005

Statistics based on 12562 proteins (5900208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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