Amino acid dipepetide frequency for Mycobacterium numidiamassiliense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.542AlaAla: 19.542 ± 0.154	1.009AlaCys: 1.009 ± 0.022	8.17AlaAsp: 8.17 ± 0.07	7.547AlaGlu: 7.547 ± 0.074	3.524AlaPhe: 3.524 ± 0.046	11.608AlaGly: 11.608 ± 0.095	2.669AlaHis: 2.669 ± 0.04	5.479AlaIle: 5.479 ± 0.058	3.16AlaLys: 3.16 ± 0.046	12.472AlaLeu: 12.472 ± 0.086	2.804AlaMet: 2.804 ± 0.041	2.813AlaAsn: 2.813 ± 0.036	6.236AlaPro: 6.236 ± 0.079	4.231AlaGln: 4.231 ± 0.052	8.318AlaArg: 8.318 ± 0.07	6.219AlaSer: 6.219 ± 0.062	7.129AlaThr: 7.129 ± 0.072	11.271AlaVal: 11.271 ± 0.095	1.666AlaTrp: 1.666 ± 0.035	2.365AlaTyr: 2.365 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.131CysAla: 1.131 ± 0.026	0.089CysCys: 0.089 ± 0.007	0.555CysAsp: 0.555 ± 0.017	0.441CysGlu: 0.441 ± 0.017	0.249CysPhe: 0.249 ± 0.01	0.958CysGly: 0.958 ± 0.022	0.203CysHis: 0.203 ± 0.01	0.29CysIle: 0.29 ± 0.013	0.133CysLys: 0.133 ± 0.009	0.671CysLeu: 0.671 ± 0.021	0.128CysMet: 0.128 ± 0.008	0.183CysAsn: 0.183 ± 0.011	0.525CysPro: 0.525 ± 0.016	0.247CysGln: 0.247 ± 0.011	0.594CysArg: 0.594 ± 0.017	0.469CysSer: 0.469 ± 0.019	0.504CysThr: 0.504 ± 0.017	0.68CysVal: 0.68 ± 0.021	0.143CysTrp: 0.143 ± 0.01	0.201CysTyr: 0.201 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.633AspAla: 7.633 ± 0.065	0.471AspCys: 0.471 ± 0.017	4.3AspAsp: 4.3 ± 0.055	4.042AspGlu: 4.042 ± 0.054	1.893AspPhe: 1.893 ± 0.031	5.781AspGly: 5.781 ± 0.06	1.431AspHis: 1.431 ± 0.027	2.77AspIle: 2.77 ± 0.042	1.425AspLys: 1.425 ± 0.029	5.98AspLeu: 5.98 ± 0.069	0.992AspMet: 0.992 ± 0.026	1.37AspAsn: 1.37 ± 0.029	4.349AspPro: 4.349 ± 0.047	1.895AspGln: 1.895 ± 0.031	4.316AspArg: 4.316 ± 0.048	2.996AspSer: 2.996 ± 0.052	3.124AspThr: 3.124 ± 0.043	5.385AspVal: 5.385 ± 0.055	1.016AspTrp: 1.016 ± 0.025	1.538AspTyr: 1.538 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.009GluAla: 6.009 ± 0.067	0.378GluCys: 0.378 ± 0.015	2.366GluAsp: 2.366 ± 0.041	2.506GluGlu: 2.506 ± 0.044	1.892GluPhe: 1.892 ± 0.035	3.318GluGly: 3.318 ± 0.045	1.572GluHis: 1.572 ± 0.031	2.773GluIle: 2.773 ± 0.036	1.315GluLys: 1.315 ± 0.03	6.642GluLeu: 6.642 ± 0.074	1.065GluMet: 1.065 ± 0.024	1.093GluAsn: 1.093 ± 0.026	2.984GluPro: 2.984 ± 0.042	2.204GluGln: 2.204 ± 0.037	4.253GluArg: 4.253 ± 0.056	2.822GluSer: 2.822 ± 0.038	2.635GluThr: 2.635 ± 0.041	4.249GluVal: 4.249 ± 0.05	0.761GluTrp: 0.761 ± 0.022	1.125GluTyr: 1.125 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.083PheAla: 4.083 ± 0.046	0.361PheCys: 0.361 ± 0.013	2.527PheAsp: 2.527 ± 0.041	1.626PheGlu: 1.626 ± 0.031	1.036PhePhe: 1.036 ± 0.026	3.506PheGly: 3.506 ± 0.041	0.69PheHis: 0.69 ± 0.021	1.161PheIle: 1.161 ± 0.025	0.577PheLys: 0.577 ± 0.021	2.512PheLeu: 2.512 ± 0.042	0.492PheMet: 0.492 ± 0.016	0.806PheAsn: 0.806 ± 0.02	1.544PhePro: 1.544 ± 0.032	0.725PheGln: 0.725 ± 0.02	1.714PheArg: 1.714 ± 0.03	1.843PheSer: 1.843 ± 0.033	2.073PheThr: 2.073 ± 0.042	2.671PheVal: 2.671 ± 0.039	0.475PheTrp: 0.475 ± 0.016	0.741PheTyr: 0.741 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.917GlyAla: 9.917 ± 0.085	0.829GlyCys: 0.829 ± 0.023	4.929GlyAsp: 4.929 ± 0.054	4.314GlyGlu: 4.314 ± 0.048	3.103GlyPhe: 3.103 ± 0.039	7.742GlyGly: 7.742 ± 0.097	2.106GlyHis: 2.106 ± 0.039	4.191GlyIle: 4.191 ± 0.052	2.432GlyLys: 2.432 ± 0.037	8.551GlyLeu: 8.551 ± 0.075	2.046GlyMet: 2.046 ± 0.038	2.018GlyAsn: 2.018 ± 0.035	4.698GlyPro: 4.698 ± 0.063	3.001GlyGln: 3.001 ± 0.041	6.097GlyArg: 6.097 ± 0.056	5.376GlySer: 5.376 ± 0.053	5.07GlyThr: 5.07 ± 0.058	7.569GlyVal: 7.569 ± 0.078	1.67GlyTrp: 1.67 ± 0.033	2.438GlyTyr: 2.438 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.571HisAla: 2.571 ± 0.044	0.244HisCys: 0.244 ± 0.012	1.454HisAsp: 1.454 ± 0.03	1.058HisGlu: 1.058 ± 0.024	0.712HisPhe: 0.712 ± 0.02	2.153HisGly: 2.153 ± 0.034	0.689HisHis: 0.689 ± 0.023	0.887HisIle: 0.887 ± 0.02	0.41HisLys: 0.41 ± 0.017	2.126HisLeu: 2.126 ± 0.035	0.349HisMet: 0.349 ± 0.013	0.542HisAsn: 0.542 ± 0.018	1.719HisPro: 1.719 ± 0.033	0.731HisGln: 0.731 ± 0.02	1.877HisArg: 1.877 ± 0.03	1.186HisSer: 1.186 ± 0.025	1.265HisThr: 1.265 ± 0.027	1.793HisVal: 1.793 ± 0.031	0.417HisTrp: 0.417 ± 0.014	0.594HisTyr: 0.594 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.432IleAla: 6.432 ± 0.059	0.435IleCys: 0.435 ± 0.016	3.583IleAsp: 3.583 ± 0.046	2.737IleGlu: 2.737 ± 0.047	1.181IlePhe: 1.181 ± 0.025	4.498IleGly: 4.498 ± 0.053	0.878IleHis: 0.878 ± 0.024	1.566IleIle: 1.566 ± 0.032	1.019IleLys: 1.019 ± 0.024	3.106IleLeu: 3.106 ± 0.037	0.634IleMet: 0.634 ± 0.018	1.284IleAsn: 1.284 ± 0.029	2.516IlePro: 2.516 ± 0.035	1.024IleGln: 1.024 ± 0.025	2.676IleArg: 2.676 ± 0.039	2.48IleSer: 2.48 ± 0.035	2.865IleThr: 2.865 ± 0.04	3.857IleVal: 3.857 ± 0.046	0.513IleTrp: 0.513 ± 0.017	0.877IleTyr: 0.877 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.743LysAla: 2.743 ± 0.052	0.126LysCys: 0.126 ± 0.008	1.17LysAsp: 1.17 ± 0.026	0.982LysGlu: 0.982 ± 0.026	0.695LysPhe: 0.695 ± 0.021	1.595LysGly: 1.595 ± 0.033	0.561LysHis: 0.561 ± 0.018	1.121LysIle: 1.121 ± 0.024	0.674LysLys: 0.674 ± 0.025	2.359LysLeu: 2.359 ± 0.045	0.489LysMet: 0.489 ± 0.019	0.575LysAsn: 0.575 ± 0.017	1.562LysPro: 1.562 ± 0.034	0.777LysGln: 0.777 ± 0.023	1.69LysArg: 1.69 ± 0.038	1.348LysSer: 1.348 ± 0.03	1.435LysThr: 1.435 ± 0.03	2.021LysVal: 2.021 ± 0.036	0.315LysTrp: 0.315 ± 0.013	0.526LysTyr: 0.526 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.698LeuAla: 13.698 ± 0.096	0.852LeuCys: 0.852 ± 0.02	6.451LeuAsp: 6.451 ± 0.068	4.363LeuGlu: 4.363 ± 0.052	2.725LeuPhe: 2.725 ± 0.041	8.654LeuGly: 8.654 ± 0.077	2.109LeuHis: 2.109 ± 0.031	4.285LeuIle: 4.285 ± 0.056	1.956LeuLys: 1.956 ± 0.037	9.531LeuLeu: 9.531 ± 0.091	1.719LeuMet: 1.719 ± 0.034	2.362LeuAsn: 2.362 ± 0.04	5.867LeuPro: 5.867 ± 0.065	2.683LeuGln: 2.683 ± 0.042	7.392LeuArg: 7.392 ± 0.068	5.857LeuSer: 5.857 ± 0.057	6.223LeuThr: 6.223 ± 0.06	8.18LeuVal: 8.18 ± 0.076	1.188LeuTrp: 1.188 ± 0.028	1.689LeuTyr: 1.689 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.476MetAla: 2.476 ± 0.036	0.196MetCys: 0.196 ± 0.01	0.852MetAsp: 0.852 ± 0.02	0.683MetGlu: 0.683 ± 0.019	0.653MetPhe: 0.653 ± 0.019	1.53MetGly: 1.53 ± 0.03	0.441MetHis: 0.441 ± 0.016	0.909MetIle: 0.909 ± 0.021	0.436MetLys: 0.436 ± 0.017	2.026MetLeu: 2.026 ± 0.032	0.417MetMet: 0.417 ± 0.016	0.486MetAsn: 0.486 ± 0.017	1.231MetPro: 1.231 ± 0.028	0.569MetGln: 0.569 ± 0.016	1.467MetArg: 1.467 ± 0.028	1.39MetSer: 1.39 ± 0.027	1.646MetThr: 1.646 ± 0.033	1.577MetVal: 1.577 ± 0.034	0.277MetTrp: 0.277 ± 0.013	0.372MetTyr: 0.372 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.833AsnAla: 2.833 ± 0.044	0.218AsnCys: 0.218 ± 0.011	1.403AsnAsp: 1.403 ± 0.028	1.101AsnGlu: 1.101 ± 0.031	0.776AsnPhe: 0.776 ± 0.02	2.22AsnGly: 2.22 ± 0.038	0.524AsnHis: 0.524 ± 0.015	1.028AsnIle: 1.028 ± 0.025	0.507AsnLys: 0.507 ± 0.018	2.18AsnLeu: 2.18 ± 0.034	0.446AsnMet: 0.446 ± 0.017	0.638AsnAsn: 0.638 ± 0.02	1.875AsnPro: 1.875 ± 0.038	0.76AsnGln: 0.76 ± 0.021	1.597AsnArg: 1.597 ± 0.03	1.313AsnSer: 1.313 ± 0.028	1.39AsnThr: 1.39 ± 0.032	1.916AsnVal: 1.916 ± 0.03	0.448AsnTrp: 0.448 ± 0.017	0.623AsnTyr: 0.623 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.318ProAla: 7.318 ± 0.082	0.314ProCys: 0.314 ± 0.015	4.447ProAsp: 4.447 ± 0.051	3.59ProGlu: 3.59 ± 0.046	1.735ProPhe: 1.735 ± 0.032	5.816ProGly: 5.816 ± 0.066	1.257ProHis: 1.257 ± 0.031	2.367ProIle: 2.367 ± 0.041	1.396ProLys: 1.396 ± 0.028	4.99ProLeu: 4.99 ± 0.056	1.159ProMet: 1.159 ± 0.023	1.441ProAsn: 1.441 ± 0.031	3.946ProPro: 3.946 ± 0.098	1.965ProGln: 1.965 ± 0.033	3.333ProArg: 3.333 ± 0.045	3.22ProSer: 3.22 ± 0.041	3.471ProThr: 3.471 ± 0.051	4.956ProVal: 4.956 ± 0.061	0.849ProTrp: 0.849 ± 0.022	1.245ProTyr: 1.245 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.76GlnAla: 3.76 ± 0.056	0.236GlnCys: 0.236 ± 0.013	1.338GlnAsp: 1.338 ± 0.023	1.157GlnGlu: 1.157 ± 0.026	1.049GlnPhe: 1.049 ± 0.025	2.045GlnGly: 2.045 ± 0.036	0.829GlnHis: 0.829 ± 0.019	1.605GlnIle: 1.605 ± 0.032	0.641GlnLys: 0.641 ± 0.018	3.863GlnLeu: 3.863 ± 0.052	0.699GlnMet: 0.699 ± 0.019	0.683GlnAsn: 0.683 ± 0.018	2.054GlnPro: 2.054 ± 0.035	1.377GlnGln: 1.377 ± 0.031	2.817GlnArg: 2.817 ± 0.038	1.645GlnSer: 1.645 ± 0.028	1.691GlnThr: 1.691 ± 0.033	2.66GlnVal: 2.66 ± 0.043	0.614GlnTrp: 0.614 ± 0.02	0.702GlnTyr: 0.702 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.028ArgAla: 8.028 ± 0.071	0.62ArgCys: 0.62 ± 0.02	4.202ArgAsp: 4.202 ± 0.053	3.689ArgGlu: 3.689 ± 0.05	2.372ArgPhe: 2.372 ± 0.036	5.069ArgGly: 5.069 ± 0.059	1.721ArgHis: 1.721 ± 0.032	3.4ArgIle: 3.4 ± 0.044	1.588ArgLys: 1.588 ± 0.029	7.394ArgLeu: 7.394 ± 0.073	1.555ArgMet: 1.555 ± 0.026	1.672ArgAsn: 1.672 ± 0.031	3.885ArgPro: 3.885 ± 0.052	2.327ArgGln: 2.327 ± 0.032	6.015ArgArg: 6.015 ± 0.08	4.032ArgSer: 4.032 ± 0.052	3.824ArgThr: 3.824 ± 0.047	5.543ArgVal: 5.543 ± 0.058	1.357ArgTrp: 1.357 ± 0.032	1.914ArgTyr: 1.914 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.166SerAla: 7.166 ± 0.072	0.425SerCys: 0.425 ± 0.017	3.423SerAsp: 3.423 ± 0.043	2.712SerGlu: 2.712 ± 0.039	1.797SerPhe: 1.797 ± 0.028	5.778SerGly: 5.778 ± 0.063	1.14SerHis: 1.14 ± 0.024	2.358SerIle: 2.358 ± 0.034	1.282SerLys: 1.282 ± 0.027	5.008SerLeu: 5.008 ± 0.06	1.296SerMet: 1.296 ± 0.029	1.292SerAsn: 1.292 ± 0.029	3.251SerPro: 3.251 ± 0.043	1.677SerGln: 1.677 ± 0.023	3.675SerArg: 3.675 ± 0.043	3.397SerSer: 3.397 ± 0.05	3.357SerThr: 3.357 ± 0.05	4.656SerVal: 4.656 ± 0.06	0.975SerTrp: 0.975 ± 0.025	1.324SerTyr: 1.324 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.532ThrAla: 7.532 ± 0.072	0.407ThrCys: 0.407 ± 0.015	3.619ThrAsp: 3.619 ± 0.049	3.068ThrGlu: 3.068 ± 0.044	1.798ThrPhe: 1.798 ± 0.038	5.675ThrGly: 5.675 ± 0.052	1.2ThrHis: 1.2 ± 0.027	2.54ThrIle: 2.54 ± 0.037	1.327ThrLys: 1.327 ± 0.029	5.598ThrLeu: 5.598 ± 0.056	1.165ThrMet: 1.165 ± 0.028	1.339ThrAsn: 1.339 ± 0.027	3.829ThrPro: 3.829 ± 0.048	1.618ThrGln: 1.618 ± 0.031	3.501ThrArg: 3.501 ± 0.047	3.256ThrSer: 3.256 ± 0.047	3.828ThrThr: 3.828 ± 0.057	5.571ThrVal: 5.571 ± 0.058	0.86ThrTrp: 0.86 ± 0.021	1.304ThrTyr: 1.304 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.327ValAla: 11.327 ± 0.089	0.768ValCys: 0.768 ± 0.02	5.669ValAsp: 5.669 ± 0.066	4.532ValGlu: 4.532 ± 0.058	2.597ValPhe: 2.597 ± 0.036	6.963ValGly: 6.963 ± 0.064	1.877ValHis: 1.877 ± 0.031	4.031ValIle: 4.031 ± 0.052	1.754ValLys: 1.754 ± 0.035	8.605ValLeu: 8.605 ± 0.087	1.539ValMet: 1.539 ± 0.029	2.25ValAsn: 2.25 ± 0.038	4.588ValPro: 4.588 ± 0.048	2.213ValGln: 2.213 ± 0.031	5.698ValArg: 5.698 ± 0.058	4.939ValSer: 4.939 ± 0.059	5.396ValThr: 5.396 ± 0.058	8.303ValVal: 8.303 ± 0.08	1.044ValTrp: 1.044 ± 0.024	1.58ValTyr: 1.58 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.583TrpAla: 1.583 ± 0.036	0.162TrpCys: 0.162 ± 0.009	0.819TrpAsp: 0.819 ± 0.023	0.711TrpGlu: 0.711 ± 0.019	0.527TrpPhe: 0.527 ± 0.019	1.052TrpGly: 1.052 ± 0.026	0.37TrpHis: 0.37 ± 0.013	0.681TrpIle: 0.681 ± 0.019	0.342TrpLys: 0.342 ± 0.015	1.772TrpLeu: 1.772 ± 0.034	0.346TrpMet: 0.346 ± 0.014	0.435TrpAsn: 0.435 ± 0.018	0.865TrpPro: 0.865 ± 0.022	0.676TrpGln: 0.676 ± 0.018	1.273TrpArg: 1.273 ± 0.03	0.998TrpSer: 0.998 ± 0.025	0.91TrpThr: 0.91 ± 0.023	1.105TrpVal: 1.105 ± 0.025	0.322TrpTrp: 0.322 ± 0.014	0.341TrpTyr: 0.341 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.449TyrAla: 2.449 ± 0.034	0.251TyrCys: 0.251 ± 0.01	1.433TyrAsp: 1.433 ± 0.032	1.101TyrGlu: 1.101 ± 0.025	0.849TyrPhe: 0.849 ± 0.022	2.137TyrGly: 2.137 ± 0.035	0.51TyrHis: 0.51 ± 0.017	0.718TyrIle: 0.718 ± 0.021	0.391TyrLys: 0.391 ± 0.017	2.399TyrLeu: 2.399 ± 0.036	0.294TyrMet: 0.294 ± 0.012	0.517TyrAsn: 0.517 ± 0.017	1.289TyrPro: 1.289 ± 0.027	0.767TyrGln: 0.767 ± 0.018	1.902TyrArg: 1.902 ± 0.034	1.202TyrSer: 1.202 ± 0.023	1.201TyrThr: 1.201 ± 0.024	1.708TyrVal: 1.708 ± 0.034	0.381TyrTrp: 0.381 ± 0.015	0.549TyrTyr: 0.549 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5720 proteins (1842979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---