Amino acid dipepetide frequency for Legionella endosymbiont of Polyplax serrata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.671AlaAla: 1.671 ± 0.124
0.622AlaCys: 0.622 ± 0.071
1.177AlaAsp: 1.177 ± 0.115
1.458AlaGlu: 1.458 ± 0.111
1.805AlaPhe: 1.805 ± 0.109
1.859AlaGly: 1.859 ± 0.132
0.642AlaHis: 0.642 ± 0.063
4.627AlaIle: 4.627 ± 0.199
3.477AlaLys: 3.477 ± 0.186
3.998AlaLeu: 3.998 ± 0.178
0.849AlaMet: 0.849 ± 0.079
1.899AlaAsn: 1.899 ± 0.114
0.876AlaPro: 0.876 ± 0.079
0.936AlaGln: 0.936 ± 0.083
1.511AlaArg: 1.511 ± 0.102
2.447AlaSer: 2.447 ± 0.131
1.585AlaThr: 1.585 ± 0.11
1.912AlaVal: 1.912 ± 0.123
0.254AlaTrp: 0.254 ± 0.041
1.424AlaTyr: 1.424 ± 0.092
0.0AlaXaa: 0.0 ± 0.0
Cys
0.481CysAla: 0.481 ± 0.063
0.254CysCys: 0.254 ± 0.036
0.495CysAsp: 0.495 ± 0.054
0.515CysGlu: 0.515 ± 0.051
1.143CysPhe: 1.143 ± 0.079
1.15CysGly: 1.15 ± 0.093
0.287CysHis: 0.287 ± 0.052
1.765CysIle: 1.765 ± 0.127
1.31CysLys: 1.31 ± 0.103
1.491CysLeu: 1.491 ± 0.093
0.281CysMet: 0.281 ± 0.039
1.01CysAsn: 1.01 ± 0.092
0.428CysPro: 0.428 ± 0.054
0.388CysGln: 0.388 ± 0.051
0.481CysArg: 0.481 ± 0.059
1.217CysSer: 1.217 ± 0.098
0.709CysThr: 0.709 ± 0.069
0.649CysVal: 0.649 ± 0.072
0.1CysTrp: 0.1 ± 0.027
0.749CysTyr: 0.749 ± 0.075
0.0CysXaa: 0.0 ± 0.0
Asp
1.451AspAla: 1.451 ± 0.105
0.582AspCys: 0.582 ± 0.068
1.484AspAsp: 1.484 ± 0.105
1.792AspGlu: 1.792 ± 0.128
2.842AspPhe: 2.842 ± 0.163
1.952AspGly: 1.952 ± 0.139
0.802AspHis: 0.802 ± 0.07
5.81AspIle: 5.81 ± 0.261
3.717AspLys: 3.717 ± 0.171
4.754AspLeu: 4.754 ± 0.183
0.789AspMet: 0.789 ± 0.069
2.801AspAsn: 2.801 ± 0.145
1.11AspPro: 1.11 ± 0.073
1.01AspGln: 1.01 ± 0.072
1.645AspArg: 1.645 ± 0.119
2.494AspSer: 2.494 ± 0.138
1.551AspThr: 1.551 ± 0.096
2.36AspVal: 2.36 ± 0.132
0.388AspTrp: 0.388 ± 0.062
2.079AspTyr: 2.079 ± 0.137
0.0AspXaa: 0.0 ± 0.0
Glu
1.899GluAla: 1.899 ± 0.143
0.662GluCys: 0.662 ± 0.065
1.819GluAsp: 1.819 ± 0.124
2.608GluGlu: 2.608 ± 0.176
2.273GluPhe: 2.273 ± 0.122
1.772GluGly: 1.772 ± 0.134
0.655GluHis: 0.655 ± 0.056
6.024GluIle: 6.024 ± 0.227
5.402GluLys: 5.402 ± 0.208
4.192GluLeu: 4.192 ± 0.184
1.063GluMet: 1.063 ± 0.104
3.276GluAsn: 3.276 ± 0.142
0.903GluPro: 0.903 ± 0.076
1.143GluGln: 1.143 ± 0.074
1.778GluArg: 1.778 ± 0.132
2.721GluSer: 2.721 ± 0.15
1.738GluThr: 1.738 ± 0.111
2.353GluVal: 2.353 ± 0.152
0.374GluTrp: 0.374 ± 0.058
1.785GluTyr: 1.785 ± 0.116
0.0GluXaa: 0.0 ± 0.0
Phe
1.765PheAla: 1.765 ± 0.099
1.043PheCys: 1.043 ± 0.092
2.447PheAsp: 2.447 ± 0.138
2.019PheGlu: 2.019 ± 0.12
5.081PhePhe: 5.081 ± 0.273
3.249PheGly: 3.249 ± 0.18
1.043PheHis: 1.043 ± 0.076
7.248PheIle: 7.248 ± 0.267
4.607PheLys: 4.607 ± 0.201
7.114PheLeu: 7.114 ± 0.293
1.17PheMet: 1.17 ± 0.082
4.312PheAsn: 4.312 ± 0.179
2.14PhePro: 2.14 ± 0.13
1.351PheGln: 1.351 ± 0.081
1.718PheArg: 1.718 ± 0.101
5.155PheSer: 5.155 ± 0.228
1.899PheThr: 1.899 ± 0.1
2.44PheVal: 2.44 ± 0.144
0.588PheTrp: 0.588 ± 0.068
3.316PheTyr: 3.316 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
2.267GlyAla: 2.267 ± 0.141
0.943GlyCys: 0.943 ± 0.076
2.14GlyAsp: 2.14 ± 0.149
2.26GlyGlu: 2.26 ± 0.123
3.069GlyPhe: 3.069 ± 0.158
3.443GlyGly: 3.443 ± 0.195
1.05GlyHis: 1.05 ± 0.091
6.94GlyIle: 6.94 ± 0.271
5.061GlyLys: 5.061 ± 0.231
4.794GlyLeu: 4.794 ± 0.2
1.364GlyMet: 1.364 ± 0.106
2.949GlyAsn: 2.949 ± 0.133
1.23GlyPro: 1.23 ± 0.079
1.177GlyGln: 1.177 ± 0.09
1.986GlyArg: 1.986 ± 0.157
3.497GlySer: 3.497 ± 0.19
2.367GlyThr: 2.367 ± 0.142
3.029GlyVal: 3.029 ± 0.151
0.495GlyTrp: 0.495 ± 0.067
2.34GlyTyr: 2.34 ± 0.137
0.0GlyXaa: 0.0 ± 0.0
His
0.816HisAla: 0.816 ± 0.077
0.334HisCys: 0.334 ± 0.05
0.622HisAsp: 0.622 ± 0.069
0.642HisGlu: 0.642 ± 0.063
0.876HisPhe: 0.876 ± 0.086
1.01HisGly: 1.01 ± 0.077
0.435HisHis: 0.435 ± 0.066
2.233HisIle: 2.233 ± 0.126
1.625HisLys: 1.625 ± 0.115
1.692HisLeu: 1.692 ± 0.112
0.287HisMet: 0.287 ± 0.046
1.157HisAsn: 1.157 ± 0.093
1.023HisPro: 1.023 ± 0.082
0.455HisGln: 0.455 ± 0.051
0.789HisArg: 0.789 ± 0.075
1.203HisSer: 1.203 ± 0.076
0.836HisThr: 0.836 ± 0.074
0.923HisVal: 0.923 ± 0.078
0.207HisTrp: 0.207 ± 0.036
0.883HisTyr: 0.883 ± 0.086
0.0HisXaa: 0.0 ± 0.0
Ile
4.867IleAla: 4.867 ± 0.178
1.812IleCys: 1.812 ± 0.123
6.171IleAsp: 6.171 ± 0.215
5.89IleGlu: 5.89 ± 0.227
6.987IlePhe: 6.987 ± 0.263
6.592IleGly: 6.592 ± 0.222
2.267IleHis: 2.267 ± 0.125
13.9IleIle: 13.9 ± 0.45
13.078IleLys: 13.078 ± 0.407
12.723IleLeu: 12.723 ± 0.339
2.313IleMet: 2.313 ± 0.116
10.791IleAsn: 10.791 ± 0.329
4.366IlePro: 4.366 ± 0.166
2.848IleGln: 2.848 ± 0.145
4.032IleArg: 4.032 ± 0.162
9.434IleSer: 9.434 ± 0.251
4.874IleThr: 4.874 ± 0.228
5.576IleVal: 5.576 ± 0.237
1.03IleTrp: 1.03 ± 0.082
5.75IleTyr: 5.75 ± 0.217
0.0IleXaa: 0.0 ± 0.0
Lys
2.514LysAla: 2.514 ± 0.142
1.05LysCys: 1.05 ± 0.086
4.246LysAsp: 4.246 ± 0.208
5.523LysGlu: 5.523 ± 0.202
4.834LysPhe: 4.834 ± 0.187
3.524LysGly: 3.524 ± 0.164
1.685LysHis: 1.685 ± 0.104
14.02LysIle: 14.02 ± 0.402
15.585LysLys: 15.585 ± 0.518
8.719LysLeu: 8.719 ± 0.284
2.233LysMet: 2.233 ± 0.114
10.851LysAsn: 10.851 ± 0.355
2.006LysPro: 2.006 ± 0.11
2.761LysGln: 2.761 ± 0.15
3.791LysArg: 3.791 ± 0.167
6.057LysSer: 6.057 ± 0.217
4.292LysThr: 4.292 ± 0.231
3.978LysVal: 3.978 ± 0.16
0.809LysTrp: 0.809 ± 0.081
5.449LysTyr: 5.449 ± 0.2
0.0LysXaa: 0.0 ± 0.0
Leu
3.283LeuAla: 3.283 ± 0.159
1.411LeuCys: 1.411 ± 0.089
4.466LeuAsp: 4.466 ± 0.201
4.299LeuGlu: 4.299 ± 0.186
6.144LeuPhe: 6.144 ± 0.281
5.777LeuGly: 5.777 ± 0.243
2.033LeuHis: 2.033 ± 0.11
11.333LeuIle: 11.333 ± 0.325
10.102LeuLys: 10.102 ± 0.295
10.932LeuLeu: 10.932 ± 0.312
2.233LeuMet: 2.233 ± 0.152
7.99LeuAsn: 7.99 ± 0.26
3.149LeuPro: 3.149 ± 0.139
2.534LeuGln: 2.534 ± 0.14
3.624LeuArg: 3.624 ± 0.145
8.471LeuSer: 8.471 ± 0.281
3.951LeuThr: 3.951 ± 0.183
4.841LeuVal: 4.841 ± 0.203
0.883LeuTrp: 0.883 ± 0.089
4.139LeuTyr: 4.139 ± 0.186
0.0LeuXaa: 0.0 ± 0.0
Met
0.842MetAla: 0.842 ± 0.083
0.274MetCys: 0.274 ± 0.04
0.996MetAsp: 0.996 ± 0.085
0.909MetGlu: 0.909 ± 0.086
1.083MetPhe: 1.083 ± 0.09
1.257MetGly: 1.257 ± 0.089
0.388MetHis: 0.388 ± 0.053
2.313MetIle: 2.313 ± 0.131
2.28MetLys: 2.28 ± 0.111
2.16MetLeu: 2.16 ± 0.118
0.528MetMet: 0.528 ± 0.064
1.544MetAsn: 1.544 ± 0.096
0.769MetPro: 0.769 ± 0.077
0.649MetGln: 0.649 ± 0.067
0.862MetArg: 0.862 ± 0.079
1.605MetSer: 1.605 ± 0.094
0.816MetThr: 0.816 ± 0.064
1.177MetVal: 1.177 ± 0.092
0.094MetTrp: 0.094 ± 0.031
0.769MetTyr: 0.769 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
2.24AsnAla: 2.24 ± 0.14
0.956AsnCys: 0.956 ± 0.067
2.761AsnAsp: 2.761 ± 0.151
3.183AsnGlu: 3.183 ± 0.164
5.275AsnPhe: 5.275 ± 0.217
3.316AsnGly: 3.316 ± 0.141
1.471AsnHis: 1.471 ± 0.113
11.246AsnIle: 11.246 ± 0.312
9.059AsnLys: 9.059 ± 0.338
7.281AsnLeu: 7.281 ± 0.284
1.437AsnMet: 1.437 ± 0.091
6.98AsnAsn: 6.98 ± 0.278
2.34AsnPro: 2.34 ± 0.104
2.193AsnGln: 2.193 ± 0.119
2.46AsnArg: 2.46 ± 0.128
5.235AsnSer: 5.235 ± 0.189
2.915AsnThr: 2.915 ± 0.177
3.276AsnVal: 3.276 ± 0.159
0.762AsnTrp: 0.762 ± 0.069
3.731AsnTyr: 3.731 ± 0.174
0.0AsnXaa: 0.0 ± 0.0
Pro
0.829ProAla: 0.829 ± 0.083
0.468ProCys: 0.468 ± 0.061
0.996ProAsp: 0.996 ± 0.082
1.437ProGlu: 1.437 ± 0.088
1.745ProPhe: 1.745 ± 0.107
2.006ProGly: 2.006 ± 0.116
0.495ProHis: 0.495 ± 0.055
4.005ProIle: 4.005 ± 0.186
2.567ProLys: 2.567 ± 0.132
2.728ProLeu: 2.728 ± 0.144
0.689ProMet: 0.689 ± 0.071
2.38ProAsn: 2.38 ± 0.154
0.722ProPro: 0.722 ± 0.071
0.622ProGln: 0.622 ± 0.085
0.649ProArg: 0.649 ± 0.072
1.912ProSer: 1.912 ± 0.105
1.27ProThr: 1.27 ± 0.098
1.685ProVal: 1.685 ± 0.118
0.348ProTrp: 0.348 ± 0.048
1.351ProTyr: 1.351 ± 0.094
0.0ProXaa: 0.0 ± 0.0
Gln
1.09GlnAla: 1.09 ± 0.09
0.374GlnCys: 0.374 ± 0.051
1.063GlnAsp: 1.063 ± 0.076
1.304GlnGlu: 1.304 ± 0.104
1.391GlnPhe: 1.391 ± 0.115
1.036GlnGly: 1.036 ± 0.086
0.441GlnHis: 0.441 ± 0.062
2.902GlnIle: 2.902 ± 0.141
2.728GlnLys: 2.728 ± 0.151
2.521GlnLeu: 2.521 ± 0.131
0.408GlnMet: 0.408 ± 0.054
1.979GlnAsn: 1.979 ± 0.117
0.508GlnPro: 0.508 ± 0.054
0.735GlnGln: 0.735 ± 0.077
0.896GlnArg: 0.896 ± 0.078
1.631GlnSer: 1.631 ± 0.109
1.063GlnThr: 1.063 ± 0.077
1.143GlnVal: 1.143 ± 0.091
0.374GlnTrp: 0.374 ± 0.049
1.464GlnTyr: 1.464 ± 0.104
0.0GlnXaa: 0.0 ± 0.0
Arg
1.304ArgAla: 1.304 ± 0.114
0.562ArgCys: 0.562 ± 0.064
1.571ArgAsp: 1.571 ± 0.112
1.959ArgGlu: 1.959 ± 0.129
2.019ArgPhe: 2.019 ± 0.131
1.598ArgGly: 1.598 ± 0.131
0.588ArgHis: 0.588 ± 0.068
4.165ArgIle: 4.165 ± 0.169
3.363ArgLys: 3.363 ± 0.158
3.383ArgLeu: 3.383 ± 0.156
0.849ArgMet: 0.849 ± 0.069
2.467ArgAsn: 2.467 ± 0.123
0.856ArgPro: 0.856 ± 0.071
0.923ArgGln: 0.923 ± 0.095
1.511ArgArg: 1.511 ± 0.142
2.527ArgSer: 2.527 ± 0.137
1.391ArgThr: 1.391 ± 0.102
2.113ArgVal: 2.113 ± 0.133
0.294ArgTrp: 0.294 ± 0.043
1.665ArgTyr: 1.665 ± 0.104
0.0ArgXaa: 0.0 ± 0.0
Ser
2.427SerAla: 2.427 ± 0.141
1.137SerCys: 1.137 ± 0.085
2.902SerAsp: 2.902 ± 0.166
2.821SerGlu: 2.821 ± 0.136
4.419SerPhe: 4.419 ± 0.215
4.473SerGly: 4.473 ± 0.19
1.13SerHis: 1.13 ± 0.078
9.334SerIle: 9.334 ± 0.26
6.512SerLys: 6.512 ± 0.225
7.482SerLeu: 7.482 ± 0.215
1.752SerMet: 1.752 ± 0.101
5.382SerAsn: 5.382 ± 0.199
1.698SerPro: 1.698 ± 0.107
1.397SerGln: 1.397 ± 0.098
2.327SerArg: 2.327 ± 0.149
4.887SerSer: 4.887 ± 0.232
2.761SerThr: 2.761 ± 0.153
4.005SerVal: 4.005 ± 0.166
0.588SerTrp: 0.588 ± 0.062
3.149SerTyr: 3.149 ± 0.157
0.0SerXaa: 0.0 ± 0.0
Thr
1.678ThrAla: 1.678 ± 0.13
0.475ThrCys: 0.475 ± 0.056
1.578ThrAsp: 1.578 ± 0.113
1.571ThrGlu: 1.571 ± 0.105
2.086ThrPhe: 2.086 ± 0.115
2.641ThrGly: 2.641 ± 0.136
0.822ThrHis: 0.822 ± 0.064
5.108ThrIle: 5.108 ± 0.222
3.584ThrLys: 3.584 ± 0.187
4.246ThrLeu: 4.246 ± 0.207
0.856ThrMet: 0.856 ± 0.077
2.995ThrAsn: 2.995 ± 0.181
1.324ThrPro: 1.324 ± 0.093
1.123ThrGln: 1.123 ± 0.102
1.304ThrArg: 1.304 ± 0.1
2.427ThrSer: 2.427 ± 0.119
1.959ThrThr: 1.959 ± 0.136
2.166ThrVal: 2.166 ± 0.132
0.308ThrTrp: 0.308 ± 0.044
1.651ThrTyr: 1.651 ± 0.103
0.0ThrXaa: 0.0 ± 0.0
Val
1.885ValAla: 1.885 ± 0.124
0.903ValCys: 0.903 ± 0.082
2.287ValAsp: 2.287 ± 0.14
2.012ValGlu: 2.012 ± 0.135
2.955ValPhe: 2.955 ± 0.188
2.808ValGly: 2.808 ± 0.161
0.883ValHis: 0.883 ± 0.068
5.703ValIle: 5.703 ± 0.232
4.045ValLys: 4.045 ± 0.201
5.289ValLeu: 5.289 ± 0.204
1.19ValMet: 1.19 ± 0.076
3.323ValAsn: 3.323 ± 0.155
1.718ValPro: 1.718 ± 0.103
1.11ValGln: 1.11 ± 0.101
1.819ValArg: 1.819 ± 0.136
3.818ValSer: 3.818 ± 0.183
1.912ValThr: 1.912 ± 0.121
3.089ValVal: 3.089 ± 0.165
0.408ValTrp: 0.408 ± 0.059
1.992ValTyr: 1.992 ± 0.129
0.0ValXaa: 0.0 ± 0.0
Trp
0.254TrpAla: 0.254 ± 0.043
0.154TrpCys: 0.154 ± 0.034
0.334TrpAsp: 0.334 ± 0.045
0.321TrpGlu: 0.321 ± 0.049
0.608TrpPhe: 0.608 ± 0.069
0.421TrpGly: 0.421 ± 0.052
0.127TrpHis: 0.127 ± 0.026
1.511TrpIle: 1.511 ± 0.127
0.99TrpLys: 0.99 ± 0.085
0.869TrpLeu: 0.869 ± 0.088
0.194TrpMet: 0.194 ± 0.036
0.675TrpAsn: 0.675 ± 0.066
0.334TrpPro: 0.334 ± 0.044
0.194TrpGln: 0.194 ± 0.036
0.267TrpArg: 0.267 ± 0.041
0.528TrpSer: 0.528 ± 0.063
0.321TrpThr: 0.321 ± 0.063
0.381TrpVal: 0.381 ± 0.054
0.127TrpTrp: 0.127 ± 0.036
0.301TrpTyr: 0.301 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.464TyrAla: 1.464 ± 0.099
0.889TyrCys: 0.889 ± 0.072
1.859TyrAsp: 1.859 ± 0.125
1.919TyrGlu: 1.919 ± 0.101
3.069TyrPhe: 3.069 ± 0.165
2.514TyrGly: 2.514 ± 0.121
0.802TyrHis: 0.802 ± 0.068
5.121TyrIle: 5.121 ± 0.208
4.834TyrLys: 4.834 ± 0.205
5.228TyrLeu: 5.228 ± 0.212
0.822TyrMet: 0.822 ± 0.085
3.356TyrAsn: 3.356 ± 0.156
1.404TyrPro: 1.404 ± 0.094
1.504TyrGln: 1.504 ± 0.128
1.658TyrArg: 1.658 ± 0.107
3.316TyrSer: 3.316 ± 0.142
1.692TyrThr: 1.692 ± 0.104
2.053TyrVal: 2.053 ± 0.121
0.481TyrTrp: 0.481 ± 0.065
2.213TyrTyr: 2.213 ± 0.139
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 473 proteins (149568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski