Amino acid dipepetide frequency for Mycobacterium virus Doom

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.203AlaAla: 12.203 ± 1.316
0.692AlaCys: 0.692 ± 0.172
6.856AlaAsp: 6.856 ± 0.701
6.353AlaGlu: 6.353 ± 0.776
3.46AlaPhe: 3.46 ± 0.528
8.68AlaGly: 8.68 ± 0.95
1.258AlaHis: 1.258 ± 0.324
4.403AlaIle: 4.403 ± 0.562
4.655AlaLys: 4.655 ± 0.53
8.555AlaLeu: 8.555 ± 0.946
2.516AlaMet: 2.516 ± 0.489
2.516AlaAsn: 2.516 ± 0.37
5.158AlaPro: 5.158 ± 0.633
2.768AlaGln: 2.768 ± 0.423
6.416AlaArg: 6.416 ± 0.677
4.78AlaSer: 4.78 ± 0.426
6.164AlaThr: 6.164 ± 0.751
7.737AlaVal: 7.737 ± 0.802
2.013AlaTrp: 2.013 ± 0.346
2.768AlaTyr: 2.768 ± 0.397
0.0AlaXaa: 0.0 ± 0.0
Cys
0.692CysAla: 0.692 ± 0.232
0.0CysCys: 0.0 ± 0.0
0.566CysAsp: 0.566 ± 0.187
0.566CysGlu: 0.566 ± 0.179
0.126CysPhe: 0.126 ± 0.083
0.315CysGly: 0.315 ± 0.147
0.126CysHis: 0.126 ± 0.091
0.377CysIle: 0.377 ± 0.183
0.315CysLys: 0.315 ± 0.123
0.44CysLeu: 0.44 ± 0.172
0.252CysMet: 0.252 ± 0.139
0.315CysAsn: 0.315 ± 0.123
0.377CysPro: 0.377 ± 0.156
0.252CysGln: 0.252 ± 0.118
0.566CysArg: 0.566 ± 0.213
0.252CysSer: 0.252 ± 0.138
0.44CysThr: 0.44 ± 0.18
0.252CysVal: 0.252 ± 0.121
0.252CysTrp: 0.252 ± 0.126
0.063CysTyr: 0.063 ± 0.062
0.0CysXaa: 0.0 ± 0.0
Asp
6.856AspAla: 6.856 ± 0.621
0.566AspCys: 0.566 ± 0.159
4.718AspAsp: 4.718 ± 0.508
3.648AspGlu: 3.648 ± 0.497
2.642AspPhe: 2.642 ± 0.309
5.787AspGly: 5.787 ± 0.652
1.006AspHis: 1.006 ± 0.26
2.39AspIle: 2.39 ± 0.455
2.705AspLys: 2.705 ± 0.39
6.982AspLeu: 6.982 ± 0.744
1.321AspMet: 1.321 ± 0.284
2.202AspAsn: 2.202 ± 0.36
4.592AspPro: 4.592 ± 0.495
1.51AspGln: 1.51 ± 0.351
3.522AspArg: 3.522 ± 0.395
3.397AspSer: 3.397 ± 0.477
3.774AspThr: 3.774 ± 0.419
4.843AspVal: 4.843 ± 0.628
2.076AspTrp: 2.076 ± 0.331
2.013AspTyr: 2.013 ± 0.32
0.0AspXaa: 0.0 ± 0.0
Glu
6.101GluAla: 6.101 ± 0.675
0.315GluCys: 0.315 ± 0.162
4.969GluAsp: 4.969 ± 0.546
4.969GluGlu: 4.969 ± 0.611
2.139GluPhe: 2.139 ± 0.423
4.151GluGly: 4.151 ± 0.558
1.447GluHis: 1.447 ± 0.363
3.585GluIle: 3.585 ± 0.487
2.768GluLys: 2.768 ± 0.437
6.73GluLeu: 6.73 ± 0.671
1.258GluMet: 1.258 ± 0.327
1.573GluAsn: 1.573 ± 0.336
2.831GluPro: 2.831 ± 0.466
2.768GluGln: 2.768 ± 0.452
3.648GluArg: 3.648 ± 0.659
3.711GluSer: 3.711 ± 0.487
4.026GluThr: 4.026 ± 0.442
5.598GluVal: 5.598 ± 0.495
1.51GluTrp: 1.51 ± 0.327
2.39GluTyr: 2.39 ± 0.436
0.0GluXaa: 0.0 ± 0.0
Phe
2.579PheAla: 2.579 ± 0.473
0.315PheCys: 0.315 ± 0.159
2.893PheAsp: 2.893 ± 0.36
2.264PheGlu: 2.264 ± 0.403
0.692PhePhe: 0.692 ± 0.215
3.9PheGly: 3.9 ± 0.478
0.818PheHis: 0.818 ± 0.308
1.51PheIle: 1.51 ± 0.288
1.384PheLys: 1.384 ± 0.289
2.516PheLeu: 2.516 ± 0.445
0.629PheMet: 0.629 ± 0.209
1.51PheAsn: 1.51 ± 0.352
1.887PhePro: 1.887 ± 0.355
1.132PheGln: 1.132 ± 0.299
1.635PheArg: 1.635 ± 0.375
1.761PheSer: 1.761 ± 0.296
2.453PheThr: 2.453 ± 0.392
1.635PheVal: 1.635 ± 0.334
0.566PheTrp: 0.566 ± 0.161
0.881PheTyr: 0.881 ± 0.222
0.0PheXaa: 0.0 ± 0.0
Gly
7.674GlyAla: 7.674 ± 1.165
0.755GlyCys: 0.755 ± 0.218
5.347GlyAsp: 5.347 ± 0.476
4.718GlyGlu: 4.718 ± 0.491
3.019GlyPhe: 3.019 ± 0.526
8.429GlyGly: 8.429 ± 1.85
1.573GlyHis: 1.573 ± 0.309
4.592GlyIle: 4.592 ± 0.764
3.963GlyLys: 3.963 ± 0.51
7.359GlyLeu: 7.359 ± 0.736
1.761GlyMet: 1.761 ± 0.373
3.145GlyAsn: 3.145 ± 0.404
4.089GlyPro: 4.089 ± 0.579
2.139GlyGln: 2.139 ± 0.355
4.466GlyArg: 4.466 ± 0.535
5.976GlySer: 5.976 ± 0.726
4.843GlyThr: 4.843 ± 0.489
5.409GlyVal: 5.409 ± 0.586
2.39GlyTrp: 2.39 ± 0.314
2.768GlyTyr: 2.768 ± 0.312
0.0GlyXaa: 0.0 ± 0.0
His
1.698HisAla: 1.698 ± 0.3
0.0HisCys: 0.0 ± 0.0
1.132HisAsp: 1.132 ± 0.244
1.635HisGlu: 1.635 ± 0.34
0.818HisPhe: 0.818 ± 0.222
1.321HisGly: 1.321 ± 0.371
0.692HisHis: 0.692 ± 0.22
0.881HisIle: 0.881 ± 0.222
1.006HisLys: 1.006 ± 0.287
1.258HisLeu: 1.258 ± 0.293
0.126HisMet: 0.126 ± 0.11
0.377HisAsn: 0.377 ± 0.156
1.447HisPro: 1.447 ± 0.268
0.881HisGln: 0.881 ± 0.26
1.195HisArg: 1.195 ± 0.231
0.629HisSer: 0.629 ± 0.182
1.195HisThr: 1.195 ± 0.352
1.447HisVal: 1.447 ± 0.327
0.503HisTrp: 0.503 ± 0.15
0.566HisTyr: 0.566 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
6.793IleAla: 6.793 ± 0.652
0.252IleCys: 0.252 ± 0.095
3.9IleAsp: 3.9 ± 0.461
3.837IleGlu: 3.837 ± 0.514
0.881IlePhe: 0.881 ± 0.255
3.711IleGly: 3.711 ± 0.497
0.944IleHis: 0.944 ± 0.259
1.761IleIle: 1.761 ± 0.326
2.013IleLys: 2.013 ± 0.347
3.334IleLeu: 3.334 ± 0.414
0.629IleMet: 0.629 ± 0.182
1.761IleAsn: 1.761 ± 0.277
3.271IlePro: 3.271 ± 0.339
1.321IleGln: 1.321 ± 0.329
3.648IleArg: 3.648 ± 0.497
3.334IleSer: 3.334 ± 0.43
3.522IleThr: 3.522 ± 0.391
2.831IleVal: 2.831 ± 0.504
0.692IleTrp: 0.692 ± 0.186
1.321IleTyr: 1.321 ± 0.28
0.0IleXaa: 0.0 ± 0.0
Lys
4.026LysAla: 4.026 ± 0.563
0.377LysCys: 0.377 ± 0.16
2.579LysAsp: 2.579 ± 0.432
2.642LysGlu: 2.642 ± 0.436
1.761LysPhe: 1.761 ± 0.315
2.39LysGly: 2.39 ± 0.366
1.006LysHis: 1.006 ± 0.271
2.642LysIle: 2.642 ± 0.376
2.076LysLys: 2.076 ± 0.451
3.145LysLeu: 3.145 ± 0.412
1.132LysMet: 1.132 ± 0.241
1.384LysAsn: 1.384 ± 0.272
2.893LysPro: 2.893 ± 0.441
1.824LysGln: 1.824 ± 0.418
2.893LysArg: 2.893 ± 0.412
2.453LysSer: 2.453 ± 0.379
2.327LysThr: 2.327 ± 0.397
3.271LysVal: 3.271 ± 0.524
0.818LysTrp: 0.818 ± 0.25
1.258LysTyr: 1.258 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
8.932LeuAla: 8.932 ± 0.82
0.315LeuCys: 0.315 ± 0.131
6.227LeuAsp: 6.227 ± 0.624
5.347LeuGlu: 5.347 ± 0.644
2.39LeuPhe: 2.39 ± 0.396
7.297LeuGly: 7.297 ± 0.705
1.384LeuHis: 1.384 ± 0.275
4.78LeuIle: 4.78 ± 0.541
4.277LeuLys: 4.277 ± 0.55
5.598LeuLeu: 5.598 ± 0.584
1.761LeuMet: 1.761 ± 0.308
3.082LeuAsn: 3.082 ± 0.418
4.906LeuPro: 4.906 ± 0.561
2.831LeuGln: 2.831 ± 0.561
5.661LeuArg: 5.661 ± 0.636
5.787LeuSer: 5.787 ± 0.612
5.661LeuThr: 5.661 ± 0.462
4.78LeuVal: 4.78 ± 0.67
1.132LeuTrp: 1.132 ± 0.325
2.327LeuTyr: 2.327 ± 0.438
0.0LeuXaa: 0.0 ± 0.0
Met
1.95MetAla: 1.95 ± 0.35
0.0MetCys: 0.0 ± 0.0
0.881MetAsp: 0.881 ± 0.234
1.384MetGlu: 1.384 ± 0.27
0.629MetPhe: 0.629 ± 0.174
1.51MetGly: 1.51 ± 0.289
0.377MetHis: 0.377 ± 0.139
0.881MetIle: 0.881 ± 0.228
0.944MetLys: 0.944 ± 0.25
1.132MetLeu: 1.132 ± 0.237
0.189MetMet: 0.189 ± 0.089
1.006MetAsn: 1.006 ± 0.214
1.195MetPro: 1.195 ± 0.273
0.503MetGln: 0.503 ± 0.186
1.321MetArg: 1.321 ± 0.291
2.139MetSer: 2.139 ± 0.398
2.076MetThr: 2.076 ± 0.315
1.132MetVal: 1.132 ± 0.337
0.189MetTrp: 0.189 ± 0.106
0.44MetTyr: 0.44 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
3.019AsnAla: 3.019 ± 0.447
0.189AsnCys: 0.189 ± 0.122
2.076AsnAsp: 2.076 ± 0.416
2.013AsnGlu: 2.013 ± 0.316
1.069AsnPhe: 1.069 ± 0.291
3.522AsnGly: 3.522 ± 0.49
0.755AsnHis: 0.755 ± 0.207
1.887AsnIle: 1.887 ± 0.354
0.692AsnLys: 0.692 ± 0.251
2.139AsnLeu: 2.139 ± 0.397
0.629AsnMet: 0.629 ± 0.197
0.818AsnAsn: 0.818 ± 0.205
2.831AsnPro: 2.831 ± 0.398
1.195AsnGln: 1.195 ± 0.267
0.944AsnArg: 0.944 ± 0.288
1.573AsnSer: 1.573 ± 0.351
2.139AsnThr: 2.139 ± 0.419
2.642AsnVal: 2.642 ± 0.406
0.818AsnTrp: 0.818 ± 0.212
1.258AsnTyr: 1.258 ± 0.302
0.0AsnXaa: 0.0 ± 0.0
Pro
5.221ProAla: 5.221 ± 0.619
0.377ProCys: 0.377 ± 0.148
4.214ProAsp: 4.214 ± 0.464
4.529ProGlu: 4.529 ± 0.569
2.327ProPhe: 2.327 ± 0.372
4.843ProGly: 4.843 ± 0.627
0.881ProHis: 0.881 ± 0.247
2.453ProIle: 2.453 ± 0.391
2.139ProLys: 2.139 ± 0.321
4.655ProLeu: 4.655 ± 0.587
0.818ProMet: 0.818 ± 0.219
1.573ProAsn: 1.573 ± 0.354
2.831ProPro: 2.831 ± 0.485
1.573ProGln: 1.573 ± 0.277
3.082ProArg: 3.082 ± 0.44
3.711ProSer: 3.711 ± 0.462
4.026ProThr: 4.026 ± 0.604
3.963ProVal: 3.963 ± 0.472
0.944ProTrp: 0.944 ± 0.302
1.698ProTyr: 1.698 ± 0.391
0.0ProXaa: 0.0 ± 0.0
Gln
3.145GlnAla: 3.145 ± 0.57
0.126GlnCys: 0.126 ± 0.102
1.195GlnAsp: 1.195 ± 0.296
1.573GlnGlu: 1.573 ± 0.312
1.132GlnPhe: 1.132 ± 0.269
2.579GlnGly: 2.579 ± 0.334
0.44GlnHis: 0.44 ± 0.155
2.516GlnIle: 2.516 ± 0.557
1.447GlnLys: 1.447 ± 0.393
4.089GlnLeu: 4.089 ± 0.558
0.944GlnMet: 0.944 ± 0.285
0.566GlnAsn: 0.566 ± 0.173
1.698GlnPro: 1.698 ± 0.343
1.698GlnGln: 1.698 ± 0.398
1.51GlnArg: 1.51 ± 0.367
2.013GlnSer: 2.013 ± 0.315
1.824GlnThr: 1.824 ± 0.431
2.264GlnVal: 2.264 ± 0.313
0.755GlnTrp: 0.755 ± 0.266
0.629GlnTyr: 0.629 ± 0.187
0.0GlnXaa: 0.0 ± 0.0
Arg
5.347ArgAla: 5.347 ± 0.624
0.692ArgCys: 0.692 ± 0.228
3.082ArgAsp: 3.082 ± 0.46
4.529ArgGlu: 4.529 ± 0.673
1.635ArgPhe: 1.635 ± 0.334
4.78ArgGly: 4.78 ± 0.659
1.069ArgHis: 1.069 ± 0.248
3.082ArgIle: 3.082 ± 0.471
2.956ArgLys: 2.956 ± 0.407
5.661ArgLeu: 5.661 ± 0.547
1.824ArgMet: 1.824 ± 0.358
2.076ArgAsn: 2.076 ± 0.483
2.453ArgPro: 2.453 ± 0.444
2.076ArgGln: 2.076 ± 0.369
5.85ArgArg: 5.85 ± 0.817
3.397ArgSer: 3.397 ± 0.47
2.705ArgThr: 2.705 ± 0.525
5.724ArgVal: 5.724 ± 0.693
1.384ArgTrp: 1.384 ± 0.308
1.698ArgTyr: 1.698 ± 0.303
0.0ArgXaa: 0.0 ± 0.0
Ser
6.416SerAla: 6.416 ± 0.778
0.503SerCys: 0.503 ± 0.199
3.711SerAsp: 3.711 ± 0.47
3.963SerGlu: 3.963 ± 0.516
2.076SerPhe: 2.076 ± 0.418
5.787SerGly: 5.787 ± 0.535
1.195SerHis: 1.195 ± 0.299
2.642SerIle: 2.642 ± 0.359
2.39SerLys: 2.39 ± 0.346
4.78SerLeu: 4.78 ± 0.582
1.321SerMet: 1.321 ± 0.232
2.202SerAsn: 2.202 ± 0.37
3.082SerPro: 3.082 ± 0.52
1.887SerGln: 1.887 ± 0.29
3.145SerArg: 3.145 ± 0.437
3.46SerSer: 3.46 ± 0.676
3.774SerThr: 3.774 ± 0.516
3.648SerVal: 3.648 ± 0.518
1.447SerTrp: 1.447 ± 0.353
1.635SerTyr: 1.635 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
6.227ThrAla: 6.227 ± 0.874
0.315ThrCys: 0.315 ± 0.157
3.963ThrAsp: 3.963 ± 0.556
4.34ThrGlu: 4.34 ± 0.497
2.579ThrPhe: 2.579 ± 0.451
6.353ThrGly: 6.353 ± 0.61
1.384ThrHis: 1.384 ± 0.397
2.642ThrIle: 2.642 ± 0.503
2.579ThrLys: 2.579 ± 0.39
5.85ThrLeu: 5.85 ± 0.724
0.755ThrMet: 0.755 ± 0.207
1.761ThrAsn: 1.761 ± 0.405
4.089ThrPro: 4.089 ± 0.58
1.573ThrGln: 1.573 ± 0.258
3.774ThrArg: 3.774 ± 0.61
3.522ThrSer: 3.522 ± 0.642
4.026ThrThr: 4.026 ± 0.656
5.598ThrVal: 5.598 ± 0.684
1.132ThrTrp: 1.132 ± 0.237
2.013ThrTyr: 2.013 ± 0.385
0.0ThrXaa: 0.0 ± 0.0
Val
7.234ValAla: 7.234 ± 0.766
0.315ValCys: 0.315 ± 0.137
5.472ValAsp: 5.472 ± 0.631
4.655ValGlu: 4.655 ± 0.529
2.139ValPhe: 2.139 ± 0.324
4.843ValGly: 4.843 ± 0.723
1.132ValHis: 1.132 ± 0.232
3.837ValIle: 3.837 ± 0.436
3.208ValLys: 3.208 ± 0.442
5.598ValLeu: 5.598 ± 0.585
0.881ValMet: 0.881 ± 0.287
2.705ValAsn: 2.705 ± 0.363
4.089ValPro: 4.089 ± 0.453
2.139ValGln: 2.139 ± 0.396
4.969ValArg: 4.969 ± 0.699
4.466ValSer: 4.466 ± 0.471
5.661ValThr: 5.661 ± 0.665
5.347ValVal: 5.347 ± 0.78
1.258ValTrp: 1.258 ± 0.278
2.076ValTyr: 2.076 ± 0.361
0.0ValXaa: 0.0 ± 0.0
Trp
1.321TrpAla: 1.321 ± 0.304
0.252TrpCys: 0.252 ± 0.123
1.51TrpAsp: 1.51 ± 0.252
1.132TrpGlu: 1.132 ± 0.246
0.881TrpPhe: 0.881 ± 0.22
1.698TrpGly: 1.698 ± 0.312
0.503TrpHis: 0.503 ± 0.153
1.321TrpIle: 1.321 ± 0.238
0.377TrpLys: 0.377 ± 0.216
1.887TrpLeu: 1.887 ± 0.336
0.503TrpMet: 0.503 ± 0.168
0.503TrpAsn: 0.503 ± 0.168
0.881TrpPro: 0.881 ± 0.249
0.818TrpGln: 0.818 ± 0.21
1.384TrpArg: 1.384 ± 0.313
1.132TrpSer: 1.132 ± 0.288
1.824TrpThr: 1.824 ± 0.382
1.887TrpVal: 1.887 ± 0.326
0.692TrpTrp: 0.692 ± 0.285
0.315TrpTyr: 0.315 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.579TyrAla: 2.579 ± 0.426
0.189TyrCys: 0.189 ± 0.134
1.258TyrAsp: 1.258 ± 0.299
2.39TyrGlu: 2.39 ± 0.338
0.566TyrPhe: 0.566 ± 0.162
2.516TyrGly: 2.516 ± 0.423
0.818TyrHis: 0.818 ± 0.226
1.573TyrIle: 1.573 ± 0.326
1.006TyrLys: 1.006 ± 0.216
2.768TyrLeu: 2.768 ± 0.42
0.566TyrMet: 0.566 ± 0.16
1.132TyrAsn: 1.132 ± 0.269
1.258TyrPro: 1.258 ± 0.311
1.258TyrGln: 1.258 ± 0.288
2.39TyrArg: 2.39 ± 0.407
1.573TyrSer: 1.573 ± 0.283
2.013TyrThr: 2.013 ± 0.378
2.013TyrVal: 2.013 ± 0.317
0.252TyrTrp: 0.252 ± 0.124
0.566TyrTyr: 0.566 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (15899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski