Amino acid dipepetide frequency for Hubei picorna-like virus 17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.328AlaAla: 5.328 ± 1.667
1.332AlaCys: 1.332 ± 0.691
4.995AlaAsp: 4.995 ± 0.178
0.999AlaGlu: 0.999 ± 0.518
5.328AlaPhe: 5.328 ± 1.102
2.331AlaGly: 2.331 ± 0.452
0.999AlaHis: 0.999 ± 0.589
3.996AlaIle: 3.996 ± 1.804
5.328AlaLys: 5.328 ± 1.102
7.992AlaLeu: 7.992 ± 0.822
1.665AlaMet: 1.665 ± 0.244
2.331AlaAsn: 2.331 ± 0.655
2.997AlaPro: 2.997 ± 1.214
2.664AlaGln: 2.664 ± 1.387
4.329AlaArg: 4.329 ± 0.03
5.994AlaSer: 5.994 ± 2.429
4.329AlaThr: 4.329 ± 0.03
4.662AlaVal: 4.662 ± 0.203
0.666AlaTrp: 0.666 ± 0.208
2.664AlaTyr: 2.664 ± 0.828
0.0AlaXaa: 0.0 ± 0.0
Cys
1.332CysAla: 1.332 ± 0.137
0.0CysCys: 0.0 ± 0.0
0.666CysAsp: 0.666 ± 0.345
1.332CysGlu: 1.332 ± 0.691
0.0CysPhe: 0.0 ± 0.0
1.332CysGly: 1.332 ± 0.137
0.0CysHis: 0.0 ± 0.0
0.666CysIle: 0.666 ± 0.208
2.331CysLys: 2.331 ± 0.655
1.665CysLeu: 1.665 ± 0.31
0.666CysMet: 0.666 ± 0.345
0.0CysAsn: 0.0 ± 0.0
0.999CysPro: 0.999 ± 1.143
0.0CysGln: 0.0 ± 0.0
0.666CysArg: 0.666 ± 0.345
1.665CysSer: 1.665 ± 0.863
0.0CysThr: 0.0 ± 0.0
0.666CysVal: 0.666 ± 0.208
0.333CysTrp: 0.333 ± 0.173
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.994AspAla: 5.994 ± 0.893
0.333AspCys: 0.333 ± 0.173
1.332AspAsp: 1.332 ± 0.417
5.328AspGlu: 5.328 ± 0.548
2.331AspPhe: 2.331 ± 1.006
3.33AspGly: 3.33 ± 1.173
0.333AspHis: 0.333 ± 0.173
2.331AspIle: 2.331 ± 0.452
1.998AspLys: 1.998 ± 0.482
5.661AspLeu: 5.661 ± 0.167
2.331AspMet: 2.331 ± 1.209
0.999AspAsn: 0.999 ± 0.036
1.998AspPro: 1.998 ± 0.071
1.332AspGln: 1.332 ± 0.137
2.664AspArg: 2.664 ± 0.28
2.331AspSer: 2.331 ± 1.209
1.332AspThr: 1.332 ± 0.417
4.995AspVal: 4.995 ± 0.732
0.666AspTrp: 0.666 ± 0.208
1.332AspTyr: 1.332 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
3.33GluAla: 3.33 ± 1.173
1.998GluCys: 1.998 ± 0.071
3.33GluAsp: 3.33 ± 0.488
6.66GluGlu: 6.66 ± 1.792
4.995GluPhe: 4.995 ± 0.929
3.996GluGly: 3.996 ± 1.25
0.666GluHis: 0.666 ± 0.208
3.663GluIle: 3.663 ± 1.346
4.662GluLys: 4.662 ± 1.31
5.994GluLeu: 5.994 ± 0.893
2.331GluMet: 2.331 ± 0.655
2.997GluAsn: 2.997 ± 0.661
0.333GluPro: 0.333 ± 0.173
3.663GluGln: 3.663 ± 0.315
1.665GluArg: 1.665 ± 0.244
4.662GluSer: 4.662 ± 1.863
0.999GluThr: 0.999 ± 0.518
3.663GluVal: 3.663 ± 0.869
1.665GluTrp: 1.665 ± 0.31
1.332GluTyr: 1.332 ± 0.137
0.0GluXaa: 0.0 ± 0.0
Phe
3.33PheAla: 3.33 ± 0.066
0.999PheCys: 0.999 ± 0.518
2.331PheAsp: 2.331 ± 0.655
2.997PheGlu: 2.997 ± 0.661
2.664PhePhe: 2.664 ± 0.28
2.664PheGly: 2.664 ± 0.274
1.998PheHis: 1.998 ± 0.071
3.33PheIle: 3.33 ± 0.066
3.663PheLys: 3.663 ± 1.346
4.662PheLeu: 4.662 ± 0.203
1.998PheMet: 1.998 ± 0.759
1.665PheAsn: 1.665 ± 0.863
1.332PhePro: 1.332 ± 0.97
1.665PheGln: 1.665 ± 0.31
2.997PheArg: 2.997 ± 0.447
2.664PheSer: 2.664 ± 0.274
4.995PheThr: 4.995 ± 0.178
6.66PheVal: 6.66 ± 1.792
0.333PheTrp: 0.333 ± 0.173
2.331PheTyr: 2.331 ± 0.452
0.0PheXaa: 0.0 ± 0.0
Gly
4.329GlyAla: 4.329 ± 1.077
0.333GlyCys: 0.333 ± 0.381
3.33GlyAsp: 3.33 ± 2.149
3.663GlyGlu: 3.663 ± 1.423
1.665GlyPhe: 1.665 ± 0.244
3.33GlyGly: 3.33 ± 3.256
1.665GlyHis: 1.665 ± 0.863
3.663GlyIle: 3.663 ± 0.238
3.33GlyLys: 3.33 ± 1.173
4.329GlyLeu: 4.329 ± 1.137
1.665GlyMet: 1.665 ± 0.244
1.665GlyAsn: 1.665 ± 0.31
1.665GlyPro: 1.665 ± 0.244
2.331GlyGln: 2.331 ± 0.101
1.332GlyArg: 1.332 ± 0.137
3.996GlySer: 3.996 ± 0.143
2.331GlyThr: 2.331 ± 1.006
4.329GlyVal: 4.329 ± 1.691
1.332GlyTrp: 1.332 ± 0.137
2.331GlyTyr: 2.331 ± 0.101
0.0GlyXaa: 0.0 ± 0.0
His
0.333HisAla: 0.333 ± 0.173
0.333HisCys: 0.333 ± 0.173
0.999HisAsp: 0.999 ± 0.036
0.0HisGlu: 0.0 ± 0.0
0.333HisPhe: 0.333 ± 0.173
0.999HisGly: 0.999 ± 0.518
0.666HisHis: 0.666 ± 0.208
0.666HisIle: 0.666 ± 0.345
1.332HisLys: 1.332 ± 0.691
1.665HisLeu: 1.665 ± 0.244
0.666HisMet: 0.666 ± 0.345
1.332HisAsn: 1.332 ± 0.691
1.665HisPro: 1.665 ± 0.244
0.666HisGln: 0.666 ± 0.208
0.999HisArg: 0.999 ± 0.036
2.331HisSer: 2.331 ± 1.006
1.332HisThr: 1.332 ± 0.97
1.665HisVal: 1.665 ± 0.798
0.333HisTrp: 0.333 ± 0.173
0.666HisTyr: 0.666 ± 0.345
0.0HisXaa: 0.0 ± 0.0
Ile
4.329IleAla: 4.329 ± 0.524
1.332IleCys: 1.332 ± 0.691
3.33IleAsp: 3.33 ± 0.619
2.331IleGlu: 2.331 ± 0.101
1.332IlePhe: 1.332 ± 0.137
3.663IleGly: 3.663 ± 0.869
1.665IleHis: 1.665 ± 0.798
1.998IleIle: 1.998 ± 0.482
2.331IleLys: 2.331 ± 0.452
4.329IleLeu: 4.329 ± 2.244
0.666IleMet: 0.666 ± 0.208
3.663IleAsn: 3.663 ± 1.423
2.664IlePro: 2.664 ± 0.274
0.999IleGln: 0.999 ± 0.036
3.663IleArg: 3.663 ± 1.899
3.996IleSer: 3.996 ± 0.696
3.33IleThr: 3.33 ± 0.619
2.331IleVal: 2.331 ± 0.452
0.666IleTrp: 0.666 ± 0.208
1.665IleTyr: 1.665 ± 0.31
0.0IleXaa: 0.0 ± 0.0
Lys
3.33LysAla: 3.33 ± 1.173
0.333LysCys: 0.333 ± 0.173
5.328LysAsp: 5.328 ± 1.655
4.329LysGlu: 4.329 ± 2.244
3.663LysPhe: 3.663 ± 1.346
2.997LysGly: 2.997 ± 0.107
1.332LysHis: 1.332 ± 0.691
4.329LysIle: 4.329 ± 1.691
2.997LysLys: 2.997 ± 1.0
5.994LysLeu: 5.994 ± 1.447
2.331LysMet: 2.331 ± 0.655
1.332LysAsn: 1.332 ± 0.417
1.998LysPro: 1.998 ± 0.625
4.662LysGln: 4.662 ± 0.203
3.33LysArg: 3.33 ± 1.173
2.664LysSer: 2.664 ± 0.274
2.331LysThr: 2.331 ± 0.101
2.664LysVal: 2.664 ± 0.274
0.999LysTrp: 0.999 ± 0.518
1.665LysTyr: 1.665 ± 0.31
0.0LysXaa: 0.0 ± 0.0
Leu
7.659LeuAla: 7.659 ± 0.096
0.999LeuCys: 0.999 ± 0.518
4.995LeuAsp: 4.995 ± 0.375
4.995LeuGlu: 4.995 ± 0.929
5.328LeuPhe: 5.328 ± 1.102
2.664LeuGly: 2.664 ± 1.381
1.332LeuHis: 1.332 ± 0.137
5.661LeuIle: 5.661 ± 0.167
6.66LeuLys: 6.66 ± 1.792
10.323LeuLeu: 10.323 ± 0.184
1.998LeuMet: 1.998 ± 0.625
4.329LeuAsn: 4.329 ± 0.524
4.995LeuPro: 4.995 ± 0.375
3.33LeuGln: 3.33 ± 0.619
3.663LeuArg: 3.663 ± 0.238
7.326LeuSer: 7.326 ± 1.184
4.995LeuThr: 4.995 ± 1.482
8.658LeuVal: 8.658 ± 1.601
1.998LeuTrp: 1.998 ± 0.482
3.663LeuTyr: 3.663 ± 1.899
0.0LeuXaa: 0.0 ± 0.0
Met
2.997MetAla: 2.997 ± 1.214
0.666MetCys: 0.666 ± 0.208
1.998MetAsp: 1.998 ± 0.625
1.665MetGlu: 1.665 ± 0.31
2.664MetPhe: 2.664 ± 0.274
0.999MetGly: 0.999 ± 0.518
0.0MetHis: 0.0 ± 0.0
1.332MetIle: 1.332 ± 0.137
1.665MetLys: 1.665 ± 0.244
2.664MetLeu: 2.664 ± 0.828
0.0MetMet: 0.0 ± 0.0
0.333MetAsn: 0.333 ± 0.173
2.664MetPro: 2.664 ± 0.833
0.999MetGln: 0.999 ± 0.036
1.665MetArg: 1.665 ± 0.31
2.664MetSer: 2.664 ± 0.28
2.331MetThr: 2.331 ± 0.655
2.997MetVal: 2.997 ± 1.0
1.332MetTrp: 1.332 ± 0.137
0.999MetTyr: 0.999 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
1.998AsnAla: 1.998 ± 1.179
0.0AsnCys: 0.0 ± 0.0
1.332AsnAsp: 1.332 ± 0.691
1.332AsnGlu: 1.332 ± 0.691
2.997AsnPhe: 2.997 ± 0.447
0.333AsnGly: 0.333 ± 0.381
0.666AsnHis: 0.666 ± 0.208
0.666AsnIle: 0.666 ± 0.208
1.998AsnLys: 1.998 ± 0.071
3.663AsnLeu: 3.663 ± 0.792
2.331AsnMet: 2.331 ± 0.452
1.665AsnAsn: 1.665 ± 0.244
3.33AsnPro: 3.33 ± 1.042
1.332AsnGln: 1.332 ± 0.691
2.997AsnArg: 2.997 ± 0.661
2.997AsnSer: 2.997 ± 0.661
2.997AsnThr: 2.997 ± 0.107
4.995AsnVal: 4.995 ± 1.839
0.666AsnTrp: 0.666 ± 0.345
0.666AsnTyr: 0.666 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
2.997ProAla: 2.997 ± 0.447
0.999ProCys: 0.999 ± 0.518
1.665ProAsp: 1.665 ± 0.244
3.663ProGlu: 3.663 ± 0.238
1.998ProPhe: 1.998 ± 0.071
2.997ProGly: 2.997 ± 1.214
0.333ProHis: 0.333 ± 0.381
1.665ProIle: 1.665 ± 0.798
1.665ProLys: 1.665 ± 0.863
4.662ProLeu: 4.662 ± 0.351
0.666ProMet: 0.666 ± 0.208
1.332ProAsn: 1.332 ± 0.97
2.664ProPro: 2.664 ± 0.28
2.331ProGln: 2.331 ± 0.452
3.33ProArg: 3.33 ± 0.066
2.664ProSer: 2.664 ± 1.941
2.664ProThr: 2.664 ± 1.387
4.995ProVal: 4.995 ± 2.393
1.332ProTrp: 1.332 ± 0.137
1.998ProTyr: 1.998 ± 0.625
0.0ProXaa: 0.0 ± 0.0
Gln
2.997GlnAla: 2.997 ± 0.447
0.333GlnCys: 0.333 ± 0.381
1.332GlnAsp: 1.332 ± 0.691
2.664GlnGlu: 2.664 ± 0.274
2.664GlnPhe: 2.664 ± 1.381
1.665GlnGly: 1.665 ± 0.31
0.999GlnHis: 0.999 ± 0.518
0.666GlnIle: 0.666 ± 0.345
2.997GlnLys: 2.997 ± 0.107
4.329GlnLeu: 4.329 ± 1.077
0.666GlnMet: 0.666 ± 0.762
2.997GlnAsn: 2.997 ± 0.661
2.331GlnPro: 2.331 ± 0.452
1.998GlnGln: 1.998 ± 0.071
1.665GlnArg: 1.665 ± 0.244
3.33GlnSer: 3.33 ± 0.488
1.998GlnThr: 1.998 ± 0.625
3.663GlnVal: 3.663 ± 1.976
0.666GlnTrp: 0.666 ± 0.345
1.665GlnTyr: 1.665 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
1.665ArgAla: 1.665 ± 0.798
0.999ArgCys: 0.999 ± 0.036
1.665ArgAsp: 1.665 ± 0.31
3.663ArgGlu: 3.663 ± 1.346
1.665ArgPhe: 1.665 ± 0.863
1.665ArgGly: 1.665 ± 0.31
0.333ArgHis: 0.333 ± 0.173
0.666ArgIle: 0.666 ± 0.208
3.33ArgLys: 3.33 ± 1.173
3.663ArgLeu: 3.663 ± 0.238
1.332ArgMet: 1.332 ± 0.137
2.664ArgAsn: 2.664 ± 0.828
1.998ArgPro: 1.998 ± 1.179
2.664ArgGln: 2.664 ± 0.28
1.998ArgArg: 1.998 ± 0.071
4.995ArgSer: 4.995 ± 0.375
3.663ArgThr: 3.663 ± 0.238
2.997ArgVal: 2.997 ± 0.447
0.333ArgTrp: 0.333 ± 0.173
3.663ArgTyr: 3.663 ± 0.315
0.0ArgXaa: 0.0 ± 0.0
Ser
3.996SerAla: 3.996 ± 0.411
0.666SerCys: 0.666 ± 0.208
3.33SerAsp: 3.33 ± 0.488
4.329SerGlu: 4.329 ± 1.137
3.663SerPhe: 3.663 ± 0.792
5.994SerGly: 5.994 ± 0.768
1.665SerHis: 1.665 ± 0.31
4.329SerIle: 4.329 ± 2.185
2.997SerLys: 2.997 ± 1.0
9.324SerLeu: 9.324 ± 1.256
0.999SerMet: 0.999 ± 0.589
2.997SerAsn: 2.997 ± 0.447
2.331SerPro: 2.331 ± 0.101
4.995SerGln: 4.995 ± 2.393
0.999SerArg: 0.999 ± 0.518
3.663SerSer: 3.663 ± 1.423
5.328SerThr: 5.328 ± 0.006
6.327SerVal: 6.327 ± 2.256
0.333SerTrp: 0.333 ± 0.173
1.665SerTyr: 1.665 ± 0.244
0.0SerXaa: 0.0 ± 0.0
Thr
5.994ThrAla: 5.994 ± 0.768
1.332ThrCys: 1.332 ± 0.137
1.332ThrAsp: 1.332 ± 0.417
4.662ThrGlu: 4.662 ± 0.905
3.33ThrPhe: 3.33 ± 1.042
2.997ThrGly: 2.997 ± 0.447
2.331ThrHis: 2.331 ± 0.101
3.663ThrIle: 3.663 ± 0.792
2.664ThrLys: 2.664 ± 0.828
4.329ThrLeu: 4.329 ± 0.584
1.998ThrMet: 1.998 ± 0.625
0.666ThrAsn: 0.666 ± 0.762
2.664ThrPro: 2.664 ± 0.833
1.998ThrGln: 1.998 ± 0.482
0.999ThrArg: 0.999 ± 0.518
4.329ThrSer: 4.329 ± 0.584
4.662ThrThr: 4.662 ± 0.351
6.327ThrVal: 6.327 ± 2.256
0.666ThrTrp: 0.666 ± 0.762
2.331ThrTyr: 2.331 ± 1.209
0.0ThrXaa: 0.0 ± 0.0
Val
5.994ValAla: 5.994 ± 2.429
0.666ValCys: 0.666 ± 0.208
3.996ValAsp: 3.996 ± 1.518
5.661ValGlu: 5.661 ± 1.494
4.995ValPhe: 4.995 ± 0.178
5.328ValGly: 5.328 ± 1.667
1.665ValHis: 1.665 ± 0.244
3.33ValIle: 3.33 ± 0.619
4.329ValLys: 4.329 ± 0.584
5.328ValLeu: 5.328 ± 0.548
4.995ValMet: 4.995 ± 0.375
1.998ValAsn: 1.998 ± 0.625
5.994ValPro: 5.994 ± 0.768
2.331ValGln: 2.331 ± 0.452
3.663ValArg: 3.663 ± 0.238
4.995ValSer: 4.995 ± 1.839
6.327ValThr: 6.327 ± 1.149
6.327ValVal: 6.327 ± 3.363
1.665ValTrp: 1.665 ± 0.798
3.33ValTyr: 3.33 ± 1.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.999TrpAla: 0.999 ± 0.518
0.333TrpCys: 0.333 ± 0.173
0.0TrpAsp: 0.0 ± 0.0
0.666TrpGlu: 0.666 ± 0.208
1.665TrpPhe: 1.665 ± 0.244
0.333TrpGly: 0.333 ± 0.173
0.0TrpHis: 0.0 ± 0.0
1.998TrpIle: 1.998 ± 0.482
0.0TrpLys: 0.0 ± 0.0
1.332TrpLeu: 1.332 ± 0.137
2.331TrpMet: 2.331 ± 0.101
0.999TrpAsn: 0.999 ± 0.589
0.0TrpPro: 0.0 ± 0.0
0.666TrpGln: 0.666 ± 0.345
0.666TrpArg: 0.666 ± 0.762
0.999TrpSer: 0.999 ± 0.036
1.332TrpThr: 1.332 ± 0.137
1.665TrpVal: 1.665 ± 0.31
0.666TrpTrp: 0.666 ± 0.208
0.999TrpTyr: 0.999 ± 0.518
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.998TyrAla: 1.998 ± 0.071
0.333TyrCys: 0.333 ± 0.173
1.665TyrAsp: 1.665 ± 0.31
1.665TyrGlu: 1.665 ± 0.863
2.331TyrPhe: 2.331 ± 0.452
2.997TyrGly: 2.997 ± 0.447
0.333TyrHis: 0.333 ± 0.381
1.665TyrIle: 1.665 ± 0.863
2.331TyrLys: 2.331 ± 0.655
3.663TyrLeu: 3.663 ± 0.238
0.666TyrMet: 0.666 ± 0.345
2.997TyrAsn: 2.997 ± 0.661
1.998TyrPro: 1.998 ± 0.071
0.999TyrGln: 0.999 ± 0.036
2.331TyrArg: 2.331 ± 0.101
1.665TyrSer: 1.665 ± 0.244
1.998TyrThr: 1.998 ± 0.625
2.331TyrVal: 2.331 ± 0.655
0.999TyrTrp: 0.999 ± 0.036
1.665TyrTyr: 1.665 ± 0.798
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski