Amino acid dipepetide frequency for Botrimarina mediterranea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.209AlaAla: 16.209 ± 0.153	1.218AlaCys: 1.218 ± 0.031	7.277AlaAsp: 7.277 ± 0.071	7.968AlaGlu: 7.968 ± 0.087	3.662AlaPhe: 3.662 ± 0.057	9.676AlaGly: 9.676 ± 0.09	1.691AlaHis: 1.691 ± 0.032	5.964AlaIle: 5.964 ± 0.068	4.042AlaLys: 4.042 ± 0.061	10.229AlaLeu: 10.229 ± 0.107	2.876AlaMet: 2.876 ± 0.043	3.114AlaAsn: 3.114 ± 0.051	5.906AlaPro: 5.906 ± 0.075	3.377AlaGln: 3.377 ± 0.047	6.298AlaArg: 6.298 ± 0.074	7.114AlaSer: 7.114 ± 0.065	7.22AlaThr: 7.22 ± 0.079	8.636AlaVal: 8.636 ± 0.08	1.754AlaTrp: 1.754 ± 0.035	2.669AlaTyr: 2.669 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.821CysAla: 0.821 ± 0.027	0.269CysCys: 0.269 ± 0.027	0.738CysAsp: 0.738 ± 0.023	0.683CysGlu: 0.683 ± 0.023	0.344CysPhe: 0.344 ± 0.015	1.074CysGly: 1.074 ± 0.04	0.315CysHis: 0.315 ± 0.018	0.304CysIle: 0.304 ± 0.012	0.275CysLys: 0.275 ± 0.019	1.01CysLeu: 1.01 ± 0.025	0.148CysMet: 0.148 ± 0.009	0.252CysAsn: 0.252 ± 0.013	0.604CysPro: 0.604 ± 0.019	0.335CysGln: 0.335 ± 0.014	0.854CysArg: 0.854 ± 0.023	0.503CysSer: 0.503 ± 0.016	0.412CysThr: 0.412 ± 0.017	0.842CysVal: 0.842 ± 0.02	0.175CysTrp: 0.175 ± 0.01	0.263CysTyr: 0.263 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.497AspAla: 7.497 ± 0.086	0.579AspCys: 0.579 ± 0.02	4.042AspAsp: 4.042 ± 0.067	4.336AspGlu: 4.336 ± 0.059	2.383AspPhe: 2.383 ± 0.04	6.123AspGly: 6.123 ± 0.101	1.227AspHis: 1.227 ± 0.029	2.28AspIle: 2.28 ± 0.041	1.657AspLys: 1.657 ± 0.035	5.955AspLeu: 5.955 ± 0.075	0.89AspMet: 0.89 ± 0.025	1.687AspAsn: 1.687 ± 0.037	3.68AspPro: 3.68 ± 0.056	1.888AspGln: 1.888 ± 0.034	4.355AspArg: 4.355 ± 0.059	3.225AspSer: 3.225 ± 0.05	2.572AspThr: 2.572 ± 0.043	4.092AspVal: 4.092 ± 0.06	1.15AspTrp: 1.15 ± 0.026	1.956AspTyr: 1.956 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.669GluAla: 7.669 ± 0.086	0.519GluCys: 0.519 ± 0.02	2.883GluAsp: 2.883 ± 0.052	4.058GluGlu: 4.058 ± 0.073	2.113GluPhe: 2.113 ± 0.036	4.851GluGly: 4.851 ± 0.053	1.38GluHis: 1.38 ± 0.03	2.725GluIle: 2.725 ± 0.048	2.181GluLys: 2.181 ± 0.037	6.728GluLeu: 6.728 ± 0.076	1.37GluMet: 1.37 ± 0.03	1.573GluAsn: 1.573 ± 0.034	3.532GluPro: 3.532 ± 0.053	2.501GluGln: 2.501 ± 0.045	4.911GluArg: 4.911 ± 0.06	3.909GluSer: 3.909 ± 0.05	3.447GluThr: 3.447 ± 0.049	4.741GluVal: 4.741 ± 0.059	0.959GluTrp: 0.959 ± 0.028	1.386GluTyr: 1.386 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.999PheAla: 3.999 ± 0.056	0.425PheCys: 0.425 ± 0.016	2.758PheAsp: 2.758 ± 0.048	2.164PheGlu: 2.164 ± 0.038	1.224PhePhe: 1.224 ± 0.034	3.295PheGly: 3.295 ± 0.048	0.644PheHis: 0.644 ± 0.019	1.189PheIle: 1.189 ± 0.029	0.827PheLys: 0.827 ± 0.024	2.816PheLeu: 2.816 ± 0.044	0.542PheMet: 0.542 ± 0.02	1.217PheAsn: 1.217 ± 0.032	1.403PhePro: 1.403 ± 0.034	0.982PheGln: 0.982 ± 0.026	2.062PheArg: 2.062 ± 0.031	1.992PheSer: 1.992 ± 0.039	2.014PheThr: 2.014 ± 0.035	2.748PheVal: 2.748 ± 0.048	0.553PheTrp: 0.553 ± 0.02	0.941PheTyr: 0.941 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.101GlyAla: 9.101 ± 0.1	0.971GlyCys: 0.971 ± 0.035	5.885GlyAsp: 5.885 ± 0.093	5.508GlyGlu: 5.508 ± 0.066	3.049GlyPhe: 3.049 ± 0.047	7.975GlyGly: 7.975 ± 0.13	1.57GlyHis: 1.57 ± 0.033	3.043GlyIle: 3.043 ± 0.048	3.161GlyLys: 3.161 ± 0.052	7.599GlyLeu: 7.599 ± 0.071	1.958GlyMet: 1.958 ± 0.04	2.183GlyAsn: 2.183 ± 0.044	3.778GlyPro: 3.778 ± 0.049	2.743GlyGln: 2.743 ± 0.042	5.545GlyArg: 5.545 ± 0.065	5.124GlySer: 5.124 ± 0.075	3.783GlyThr: 3.783 ± 0.067	7.992GlyVal: 7.992 ± 0.074	1.534GlyTrp: 1.534 ± 0.033	2.381GlyTyr: 2.381 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.078HisAla: 2.078 ± 0.035	0.262HisCys: 0.262 ± 0.014	1.264HisAsp: 1.264 ± 0.034	1.253HisGlu: 1.253 ± 0.03	0.785HisPhe: 0.785 ± 0.022	1.711HisGly: 1.711 ± 0.037	0.593HisHis: 0.593 ± 0.02	0.621HisIle: 0.621 ± 0.023	0.493HisLys: 0.493 ± 0.019	1.878HisLeu: 1.878 ± 0.042	0.302HisMet: 0.302 ± 0.013	0.564HisAsn: 0.564 ± 0.017	1.155HisPro: 1.155 ± 0.025	0.65HisGln: 0.65 ± 0.02	1.444HisArg: 1.444 ± 0.033	1.064HisSer: 1.064 ± 0.026	0.965HisThr: 0.965 ± 0.024	1.418HisVal: 1.418 ± 0.029	0.356HisTrp: 0.356 ± 0.014	0.63HisTyr: 0.63 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.974IleAla: 5.974 ± 0.063	0.381IleCys: 0.381 ± 0.016	4.009IleAsp: 4.009 ± 0.055	3.632IleGlu: 3.632 ± 0.048	0.99IlePhe: 0.99 ± 0.025	4.148IleGly: 4.148 ± 0.058	0.8IleHis: 0.8 ± 0.022	1.313IleIle: 1.313 ± 0.03	1.098IleLys: 1.098 ± 0.027	2.908IleLeu: 2.908 ± 0.045	0.447IleMet: 0.447 ± 0.015	1.35IleAsn: 1.35 ± 0.034	1.951IlePro: 1.951 ± 0.036	1.17IleGln: 1.17 ± 0.029	2.508IleArg: 2.508 ± 0.039	2.074IleSer: 2.074 ± 0.038	2.338IleThr: 2.338 ± 0.043	3.491IleVal: 3.491 ± 0.058	0.424IleTrp: 0.424 ± 0.015	0.884IleTyr: 0.884 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.187LysAla: 3.187 ± 0.051	0.261LysCys: 0.261 ± 0.013	1.378LysAsp: 1.378 ± 0.031	1.651LysGlu: 1.651 ± 0.04	0.906LysPhe: 0.906 ± 0.023	2.025LysGly: 2.025 ± 0.038	0.723LysHis: 0.723 ± 0.023	1.26LysIle: 1.26 ± 0.033	1.478LysLys: 1.478 ± 0.051	3.425LysLeu: 3.425 ± 0.049	0.629LysMet: 0.629 ± 0.022	0.863LysAsn: 0.863 ± 0.023	2.179LysPro: 2.179 ± 0.039	1.306LysGln: 1.306 ± 0.031	2.302LysArg: 2.302 ± 0.044	1.883LysSer: 1.883 ± 0.039	1.844LysThr: 1.844 ± 0.039	2.086LysVal: 2.086 ± 0.039	0.407LysTrp: 0.407 ± 0.014	0.725LysTyr: 0.725 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.853LeuAla: 12.853 ± 0.111	1.049LeuCys: 1.049 ± 0.027	5.85LeuAsp: 5.85 ± 0.071	5.695LeuGlu: 5.695 ± 0.066	3.121LeuPhe: 3.121 ± 0.05	7.945LeuGly: 7.945 ± 0.073	1.774LeuHis: 1.774 ± 0.035	3.772LeuIle: 3.772 ± 0.05	2.81LeuLys: 2.81 ± 0.048	10.095LeuLeu: 10.095 ± 0.104	1.927LeuMet: 1.927 ± 0.034	2.543LeuAsn: 2.543 ± 0.04	5.442LeuPro: 5.442 ± 0.058	2.955LeuGln: 2.955 ± 0.042	7.347LeuArg: 7.347 ± 0.091	6.134LeuSer: 6.134 ± 0.063	5.852LeuThr: 5.852 ± 0.064	8.028LeuVal: 8.028 ± 0.078	1.267LeuTrp: 1.267 ± 0.032	2.144LeuTyr: 2.144 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.403MetAla: 2.403 ± 0.041	0.147MetCys: 0.147 ± 0.009	0.851MetAsp: 0.851 ± 0.022	0.86MetGlu: 0.86 ± 0.025	0.564MetPhe: 0.564 ± 0.019	1.377MetGly: 1.377 ± 0.035	0.425MetHis: 0.425 ± 0.015	0.932MetIle: 0.932 ± 0.025	0.783MetLys: 0.783 ± 0.023	2.138MetLeu: 2.138 ± 0.039	0.445MetMet: 0.445 ± 0.018	0.64MetAsn: 0.64 ± 0.021	1.302MetPro: 1.302 ± 0.025	0.769MetGln: 0.769 ± 0.023	1.494MetArg: 1.494 ± 0.035	1.448MetSer: 1.448 ± 0.027	1.394MetThr: 1.394 ± 0.032	1.403MetVal: 1.403 ± 0.033	0.209MetTrp: 0.209 ± 0.012	0.341MetTyr: 0.341 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.087AsnAla: 3.087 ± 0.046	0.298AsnCys: 0.298 ± 0.013	1.863AsnAsp: 1.863 ± 0.044	1.629AsnGlu: 1.629 ± 0.037	0.997AsnPhe: 0.997 ± 0.027	2.795AsnGly: 2.795 ± 0.059	0.614AsnHis: 0.614 ± 0.023	0.932AsnIle: 0.932 ± 0.022	0.627AsnLys: 0.627 ± 0.019	2.725AsnLeu: 2.725 ± 0.046	0.398AsnMet: 0.398 ± 0.017	0.971AsnAsn: 0.971 ± 0.034	1.924AsnPro: 1.924 ± 0.039	0.996AsnGln: 0.996 ± 0.028	1.955AsnArg: 1.955 ± 0.034	1.579AsnSer: 1.579 ± 0.039	1.397AsnThr: 1.397 ± 0.036	2.054AsnVal: 2.054 ± 0.035	0.479AsnTrp: 0.479 ± 0.018	0.901AsnTyr: 0.901 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.307ProAla: 6.307 ± 0.083	0.434ProCys: 0.434 ± 0.018	3.22ProAsp: 3.22 ± 0.046	3.897ProGlu: 3.897 ± 0.059	1.743ProPhe: 1.743 ± 0.032	4.477ProGly: 4.477 ± 0.054	1.03ProHis: 1.03 ± 0.028	2.512ProIle: 2.512 ± 0.038	1.6ProLys: 1.6 ± 0.039	5.004ProLeu: 5.004 ± 0.059	1.095ProMet: 1.095 ± 0.024	1.666ProAsn: 1.666 ± 0.035	3.104ProPro: 3.104 ± 0.062	1.821ProGln: 1.821 ± 0.037	3.039ProArg: 3.039 ± 0.049	3.578ProSer: 3.578 ± 0.049	3.675ProThr: 3.675 ± 0.057	3.91ProVal: 3.91 ± 0.048	0.779ProTrp: 0.779 ± 0.02	1.23ProTyr: 1.23 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.851GlnAla: 3.851 ± 0.055	0.313GlnCys: 0.313 ± 0.015	1.302GlnAsp: 1.302 ± 0.028	1.623GlnGlu: 1.623 ± 0.028	1.14GlnPhe: 1.14 ± 0.025	2.237GlnGly: 2.237 ± 0.038	0.731GlnHis: 0.731 ± 0.024	1.515GlnIle: 1.515 ± 0.029	0.996GlnLys: 0.996 ± 0.027	3.833GlnLeu: 3.833 ± 0.051	0.779GlnMet: 0.779 ± 0.022	0.861GlnAsn: 0.861 ± 0.024	2.001GlnPro: 2.001 ± 0.042	1.65GlnGln: 1.65 ± 0.041	2.755GlnArg: 2.755 ± 0.045	2.117GlnSer: 2.117 ± 0.034	1.918GlnThr: 1.918 ± 0.042	2.397GlnVal: 2.397 ± 0.038	0.539GlnTrp: 0.539 ± 0.019	0.732GlnTyr: 0.732 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	5.814ArgAla: 5.814 ± 0.065	0.733ArgCys: 0.733 ± 0.021	4.154ArgAsp: 4.154 ± 0.052	4.316ArgGlu: 4.316 ± 0.062	2.656ArgPhe: 2.656 ± 0.039	4.842ArgGly: 4.842 ± 0.055	1.519ArgHis: 1.519 ± 0.033	3.064ArgIle: 3.064 ± 0.047	2.038ArgLys: 2.038 ± 0.04	8.177ArgLeu: 8.177 ± 0.096	1.664ArgMet: 1.664 ± 0.036	1.77ArgAsn: 1.77 ± 0.031	3.435ArgPro: 3.435 ± 0.056	2.65ArgGln: 2.65 ± 0.048	6.188ArgArg: 6.188 ± 0.079	3.927ArgSer: 3.927 ± 0.05	3.308ArgThr: 3.308 ± 0.047	5.512ArgVal: 5.512 ± 0.066	1.266ArgTrp: 1.266 ± 0.028	1.943ArgTyr: 1.943 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.096SerAla: 6.096 ± 0.072	0.536SerCys: 0.536 ± 0.022	3.662SerAsp: 3.662 ± 0.055	3.37SerGlu: 3.37 ± 0.047	2.026SerPhe: 2.026 ± 0.038	5.681SerGly: 5.681 ± 0.073	1.18SerHis: 1.18 ± 0.027	2.789SerIle: 2.789 ± 0.05	1.724SerLys: 1.724 ± 0.028	6.316SerLeu: 6.316 ± 0.064	1.173SerMet: 1.173 ± 0.025	1.675SerAsn: 1.675 ± 0.038	3.569SerPro: 3.569 ± 0.048	2.094SerGln: 2.094 ± 0.036	3.957SerArg: 3.957 ± 0.053	3.761SerSer: 3.761 ± 0.061	3.375SerThr: 3.375 ± 0.054	4.385SerVal: 4.385 ± 0.055	0.857SerTrp: 0.857 ± 0.023	1.46SerTyr: 1.46 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.282ThrAla: 6.282 ± 0.071	0.512ThrCys: 0.512 ± 0.022	3.08ThrAsp: 3.08 ± 0.044	2.894ThrGlu: 2.894 ± 0.046	1.973ThrPhe: 1.973 ± 0.04	5.006ThrGly: 5.006 ± 0.072	1.113ThrHis: 1.113 ± 0.03	2.864ThrIle: 2.864 ± 0.045	1.557ThrLys: 1.557 ± 0.037	6.113ThrLeu: 6.113 ± 0.067	1.003ThrMet: 1.003 ± 0.026	1.621ThrAsn: 1.621 ± 0.038	4.099ThrPro: 4.099 ± 0.058	1.735ThrGln: 1.735 ± 0.031	3.044ThrArg: 3.044 ± 0.045	3.351ThrSer: 3.351 ± 0.052	3.566ThrThr: 3.566 ± 0.054	4.322ThrVal: 4.322 ± 0.059	0.728ThrTrp: 0.728 ± 0.022	1.278ThrTyr: 1.278 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.662ValAla: 9.662 ± 0.086	0.833ValCys: 0.833 ± 0.029	4.693ValAsp: 4.693 ± 0.058	5.477ValGlu: 5.477 ± 0.065	2.611ValPhe: 2.611 ± 0.043	6.356ValGly: 6.356 ± 0.073	1.304ValHis: 1.304 ± 0.029	3.462ValIle: 3.462 ± 0.049	2.029ValLys: 2.029 ± 0.04	7.431ValLeu: 7.431 ± 0.079	1.552ValMet: 1.552 ± 0.036	2.304ValAsn: 2.304 ± 0.043	3.266ValPro: 3.266 ± 0.049	2.196ValGln: 2.196 ± 0.039	5.238ValArg: 5.238 ± 0.063	4.507ValSer: 4.507 ± 0.064	4.854ValThr: 4.854 ± 0.059	7.113ValVal: 7.113 ± 0.072	1.24ValTrp: 1.24 ± 0.027	1.874ValTyr: 1.874 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.376TrpAla: 1.376 ± 0.032	0.171TrpCys: 0.171 ± 0.01	0.843TrpAsp: 0.843 ± 0.027	0.781TrpGlu: 0.781 ± 0.021	0.58TrpPhe: 0.58 ± 0.021	1.066TrpGly: 1.066 ± 0.028	0.313TrpHis: 0.313 ± 0.014	0.66TrpIle: 0.66 ± 0.025	0.474TrpLys: 0.474 ± 0.02	1.76TrpLeu: 1.76 ± 0.039	0.372TrpMet: 0.372 ± 0.016	0.545TrpAsn: 0.545 ± 0.017	0.711TrpPro: 0.711 ± 0.023	0.558TrpGln: 0.558 ± 0.019	1.671TrpArg: 1.671 ± 0.034	0.988TrpSer: 0.988 ± 0.028	0.879TrpThr: 0.879 ± 0.028	1.013TrpVal: 1.013 ± 0.024	0.301TrpTrp: 0.301 ± 0.015	0.353TrpTyr: 0.353 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.636TyrAla: 2.636 ± 0.037	0.312TyrCys: 0.312 ± 0.017	1.818TyrAsp: 1.818 ± 0.039	1.642TyrGlu: 1.642 ± 0.033	0.928TyrPhe: 0.928 ± 0.028	2.224TyrGly: 2.224 ± 0.04	0.537TyrHis: 0.537 ± 0.02	0.687TyrIle: 0.687 ± 0.022	0.668TyrLys: 0.668 ± 0.023	2.465TyrLeu: 2.465 ± 0.04	0.352TyrMet: 0.352 ± 0.015	0.822TyrAsn: 0.822 ± 0.028	1.082TyrPro: 1.082 ± 0.029	0.914TyrGln: 0.914 ± 0.022	2.009TyrArg: 2.009 ± 0.039	1.409TyrSer: 1.409 ± 0.031	1.33TyrThr: 1.33 ± 0.036	1.816TyrVal: 1.816 ± 0.041	0.44TyrTrp: 0.44 ± 0.016	0.832TyrTyr: 0.832 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4587 proteins (1667008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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