Amino acid dipepetide frequency for Streptosporangium nondiastaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.097AlaAla: 24.097 ± 0.183	1.233AlaCys: 1.233 ± 0.023	8.26AlaAsp: 8.26 ± 0.063	9.116AlaGlu: 9.116 ± 0.09	3.798AlaPhe: 3.798 ± 0.052	15.0AlaGly: 15.0 ± 0.105	3.043AlaHis: 3.043 ± 0.038	3.151AlaIle: 3.151 ± 0.04	2.845AlaLys: 2.845 ± 0.049	15.067AlaLeu: 15.067 ± 0.105	2.557AlaMet: 2.557 ± 0.035	1.783AlaAsn: 1.783 ± 0.03	7.829AlaPro: 7.829 ± 0.069	3.575AlaGln: 3.575 ± 0.043	11.053AlaArg: 11.053 ± 0.083	5.924AlaSer: 5.924 ± 0.056	6.617AlaThr: 6.617 ± 0.056	12.952AlaVal: 12.952 ± 0.098	1.886AlaTrp: 1.886 ± 0.033	2.868AlaTyr: 2.868 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.245CysAla: 1.245 ± 0.024	0.092CysCys: 0.092 ± 0.007	0.513CysAsp: 0.513 ± 0.015	0.405CysGlu: 0.405 ± 0.014	0.238CysPhe: 0.238 ± 0.012	1.039CysGly: 1.039 ± 0.026	0.201CysHis: 0.201 ± 0.01	0.178CysIle: 0.178 ± 0.009	0.124CysLys: 0.124 ± 0.007	0.801CysLeu: 0.801 ± 0.019	0.136CysMet: 0.136 ± 0.008	0.138CysAsn: 0.138 ± 0.008	0.511CysPro: 0.511 ± 0.019	0.155CysGln: 0.155 ± 0.007	0.697CysArg: 0.697 ± 0.02	0.464CysSer: 0.464 ± 0.015	0.582CysThr: 0.582 ± 0.017	0.672CysVal: 0.672 ± 0.018	0.119CysTrp: 0.119 ± 0.008	0.163CysTyr: 0.163 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.903AspAla: 7.903 ± 0.074	0.44AspCys: 0.44 ± 0.014	3.323AspAsp: 3.323 ± 0.045	3.643AspGlu: 3.643 ± 0.042	1.608AspPhe: 1.608 ± 0.027	6.374AspGly: 6.374 ± 0.06	1.406AspHis: 1.406 ± 0.03	1.7AspIle: 1.7 ± 0.029	1.182AspLys: 1.182 ± 0.028	5.823AspLeu: 5.823 ± 0.061	0.753AspMet: 0.753 ± 0.018	0.849AspAsn: 0.849 ± 0.022	4.474AspPro: 4.474 ± 0.049	1.308AspGln: 1.308 ± 0.024	4.976AspArg: 4.976 ± 0.048	2.241AspSer: 2.241 ± 0.033	2.886AspThr: 2.886 ± 0.038	4.602AspVal: 4.602 ± 0.048	0.959AspTrp: 0.959 ± 0.025	1.083AspTyr: 1.083 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.915GluAla: 7.915 ± 0.078	0.414GluCys: 0.414 ± 0.016	2.852GluAsp: 2.852 ± 0.037	3.7GluGlu: 3.7 ± 0.054	1.424GluPhe: 1.424 ± 0.024	4.551GluGly: 4.551 ± 0.05	1.605GluHis: 1.605 ± 0.025	2.115GluIle: 2.115 ± 0.037	1.44GluLys: 1.44 ± 0.029	6.793GluLeu: 6.793 ± 0.063	0.844GluMet: 0.844 ± 0.019	0.937GluAsn: 0.937 ± 0.023	3.38GluPro: 3.38 ± 0.039	2.177GluGln: 2.177 ± 0.034	5.591GluArg: 5.591 ± 0.058	2.3GluSer: 2.3 ± 0.032	2.818GluThr: 2.818 ± 0.041	4.168GluVal: 4.168 ± 0.044	0.771GluTrp: 0.771 ± 0.018	0.993GluTyr: 0.993 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.919PheAla: 3.919 ± 0.043	0.304PheCys: 0.304 ± 0.012	1.926PheAsp: 1.926 ± 0.033	1.394PheGlu: 1.394 ± 0.027	0.905PhePhe: 0.905 ± 0.023	2.991PheGly: 2.991 ± 0.043	0.633PheHis: 0.633 ± 0.017	0.683PheIle: 0.683 ± 0.018	0.482PheLys: 0.482 ± 0.015	2.595PheLeu: 2.595 ± 0.037	0.398PheMet: 0.398 ± 0.013	0.528PheAsn: 0.528 ± 0.016	1.45PhePro: 1.45 ± 0.025	0.629PheGln: 0.629 ± 0.014	1.936PheArg: 1.936 ± 0.031	1.464PheSer: 1.464 ± 0.027	1.987PheThr: 1.987 ± 0.032	2.221PheVal: 2.221 ± 0.036	0.417PheTrp: 0.417 ± 0.013	0.556PheTyr: 0.556 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.955GlyAla: 11.955 ± 0.098	0.907GlyCys: 0.907 ± 0.02	5.201GlyAsp: 5.201 ± 0.047	5.371GlyGlu: 5.371 ± 0.049	2.892GlyPhe: 2.892 ± 0.04	9.365GlyGly: 9.365 ± 0.088	2.478GlyHis: 2.478 ± 0.037	3.464GlyIle: 3.464 ± 0.043	2.65GlyLys: 2.65 ± 0.042	9.86GlyLeu: 9.86 ± 0.064	2.065GlyMet: 2.065 ± 0.034	1.676GlyAsn: 1.676 ± 0.033	5.805GlyPro: 5.805 ± 0.067	2.551GlyGln: 2.551 ± 0.045	8.468GlyArg: 8.468 ± 0.076	5.508GlySer: 5.508 ± 0.065	6.486GlyThr: 6.486 ± 0.064	7.444GlyVal: 7.444 ± 0.075	1.674GlyTrp: 1.674 ± 0.026	2.205GlyTyr: 2.205 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.933HisAla: 2.933 ± 0.035	0.231HisCys: 0.231 ± 0.012	1.379HisAsp: 1.379 ± 0.028	1.274HisGlu: 1.274 ± 0.024	0.681HisPhe: 0.681 ± 0.015	2.571HisGly: 2.571 ± 0.038	0.758HisHis: 0.758 ± 0.024	0.633HisIle: 0.633 ± 0.016	0.39HisLys: 0.39 ± 0.015	2.467HisLeu: 2.467 ± 0.029	0.355HisMet: 0.355 ± 0.012	0.347HisAsn: 0.347 ± 0.013	1.847HisPro: 1.847 ± 0.031	0.635HisGln: 0.635 ± 0.014	2.177HisArg: 2.177 ± 0.029	1.038HisSer: 1.038 ± 0.022	1.295HisThr: 1.295 ± 0.024	1.825HisVal: 1.825 ± 0.032	0.408HisTrp: 0.408 ± 0.013	0.488HisTyr: 0.488 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.692IleAla: 4.692 ± 0.053	0.289IleCys: 0.289 ± 0.011	1.981IleAsp: 1.981 ± 0.031	1.859IleGlu: 1.859 ± 0.029	0.627IlePhe: 0.627 ± 0.018	3.351IleGly: 3.351 ± 0.044	0.583IleHis: 0.583 ± 0.018	0.789IleIle: 0.789 ± 0.025	0.726IleLys: 0.726 ± 0.02	2.165IleLeu: 2.165 ± 0.038	0.405IleMet: 0.405 ± 0.013	0.637IleAsn: 0.637 ± 0.021	1.69IlePro: 1.69 ± 0.033	0.609IleGln: 0.609 ± 0.016	2.207IleArg: 2.207 ± 0.03	1.607IleSer: 1.607 ± 0.031	2.036IleThr: 2.036 ± 0.029	2.56IleVal: 2.56 ± 0.036	0.327IleTrp: 0.327 ± 0.012	0.5IleTyr: 0.5 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.019LysAla: 3.019 ± 0.051	0.125LysCys: 0.125 ± 0.007	1.391LysAsp: 1.391 ± 0.033	1.206LysGlu: 1.206 ± 0.026	0.457LysPhe: 0.457 ± 0.016	1.932LysGly: 1.932 ± 0.038	0.429LysHis: 0.429 ± 0.015	0.783LysIle: 0.783 ± 0.022	0.846LysLys: 0.846 ± 0.032	1.954LysLeu: 1.954 ± 0.035	0.4LysMet: 0.4 ± 0.014	0.518LysAsn: 0.518 ± 0.016	1.396LysPro: 1.396 ± 0.03	0.684LysGln: 0.684 ± 0.019	1.457LysArg: 1.457 ± 0.028	1.105LysSer: 1.105 ± 0.024	1.221LysThr: 1.221 ± 0.028	1.797LysVal: 1.797 ± 0.035	0.262LysTrp: 0.262 ± 0.011	0.403LysTyr: 0.403 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.524LeuAla: 15.524 ± 0.1	0.886LeuCys: 0.886 ± 0.023	6.41LeuAsp: 6.41 ± 0.066	4.7LeuGlu: 4.7 ± 0.048	2.666LeuPhe: 2.666 ± 0.039	9.416LeuGly: 9.416 ± 0.073	2.473LeuHis: 2.473 ± 0.034	3.038LeuIle: 3.038 ± 0.048	1.929LeuLys: 1.929 ± 0.034	11.435LeuLeu: 11.435 ± 0.089	1.662LeuMet: 1.662 ± 0.024	1.536LeuAsn: 1.536 ± 0.029	6.776LeuPro: 6.776 ± 0.054	2.223LeuGln: 2.223 ± 0.039	8.937LeuArg: 8.937 ± 0.077	5.243LeuSer: 5.243 ± 0.057	6.7LeuThr: 6.7 ± 0.061	8.519LeuVal: 8.519 ± 0.075	1.313LeuTrp: 1.313 ± 0.026	1.844LeuTyr: 1.844 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.316MetAla: 2.316 ± 0.035	0.146MetCys: 0.146 ± 0.008	0.898MetAsp: 0.898 ± 0.018	0.775MetGlu: 0.775 ± 0.02	0.419MetPhe: 0.419 ± 0.015	1.373MetGly: 1.373 ± 0.027	0.351MetHis: 0.351 ± 0.012	0.601MetIle: 0.601 ± 0.017	0.405MetLys: 0.405 ± 0.014	1.686MetLeu: 1.686 ± 0.029	0.292MetMet: 0.292 ± 0.011	0.414MetAsn: 0.414 ± 0.013	1.17MetPro: 1.17 ± 0.023	0.448MetGln: 0.448 ± 0.015	1.467MetArg: 1.467 ± 0.027	1.218MetSer: 1.218 ± 0.022	1.515MetThr: 1.515 ± 0.028	1.208MetVal: 1.208 ± 0.024	0.2MetTrp: 0.2 ± 0.009	0.303MetTyr: 0.303 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.091AsnAla: 2.091 ± 0.029	0.143AsnCys: 0.143 ± 0.008	0.875AsnAsp: 0.875 ± 0.022	0.751AsnGlu: 0.751 ± 0.019	0.446AsnPhe: 0.446 ± 0.014	1.836AsnGly: 1.836 ± 0.038	0.387AsnHis: 0.387 ± 0.013	0.586AsnIle: 0.586 ± 0.017	0.409AsnLys: 0.409 ± 0.015	1.528AsnLeu: 1.528 ± 0.027	0.287AsnMet: 0.287 ± 0.012	0.375AsnAsn: 0.375 ± 0.016	1.255AsnPro: 1.255 ± 0.027	0.434AsnGln: 0.434 ± 0.017	1.211AsnArg: 1.211 ± 0.025	0.813AsnSer: 0.813 ± 0.022	1.007AsnThr: 1.007 ± 0.021	1.278AsnVal: 1.278 ± 0.025	0.268AsnTrp: 0.268 ± 0.011	0.388AsnTyr: 0.388 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.871ProAla: 9.871 ± 0.089	0.401ProCys: 0.401 ± 0.013	4.3ProAsp: 4.3 ± 0.052	4.445ProGlu: 4.445 ± 0.049	1.566ProPhe: 1.566 ± 0.029	7.552ProGly: 7.552 ± 0.075	1.482ProHis: 1.482 ± 0.028	1.075ProIle: 1.075 ± 0.023	1.163ProLys: 1.163 ± 0.025	5.566ProLeu: 5.566 ± 0.059	1.036ProMet: 1.036 ± 0.022	0.8ProAsn: 0.8 ± 0.021	3.821ProPro: 3.821 ± 0.063	1.711ProGln: 1.711 ± 0.03	4.313ProArg: 4.313 ± 0.048	3.094ProSer: 3.094 ± 0.044	2.632ProThr: 2.632 ± 0.035	5.746ProVal: 5.746 ± 0.054	0.967ProTrp: 0.967 ± 0.023	1.441ProTyr: 1.441 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.562GlnAla: 3.562 ± 0.048	0.179GlnCys: 0.179 ± 0.01	1.374GlnAsp: 1.374 ± 0.024	1.457GlnGlu: 1.457 ± 0.029	0.642GlnPhe: 0.642 ± 0.017	2.215GlnGly: 2.215 ± 0.035	0.664GlnHis: 0.664 ± 0.018	0.955GlnIle: 0.955 ± 0.021	0.582GlnLys: 0.582 ± 0.018	2.803GlnLeu: 2.803 ± 0.035	0.439GlnMet: 0.439 ± 0.013	0.429GlnAsn: 0.429 ± 0.016	1.668GlnPro: 1.668 ± 0.029	1.26GlnGln: 1.26 ± 0.033	2.379GlnArg: 2.379 ± 0.032	1.125GlnSer: 1.125 ± 0.024	1.146GlnThr: 1.146 ± 0.025	2.139GlnVal: 2.139 ± 0.032	0.461GlnTrp: 0.461 ± 0.015	0.57GlnTyr: 0.57 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.549ArgAla: 10.549 ± 0.083	0.656ArgCys: 0.656 ± 0.018	4.285ArgAsp: 4.285 ± 0.049	4.904ArgGlu: 4.904 ± 0.05	2.444ArgPhe: 2.444 ± 0.033	6.107ArgGly: 6.107 ± 0.052	2.23ArgHis: 2.23 ± 0.035	3.289ArgIle: 3.289 ± 0.042	1.719ArgLys: 1.719 ± 0.029	9.066ArgLeu: 9.066 ± 0.08	1.804ArgMet: 1.804 ± 0.033	1.405ArgAsn: 1.405 ± 0.028	5.446ArgPro: 5.446 ± 0.059	2.256ArgGln: 2.256 ± 0.037	7.968ArgArg: 7.968 ± 0.072	4.083ArgSer: 4.083 ± 0.045	5.687ArgThr: 5.687 ± 0.055	5.774ArgVal: 5.774 ± 0.057	1.367ArgTrp: 1.367 ± 0.029	1.746ArgTyr: 1.746 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.771SerAla: 6.771 ± 0.064	0.442SerCys: 0.442 ± 0.015	2.315SerAsp: 2.315 ± 0.033	2.224SerGlu: 2.224 ± 0.036	1.557SerPhe: 1.557 ± 0.029	6.02SerGly: 6.02 ± 0.061	1.018SerHis: 1.018 ± 0.021	1.28SerIle: 1.28 ± 0.023	0.979SerLys: 0.979 ± 0.024	4.804SerLeu: 4.804 ± 0.055	0.988SerMet: 0.988 ± 0.024	0.796SerAsn: 0.796 ± 0.022	3.298SerPro: 3.298 ± 0.042	1.072SerGln: 1.072 ± 0.026	3.645SerArg: 3.645 ± 0.044	2.759SerSer: 2.759 ± 0.047	2.733SerThr: 2.733 ± 0.044	4.161SerVal: 4.161 ± 0.046	0.869SerTrp: 0.869 ± 0.02	1.177SerTyr: 1.177 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.06ThrAla: 9.06 ± 0.076	0.441ThrCys: 0.441 ± 0.014	3.428ThrAsp: 3.428 ± 0.037	3.079ThrGlu: 3.079 ± 0.038	1.519ThrPhe: 1.519 ± 0.028	6.965ThrGly: 6.965 ± 0.063	1.187ThrHis: 1.187 ± 0.024	1.533ThrIle: 1.533 ± 0.028	1.082ThrLys: 1.082 ± 0.028	5.392ThrLeu: 5.392 ± 0.048	0.858ThrMet: 0.858 ± 0.019	0.891ThrAsn: 0.891 ± 0.021	3.879ThrPro: 3.879 ± 0.04	1.178ThrGln: 1.178 ± 0.025	3.762ThrArg: 3.762 ± 0.044	2.851ThrSer: 2.851 ± 0.043	3.55ThrThr: 3.55 ± 0.055	5.75ThrVal: 5.75 ± 0.055	0.851ThrTrp: 0.851 ± 0.02	1.309ThrTyr: 1.309 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.7ValAla: 10.7 ± 0.08	0.788ValCys: 0.788 ± 0.02	4.574ValAsp: 4.574 ± 0.045	4.48ValGlu: 4.48 ± 0.049	2.419ValPhe: 2.419 ± 0.032	6.021ValGly: 6.021 ± 0.054	2.013ValHis: 2.013 ± 0.027	2.847ValIle: 2.847 ± 0.046	1.687ValLys: 1.687 ± 0.033	9.653ValLeu: 9.653 ± 0.073	1.391ValMet: 1.391 ± 0.027	1.547ValAsn: 1.547 ± 0.03	5.428ValPro: 5.428 ± 0.052	2.012ValGln: 2.012 ± 0.031	7.382ValArg: 7.382 ± 0.057	4.276ValSer: 4.276 ± 0.05	5.561ValThr: 5.561 ± 0.059	7.637ValVal: 7.637 ± 0.07	1.106ValTrp: 1.106 ± 0.023	1.496ValTyr: 1.496 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.664TrpAla: 1.664 ± 0.031	0.173TrpCys: 0.173 ± 0.009	0.824TrpAsp: 0.824 ± 0.026	0.766TrpGlu: 0.766 ± 0.019	0.492TrpPhe: 0.492 ± 0.015	1.05TrpGly: 1.05 ± 0.024	0.399TrpHis: 0.399 ± 0.014	0.523TrpIle: 0.523 ± 0.017	0.37TrpLys: 0.37 ± 0.012	1.753TrpLeu: 1.753 ± 0.026	0.305TrpMet: 0.305 ± 0.012	0.367TrpAsn: 0.367 ± 0.016	0.788TrpPro: 0.788 ± 0.019	0.61TrpGln: 0.61 ± 0.017	1.311TrpArg: 1.311 ± 0.026	0.926TrpSer: 0.926 ± 0.018	1.003TrpThr: 1.003 ± 0.023	0.917TrpVal: 0.917 ± 0.021	0.337TrpTrp: 0.337 ± 0.013	0.344TrpTyr: 0.344 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.864TyrAla: 2.864 ± 0.036	0.182TyrCys: 0.182 ± 0.009	1.422TyrAsp: 1.422 ± 0.037	1.24TyrGlu: 1.24 ± 0.028	0.617TyrPhe: 0.617 ± 0.017	2.297TyrGly: 2.297 ± 0.033	0.392TyrHis: 0.392 ± 0.013	0.42TyrIle: 0.42 ± 0.015	0.378TyrLys: 0.378 ± 0.016	2.019TyrLeu: 2.019 ± 0.037	0.23TyrMet: 0.23 ± 0.01	0.395TyrAsn: 0.395 ± 0.014	1.072TyrPro: 1.072 ± 0.026	0.523TyrGln: 0.523 ± 0.017	1.846TyrArg: 1.846 ± 0.035	0.868TyrSer: 0.868 ± 0.02	1.103TyrThr: 1.103 ± 0.026	1.648TyrVal: 1.648 ± 0.031	0.359TyrTrp: 0.359 ± 0.015	0.439TyrTyr: 0.439 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6915 proteins (2256005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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