Amino acid dipepetide frequency for Candidatus Omnitrophus magneticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.091AlaAla: 3.091 ± 0.086	0.749AlaCys: 0.749 ± 0.033	3.007AlaAsp: 3.007 ± 0.072	4.117AlaGlu: 4.117 ± 0.084	2.756AlaPhe: 2.756 ± 0.057	5.134AlaGly: 5.134 ± 0.097	1.293AlaHis: 1.293 ± 0.036	5.297AlaIle: 5.297 ± 0.093	4.738AlaLys: 4.738 ± 0.081	6.208AlaLeu: 6.208 ± 0.106	1.645AlaMet: 1.645 ± 0.056	2.655AlaAsn: 2.655 ± 0.057	1.876AlaPro: 1.876 ± 0.054	1.589AlaGln: 1.589 ± 0.055	3.622AlaArg: 3.622 ± 0.072	3.697AlaSer: 3.697 ± 0.069	2.396AlaThr: 2.396 ± 0.068	4.729AlaVal: 4.729 ± 0.101	0.561AlaTrp: 0.561 ± 0.034	1.94AlaTyr: 1.94 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.72CysAla: 0.72 ± 0.032	0.137CysCys: 0.137 ± 0.013	0.509CysAsp: 0.509 ± 0.024	0.686CysGlu: 0.686 ± 0.034	0.563CysPhe: 0.563 ± 0.029	0.881CysGly: 0.881 ± 0.044	0.269CysHis: 0.269 ± 0.019	0.599CysIle: 0.599 ± 0.029	0.545CysLys: 0.545 ± 0.028	1.045CysLeu: 1.045 ± 0.036	0.274CysMet: 0.274 ± 0.017	0.371CysAsn: 0.371 ± 0.021	0.621CysPro: 0.621 ± 0.03	0.231CysGln: 0.231 ± 0.018	0.513CysArg: 0.513 ± 0.026	0.693CysSer: 0.693 ± 0.035	0.27CysThr: 0.27 ± 0.02	0.845CysVal: 0.845 ± 0.037	0.091CysTrp: 0.091 ± 0.01	0.357CysTyr: 0.357 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.242AspAla: 3.242 ± 0.082	0.404AspCys: 0.404 ± 0.023	2.295AspAsp: 2.295 ± 0.054	3.684AspGlu: 3.684 ± 0.078	2.842AspPhe: 2.842 ± 0.066	3.244AspGly: 3.244 ± 0.087	0.559AspHis: 0.559 ± 0.025	5.777AspIle: 5.777 ± 0.111	4.894AspLys: 4.894 ± 0.098	4.575AspLeu: 4.575 ± 0.085	1.32AspMet: 1.32 ± 0.038	2.737AspAsn: 2.737 ± 0.077	1.433AspPro: 1.433 ± 0.048	0.809AspGln: 0.809 ± 0.033	2.035AspArg: 2.035 ± 0.056	3.463AspSer: 3.463 ± 0.07	2.93AspThr: 2.93 ± 0.063	3.339AspVal: 3.339 ± 0.069	0.613AspTrp: 0.613 ± 0.031	2.129AspTyr: 2.129 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	3.732GluAla: 3.732 ± 0.083	0.521GluCys: 0.521 ± 0.025	3.204GluAsp: 3.204 ± 0.061	6.044GluGlu: 6.044 ± 0.119	2.91GluPhe: 2.91 ± 0.062	3.78GluGly: 3.78 ± 0.081	1.13GluHis: 1.13 ± 0.039	7.661GluIle: 7.661 ± 0.114	8.505GluLys: 8.505 ± 0.142	6.411GluLeu: 6.411 ± 0.106	1.854GluMet: 1.854 ± 0.05	4.3GluAsn: 4.3 ± 0.1	1.498GluPro: 1.498 ± 0.052	1.854GluGln: 1.854 ± 0.052	3.352GluArg: 3.352 ± 0.066	3.68GluSer: 3.68 ± 0.081	3.812GluThr: 3.812 ± 0.081	3.629GluVal: 3.629 ± 0.073	0.64GluTrp: 0.64 ± 0.031	2.912GluTyr: 2.912 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.453PheAla: 2.453 ± 0.061	0.764PheCys: 0.764 ± 0.039	2.801PheAsp: 2.801 ± 0.061	2.69PheGlu: 2.69 ± 0.054	3.164PhePhe: 3.164 ± 0.104	2.711PheGly: 2.711 ± 0.068	0.79PheHis: 0.79 ± 0.029	4.588PheIle: 4.588 ± 0.098	3.695PheLys: 3.695 ± 0.075	5.432PheLeu: 5.432 ± 0.11	1.103PheMet: 1.103 ± 0.039	2.964PheAsn: 2.964 ± 0.068	1.678PhePro: 1.678 ± 0.049	1.313PheGln: 1.313 ± 0.042	1.612PheArg: 1.612 ± 0.05	4.297PheSer: 4.297 ± 0.08	2.562PheThr: 2.562 ± 0.058	2.671PheVal: 2.671 ± 0.063	0.504PheTrp: 0.504 ± 0.027	2.08PheTyr: 2.08 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.181GlyAla: 4.181 ± 0.098	0.572GlyCys: 0.572 ± 0.029	3.261GlyAsp: 3.261 ± 0.072	4.231GlyGlu: 4.231 ± 0.087	3.082GlyPhe: 3.082 ± 0.065	4.096GlyGly: 4.096 ± 0.095	1.068GlyHis: 1.068 ± 0.042	6.248GlyIle: 6.248 ± 0.095	5.619GlyLys: 5.619 ± 0.1	5.236GlyLeu: 5.236 ± 0.102	1.851GlyMet: 1.851 ± 0.047	2.842GlyAsn: 2.842 ± 0.081	1.296GlyPro: 1.296 ± 0.049	1.727GlyGln: 1.727 ± 0.05	2.915GlyArg: 2.915 ± 0.066	3.285GlySer: 3.285 ± 0.074	3.204GlyThr: 3.204 ± 0.081	4.399GlyVal: 4.399 ± 0.095	0.62GlyTrp: 0.62 ± 0.031	2.796GlyTyr: 2.796 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.153HisAla: 1.153 ± 0.041	0.212HisCys: 0.212 ± 0.018	0.659HisAsp: 0.659 ± 0.033	0.988HisGlu: 0.988 ± 0.039	0.86HisPhe: 0.86 ± 0.031	1.1HisGly: 1.1 ± 0.043	0.3HisHis: 0.3 ± 0.021	1.345HisIle: 1.345 ± 0.045	1.032HisLys: 1.032 ± 0.041	1.636HisLeu: 1.636 ± 0.046	0.314HisMet: 0.314 ± 0.023	0.744HisAsn: 0.744 ± 0.029	0.778HisPro: 0.778 ± 0.032	0.509HisGln: 0.509 ± 0.03	0.759HisArg: 0.759 ± 0.032	1.0HisSer: 1.0 ± 0.039	0.892HisThr: 0.892 ± 0.036	0.855HisVal: 0.855 ± 0.033	0.175HisTrp: 0.175 ± 0.013	0.603HisTyr: 0.603 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.893IleAla: 5.893 ± 0.098	1.001IleCys: 1.001 ± 0.038	5.25IleAsp: 5.25 ± 0.095	6.245IleGlu: 6.245 ± 0.097	5.416IlePhe: 5.416 ± 0.104	4.756IleGly: 4.756 ± 0.092	1.362IleHis: 1.362 ± 0.036	8.488IleIle: 8.488 ± 0.17	8.659IleLys: 8.659 ± 0.126	8.738IleLeu: 8.738 ± 0.133	1.914IleMet: 1.914 ± 0.051	4.908IleAsn: 4.908 ± 0.086	3.664IlePro: 3.664 ± 0.076	2.139IleGln: 2.139 ± 0.051	3.292IleArg: 3.292 ± 0.074	6.822IleSer: 6.822 ± 0.091	4.914IleThr: 4.914 ± 0.077	5.747IleVal: 5.747 ± 0.086	0.584IleTrp: 0.584 ± 0.026	3.187IleTyr: 3.187 ± 0.08	0.0IleXaa: 0.0 ± 0.0
Lys	4.582LysAla: 4.582 ± 0.099	0.681LysCys: 0.681 ± 0.031	4.908LysAsp: 4.908 ± 0.088	8.511LysGlu: 8.511 ± 0.131	3.542LysPhe: 3.542 ± 0.075	4.68LysGly: 4.68 ± 0.077	1.421LysHis: 1.421 ± 0.044	9.522LysIle: 9.522 ± 0.133	9.313LysLys: 9.313 ± 0.136	6.894LysLeu: 6.894 ± 0.107	1.968LysMet: 1.968 ± 0.051	6.302LysAsn: 6.302 ± 0.119	2.272LysPro: 2.272 ± 0.063	2.405LysGln: 2.405 ± 0.07	3.491LysArg: 3.491 ± 0.073	4.771LysSer: 4.771 ± 0.075	5.063LysThr: 5.063 ± 0.091	4.045LysVal: 4.045 ± 0.076	0.907LysTrp: 0.907 ± 0.032	3.731LysTyr: 3.731 ± 0.085	0.0LysXaa: 0.0 ± 0.0
Leu	6.179LeuAla: 6.179 ± 0.102	0.85LeuCys: 0.85 ± 0.042	5.184LeuAsp: 5.184 ± 0.083	6.386LeuGlu: 6.386 ± 0.095	4.667LeuPhe: 4.667 ± 0.103	6.017LeuGly: 6.017 ± 0.101	1.305LeuHis: 1.305 ± 0.046	6.989LeuIle: 6.989 ± 0.111	8.92LeuLys: 8.92 ± 0.135	8.938LeuLeu: 8.938 ± 0.135	2.064LeuMet: 2.064 ± 0.055	4.888LeuAsn: 4.888 ± 0.1	3.182LeuPro: 3.182 ± 0.066	2.053LeuGln: 2.053 ± 0.051	4.214LeuArg: 4.214 ± 0.074	7.322LeuSer: 7.322 ± 0.122	4.781LeuThr: 4.781 ± 0.083	4.961LeuVal: 4.961 ± 0.091	0.926LeuTrp: 0.926 ± 0.033	3.604LeuTyr: 3.604 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	1.964MetAla: 1.964 ± 0.055	0.222MetCys: 0.222 ± 0.016	1.495MetAsp: 1.495 ± 0.047	1.622MetGlu: 1.622 ± 0.041	1.011MetPhe: 1.011 ± 0.043	1.485MetGly: 1.485 ± 0.045	0.256MetHis: 0.256 ± 0.019	1.791MetIle: 1.791 ± 0.053	2.123MetLys: 2.123 ± 0.051	1.864MetLeu: 1.864 ± 0.052	0.612MetMet: 0.612 ± 0.024	1.282MetAsn: 1.282 ± 0.037	1.189MetPro: 1.189 ± 0.043	0.492MetGln: 0.492 ± 0.024	1.219MetArg: 1.219 ± 0.043	1.408MetSer: 1.408 ± 0.043	1.19MetThr: 1.19 ± 0.039	1.303MetVal: 1.303 ± 0.041	0.213MetTrp: 0.213 ± 0.016	0.604MetTyr: 0.604 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.005AsnAla: 3.005 ± 0.071	0.487AsnCys: 0.487 ± 0.023	2.486AsnAsp: 2.486 ± 0.072	3.27AsnGlu: 3.27 ± 0.073	2.82AsnPhe: 2.82 ± 0.075	3.37AsnGly: 3.37 ± 0.086	0.617AsnHis: 0.617 ± 0.029	6.13AsnIle: 6.13 ± 0.1	4.648AsnLys: 4.648 ± 0.1	4.754AsnLeu: 4.754 ± 0.087	1.118AsnMet: 1.118 ± 0.036	3.244AsnAsn: 3.244 ± 0.101	2.039AsnPro: 2.039 ± 0.064	1.299AsnGln: 1.299 ± 0.045	1.886AsnArg: 1.886 ± 0.048	3.334AsnSer: 3.334 ± 0.081	2.796AsnThr: 2.796 ± 0.08	2.959AsnVal: 2.959 ± 0.072	0.459AsnTrp: 0.459 ± 0.028	2.044AsnTyr: 2.044 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.026ProAla: 2.026 ± 0.058	0.395ProCys: 0.395 ± 0.024	1.851ProAsp: 1.851 ± 0.052	2.592ProGlu: 2.592 ± 0.06	1.698ProPhe: 1.698 ± 0.048	1.745ProGly: 1.745 ± 0.047	0.566ProHis: 0.566 ± 0.025	2.695ProIle: 2.695 ± 0.069	2.438ProLys: 2.438 ± 0.056	2.901ProLeu: 2.901 ± 0.066	0.667ProMet: 0.667 ± 0.028	1.414ProAsn: 1.414 ± 0.048	1.004ProPro: 1.004 ± 0.039	0.773ProGln: 0.773 ± 0.033	1.665ProArg: 1.665 ± 0.051	2.708ProSer: 2.708 ± 0.07	1.208ProThr: 1.208 ± 0.049	2.419ProVal: 2.419 ± 0.063	0.542ProTrp: 0.542 ± 0.033	1.233ProTyr: 1.233 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.556GlnAla: 1.556 ± 0.046	0.236GlnCys: 0.236 ± 0.018	1.222GlnAsp: 1.222 ± 0.039	1.957GlnGlu: 1.957 ± 0.054	0.963GlnPhe: 0.963 ± 0.038	1.514GlnGly: 1.514 ± 0.046	0.516GlnHis: 0.516 ± 0.022	2.362GlnIle: 2.362 ± 0.066	2.659GlnLys: 2.659 ± 0.067	2.009GlnLeu: 2.009 ± 0.057	0.545GlnMet: 0.545 ± 0.025	1.483GlnAsn: 1.483 ± 0.048	0.722GlnPro: 0.722 ± 0.033	0.534GlnGln: 0.534 ± 0.036	1.162GlnArg: 1.162 ± 0.043	1.454GlnSer: 1.454 ± 0.04	1.357GlnThr: 1.357 ± 0.046	1.357GlnVal: 1.357 ± 0.045	0.274GlnTrp: 0.274 ± 0.02	1.059GlnTyr: 1.059 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.768ArgAla: 2.768 ± 0.068	0.409ArgCys: 0.409 ± 0.022	2.666ArgAsp: 2.666 ± 0.066	3.94ArgGlu: 3.94 ± 0.072	2.034ArgPhe: 2.034 ± 0.051	2.717ArgGly: 2.717 ± 0.076	0.8ArgHis: 0.8 ± 0.037	3.94ArgIle: 3.94 ± 0.066	3.249ArgLys: 3.249 ± 0.066	4.072ArgLeu: 4.072 ± 0.086	1.1ArgMet: 1.1 ± 0.035	2.149ArgAsn: 2.149 ± 0.054	1.419ArgPro: 1.419 ± 0.046	1.457ArgGln: 1.457 ± 0.048	2.036ArgArg: 2.036 ± 0.053	2.105ArgSer: 2.105 ± 0.049	1.825ArgThr: 1.825 ± 0.053	3.263ArgVal: 3.263 ± 0.059	0.413ArgTrp: 0.413 ± 0.028	1.889ArgTyr: 1.889 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.029SerAla: 5.029 ± 0.068	0.802SerCys: 0.802 ± 0.036	3.341SerAsp: 3.341 ± 0.066	4.178SerGlu: 4.178 ± 0.084	3.432SerPhe: 3.432 ± 0.075	4.917SerGly: 4.917 ± 0.09	1.075SerHis: 1.075 ± 0.034	5.501SerIle: 5.501 ± 0.078	4.901SerLys: 4.901 ± 0.09	6.621SerLeu: 6.621 ± 0.099	1.49SerMet: 1.49 ± 0.041	2.967SerAsn: 2.967 ± 0.072	2.343SerPro: 2.343 ± 0.061	1.917SerGln: 1.917 ± 0.051	3.129SerArg: 3.129 ± 0.068	4.61SerSer: 4.61 ± 0.095	2.616SerThr: 2.616 ± 0.06	4.026SerVal: 4.026 ± 0.082	0.618SerTrp: 0.618 ± 0.031	2.241SerTyr: 2.241 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.56ThrAla: 3.56 ± 0.079	0.438ThrCys: 0.438 ± 0.02	2.427ThrAsp: 2.427 ± 0.058	2.936ThrGlu: 2.936 ± 0.065	2.147ThrPhe: 2.147 ± 0.055	4.268ThrGly: 4.268 ± 0.079	0.953ThrHis: 0.953 ± 0.034	4.664ThrIle: 4.664 ± 0.074	4.136ThrLys: 4.136 ± 0.095	4.821ThrLeu: 4.821 ± 0.094	0.973ThrMet: 0.973 ± 0.04	2.182ThrAsn: 2.182 ± 0.067	1.969ThrPro: 1.969 ± 0.059	1.343ThrGln: 1.343 ± 0.045	2.325ThrArg: 2.325 ± 0.056	3.015ThrSer: 3.015 ± 0.07	2.466ThrThr: 2.466 ± 0.068	3.068ThrVal: 3.068 ± 0.069	0.468ThrTrp: 0.468 ± 0.028	1.555ThrTyr: 1.555 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	3.453ValAla: 3.453 ± 0.073	0.719ValCys: 0.719 ± 0.036	3.083ValAsp: 3.083 ± 0.079	4.016ValGlu: 4.016 ± 0.073	3.191ValPhe: 3.191 ± 0.068	3.034ValGly: 3.034 ± 0.077	0.778ValHis: 0.778 ± 0.033	5.582ValIle: 5.582 ± 0.098	5.046ValLys: 5.046 ± 0.096	6.137ValLeu: 6.137 ± 0.111	1.45ValMet: 1.45 ± 0.046	2.921ValAsn: 2.921 ± 0.062	1.881ValPro: 1.881 ± 0.058	1.184ValGln: 1.184 ± 0.042	2.673ValArg: 2.673 ± 0.054	4.767ValSer: 4.767 ± 0.078	3.119ValThr: 3.119 ± 0.072	3.807ValVal: 3.807 ± 0.079	0.725ValTrp: 0.725 ± 0.036	2.22ValTyr: 2.22 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.71TrpAla: 0.71 ± 0.03	0.093TrpCys: 0.093 ± 0.009	0.508TrpAsp: 0.508 ± 0.032	0.857TrpGlu: 0.857 ± 0.033	0.457TrpPhe: 0.457 ± 0.027	0.637TrpGly: 0.637 ± 0.037	0.204TrpHis: 0.204 ± 0.018	0.792TrpIle: 0.792 ± 0.034	0.689TrpLys: 0.689 ± 0.033	1.045TrpLeu: 1.045 ± 0.033	0.228TrpMet: 0.228 ± 0.016	0.52TrpAsn: 0.52 ± 0.028	0.29TrpPro: 0.29 ± 0.02	0.365TrpGln: 0.365 ± 0.025	0.49TrpArg: 0.49 ± 0.029	0.474TrpSer: 0.474 ± 0.027	0.497TrpThr: 0.497 ± 0.033	0.525TrpVal: 0.525 ± 0.031	0.133TrpTrp: 0.133 ± 0.019	0.37TrpTyr: 0.37 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.805TyrAla: 1.805 ± 0.05	0.53TyrCys: 0.53 ± 0.028	2.168TyrAsp: 2.168 ± 0.063	2.479TyrGlu: 2.479 ± 0.057	2.315TyrPhe: 2.315 ± 0.059	2.442TyrGly: 2.442 ± 0.07	0.654TyrHis: 0.654 ± 0.032	3.01TyrIle: 3.01 ± 0.064	3.2TyrLys: 3.2 ± 0.071	4.096TyrLeu: 4.096 ± 0.074	0.854TyrMet: 0.854 ± 0.035	1.888TyrAsn: 1.888 ± 0.061	1.388TyrPro: 1.388 ± 0.049	0.947TyrGln: 0.947 ± 0.037	1.862TyrArg: 1.862 ± 0.047	2.848TyrSer: 2.848 ± 0.076	1.817TyrThr: 1.817 ± 0.055	1.836TyrVal: 1.836 ± 0.061	0.417TyrTrp: 0.417 ± 0.031	1.646TyrTyr: 1.646 ± 0.079	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2573 proteins (789100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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