Amino acid dipepetide frequency for Mucispirillum schaedleri ASF457

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.737AlaAla: 6.737 ± 0.141
0.959AlaCys: 0.959 ± 0.045
4.0AlaAsp: 4.0 ± 0.081
5.154AlaGlu: 5.154 ± 0.104
3.041AlaPhe: 3.041 ± 0.074
5.816AlaGly: 5.816 ± 0.123
0.932AlaHis: 0.932 ± 0.039
4.032AlaIle: 4.032 ± 0.09
5.033AlaLys: 5.033 ± 0.083
6.54AlaLeu: 6.54 ± 0.103
1.637AlaMet: 1.637 ± 0.054
2.928AlaAsn: 2.928 ± 0.068
1.84AlaPro: 1.84 ± 0.058
1.772AlaGln: 1.772 ± 0.057
2.223AlaArg: 2.223 ± 0.064
4.156AlaSer: 4.156 ± 0.08
2.632AlaThr: 2.632 ± 0.084
6.888AlaVal: 6.888 ± 0.123
0.406AlaTrp: 0.406 ± 0.028
2.79AlaTyr: 2.79 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.034
0.168CysCys: 0.168 ± 0.017
0.646CysAsp: 0.646 ± 0.035
0.648CysGlu: 0.648 ± 0.034
0.483CysPhe: 0.483 ± 0.032
0.955CysGly: 0.955 ± 0.044
0.344CysHis: 0.344 ± 0.037
1.022CysIle: 1.022 ± 0.044
0.752CysLys: 0.752 ± 0.037
0.801CysLeu: 0.801 ± 0.036
0.286CysMet: 0.286 ± 0.022
0.534CysAsn: 0.534 ± 0.029
0.526CysPro: 0.526 ± 0.032
0.28CysGln: 0.28 ± 0.021
0.404CysArg: 0.404 ± 0.025
1.046CysSer: 1.046 ± 0.042
0.445CysThr: 0.445 ± 0.026
0.594CysVal: 0.594 ± 0.032
0.059CysTrp: 0.059 ± 0.009
0.424CysTyr: 0.424 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.289AspAla: 3.289 ± 0.085
0.54AspCys: 0.54 ± 0.029
3.251AspAsp: 3.251 ± 0.08
4.159AspGlu: 4.159 ± 0.09
2.93AspPhe: 2.93 ± 0.062
3.2AspGly: 3.2 ± 0.067
0.541AspHis: 0.541 ± 0.03
6.866AspIle: 6.866 ± 0.113
5.65AspLys: 5.65 ± 0.106
4.242AspLeu: 4.242 ± 0.074
1.859AspMet: 1.859 ± 0.053
4.428AspAsn: 4.428 ± 0.088
1.224AspPro: 1.224 ± 0.043
0.628AspGln: 0.628 ± 0.028
1.678AspArg: 1.678 ± 0.059
2.731AspSer: 2.731 ± 0.058
3.154AspThr: 3.154 ± 0.066
3.196AspVal: 3.196 ± 0.075
0.388AspTrp: 0.388 ± 0.022
2.865AspTyr: 2.865 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
3.943GluAla: 3.943 ± 0.093
0.685GluCys: 0.685 ± 0.034
3.265GluAsp: 3.265 ± 0.079
4.636GluGlu: 4.636 ± 0.127
2.614GluPhe: 2.614 ± 0.066
2.649GluGly: 2.649 ± 0.076
1.108GluHis: 1.108 ± 0.043
6.207GluIle: 6.207 ± 0.094
7.042GluLys: 7.042 ± 0.128
5.796GluLeu: 5.796 ± 0.093
1.9GluMet: 1.9 ± 0.058
5.243GluAsn: 5.243 ± 0.101
1.539GluPro: 1.539 ± 0.049
2.121GluGln: 2.121 ± 0.063
2.534GluArg: 2.534 ± 0.07
3.292GluSer: 3.292 ± 0.075
3.241GluThr: 3.241 ± 0.072
3.609GluVal: 3.609 ± 0.082
0.38GluTrp: 0.38 ± 0.024
3.732GluTyr: 3.732 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
3.366PheAla: 3.366 ± 0.081
0.501PheCys: 0.501 ± 0.027
2.599PheAsp: 2.599 ± 0.057
2.545PheGlu: 2.545 ± 0.058
2.503PhePhe: 2.503 ± 0.081
2.963PheGly: 2.963 ± 0.076
0.761PheHis: 0.761 ± 0.034
5.009PheIle: 5.009 ± 0.107
3.49PheLys: 3.49 ± 0.082
4.289PheLeu: 4.289 ± 0.103
1.336PheMet: 1.336 ± 0.05
2.913PheAsn: 2.913 ± 0.077
1.401PhePro: 1.401 ± 0.053
1.136PheGln: 1.136 ± 0.038
1.392PheArg: 1.392 ± 0.052
3.307PheSer: 3.307 ± 0.078
2.674PheThr: 2.674 ± 0.065
2.44PheVal: 2.44 ± 0.058
0.305PheTrp: 0.305 ± 0.025
2.053PheTyr: 2.053 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.455GlyAla: 4.455 ± 0.108
0.831GlyCys: 0.831 ± 0.035
2.9GlyAsp: 2.9 ± 0.076
3.393GlyGlu: 3.393 ± 0.075
3.051GlyPhe: 3.051 ± 0.066
4.003GlyGly: 4.003 ± 0.102
0.908GlyHis: 0.908 ± 0.046
6.068GlyIle: 6.068 ± 0.1
4.72GlyLys: 4.72 ± 0.096
5.189GlyLeu: 5.189 ± 0.103
1.778GlyMet: 1.778 ± 0.061
2.743GlyAsn: 2.743 ± 0.074
1.015GlyPro: 1.015 ± 0.038
1.509GlyGln: 1.509 ± 0.054
2.748GlyArg: 2.748 ± 0.069
4.036GlySer: 4.036 ± 0.084
3.146GlyThr: 3.146 ± 0.071
3.971GlyVal: 3.971 ± 0.086
0.442GlyTrp: 0.442 ± 0.026
3.048GlyTyr: 3.048 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.953HisAla: 0.953 ± 0.034
0.215HisCys: 0.215 ± 0.018
0.804HisAsp: 0.804 ± 0.037
0.8HisGlu: 0.8 ± 0.038
0.822HisPhe: 0.822 ± 0.035
1.054HisGly: 1.054 ± 0.044
0.349HisHis: 0.349 ± 0.024
1.843HisIle: 1.843 ± 0.06
1.207HisLys: 1.207 ± 0.049
1.327HisLeu: 1.327 ± 0.045
0.274HisMet: 0.274 ± 0.02
1.067HisAsn: 1.067 ± 0.042
0.716HisPro: 0.716 ± 0.034
0.385HisGln: 0.385 ± 0.023
0.552HisArg: 0.552 ± 0.03
1.108HisSer: 1.108 ± 0.037
0.929HisThr: 0.929 ± 0.045
0.774HisVal: 0.774 ± 0.032
0.093HisTrp: 0.093 ± 0.013
0.682HisTyr: 0.682 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.014IleAla: 6.014 ± 0.102
1.009IleCys: 1.009 ± 0.041
5.877IleAsp: 5.877 ± 0.085
5.98IleGlu: 5.98 ± 0.116
4.389IlePhe: 4.389 ± 0.118
4.812IleGly: 4.812 ± 0.097
1.436IleHis: 1.436 ± 0.045
8.891IleIle: 8.891 ± 0.155
7.816IleLys: 7.816 ± 0.127
8.034IleLeu: 8.034 ± 0.14
2.399IleMet: 2.399 ± 0.064
6.115IleAsn: 6.115 ± 0.125
3.233IlePro: 3.233 ± 0.067
2.085IleGln: 2.085 ± 0.066
2.776IleArg: 2.776 ± 0.059
6.979IleSer: 6.979 ± 0.131
5.375IleThr: 5.375 ± 0.1
5.264IleVal: 5.264 ± 0.106
0.525IleTrp: 0.525 ± 0.027
4.036IleTyr: 4.036 ± 0.087
0.0IleXaa: 0.0 ± 0.0
Lys
5.469LysAla: 5.469 ± 0.099
0.84LysCys: 0.84 ± 0.037
5.269LysAsp: 5.269 ± 0.102
7.012LysGlu: 7.012 ± 0.138
2.891LysPhe: 2.891 ± 0.066
4.586LysGly: 4.586 ± 0.087
1.351LysHis: 1.351 ± 0.047
7.122LysIle: 7.122 ± 0.131
7.121LysLys: 7.121 ± 0.138
6.591LysLeu: 6.591 ± 0.097
2.405LysMet: 2.405 ± 0.053
6.028LysAsn: 6.028 ± 0.117
2.187LysPro: 2.187 ± 0.055
2.602LysGln: 2.602 ± 0.074
2.718LysArg: 2.718 ± 0.072
5.243LysSer: 5.243 ± 0.085
4.385LysThr: 4.385 ± 0.084
4.544LysVal: 4.544 ± 0.085
0.543LysTrp: 0.543 ± 0.033
4.555LysTyr: 4.555 ± 0.106
0.0LysXaa: 0.0 ± 0.0
Leu
5.572LeuAla: 5.572 ± 0.097
0.9LeuCys: 0.9 ± 0.04
4.714LeuAsp: 4.714 ± 0.085
5.538LeuGlu: 5.538 ± 0.103
4.373LeuPhe: 4.373 ± 0.107
4.879LeuGly: 4.879 ± 0.107
1.496LeuHis: 1.496 ± 0.052
7.504LeuIle: 7.504 ± 0.124
7.653LeuLys: 7.653 ± 0.12
7.877LeuLeu: 7.877 ± 0.124
2.261LeuMet: 2.261 ± 0.061
5.644LeuAsn: 5.644 ± 0.088
2.937LeuPro: 2.937 ± 0.067
2.545LeuGln: 2.545 ± 0.069
2.701LeuArg: 2.701 ± 0.067
6.952LeuSer: 6.952 ± 0.122
4.287LeuThr: 4.287 ± 0.079
4.379LeuVal: 4.379 ± 0.098
0.573LeuTrp: 0.573 ± 0.031
3.884LeuTyr: 3.884 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
2.247MetAla: 2.247 ± 0.061
0.231MetCys: 0.231 ± 0.019
1.446MetAsp: 1.446 ± 0.047
1.732MetGlu: 1.732 ± 0.053
1.078MetPhe: 1.078 ± 0.047
1.649MetGly: 1.649 ± 0.054
0.428MetHis: 0.428 ± 0.026
1.972MetIle: 1.972 ± 0.057
2.27MetLys: 2.27 ± 0.063
2.683MetLeu: 2.683 ± 0.064
0.706MetMet: 0.706 ± 0.036
1.472MetAsn: 1.472 ± 0.053
1.162MetPro: 1.162 ± 0.042
1.282MetGln: 1.282 ± 0.042
1.028MetArg: 1.028 ± 0.041
1.82MetSer: 1.82 ± 0.056
1.284MetThr: 1.284 ± 0.039
1.509MetVal: 1.509 ± 0.052
0.158MetTrp: 0.158 ± 0.017
0.955MetTyr: 0.955 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.814AsnAla: 3.814 ± 0.088
0.516AsnCys: 0.516 ± 0.028
3.307AsnAsp: 3.307 ± 0.067
3.537AsnGlu: 3.537 ± 0.079
2.501AsnPhe: 2.501 ± 0.059
3.761AsnGly: 3.761 ± 0.091
0.885AsnHis: 0.885 ± 0.039
7.91AsnIle: 7.91 ± 0.121
5.865AsnLys: 5.865 ± 0.119
4.531AsnLeu: 4.531 ± 0.082
2.01AsnMet: 2.01 ± 0.063
4.795AsnAsn: 4.795 ± 0.119
2.207AsnPro: 2.207 ± 0.064
1.637AsnGln: 1.637 ± 0.061
1.757AsnArg: 1.757 ± 0.049
3.82AsnSer: 3.82 ± 0.091
3.611AsnThr: 3.611 ± 0.087
3.49AsnVal: 3.49 ± 0.081
0.356AsnTrp: 0.356 ± 0.027
2.431AsnTyr: 2.431 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.519ProAla: 2.519 ± 0.065
0.358ProCys: 0.358 ± 0.024
2.035ProAsp: 2.035 ± 0.051
2.416ProGlu: 2.416 ± 0.067
1.643ProPhe: 1.643 ± 0.048
1.287ProGly: 1.287 ± 0.047
0.531ProHis: 0.531 ± 0.029
1.789ProIle: 1.789 ± 0.057
2.122ProLys: 2.122 ± 0.056
2.821ProLeu: 2.821 ± 0.071
0.613ProMet: 0.613 ± 0.028
1.433ProAsn: 1.433 ± 0.04
0.697ProPro: 0.697 ± 0.034
0.773ProGln: 0.773 ± 0.033
0.807ProArg: 0.807 ± 0.039
1.765ProSer: 1.765 ± 0.054
1.178ProThr: 1.178 ± 0.044
3.134ProVal: 3.134 ± 0.073
0.218ProTrp: 0.218 ± 0.017
1.58ProTyr: 1.58 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
2.047GlnAla: 2.047 ± 0.054
0.26GlnCys: 0.26 ± 0.021
1.672GlnAsp: 1.672 ± 0.057
1.989GlnGlu: 1.989 ± 0.044
1.063GlnPhe: 1.063 ± 0.038
1.617GlnGly: 1.617 ± 0.054
0.496GlnHis: 0.496 ± 0.03
2.34GlnIle: 2.34 ± 0.067
2.184GlnLys: 2.184 ± 0.063
2.264GlnLeu: 2.264 ± 0.064
0.764GlnMet: 0.764 ± 0.035
1.712GlnAsn: 1.712 ± 0.052
0.603GlnPro: 0.603 ± 0.035
0.973GlnGln: 0.973 ± 0.04
0.8GlnArg: 0.8 ± 0.036
1.703GlnSer: 1.703 ± 0.05
1.371GlnThr: 1.371 ± 0.047
1.53GlnVal: 1.53 ± 0.053
0.195GlnTrp: 0.195 ± 0.02
1.215GlnTyr: 1.215 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.065ArgAla: 2.065 ± 0.059
0.38ArgCys: 0.38 ± 0.025
1.726ArgAsp: 1.726 ± 0.056
2.177ArgGlu: 2.177 ± 0.061
1.669ArgPhe: 1.669 ± 0.05
1.765ArgGly: 1.765 ± 0.053
0.631ArgHis: 0.631 ± 0.03
2.895ArgIle: 2.895 ± 0.062
2.758ArgLys: 2.758 ± 0.072
3.26ArgLeu: 3.26 ± 0.085
0.998ArgMet: 0.998 ± 0.037
1.933ArgAsn: 1.933 ± 0.054
1.069ArgPro: 1.069 ± 0.038
1.197ArgGln: 1.197 ± 0.039
1.344ArgArg: 1.344 ± 0.052
1.753ArgSer: 1.753 ± 0.053
1.425ArgThr: 1.425 ± 0.046
2.043ArgVal: 2.043 ± 0.061
0.259ArgTrp: 0.259 ± 0.022
1.676ArgTyr: 1.676 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.615SerAla: 4.615 ± 0.104
0.837SerCys: 0.837 ± 0.041
3.684SerAsp: 3.684 ± 0.073
3.914SerGlu: 3.914 ± 0.089
3.716SerPhe: 3.716 ± 0.086
4.52SerGly: 4.52 ± 0.089
1.087SerHis: 1.087 ± 0.043
6.198SerIle: 6.198 ± 0.103
5.057SerLys: 5.057 ± 0.085
6.107SerLeu: 6.107 ± 0.106
1.732SerMet: 1.732 ± 0.052
3.696SerAsn: 3.696 ± 0.092
1.849SerPro: 1.849 ± 0.052
1.697SerGln: 1.697 ± 0.051
2.255SerArg: 2.255 ± 0.055
5.299SerSer: 5.299 ± 0.12
2.823SerThr: 2.823 ± 0.076
4.007SerVal: 4.007 ± 0.094
0.48SerTrp: 0.48 ± 0.035
3.075SerTyr: 3.075 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.499ThrAla: 4.499 ± 0.106
0.528ThrCys: 0.528 ± 0.029
2.984ThrAsp: 2.984 ± 0.064
2.694ThrGlu: 2.694 ± 0.066
2.372ThrPhe: 2.372 ± 0.055
4.361ThrGly: 4.361 ± 0.091
0.953ThrHis: 0.953 ± 0.04
4.412ThrIle: 4.412 ± 0.085
3.381ThrLys: 3.381 ± 0.078
4.442ThrLeu: 4.442 ± 0.074
1.181ThrMet: 1.181 ± 0.044
2.661ThrAsn: 2.661 ± 0.079
1.987ThrPro: 1.987 ± 0.065
1.21ThrGln: 1.21 ± 0.05
1.463ThrArg: 1.463 ± 0.04
3.245ThrSer: 3.245 ± 0.066
2.361ThrThr: 2.361 ± 0.077
3.71ThrVal: 3.71 ± 0.095
0.271ThrTrp: 0.271 ± 0.019
2.151ThrTyr: 2.151 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
3.808ValAla: 3.808 ± 0.096
0.837ValCys: 0.837 ± 0.035
3.354ValAsp: 3.354 ± 0.078
3.995ValGlu: 3.995 ± 0.088
3.157ValPhe: 3.157 ± 0.078
2.855ValGly: 2.855 ± 0.086
0.773ValHis: 0.773 ± 0.039
6.038ValIle: 6.038 ± 0.106
4.914ValLys: 4.914 ± 0.098
5.548ValLeu: 5.548 ± 0.11
1.643ValMet: 1.643 ± 0.057
3.438ValAsn: 3.438 ± 0.074
1.957ValPro: 1.957 ± 0.057
1.473ValGln: 1.473 ± 0.047
2.116ValArg: 2.116 ± 0.064
4.81ValSer: 4.81 ± 0.109
3.663ValThr: 3.663 ± 0.085
3.65ValVal: 3.65 ± 0.083
0.401ValTrp: 0.401 ± 0.027
2.8ValTyr: 2.8 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.436TrpAla: 0.436 ± 0.027
0.084TrpCys: 0.084 ± 0.011
0.4TrpAsp: 0.4 ± 0.035
0.409TrpGlu: 0.409 ± 0.029
0.325TrpPhe: 0.325 ± 0.024
0.397TrpGly: 0.397 ± 0.024
0.2TrpHis: 0.2 ± 0.019
0.469TrpIle: 0.469 ± 0.029
0.454TrpLys: 0.454 ± 0.027
0.582TrpLeu: 0.582 ± 0.034
0.162TrpMet: 0.162 ± 0.017
0.377TrpAsn: 0.377 ± 0.028
0.129TrpPro: 0.129 ± 0.011
0.295TrpGln: 0.295 ± 0.02
0.218TrpArg: 0.218 ± 0.018
0.409TrpSer: 0.409 ± 0.029
0.325TrpThr: 0.325 ± 0.024
0.352TrpVal: 0.352 ± 0.023
0.069TrpTrp: 0.069 ± 0.009
0.301TrpTyr: 0.301 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.966TyrAla: 2.966 ± 0.072
0.437TyrCys: 0.437 ± 0.027
2.888TyrAsp: 2.888 ± 0.075
2.811TyrGlu: 2.811 ± 0.067
2.363TyrPhe: 2.363 ± 0.07
2.829TyrGly: 2.829 ± 0.066
0.744TyrHis: 0.744 ± 0.036
4.46TyrIle: 4.46 ± 0.095
3.973TyrLys: 3.973 ± 0.094
3.743TyrLeu: 3.743 ± 0.088
1.166TyrMet: 1.166 ± 0.038
3.579TyrAsn: 3.579 ± 0.078
1.442TyrPro: 1.442 ± 0.048
1.198TyrGln: 1.198 ± 0.044
1.508TyrArg: 1.508 ± 0.047
3.173TyrSer: 3.173 ± 0.077
2.555TyrThr: 2.555 ± 0.065
2.147TyrVal: 2.147 ± 0.066
0.272TyrTrp: 0.272 ± 0.022
2.169TyrTyr: 2.169 ± 0.075
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2091 proteins (665262 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski