Amino acid dipepetide frequency for Flavobacterium sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.935AlaAla: 3.935 ± 0.09	0.531AlaCys: 0.531 ± 0.028	3.25AlaAsp: 3.25 ± 0.059	4.066AlaGlu: 4.066 ± 0.066	3.215AlaPhe: 3.215 ± 0.063	4.012AlaGly: 4.012 ± 0.084	1.045AlaHis: 1.045 ± 0.037	5.278AlaIle: 5.278 ± 0.083	4.8AlaLys: 4.8 ± 0.098	6.105AlaLeu: 6.105 ± 0.097	1.41AlaMet: 1.41 ± 0.042	3.49AlaAsn: 3.49 ± 0.078	1.785AlaPro: 1.785 ± 0.054	2.537AlaGln: 2.537 ± 0.063	1.71AlaArg: 1.71 ± 0.047	3.853AlaSer: 3.853 ± 0.061	4.038AlaThr: 4.038 ± 0.094	4.153AlaVal: 4.153 ± 0.078	0.566AlaTrp: 0.566 ± 0.026	2.38AlaTyr: 2.38 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.421CysAla: 0.421 ± 0.02	0.108CysCys: 0.108 ± 0.012	0.46CysAsp: 0.46 ± 0.028	0.504CysGlu: 0.504 ± 0.024	0.424CysPhe: 0.424 ± 0.023	0.717CysGly: 0.717 ± 0.054	0.209CysHis: 0.209 ± 0.018	0.573CysIle: 0.573 ± 0.026	0.482CysLys: 0.482 ± 0.023	0.639CysLeu: 0.639 ± 0.027	0.161CysMet: 0.161 ± 0.015	0.528CysAsn: 0.528 ± 0.027	0.388CysPro: 0.388 ± 0.023	0.26CysGln: 0.26 ± 0.021	0.207CysArg: 0.207 ± 0.015	0.675CysSer: 0.675 ± 0.041	0.517CysThr: 0.517 ± 0.034	0.45CysVal: 0.45 ± 0.024	0.079CysTrp: 0.079 ± 0.01	0.317CysTyr: 0.317 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.407AspAla: 3.407 ± 0.067	0.529AspCys: 0.529 ± 0.043	2.754AspAsp: 2.754 ± 0.068	3.741AspGlu: 3.741 ± 0.074	3.79AspPhe: 3.79 ± 0.067	3.445AspGly: 3.445 ± 0.084	0.829AspHis: 0.829 ± 0.031	4.229AspIle: 4.229 ± 0.062	4.153AspLys: 4.153 ± 0.083	5.113AspLeu: 5.113 ± 0.079	1.073AspMet: 1.073 ± 0.035	3.159AspAsn: 3.159 ± 0.072	1.724AspPro: 1.724 ± 0.064	1.528AspGln: 1.528 ± 0.048	1.724AspArg: 1.724 ± 0.045	3.162AspSer: 3.162 ± 0.065	2.763AspThr: 2.763 ± 0.06	3.468AspVal: 3.468 ± 0.062	0.666AspTrp: 0.666 ± 0.026	2.997AspTyr: 2.997 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.4GluAla: 4.4 ± 0.09	0.374GluCys: 0.374 ± 0.024	3.422GluAsp: 3.422 ± 0.057	5.314GluGlu: 5.314 ± 0.1	3.049GluPhe: 3.049 ± 0.057	3.523GluGly: 3.523 ± 0.068	1.239GluHis: 1.239 ± 0.037	5.946GluIle: 5.946 ± 0.097	6.704GluLys: 6.704 ± 0.103	6.298GluLeu: 6.298 ± 0.099	1.636GluMet: 1.636 ± 0.034	5.125GluAsn: 5.125 ± 0.077	1.569GluPro: 1.569 ± 0.041	2.66GluGln: 2.66 ± 0.054	2.34GluArg: 2.34 ± 0.046	3.282GluSer: 3.282 ± 0.054	3.796GluThr: 3.796 ± 0.067	4.441GluVal: 4.441 ± 0.076	0.603GluTrp: 0.603 ± 0.023	2.652GluTyr: 2.652 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.981PheAla: 2.981 ± 0.059	0.521PheCys: 0.521 ± 0.024	3.271PheAsp: 3.271 ± 0.063	3.587PheGlu: 3.587 ± 0.064	2.998PhePhe: 2.998 ± 0.077	3.48PheGly: 3.48 ± 0.07	0.884PheHis: 0.884 ± 0.028	3.932PheIle: 3.932 ± 0.069	3.754PheLys: 3.754 ± 0.072	5.097PheLeu: 5.097 ± 0.091	1.147PheMet: 1.147 ± 0.038	3.289PheAsn: 3.289 ± 0.064	1.78PhePro: 1.78 ± 0.047	1.75PheGln: 1.75 ± 0.047	1.625PheArg: 1.625 ± 0.045	4.213PheSer: 4.213 ± 0.07	3.324PheThr: 3.324 ± 0.073	3.166PheVal: 3.166 ± 0.063	0.584PheTrp: 0.584 ± 0.023	2.444PheTyr: 2.444 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	3.828GlyAla: 3.828 ± 0.079	0.672GlyCys: 0.672 ± 0.039	3.053GlyAsp: 3.053 ± 0.073	3.452GlyGlu: 3.452 ± 0.06	3.555GlyPhe: 3.555 ± 0.066	4.235GlyGly: 4.235 ± 0.094	1.087GlyHis: 1.087 ± 0.033	5.229GlyIle: 5.229 ± 0.081	4.967GlyLys: 4.967 ± 0.082	5.414GlyLeu: 5.414 ± 0.086	1.494GlyMet: 1.494 ± 0.046	3.842GlyAsn: 3.842 ± 0.096	1.139GlyPro: 1.139 ± 0.037	2.004GlyGln: 2.004 ± 0.05	1.885GlyArg: 1.885 ± 0.056	4.067GlySer: 4.067 ± 0.092	4.37GlyThr: 4.37 ± 0.113	4.056GlyVal: 4.056 ± 0.076	0.676GlyTrp: 0.676 ± 0.026	2.88GlyTyr: 2.88 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.904HisAla: 0.904 ± 0.03	0.175HisCys: 0.175 ± 0.015	0.859HisAsp: 0.859 ± 0.033	0.999HisGlu: 0.999 ± 0.034	1.242HisPhe: 1.242 ± 0.042	0.953HisGly: 0.953 ± 0.032	0.493HisHis: 0.493 ± 0.027	1.345HisIle: 1.345 ± 0.038	1.117HisLys: 1.117 ± 0.032	1.745HisLeu: 1.745 ± 0.049	0.275HisMet: 0.275 ± 0.017	1.015HisAsn: 1.015 ± 0.029	0.841HisPro: 0.841 ± 0.036	0.755HisGln: 0.755 ± 0.031	0.573HisArg: 0.573 ± 0.024	1.01HisSer: 1.01 ± 0.034	0.922HisThr: 0.922 ± 0.032	0.853HisVal: 0.853 ± 0.029	0.219HisTrp: 0.219 ± 0.015	0.925HisTyr: 0.925 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.64IleAla: 5.64 ± 0.087	0.671IleCys: 0.671 ± 0.031	4.721IleAsp: 4.721 ± 0.076	5.7IleGlu: 5.7 ± 0.094	3.621IlePhe: 3.621 ± 0.076	4.828IleGly: 4.828 ± 0.089	1.408IleHis: 1.408 ± 0.039	5.766IleIle: 5.766 ± 0.103	5.75IleLys: 5.75 ± 0.08	6.845IleLeu: 6.845 ± 0.101	1.325IleMet: 1.325 ± 0.036	4.607IleAsn: 4.607 ± 0.076	3.217IlePro: 3.217 ± 0.056	2.842IleGln: 2.842 ± 0.06	2.621IleArg: 2.621 ± 0.05	5.366IleSer: 5.366 ± 0.083	4.885IleThr: 4.885 ± 0.077	4.936IleVal: 4.936 ± 0.081	0.683IleTrp: 0.683 ± 0.029	2.907IleTyr: 2.907 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.11LysAla: 5.11 ± 0.11	0.372LysCys: 0.372 ± 0.021	4.331LysAsp: 4.331 ± 0.08	6.889LysGlu: 6.889 ± 0.128	2.994LysPhe: 2.994 ± 0.057	4.453LysGly: 4.453 ± 0.076	1.25LysHis: 1.25 ± 0.038	6.728LysIle: 6.728 ± 0.098	7.151LysLys: 7.151 ± 0.108	6.348LysLeu: 6.348 ± 0.091	2.096LysMet: 2.096 ± 0.053	5.116LysAsn: 5.116 ± 0.098	2.389LysPro: 2.389 ± 0.05	2.821LysGln: 2.821 ± 0.065	2.768LysArg: 2.768 ± 0.058	4.147LysSer: 4.147 ± 0.077	4.526LysThr: 4.526 ± 0.078	5.087LysVal: 5.087 ± 0.08	0.754LysTrp: 0.754 ± 0.032	3.112LysTyr: 3.112 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.806LeuAla: 5.806 ± 0.095	0.651LeuCys: 0.651 ± 0.036	4.748LeuAsp: 4.748 ± 0.074	6.108LeuGlu: 6.108 ± 0.097	5.093LeuPhe: 5.093 ± 0.075	5.576LeuGly: 5.576 ± 0.076	1.608LeuHis: 1.608 ± 0.044	6.591LeuIle: 6.591 ± 0.098	7.603LeuLys: 7.603 ± 0.121	8.673LeuLeu: 8.673 ± 0.132	2.012LeuMet: 2.012 ± 0.049	5.638LeuAsn: 5.638 ± 0.087	3.502LeuPro: 3.502 ± 0.067	3.588LeuGln: 3.588 ± 0.069	2.911LeuArg: 2.911 ± 0.053	6.509LeuSer: 6.509 ± 0.082	5.23LeuThr: 5.23 ± 0.091	5.448LeuVal: 5.448 ± 0.089	0.763LeuTrp: 0.763 ± 0.028	3.43LeuTyr: 3.43 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.548MetAla: 1.548 ± 0.043	0.126MetCys: 0.126 ± 0.011	1.059MetAsp: 1.059 ± 0.033	1.427MetGlu: 1.427 ± 0.043	0.925MetPhe: 0.925 ± 0.034	1.267MetGly: 1.267 ± 0.038	0.36MetHis: 0.36 ± 0.02	1.515MetIle: 1.515 ± 0.047	2.246MetLys: 2.246 ± 0.053	1.861MetLeu: 1.861 ± 0.048	0.57MetMet: 0.57 ± 0.027	1.335MetAsn: 1.335 ± 0.039	0.8MetPro: 0.8 ± 0.025	0.882MetGln: 0.882 ± 0.033	0.816MetArg: 0.816 ± 0.033	1.32MetSer: 1.32 ± 0.043	1.159MetThr: 1.159 ± 0.037	1.253MetVal: 1.253 ± 0.035	0.146MetTrp: 0.146 ± 0.012	0.741MetTyr: 0.741 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.691AsnAla: 3.691 ± 0.067	0.564AsnCys: 0.564 ± 0.03	3.268AsnAsp: 3.268 ± 0.07	4.062AsnGlu: 4.062 ± 0.074	3.257AsnPhe: 3.257 ± 0.078	4.353AsnGly: 4.353 ± 0.104	1.078AsnHis: 1.078 ± 0.034	4.634AsnIle: 4.634 ± 0.075	4.218AsnLys: 4.218 ± 0.081	5.318AsnLeu: 5.318 ± 0.069	1.24AsnMet: 1.24 ± 0.039	3.922AsnAsn: 3.922 ± 0.077	2.767AsnPro: 2.767 ± 0.061	2.465AsnGln: 2.465 ± 0.053	2.097AsnArg: 2.097 ± 0.049	4.132AsnSer: 4.132 ± 0.082	3.72AsnThr: 3.72 ± 0.089	3.72AsnVal: 3.72 ± 0.068	0.86AsnTrp: 0.86 ± 0.03	3.091AsnTyr: 3.091 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.852ProAla: 1.852 ± 0.057	0.245ProCys: 0.245 ± 0.018	2.111ProAsp: 2.111 ± 0.052	2.777ProGlu: 2.777 ± 0.054	1.912ProPhe: 1.912 ± 0.05	1.757ProGly: 1.757 ± 0.046	0.535ProHis: 0.535 ± 0.025	2.488ProIle: 2.488 ± 0.051	2.53ProLys: 2.53 ± 0.064	2.855ProLeu: 2.855 ± 0.053	0.715ProMet: 0.715 ± 0.034	2.122ProAsn: 2.122 ± 0.056	0.729ProPro: 0.729 ± 0.026	1.172ProGln: 1.172 ± 0.037	0.783ProArg: 0.783 ± 0.028	2.078ProSer: 2.078 ± 0.058	2.048ProThr: 2.048 ± 0.06	2.659ProVal: 2.659 ± 0.061	0.294ProTrp: 0.294 ± 0.021	1.456ProTyr: 1.456 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.096GlnAla: 2.096 ± 0.052	0.217GlnCys: 0.217 ± 0.019	1.723GlnAsp: 1.723 ± 0.05	2.593GlnGlu: 2.593 ± 0.066	1.836GlnPhe: 1.836 ± 0.046	1.799GlnGly: 1.799 ± 0.056	0.64GlnHis: 0.64 ± 0.028	2.839GlnIle: 2.839 ± 0.053	3.399GlnLys: 3.399 ± 0.075	3.591GlnLeu: 3.591 ± 0.068	0.872GlnMet: 0.872 ± 0.033	2.609GlnAsn: 2.609 ± 0.05	1.114GlnPro: 1.114 ± 0.037	1.48GlnGln: 1.48 ± 0.042	1.114GlnArg: 1.114 ± 0.033	2.163GlnSer: 2.163 ± 0.044	2.101GlnThr: 2.101 ± 0.046	2.138GlnVal: 2.138 ± 0.055	0.351GlnTrp: 0.351 ± 0.021	1.662GlnTyr: 1.662 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	1.774ArgAla: 1.774 ± 0.048	0.174ArgCys: 0.174 ± 0.013	1.497ArgAsp: 1.497 ± 0.038	2.129ArgGlu: 2.129 ± 0.053	1.846ArgPhe: 1.846 ± 0.043	1.606ArgGly: 1.606 ± 0.043	0.527ArgHis: 0.527 ± 0.027	2.817ArgIle: 2.817 ± 0.056	2.829ArgLys: 2.829 ± 0.064	2.967ArgLeu: 2.967 ± 0.055	0.881ArgMet: 0.881 ± 0.029	2.053ArgAsn: 2.053 ± 0.044	0.872ArgPro: 0.872 ± 0.03	1.059ArgGln: 1.059 ± 0.034	1.125ArgArg: 1.125 ± 0.04	1.756ArgSer: 1.756 ± 0.051	1.754ArgThr: 1.754 ± 0.041	1.955ArgVal: 1.955 ± 0.049	0.35ArgTrp: 0.35 ± 0.019	1.505ArgTyr: 1.505 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.576SerAla: 3.576 ± 0.065	0.724SerCys: 0.724 ± 0.037	3.627SerAsp: 3.627 ± 0.073	3.969SerGlu: 3.969 ± 0.065	3.997SerPhe: 3.997 ± 0.068	5.012SerGly: 5.012 ± 0.099	1.006SerHis: 1.006 ± 0.033	4.897SerIle: 4.897 ± 0.081	4.459SerLys: 4.459 ± 0.086	5.918SerLeu: 5.918 ± 0.083	1.189SerMet: 1.189 ± 0.037	3.689SerAsn: 3.689 ± 0.099	1.988SerPro: 1.988 ± 0.053	2.256SerGln: 2.256 ± 0.051	1.967SerArg: 1.967 ± 0.052	4.27SerSer: 4.27 ± 0.089	3.618SerThr: 3.618 ± 0.084	4.294SerVal: 4.294 ± 0.071	0.679SerTrp: 0.679 ± 0.031	2.828SerTyr: 2.828 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.047ThrAla: 4.047 ± 0.093	0.449ThrCys: 0.449 ± 0.028	3.468ThrAsp: 3.468 ± 0.077	3.686ThrGlu: 3.686 ± 0.065	3.293ThrPhe: 3.293 ± 0.062	4.143ThrGly: 4.143 ± 0.101	0.992ThrHis: 0.992 ± 0.035	5.171ThrIle: 5.171 ± 0.087	3.813ThrLys: 3.813 ± 0.062	5.492ThrLeu: 5.492 ± 0.091	0.94ThrMet: 0.94 ± 0.032	3.472ThrAsn: 3.472 ± 0.079	2.524ThrPro: 2.524 ± 0.063	2.028ThrGln: 2.028 ± 0.051	1.475ThrArg: 1.475 ± 0.044	3.888ThrSer: 3.888 ± 0.11	4.108ThrThr: 4.108 ± 0.105	4.173ThrVal: 4.173 ± 0.101	0.539ThrTrp: 0.539 ± 0.031	2.533ThrTyr: 2.533 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.204ValAla: 4.204 ± 0.087	0.553ValCys: 0.553 ± 0.032	3.479ValAsp: 3.479 ± 0.063	4.164ValGlu: 4.164 ± 0.071	3.517ValPhe: 3.517 ± 0.071	3.563ValGly: 3.563 ± 0.067	0.981ValHis: 0.981 ± 0.037	4.792ValIle: 4.792 ± 0.08	4.678ValLys: 4.678 ± 0.082	6.309ValLeu: 6.309 ± 0.092	1.313ValMet: 1.313 ± 0.04	3.734ValAsn: 3.734 ± 0.067	2.224ValPro: 2.224 ± 0.056	2.023ValGln: 2.023 ± 0.05	1.923ValArg: 1.923 ± 0.047	4.587ValSer: 4.587 ± 0.084	4.107ValThr: 4.107 ± 0.09	4.463ValVal: 4.463 ± 0.087	0.598ValTrp: 0.598 ± 0.027	2.574ValTyr: 2.574 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.573TrpAla: 0.573 ± 0.026	0.093TrpCys: 0.093 ± 0.011	0.587TrpAsp: 0.587 ± 0.024	0.661TrpGlu: 0.661 ± 0.029	0.577TrpPhe: 0.577 ± 0.026	0.561TrpGly: 0.561 ± 0.028	0.214TrpHis: 0.214 ± 0.016	0.722TrpIle: 0.722 ± 0.027	0.805TrpLys: 0.805 ± 0.032	0.919TrpLeu: 0.919 ± 0.03	0.288TrpMet: 0.288 ± 0.018	0.769TrpAsn: 0.769 ± 0.024	0.206TrpPro: 0.206 ± 0.022	0.41TrpGln: 0.41 ± 0.021	0.309TrpArg: 0.309 ± 0.019	0.609TrpSer: 0.609 ± 0.03	0.579TrpThr: 0.579 ± 0.031	0.626TrpVal: 0.626 ± 0.026	0.13TrpTrp: 0.13 ± 0.014	0.424TrpTyr: 0.424 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.368TyrAla: 2.368 ± 0.054	0.371TyrCys: 0.371 ± 0.018	2.565TyrAsp: 2.565 ± 0.08	2.544TyrGlu: 2.544 ± 0.054	2.684TyrPhe: 2.684 ± 0.053	2.622TyrGly: 2.622 ± 0.056	0.835TyrHis: 0.835 ± 0.033	2.848TyrIle: 2.848 ± 0.058	2.988TyrLys: 2.988 ± 0.06	3.983TyrLeu: 3.983 ± 0.073	0.717TyrMet: 0.717 ± 0.025	2.945TyrAsn: 2.945 ± 0.066	1.557TyrPro: 1.557 ± 0.045	1.819TyrGln: 1.819 ± 0.044	1.504TyrArg: 1.504 ± 0.037	2.875TyrSer: 2.875 ± 0.066	2.67TyrThr: 2.67 ± 0.07	2.443TyrVal: 2.443 ± 0.057	0.519TyrTrp: 0.519 ± 0.026	2.227TyrTyr: 2.227 ± 0.075	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2952 proteins (964564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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