Amino acid dipepetide frequency for Lawsonia intracellularis (strain PHE/MN1-00)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.673AlaAla: 4.673 ± 0.129
0.95AlaCys: 0.95 ± 0.049
2.465AlaAsp: 2.465 ± 0.083
3.651AlaGlu: 3.651 ± 0.082
2.587AlaPhe: 2.587 ± 0.084
4.403AlaGly: 4.403 ± 0.139
1.283AlaHis: 1.283 ± 0.058
6.033AlaIle: 6.033 ± 0.152
3.874AlaLys: 3.874 ± 0.096
7.392AlaLeu: 7.392 ± 0.149
1.633AlaMet: 1.633 ± 0.061
2.48AlaAsn: 2.48 ± 0.075
2.033AlaPro: 2.033 ± 0.063
2.52AlaGln: 2.52 ± 0.078
2.707AlaArg: 2.707 ± 0.083
4.232AlaSer: 4.232 ± 0.111
3.672AlaThr: 3.672 ± 0.096
3.872AlaVal: 3.872 ± 0.108
0.851AlaTrp: 0.851 ± 0.047
2.052AlaTyr: 2.052 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.651CysAla: 0.651 ± 0.035
0.287CysCys: 0.287 ± 0.034
0.525CysAsp: 0.525 ± 0.033
0.577CysGlu: 0.577 ± 0.033
0.64CysPhe: 0.64 ± 0.039
1.076CysGly: 1.076 ± 0.054
0.335CysHis: 0.335 ± 0.03
1.464CysIle: 1.464 ± 0.059
0.771CysLys: 0.771 ± 0.041
1.403CysLeu: 1.403 ± 0.052
0.32CysMet: 0.32 ± 0.025
0.661CysAsn: 0.661 ± 0.04
0.596CysPro: 0.596 ± 0.039
0.39CysGln: 0.39 ± 0.026
0.546CysArg: 0.546 ± 0.033
1.114CysSer: 1.114 ± 0.057
0.733CysThr: 0.733 ± 0.04
0.723CysVal: 0.723 ± 0.036
0.164CysTrp: 0.164 ± 0.019
0.51CysTyr: 0.51 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
2.823AspAla: 2.823 ± 0.082
0.552AspCys: 0.552 ± 0.033
1.814AspAsp: 1.814 ± 0.086
2.823AspGlu: 2.823 ± 0.135
2.119AspPhe: 2.119 ± 0.063
2.821AspGly: 2.821 ± 0.087
0.805AspHis: 0.805 ± 0.041
4.782AspIle: 4.782 ± 0.103
2.734AspLys: 2.734 ± 0.09
4.239AspLeu: 4.239 ± 0.124
1.001AspMet: 1.001 ± 0.047
2.168AspAsn: 2.168 ± 0.064
2.065AspPro: 2.065 ± 0.057
1.277AspGln: 1.277 ± 0.058
1.626AspArg: 1.626 ± 0.069
2.979AspSer: 2.979 ± 0.136
2.88AspThr: 2.88 ± 0.082
2.817AspVal: 2.817 ± 0.066
0.55AspTrp: 0.55 ± 0.037
1.487AspTyr: 1.487 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.317GluAla: 4.317 ± 0.114
0.659GluCys: 0.659 ± 0.042
2.928GluAsp: 2.928 ± 0.147
4.997GluGlu: 4.997 ± 0.408
1.93GluPhe: 1.93 ± 0.069
3.373GluGly: 3.373 ± 0.113
1.666GluHis: 1.666 ± 0.066
4.386GluIle: 4.386 ± 0.106
5.161GluLys: 5.161 ± 0.283
6.933GluLeu: 6.933 ± 0.154
1.359GluMet: 1.359 ± 0.061
2.814GluAsn: 2.814 ± 0.084
2.092GluPro: 2.092 ± 0.078
3.442GluGln: 3.442 ± 0.162
2.871GluArg: 2.871 ± 0.124
3.644GluSer: 3.644 ± 0.161
3.137GluThr: 3.137 ± 0.077
4.036GluVal: 4.036 ± 0.118
0.6GluTrp: 0.6 ± 0.034
2.126GluTyr: 2.126 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.288PheAla: 2.288 ± 0.086
0.754PheCys: 0.754 ± 0.048
1.978PheAsp: 1.978 ± 0.06
2.256PheGlu: 2.256 ± 0.075
2.772PhePhe: 2.772 ± 0.095
2.812PheGly: 2.812 ± 0.086
0.916PheHis: 0.916 ± 0.054
3.99PheIle: 3.99 ± 0.12
1.965PheLys: 1.965 ± 0.065
4.835PheLeu: 4.835 ± 0.131
0.971PheMet: 0.971 ± 0.058
1.917PheAsn: 1.917 ± 0.061
2.043PhePro: 2.043 ± 0.069
1.548PheGln: 1.548 ± 0.068
1.565PheArg: 1.565 ± 0.063
3.75PheSer: 3.75 ± 0.112
2.553PheThr: 2.553 ± 0.078
2.294PheVal: 2.294 ± 0.079
0.619PheTrp: 0.619 ± 0.04
1.447PheTyr: 1.447 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
3.969GlyAla: 3.969 ± 0.123
1.089GlyCys: 1.089 ± 0.056
2.823GlyAsp: 2.823 ± 0.095
3.659GlyGlu: 3.659 ± 0.106
2.998GlyPhe: 2.998 ± 0.094
4.586GlyGly: 4.586 ± 0.141
1.449GlyHis: 1.449 ± 0.069
6.057GlyIle: 6.057 ± 0.142
4.222GlyLys: 4.222 ± 0.097
6.653GlyLeu: 6.653 ± 0.149
1.559GlyMet: 1.559 ± 0.061
2.724GlyAsn: 2.724 ± 0.08
1.881GlyPro: 1.881 ± 0.07
2.248GlyGln: 2.248 ± 0.073
2.838GlyArg: 2.838 ± 0.092
4.378GlySer: 4.378 ± 0.122
3.779GlyThr: 3.779 ± 0.109
4.42GlyVal: 4.42 ± 0.117
0.798GlyTrp: 0.798 ± 0.045
2.496GlyTyr: 2.496 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.052
0.356HisCys: 0.356 ± 0.027
0.895HisAsp: 0.895 ± 0.045
1.216HisGlu: 1.216 ± 0.061
0.916HisPhe: 0.916 ± 0.041
1.513HisGly: 1.513 ± 0.057
0.602HisHis: 0.602 ± 0.041
2.269HisIle: 2.269 ± 0.07
1.374HisLys: 1.374 ± 0.075
2.244HisLeu: 2.244 ± 0.066
0.508HisMet: 0.508 ± 0.033
1.306HisAsn: 1.306 ± 0.063
1.258HisPro: 1.258 ± 0.057
0.91HisGln: 0.91 ± 0.051
0.973HisArg: 0.973 ± 0.046
1.607HisSer: 1.607 ± 0.073
1.546HisThr: 1.546 ± 0.057
1.171HisVal: 1.171 ± 0.055
0.333HisTrp: 0.333 ± 0.025
0.775HisTyr: 0.775 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
6.103IleAla: 6.103 ± 0.178
1.211IleCys: 1.211 ± 0.049
4.078IleAsp: 4.078 ± 0.11
5.191IleGlu: 5.191 ± 0.114
3.834IlePhe: 3.834 ± 0.102
5.654IleGly: 5.654 ± 0.148
2.09IleHis: 2.09 ± 0.069
7.346IleIle: 7.346 ± 0.203
4.74IleLys: 4.74 ± 0.111
8.81IleLeu: 8.81 ± 0.195
1.7IleMet: 1.7 ± 0.078
3.703IleAsn: 3.703 ± 0.117
4.437IlePro: 4.437 ± 0.121
3.805IleGln: 3.805 ± 0.103
3.484IleArg: 3.484 ± 0.098
6.206IleSer: 6.206 ± 0.135
5.416IleThr: 5.416 ± 0.132
4.873IleVal: 4.873 ± 0.131
0.832IleTrp: 0.832 ± 0.043
2.48IleTyr: 2.48 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
3.874LysAla: 3.874 ± 0.099
0.518LysCys: 0.518 ± 0.034
3.187LysAsp: 3.187 ± 0.09
5.54LysGlu: 5.54 ± 0.274
1.751LysPhe: 1.751 ± 0.067
3.845LysGly: 3.845 ± 0.091
1.439LysHis: 1.439 ± 0.091
4.725LysIle: 4.725 ± 0.116
5.861LysLys: 5.861 ± 0.357
5.812LysLeu: 5.812 ± 0.105
1.321LysMet: 1.321 ± 0.051
3.929LysAsn: 3.929 ± 0.104
2.229LysPro: 2.229 ± 0.069
2.937LysGln: 2.937 ± 0.14
2.667LysArg: 2.667 ± 0.112
3.577LysSer: 3.577 ± 0.112
3.617LysThr: 3.617 ± 0.091
3.91LysVal: 3.91 ± 0.094
0.522LysTrp: 0.522 ± 0.031
2.058LysTyr: 2.058 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
7.525LeuAla: 7.525 ± 0.175
1.603LeuCys: 1.603 ± 0.062
4.681LeuAsp: 4.681 ± 0.1
6.771LeuGlu: 6.771 ± 0.168
4.936LeuPhe: 4.936 ± 0.127
6.954LeuGly: 6.954 ± 0.157
2.697LeuHis: 2.697 ± 0.083
7.59LeuIle: 7.59 ± 0.182
6.116LeuLys: 6.116 ± 0.099
11.686LeuLeu: 11.686 ± 0.229
2.134LeuMet: 2.134 ± 0.066
4.043LeuAsn: 4.043 ± 0.103
5.33LeuPro: 5.33 ± 0.115
4.649LeuGln: 4.649 ± 0.129
4.384LeuArg: 4.384 ± 0.11
8.696LeuSer: 8.696 ± 0.164
6.206LeuThr: 6.206 ± 0.111
5.427LeuVal: 5.427 ± 0.114
1.184LeuTrp: 1.184 ± 0.061
3.411LeuTyr: 3.411 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
1.696MetAla: 1.696 ± 0.073
0.2MetCys: 0.2 ± 0.018
1.207MetAsp: 1.207 ± 0.058
1.279MetGlu: 1.279 ± 0.056
0.876MetPhe: 0.876 ± 0.041
1.502MetGly: 1.502 ± 0.067
0.445MetHis: 0.445 ± 0.033
1.445MetIle: 1.445 ± 0.063
1.361MetLys: 1.361 ± 0.048
2.56MetLeu: 2.56 ± 0.081
0.47MetMet: 0.47 ± 0.034
1.072MetAsn: 1.072 ± 0.047
1.085MetPro: 1.085 ± 0.053
0.937MetGln: 0.937 ± 0.047
0.959MetArg: 0.959 ± 0.041
1.666MetSer: 1.666 ± 0.072
1.186MetThr: 1.186 ± 0.052
1.327MetVal: 1.327 ± 0.059
0.154MetTrp: 0.154 ± 0.016
0.697MetTyr: 0.697 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.656AsnAla: 2.656 ± 0.075
0.527AsnCys: 0.527 ± 0.032
1.854AsnAsp: 1.854 ± 0.069
2.399AsnGlu: 2.399 ± 0.078
1.953AsnPhe: 1.953 ± 0.072
2.446AsnGly: 2.446 ± 0.082
0.881AsnHis: 0.881 ± 0.044
4.908AsnIle: 4.908 ± 0.122
3.276AsnLys: 3.276 ± 0.097
4.312AsnLeu: 4.312 ± 0.117
1.112AsnMet: 1.112 ± 0.047
2.913AsnAsn: 2.913 ± 0.121
2.362AsnPro: 2.362 ± 0.076
1.637AsnGln: 1.637 ± 0.063
1.784AsnArg: 1.784 ± 0.068
2.975AsnSer: 2.975 ± 0.115
3.337AsnThr: 3.337 ± 0.091
2.656AsnVal: 2.656 ± 0.093
0.611AsnTrp: 0.611 ± 0.038
1.624AsnTyr: 1.624 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.113ProAla: 2.113 ± 0.069
0.554ProCys: 0.554 ± 0.037
2.09ProAsp: 2.09 ± 0.064
3.259ProGlu: 3.259 ± 0.092
2.086ProPhe: 2.086 ± 0.076
2.774ProGly: 2.774 ± 0.086
1.03ProHis: 1.03 ± 0.052
3.786ProIle: 3.786 ± 0.119
2.332ProLys: 2.332 ± 0.074
4.898ProLeu: 4.898 ± 0.109
0.828ProMet: 0.828 ± 0.044
1.984ProAsn: 1.984 ± 0.067
1.749ProPro: 1.749 ± 0.099
1.848ProGln: 1.848 ± 0.062
1.426ProArg: 1.426 ± 0.062
3.347ProSer: 3.347 ± 0.103
2.498ProThr: 2.498 ± 0.083
2.68ProVal: 2.68 ± 0.081
0.562ProTrp: 0.562 ± 0.034
1.641ProTyr: 1.641 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
2.922GlnAla: 2.922 ± 0.093
0.52GlnCys: 0.52 ± 0.037
1.845GlnAsp: 1.845 ± 0.076
3.055GlnGlu: 3.055 ± 0.209
1.479GlnPhe: 1.479 ± 0.053
2.359GlnGly: 2.359 ± 0.082
1.243GlnHis: 1.243 ± 0.059
2.496GlnIle: 2.496 ± 0.072
3.156GlnLys: 3.156 ± 0.13
4.658GlnLeu: 4.658 ± 0.096
0.822GlnMet: 0.822 ± 0.042
1.763GlnAsn: 1.763 ± 0.059
1.727GlnPro: 1.727 ± 0.06
2.69GlnGln: 2.69 ± 0.171
1.824GlnArg: 1.824 ± 0.08
2.848GlnSer: 2.848 ± 0.09
2.233GlnThr: 2.233 ± 0.069
2.33GlnVal: 2.33 ± 0.072
0.451GlnTrp: 0.451 ± 0.031
1.51GlnTyr: 1.51 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.471ArgAla: 2.471 ± 0.081
0.487ArgCys: 0.487 ± 0.033
1.706ArgAsp: 1.706 ± 0.07
2.728ArgGlu: 2.728 ± 0.101
1.818ArgPhe: 1.818 ± 0.06
2.269ArgGly: 2.269 ± 0.074
0.988ArgHis: 0.988 ± 0.046
3.493ArgIle: 3.493 ± 0.1
2.781ArgLys: 2.781 ± 0.124
4.723ArgLeu: 4.723 ± 0.117
0.992ArgMet: 0.992 ± 0.051
1.869ArgAsn: 1.869 ± 0.067
1.692ArgPro: 1.692 ± 0.072
1.936ArgGln: 1.936 ± 0.085
1.938ArgArg: 1.938 ± 0.087
2.513ArgSer: 2.513 ± 0.073
2.083ArgThr: 2.083 ± 0.073
2.381ArgVal: 2.381 ± 0.086
0.428ArgTrp: 0.428 ± 0.03
1.572ArgTyr: 1.572 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.697SerAla: 3.697 ± 0.102
1.022SerCys: 1.022 ± 0.055
3.101SerAsp: 3.101 ± 0.146
3.958SerGlu: 3.958 ± 0.153
3.295SerPhe: 3.295 ± 0.093
5.02SerGly: 5.02 ± 0.147
1.582SerHis: 1.582 ± 0.066
6.878SerIle: 6.878 ± 0.143
4.055SerLys: 4.055 ± 0.121
7.656SerLeu: 7.656 ± 0.151
1.85SerMet: 1.85 ± 0.058
3.318SerAsn: 3.318 ± 0.12
3.149SerPro: 3.149 ± 0.082
2.943SerGln: 2.943 ± 0.107
2.65SerArg: 2.65 ± 0.079
6.971SerSer: 6.971 ± 0.387
4.194SerThr: 4.194 ± 0.105
3.733SerVal: 3.733 ± 0.085
0.95SerTrp: 0.95 ± 0.043
2.406SerTyr: 2.406 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
3.815ThrAla: 3.815 ± 0.099
0.706ThrCys: 0.706 ± 0.039
2.408ThrAsp: 2.408 ± 0.083
3.065ThrGlu: 3.065 ± 0.091
2.621ThrPhe: 2.621 ± 0.082
4.081ThrGly: 4.081 ± 0.108
1.414ThrHis: 1.414 ± 0.065
5.498ThrIle: 5.498 ± 0.131
3.379ThrLys: 3.379 ± 0.091
6.516ThrLeu: 6.516 ± 0.141
1.26ThrMet: 1.26 ± 0.049
2.629ThrAsn: 2.629 ± 0.079
3.122ThrPro: 3.122 ± 0.091
2.351ThrGln: 2.351 ± 0.083
2.128ThrArg: 2.128 ± 0.071
4.618ThrSer: 4.618 ± 0.116
3.923ThrThr: 3.923 ± 0.111
3.493ThrVal: 3.493 ± 0.095
0.6ThrTrp: 0.6 ± 0.037
1.961ThrTyr: 1.961 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
3.887ValAla: 3.887 ± 0.101
0.83ValCys: 0.83 ± 0.036
2.737ValAsp: 2.737 ± 0.082
3.514ValGlu: 3.514 ± 0.093
2.555ValPhe: 2.555 ± 0.096
4.043ValGly: 4.043 ± 0.105
1.26ValHis: 1.26 ± 0.051
5.075ValIle: 5.075 ± 0.128
3.187ValLys: 3.187 ± 0.087
5.951ValLeu: 5.951 ± 0.137
1.346ValMet: 1.346 ± 0.061
2.418ValAsn: 2.418 ± 0.075
2.444ValPro: 2.444 ± 0.078
2.25ValGln: 2.25 ± 0.073
2.557ValArg: 2.557 ± 0.102
4.26ValSer: 4.26 ± 0.096
3.92ValThr: 3.92 ± 0.095
3.866ValVal: 3.866 ± 0.119
0.643ValTrp: 0.643 ± 0.036
1.631ValTyr: 1.631 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.607TrpAla: 0.607 ± 0.045
0.177TrpCys: 0.177 ± 0.021
0.596TrpAsp: 0.596 ± 0.037
0.775TrpGlu: 0.775 ± 0.04
0.516TrpPhe: 0.516 ± 0.035
0.809TrpGly: 0.809 ± 0.04
0.255TrpHis: 0.255 ± 0.028
0.959TrpIle: 0.959 ± 0.055
0.832TrpLys: 0.832 ± 0.045
1.251TrpLeu: 1.251 ± 0.051
0.295TrpMet: 0.295 ± 0.025
0.615TrpAsn: 0.615 ± 0.039
0.518TrpPro: 0.518 ± 0.033
0.398TrpGln: 0.398 ± 0.03
0.48TrpArg: 0.48 ± 0.033
0.731TrpSer: 0.731 ± 0.039
0.495TrpThr: 0.495 ± 0.035
0.636TrpVal: 0.636 ± 0.045
0.169TrpTrp: 0.169 ± 0.021
0.36TrpTyr: 0.36 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.984TyrAla: 1.984 ± 0.083
0.485TyrCys: 0.485 ± 0.03
1.441TyrAsp: 1.441 ± 0.059
1.759TyrGlu: 1.759 ± 0.064
1.595TyrPhe: 1.595 ± 0.061
2.286TyrGly: 2.286 ± 0.071
0.685TyrHis: 0.685 ± 0.039
2.812TyrIle: 2.812 ± 0.097
2.145TyrLys: 2.145 ± 0.073
3.491TyrLeu: 3.491 ± 0.105
0.643TyrMet: 0.643 ± 0.038
1.896TyrAsn: 1.896 ± 0.071
1.675TyrPro: 1.675 ± 0.064
1.218TyrGln: 1.218 ± 0.054
1.458TyrArg: 1.458 ± 0.053
2.315TyrSer: 2.315 ± 0.079
2.176TyrThr: 2.176 ± 0.065
1.73TyrVal: 1.73 ± 0.067
0.453TyrTrp: 0.453 ± 0.03
1.281TyrTyr: 1.281 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1342 proteins (474690 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski