Amino acid dipepetide frequency for Paenibacillus larvae subsp. larvae DSM 25430

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.885AlaAla: 6.885 ± 0.126	0.767AlaCys: 0.767 ± 0.028	3.786AlaAsp: 3.786 ± 0.062	5.244AlaGlu: 5.244 ± 0.092	3.073AlaPhe: 3.073 ± 0.05	6.142AlaGly: 6.142 ± 0.097	1.302AlaHis: 1.302 ± 0.037	5.119AlaIle: 5.119 ± 0.071	4.58AlaLys: 4.58 ± 0.077	7.381AlaLeu: 7.381 ± 0.1	2.194AlaMet: 2.194 ± 0.053	2.425AlaAsn: 2.425 ± 0.054	2.187AlaPro: 2.187 ± 0.05	2.283AlaGln: 2.283 ± 0.045	3.296AlaArg: 3.296 ± 0.063	4.425AlaSer: 4.425 ± 0.071	2.924AlaThr: 2.924 ± 0.059	5.864AlaVal: 5.864 ± 0.092	0.787AlaTrp: 0.787 ± 0.03	2.457AlaTyr: 2.457 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.502CysAla: 0.502 ± 0.022	0.152CysCys: 0.152 ± 0.011	0.396CysAsp: 0.396 ± 0.021	0.503CysGlu: 0.503 ± 0.019	0.423CysPhe: 0.423 ± 0.021	0.815CysGly: 0.815 ± 0.032	0.198CysHis: 0.198 ± 0.015	0.662CysIle: 0.662 ± 0.029	0.54CysLys: 0.54 ± 0.022	0.975CysLeu: 0.975 ± 0.036	0.265CysMet: 0.265 ± 0.017	0.286CysAsn: 0.286 ± 0.018	0.487CysPro: 0.487 ± 0.024	0.317CysGln: 0.317 ± 0.016	0.513CysArg: 0.513 ± 0.026	0.676CysSer: 0.676 ± 0.024	0.552CysThr: 0.552 ± 0.025	0.514CysVal: 0.514 ± 0.021	0.099CysTrp: 0.099 ± 0.009	0.312CysTyr: 0.312 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.365AspAla: 3.365 ± 0.062	0.401AspCys: 0.401 ± 0.021	2.063AspAsp: 2.063 ± 0.048	3.753AspGlu: 3.753 ± 0.071	2.137AspPhe: 2.137 ± 0.052	3.377AspGly: 3.377 ± 0.064	1.248AspHis: 1.248 ± 0.037	3.728AspIle: 3.728 ± 0.062	3.211AspLys: 3.211 ± 0.069	4.971AspLeu: 4.971 ± 0.075	1.397AspMet: 1.397 ± 0.038	1.62AspAsn: 1.62 ± 0.043	2.269AspPro: 2.269 ± 0.049	2.004AspGln: 2.004 ± 0.055	2.702AspArg: 2.702 ± 0.05	2.607AspSer: 2.607 ± 0.05	2.327AspThr: 2.327 ± 0.054	3.372AspVal: 3.372 ± 0.062	0.697AspTrp: 0.697 ± 0.031	1.902AspTyr: 1.902 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.667GluAla: 5.667 ± 0.079	0.485GluCys: 0.485 ± 0.022	3.451GluAsp: 3.451 ± 0.061	6.413GluGlu: 6.413 ± 0.101	2.214GluPhe: 2.214 ± 0.047	4.454GluGly: 4.454 ± 0.08	1.719GluHis: 1.719 ± 0.069	4.784GluIle: 4.784 ± 0.078	5.247GluLys: 5.247 ± 0.086	7.051GluLeu: 7.051 ± 0.098	2.217GluMet: 2.217 ± 0.048	2.777GluAsn: 2.777 ± 0.05	2.248GluPro: 2.248 ± 0.052	3.937GluGln: 3.937 ± 0.086	4.017GluArg: 4.017 ± 0.072	3.483GluSer: 3.483 ± 0.064	3.652GluThr: 3.652 ± 0.061	4.93GluVal: 4.93 ± 0.078	0.93GluTrp: 0.93 ± 0.034	2.206GluTyr: 2.206 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.002PheAla: 3.002 ± 0.05	0.437PheCys: 0.437 ± 0.019	2.036PheAsp: 2.036 ± 0.052	2.398PheGlu: 2.398 ± 0.056	2.034PhePhe: 2.034 ± 0.058	3.055PheGly: 3.055 ± 0.055	1.106PheHis: 1.106 ± 0.033	3.223PheIle: 3.223 ± 0.076	2.053PheLys: 2.053 ± 0.049	4.304PheLeu: 4.304 ± 0.094	1.185PheMet: 1.185 ± 0.034	1.479PheAsn: 1.479 ± 0.041	1.651PhePro: 1.651 ± 0.042	1.426PheGln: 1.426 ± 0.037	1.931PheArg: 1.931 ± 0.047	2.825PheSer: 2.825 ± 0.063	2.468PheThr: 2.468 ± 0.051	2.962PheVal: 2.962 ± 0.06	0.494PheTrp: 0.494 ± 0.028	1.498PheTyr: 1.498 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.83GlyAla: 4.83 ± 0.082	0.841GlyCys: 0.841 ± 0.035	3.168GlyAsp: 3.168 ± 0.064	4.593GlyGlu: 4.593 ± 0.075	3.299GlyPhe: 3.299 ± 0.065	5.173GlyGly: 5.173 ± 0.088	1.56GlyHis: 1.56 ± 0.041	6.155GlyIle: 6.155 ± 0.087	5.247GlyLys: 5.247 ± 0.08	7.088GlyLeu: 7.088 ± 0.1	2.341GlyMet: 2.341 ± 0.05	2.774GlyAsn: 2.774 ± 0.052	1.945GlyPro: 1.945 ± 0.063	2.543GlyGln: 2.543 ± 0.06	3.521GlyArg: 3.521 ± 0.07	4.211GlySer: 4.211 ± 0.072	4.29GlyThr: 4.29 ± 0.063	5.101GlyVal: 5.101 ± 0.083	0.895GlyTrp: 0.895 ± 0.033	2.722GlyTyr: 2.722 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.569HisAla: 1.569 ± 0.045	0.235HisCys: 0.235 ± 0.015	1.048HisAsp: 1.048 ± 0.031	1.413HisGlu: 1.413 ± 0.037	1.054HisPhe: 1.054 ± 0.035	1.51HisGly: 1.51 ± 0.048	0.691HisHis: 0.691 ± 0.032	1.597HisIle: 1.597 ± 0.051	1.148HisLys: 1.148 ± 0.036	2.42HisLeu: 2.42 ± 0.105	0.602HisMet: 0.602 ± 0.025	0.762HisAsn: 0.762 ± 0.03	1.27HisPro: 1.27 ± 0.037	0.892HisGln: 0.892 ± 0.033	1.077HisArg: 1.077 ± 0.031	1.349HisSer: 1.349 ± 0.036	1.204HisThr: 1.204 ± 0.035	1.596HisVal: 1.596 ± 0.038	0.24HisTrp: 0.24 ± 0.013	0.827HisTyr: 0.827 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.348IleAla: 5.348 ± 0.075	0.806IleCys: 0.806 ± 0.03	3.434IleAsp: 3.434 ± 0.062	4.696IleGlu: 4.696 ± 0.075	2.676IlePhe: 2.676 ± 0.053	5.705IleGly: 5.705 ± 0.099	1.79IleHis: 1.79 ± 0.041	4.741IleIle: 4.741 ± 0.084	3.731IleLys: 3.731 ± 0.054	6.733IleLeu: 6.733 ± 0.094	1.865IleMet: 1.865 ± 0.045	2.434IleAsn: 2.434 ± 0.05	3.456IlePro: 3.456 ± 0.058	2.976IleGln: 2.976 ± 0.059	4.314IleArg: 4.314 ± 0.063	4.683IleSer: 4.683 ± 0.078	3.901IleThr: 3.901 ± 0.06	4.954IleVal: 4.954 ± 0.083	0.691IleTrp: 0.691 ± 0.023	2.223IleTyr: 2.223 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.856LysAla: 4.856 ± 0.076	0.336LysCys: 0.336 ± 0.02	3.404LysAsp: 3.404 ± 0.063	5.943LysGlu: 5.943 ± 0.107	1.751LysPhe: 1.751 ± 0.041	4.35LysGly: 4.35 ± 0.067	1.348LysHis: 1.348 ± 0.035	3.885LysIle: 3.885 ± 0.066	4.817LysLys: 4.817 ± 0.078	5.941LysLeu: 5.941 ± 0.079	1.922LysMet: 1.922 ± 0.052	2.544LysAsn: 2.544 ± 0.051	2.586LysPro: 2.586 ± 0.058	3.354LysGln: 3.354 ± 0.069	3.492LysArg: 3.492 ± 0.064	3.293LysSer: 3.293 ± 0.06	3.415LysThr: 3.415 ± 0.065	4.165LysVal: 4.165 ± 0.063	0.813LysTrp: 0.813 ± 0.03	1.994LysTyr: 1.994 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.73LeuAla: 7.73 ± 0.11	0.948LeuCys: 0.948 ± 0.031	5.249LeuAsp: 5.249 ± 0.074	6.717LeuGlu: 6.717 ± 0.093	4.76LeuPhe: 4.76 ± 0.086	6.836LeuGly: 6.836 ± 0.082	2.331LeuHis: 2.331 ± 0.045	6.823LeuIle: 6.823 ± 0.112	6.076LeuLys: 6.076 ± 0.077	10.464LeuLeu: 10.464 ± 0.137	2.693LeuMet: 2.693 ± 0.054	3.946LeuAsn: 3.946 ± 0.062	4.337LeuPro: 4.337 ± 0.078	3.819LeuGln: 3.819 ± 0.064	4.583LeuArg: 4.583 ± 0.077	6.753LeuSer: 6.753 ± 0.086	5.382LeuThr: 5.382 ± 0.08	6.461LeuVal: 6.461 ± 0.092	0.918LeuTrp: 0.918 ± 0.029	3.122LeuTyr: 3.122 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.172MetAla: 2.172 ± 0.053	0.188MetCys: 0.188 ± 0.013	1.527MetAsp: 1.527 ± 0.045	2.3MetGlu: 2.3 ± 0.045	1.087MetPhe: 1.087 ± 0.031	1.956MetGly: 1.956 ± 0.051	0.51MetHis: 0.51 ± 0.02	2.178MetIle: 2.178 ± 0.045	2.477MetLys: 2.477 ± 0.051	2.792MetLeu: 2.792 ± 0.057	1.008MetMet: 1.008 ± 0.035	1.618MetAsn: 1.618 ± 0.041	1.063MetPro: 1.063 ± 0.034	1.018MetGln: 1.018 ± 0.033	1.299MetArg: 1.299 ± 0.038	1.683MetSer: 1.683 ± 0.041	1.619MetThr: 1.619 ± 0.042	1.818MetVal: 1.818 ± 0.047	0.204MetTrp: 0.204 ± 0.015	0.837MetTyr: 0.837 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.36AsnAla: 2.36 ± 0.05	0.343AsnCys: 0.343 ± 0.019	1.603AsnAsp: 1.603 ± 0.038	2.721AsnGlu: 2.721 ± 0.056	1.248AsnPhe: 1.248 ± 0.033	2.95AsnGly: 2.95 ± 0.058	0.891AsnHis: 0.891 ± 0.028	2.597AsnIle: 2.597 ± 0.047	2.614AsnLys: 2.614 ± 0.057	3.535AsnLeu: 3.535 ± 0.064	1.165AsnMet: 1.165 ± 0.032	1.507AsnAsn: 1.507 ± 0.047	2.056AsnPro: 2.056 ± 0.049	1.777AsnGln: 1.777 ± 0.045	2.355AsnArg: 2.355 ± 0.047	2.054AsnSer: 2.054 ± 0.051	1.885AsnThr: 1.885 ± 0.043	2.559AsnVal: 2.559 ± 0.057	0.513AsnTrp: 0.513 ± 0.024	1.2AsnTyr: 1.2 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.876ProAla: 2.876 ± 0.06	0.294ProCys: 0.294 ± 0.022	2.709ProAsp: 2.709 ± 0.056	3.484ProGlu: 3.484 ± 0.063	1.951ProPhe: 1.951 ± 0.045	2.907ProGly: 2.907 ± 0.061	0.882ProHis: 0.882 ± 0.029	2.415ProIle: 2.415 ± 0.052	2.281ProLys: 2.281 ± 0.045	3.727ProLeu: 3.727 ± 0.065	0.909ProMet: 0.909 ± 0.03	1.587ProAsn: 1.587 ± 0.042	1.155ProPro: 1.155 ± 0.034	1.272ProGln: 1.272 ± 0.054	1.415ProArg: 1.415 ± 0.041	2.526ProSer: 2.526 ± 0.049	1.814ProThr: 1.814 ± 0.044	3.457ProVal: 3.457 ± 0.061	0.421ProTrp: 0.421 ± 0.021	1.573ProTyr: 1.573 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.255GlnAla: 3.255 ± 0.063	0.256GlnCys: 0.256 ± 0.017	1.939GlnAsp: 1.939 ± 0.045	2.935GlnGlu: 2.935 ± 0.069	1.471GlnPhe: 1.471 ± 0.041	2.625GlnGly: 2.625 ± 0.088	0.85GlnHis: 0.85 ± 0.033	2.872GlnIle: 2.872 ± 0.059	2.658GlnLys: 2.658 ± 0.06	4.058GlnLeu: 4.058 ± 0.066	1.253GlnMet: 1.253 ± 0.039	1.469GlnAsn: 1.469 ± 0.034	1.407GlnPro: 1.407 ± 0.041	1.799GlnGln: 1.799 ± 0.053	1.81GlnArg: 1.81 ± 0.047	2.193GlnSer: 2.193 ± 0.085	2.212GlnThr: 2.212 ± 0.043	2.808GlnVal: 2.808 ± 0.06	0.386GlnTrp: 0.386 ± 0.021	1.321GlnTyr: 1.321 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.814ArgAla: 2.814 ± 0.058	0.466ArgCys: 0.466 ± 0.021	2.269ArgAsp: 2.269 ± 0.048	3.924ArgGlu: 3.924 ± 0.066	2.138ArgPhe: 2.138 ± 0.051	3.098ArgGly: 3.098 ± 0.067	1.153ArgHis: 1.153 ± 0.04	4.035ArgIle: 4.035 ± 0.065	3.881ArgLys: 3.881 ± 0.068	5.06ArgLeu: 5.06 ± 0.073	1.681ArgMet: 1.681 ± 0.045	2.181ArgAsn: 2.181 ± 0.043	1.726ArgPro: 1.726 ± 0.041	2.137ArgGln: 2.137 ± 0.051	2.781ArgArg: 2.781 ± 0.067	2.848ArgSer: 2.848 ± 0.052	2.617ArgThr: 2.617 ± 0.05	3.224ArgVal: 3.224 ± 0.06	0.596ArgTrp: 0.596 ± 0.023	1.842ArgTyr: 1.842 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.034SerAla: 4.034 ± 0.078	0.581SerCys: 0.581 ± 0.027	2.737SerAsp: 2.737 ± 0.053	3.646SerGlu: 3.646 ± 0.066	3.015SerPhe: 3.015 ± 0.057	4.97SerGly: 4.97 ± 0.078	1.331SerHis: 1.331 ± 0.036	4.425SerIle: 4.425 ± 0.081	3.56SerLys: 3.56 ± 0.061	6.264SerLeu: 6.264 ± 0.09	1.851SerMet: 1.851 ± 0.043	2.013SerAsn: 2.013 ± 0.049	2.447SerPro: 2.447 ± 0.051	2.023SerGln: 2.023 ± 0.046	3.031SerArg: 3.031 ± 0.059	4.161SerSer: 4.161 ± 0.083	2.924SerThr: 2.924 ± 0.056	4.356SerVal: 4.356 ± 0.079	0.762SerTrp: 0.762 ± 0.027	2.191SerTyr: 2.191 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.199ThrAla: 4.199 ± 0.072	0.454ThrCys: 0.454 ± 0.022	2.625ThrAsp: 2.625 ± 0.05	3.545ThrGlu: 3.545 ± 0.067	2.255ThrPhe: 2.255 ± 0.047	4.625ThrGly: 4.625 ± 0.081	1.054ThrHis: 1.054 ± 0.035	3.705ThrIle: 3.705 ± 0.067	2.89ThrLys: 2.89 ± 0.059	5.045ThrLeu: 5.045 ± 0.076	1.363ThrMet: 1.363 ± 0.04	1.882ThrAsn: 1.882 ± 0.044	2.407ThrPro: 2.407 ± 0.052	1.495ThrGln: 1.495 ± 0.036	2.396ThrArg: 2.396 ± 0.059	3.163ThrSer: 3.163 ± 0.053	2.552ThrThr: 2.552 ± 0.065	4.16ThrVal: 4.16 ± 0.062	0.574ThrTrp: 0.574 ± 0.023	1.929ThrTyr: 1.929 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.731ValAla: 4.731 ± 0.082	0.731ValCys: 0.731 ± 0.028	3.44ValAsp: 3.44 ± 0.066	4.549ValGlu: 4.549 ± 0.071	2.909ValPhe: 2.909 ± 0.061	4.522ValGly: 4.522 ± 0.083	1.559ValHis: 1.559 ± 0.042	5.116ValIle: 5.116 ± 0.076	4.475ValLys: 4.475 ± 0.069	7.429ValLeu: 7.429 ± 0.084	2.014ValMet: 2.014 ± 0.044	2.786ValAsn: 2.786 ± 0.057	3.036ValPro: 3.036 ± 0.056	2.673ValGln: 2.673 ± 0.057	3.455ValArg: 3.455 ± 0.06	4.692ValSer: 4.692 ± 0.075	4.153ValThr: 4.153 ± 0.071	4.662ValVal: 4.662 ± 0.075	0.742ValTrp: 0.742 ± 0.027	2.286ValTyr: 2.286 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.672TrpAla: 0.672 ± 0.028	0.097TrpCys: 0.097 ± 0.01	0.58TrpAsp: 0.58 ± 0.027	0.728TrpGlu: 0.728 ± 0.024	0.553TrpPhe: 0.553 ± 0.022	0.703TrpGly: 0.703 ± 0.026	0.225TrpHis: 0.225 ± 0.018	0.903TrpIle: 0.903 ± 0.032	0.843TrpLys: 0.843 ± 0.03	1.32TrpLeu: 1.32 ± 0.044	0.437TrpMet: 0.437 ± 0.021	0.562TrpAsn: 0.562 ± 0.023	0.289TrpPro: 0.289 ± 0.017	0.412TrpGln: 0.412 ± 0.02	0.511TrpArg: 0.511 ± 0.025	0.681TrpSer: 0.681 ± 0.026	0.569TrpThr: 0.569 ± 0.022	0.764TrpVal: 0.764 ± 0.029	0.174TrpTrp: 0.174 ± 0.014	0.33TrpTyr: 0.33 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.258TyrAla: 2.258 ± 0.051	0.369TyrCys: 0.369 ± 0.022	1.69TyrAsp: 1.69 ± 0.044	2.378TyrGlu: 2.378 ± 0.049	1.516TyrPhe: 1.516 ± 0.042	2.526TyrGly: 2.526 ± 0.056	0.758TyrHis: 0.758 ± 0.031	2.192TyrIle: 2.192 ± 0.047	1.88TyrLys: 1.88 ± 0.043	3.39TyrLeu: 3.39 ± 0.053	0.991TyrMet: 0.991 ± 0.033	1.278TyrAsn: 1.278 ± 0.041	1.633TyrPro: 1.633 ± 0.048	1.419TyrGln: 1.419 ± 0.036	1.972TyrArg: 1.972 ± 0.048	2.016TyrSer: 2.016 ± 0.047	1.857TyrThr: 1.857 ± 0.041	2.233TyrVal: 2.233 ± 0.042	0.417TyrTrp: 0.417 ± 0.021	1.258TyrTyr: 1.258 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3693 proteins (1008502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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