Amino acid dipepetide frequency for Ophiocordyceps camponoti-rufipedis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.635AlaAla: 11.635 ± 0.087	1.237AlaCys: 1.237 ± 0.023	5.408AlaAsp: 5.408 ± 0.04	5.645AlaGlu: 5.645 ± 0.054	3.038AlaPhe: 3.038 ± 0.03	6.596AlaGly: 6.596 ± 0.051	1.963AlaHis: 1.963 ± 0.023	3.828AlaIle: 3.828 ± 0.033	4.101AlaLys: 4.101 ± 0.045	8.475AlaLeu: 8.475 ± 0.056	2.345AlaMet: 2.345 ± 0.028	2.774AlaAsn: 2.774 ± 0.031	5.197AlaPro: 5.197 ± 0.053	3.509AlaGln: 3.509 ± 0.04	6.306AlaArg: 6.306 ± 0.045	8.404AlaSer: 8.404 ± 0.061	5.322AlaThr: 5.322 ± 0.041	6.524AlaVal: 6.524 ± 0.052	1.242AlaTrp: 1.242 ± 0.021	2.049AlaTyr: 2.049 ± 0.027	0.001AlaXaa: 0.001 ± 0.001
Cys	1.046CysAla: 1.046 ± 0.019	0.288CysCys: 0.288 ± 0.01	0.709CysAsp: 0.709 ± 0.017	0.639CysGlu: 0.639 ± 0.013	0.548CysPhe: 0.548 ± 0.013	1.014CysGly: 1.014 ± 0.022	0.381CysHis: 0.381 ± 0.011	0.622CysIle: 0.622 ± 0.011	0.499CysLys: 0.499 ± 0.014	1.37CysLeu: 1.37 ± 0.025	0.254CysMet: 0.254 ± 0.009	0.42CysAsn: 0.42 ± 0.011	0.753CysPro: 0.753 ± 0.017	0.474CysGln: 0.474 ± 0.013	0.976CysArg: 0.976 ± 0.017	0.972CysSer: 0.972 ± 0.019	0.579CysThr: 0.579 ± 0.014	0.886CysVal: 0.886 ± 0.018	0.216CysTrp: 0.216 ± 0.008	0.344CysTyr: 0.344 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.923AspAla: 5.923 ± 0.048	0.727AspCys: 0.727 ± 0.015	6.014AspAsp: 6.014 ± 0.072	5.224AspGlu: 5.224 ± 0.05	2.181AspPhe: 2.181 ± 0.025	5.234AspGly: 5.234 ± 0.049	1.23AspHis: 1.23 ± 0.019	2.43AspIle: 2.43 ± 0.028	2.637AspLys: 2.637 ± 0.032	5.008AspLeu: 5.008 ± 0.042	1.516AspMet: 1.516 ± 0.021	1.714AspAsn: 1.714 ± 0.025	3.072AspPro: 3.072 ± 0.036	1.9AspGln: 1.9 ± 0.025	3.583AspArg: 3.583 ± 0.038	4.235AspSer: 4.235 ± 0.039	2.574AspThr: 2.574 ± 0.029	4.413AspVal: 4.413 ± 0.038	0.901AspTrp: 0.901 ± 0.017	1.486AspTyr: 1.486 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.647GluAla: 6.647 ± 0.064	0.62GluCys: 0.62 ± 0.015	3.959GluAsp: 3.959 ± 0.042	4.629GluGlu: 4.629 ± 0.062	1.694GluPhe: 1.694 ± 0.024	3.576GluGly: 3.576 ± 0.037	1.226GluHis: 1.226 ± 0.019	2.187GluIle: 2.187 ± 0.025	3.095GluLys: 3.095 ± 0.041	5.17GluLeu: 5.17 ± 0.041	1.578GluMet: 1.578 ± 0.024	1.64GluAsn: 1.64 ± 0.022	3.079GluPro: 3.079 ± 0.042	2.383GluGln: 2.383 ± 0.031	4.161GluArg: 4.161 ± 0.039	4.087GluSer: 4.087 ± 0.043	3.451GluThr: 3.451 ± 0.038	3.351GluVal: 3.351 ± 0.032	0.788GluTrp: 0.788 ± 0.015	1.36GluTyr: 1.36 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.01PheAla: 3.01 ± 0.034	0.574PheCys: 0.574 ± 0.014	2.249PheAsp: 2.249 ± 0.027	1.875PheGlu: 1.875 ± 0.023	1.491PhePhe: 1.491 ± 0.027	2.625PheGly: 2.625 ± 0.035	0.861PheHis: 0.861 ± 0.015	1.493PheIle: 1.493 ± 0.02	1.309PheLys: 1.309 ± 0.02	3.14PheLeu: 3.14 ± 0.037	0.693PheMet: 0.693 ± 0.015	1.206PheAsn: 1.206 ± 0.022	1.812PhePro: 1.812 ± 0.024	1.233PheGln: 1.233 ± 0.022	2.159PheArg: 2.159 ± 0.025	2.677PheSer: 2.677 ± 0.031	1.778PheThr: 1.778 ± 0.022	2.413PheVal: 2.413 ± 0.028	0.556PheTrp: 0.556 ± 0.014	0.955PheTyr: 0.955 ± 0.018	0.001PheXaa: 0.001 ± 0.0
Gly	5.591GlyAla: 5.591 ± 0.048	0.984GlyCys: 0.984 ± 0.019	4.103GlyAsp: 4.103 ± 0.042	3.686GlyGlu: 3.686 ± 0.035	2.754GlyPhe: 2.754 ± 0.031	6.6GlyGly: 6.6 ± 0.093	1.832GlyHis: 1.832 ± 0.026	3.053GlyIle: 3.053 ± 0.036	3.187GlyLys: 3.187 ± 0.036	6.475GlyLeu: 6.475 ± 0.051	1.542GlyMet: 1.542 ± 0.023	2.304GlyAsn: 2.304 ± 0.034	3.978GlyPro: 3.978 ± 0.055	2.709GlyGln: 2.709 ± 0.028	5.239GlyArg: 5.239 ± 0.045	6.064GlySer: 6.064 ± 0.053	3.507GlyThr: 3.507 ± 0.037	4.354GlyVal: 4.354 ± 0.039	1.168GlyTrp: 1.168 ± 0.019	1.95GlyTyr: 1.95 ± 0.041	0.001GlyXaa: 0.001 ± 0.0
His	1.945HisAla: 1.945 ± 0.026	0.339HisCys: 0.339 ± 0.01	1.534HisAsp: 1.534 ± 0.022	1.273HisGlu: 1.273 ± 0.018	0.819HisPhe: 0.819 ± 0.015	1.879HisGly: 1.879 ± 0.026	1.172HisHis: 1.172 ± 0.029	0.962HisIle: 0.962 ± 0.016	0.863HisLys: 0.863 ± 0.017	2.353HisLeu: 2.353 ± 0.028	0.505HisMet: 0.505 ± 0.013	0.697HisAsn: 0.697 ± 0.015	1.652HisPro: 1.652 ± 0.02	1.135HisGln: 1.135 ± 0.022	1.767HisArg: 1.767 ± 0.025	1.6HisSer: 1.6 ± 0.025	1.007HisThr: 1.007 ± 0.018	1.66HisVal: 1.66 ± 0.023	0.323HisTrp: 0.323 ± 0.009	0.639HisTyr: 0.639 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.371IleAla: 3.371 ± 0.031	0.651IleCys: 0.651 ± 0.016	2.548IleAsp: 2.548 ± 0.027	2.249IleGlu: 2.249 ± 0.029	1.557IlePhe: 1.557 ± 0.023	2.622IleGly: 2.622 ± 0.035	0.989IleHis: 0.989 ± 0.018	1.845IleIle: 1.845 ± 0.025	1.898IleLys: 1.898 ± 0.026	3.685IleLeu: 3.685 ± 0.039	0.891IleMet: 0.891 ± 0.016	1.438IleAsn: 1.438 ± 0.021	2.341IlePro: 2.341 ± 0.027	1.49IleGln: 1.49 ± 0.02	2.778IleArg: 2.778 ± 0.026	2.999IleSer: 2.999 ± 0.028	2.033IleThr: 2.033 ± 0.028	2.912IleVal: 2.912 ± 0.029	0.581IleTrp: 0.581 ± 0.014	1.072IleTyr: 1.072 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.403LysAla: 4.403 ± 0.045	0.463LysCys: 0.463 ± 0.013	2.532LysAsp: 2.532 ± 0.031	2.694LysGlu: 2.694 ± 0.033	1.23LysPhe: 1.23 ± 0.022	2.713LysGly: 2.713 ± 0.031	0.995LysHis: 0.995 ± 0.017	1.691LysIle: 1.691 ± 0.022	2.976LysLys: 2.976 ± 0.053	3.93LysLeu: 3.93 ± 0.037	1.12LysMet: 1.12 ± 0.02	1.335LysAsn: 1.335 ± 0.022	2.786LysPro: 2.786 ± 0.036	1.751LysGln: 1.751 ± 0.028	3.445LysArg: 3.445 ± 0.041	3.056LysSer: 3.056 ± 0.038	2.879LysThr: 2.879 ± 0.033	2.43LysVal: 2.43 ± 0.031	0.546LysTrp: 0.546 ± 0.013	1.034LysTyr: 1.034 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	9.0LeuAla: 9.0 ± 0.058	1.272LeuCys: 1.272 ± 0.02	5.708LeuAsp: 5.708 ± 0.042	5.292LeuGlu: 5.292 ± 0.04	3.184LeuPhe: 3.184 ± 0.034	6.063LeuGly: 6.063 ± 0.045	2.209LeuHis: 2.209 ± 0.025	3.371LeuIle: 3.371 ± 0.037	3.691LeuLys: 3.691 ± 0.041	8.873LeuLeu: 8.873 ± 0.077	1.929LeuMet: 1.929 ± 0.023	2.697LeuAsn: 2.697 ± 0.028	5.64LeuPro: 5.64 ± 0.049	3.648LeuGln: 3.648 ± 0.042	6.775LeuArg: 6.775 ± 0.051	7.328LeuSer: 7.328 ± 0.054	4.791LeuThr: 4.791 ± 0.04	6.186LeuVal: 6.186 ± 0.052	1.213LeuTrp: 1.213 ± 0.019	2.223LeuTyr: 2.223 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.789MetAla: 2.789 ± 0.03	0.249MetCys: 0.249 ± 0.008	1.408MetAsp: 1.408 ± 0.02	1.334MetGlu: 1.334 ± 0.018	0.658MetPhe: 0.658 ± 0.015	1.534MetGly: 1.534 ± 0.025	0.473MetHis: 0.473 ± 0.011	0.799MetIle: 0.799 ± 0.016	0.911MetLys: 0.911 ± 0.017	2.029MetLeu: 2.029 ± 0.025	0.681MetMet: 0.681 ± 0.015	0.671MetAsn: 0.671 ± 0.016	1.483MetPro: 1.483 ± 0.022	0.877MetGln: 0.877 ± 0.016	1.515MetArg: 1.515 ± 0.02	1.849MetSer: 1.849 ± 0.025	1.506MetThr: 1.506 ± 0.019	1.401MetVal: 1.401 ± 0.019	0.252MetTrp: 0.252 ± 0.008	0.455MetTyr: 0.455 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.67AsnAla: 2.67 ± 0.03	0.399AsnCys: 0.399 ± 0.011	1.778AsnAsp: 1.778 ± 0.025	1.581AsnGlu: 1.581 ± 0.022	1.092AsnPhe: 1.092 ± 0.018	2.55AsnGly: 2.55 ± 0.036	0.759AsnHis: 0.759 ± 0.014	1.381AsnIle: 1.381 ± 0.019	1.444AsnLys: 1.444 ± 0.022	2.825AsnLeu: 2.825 ± 0.03	0.791AsnMet: 0.791 ± 0.013	1.208AsnAsn: 1.208 ± 0.031	2.086AsnPro: 2.086 ± 0.038	1.114AsnGln: 1.114 ± 0.019	1.932AsnArg: 1.932 ± 0.025	2.241AsnSer: 2.241 ± 0.028	1.528AsnThr: 1.528 ± 0.021	2.008AsnVal: 2.008 ± 0.027	0.465AsnTrp: 0.465 ± 0.014	0.857AsnTyr: 0.857 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	5.968ProAla: 5.968 ± 0.057	0.621ProCys: 0.621 ± 0.015	3.7ProAsp: 3.7 ± 0.044	3.645ProGlu: 3.645 ± 0.037	1.92ProPhe: 1.92 ± 0.023	4.331ProGly: 4.331 ± 0.073	1.327ProHis: 1.327 ± 0.019	2.069ProIle: 2.069 ± 0.024	2.359ProLys: 2.359 ± 0.027	5.109ProLeu: 5.109 ± 0.042	1.159ProMet: 1.159 ± 0.02	1.8ProAsn: 1.8 ± 0.027	6.195ProPro: 6.195 ± 0.093	2.544ProGln: 2.544 ± 0.035	4.217ProArg: 4.217 ± 0.038	6.26ProSer: 6.26 ± 0.066	3.699ProThr: 3.699 ± 0.041	3.901ProVal: 3.901 ± 0.038	0.792ProTrp: 0.792 ± 0.017	1.389ProTyr: 1.389 ± 0.023	0.001ProXaa: 0.001 ± 0.001
Gln	3.79GlnAla: 3.79 ± 0.046	0.414GlnCys: 0.414 ± 0.011	2.108GlnAsp: 2.108 ± 0.025	2.096GlnGlu: 2.096 ± 0.03	1.08GlnPhe: 1.08 ± 0.021	2.494GlnGly: 2.494 ± 0.027	1.202GlnHis: 1.202 ± 0.02	1.425GlnIle: 1.425 ± 0.02	1.686GlnLys: 1.686 ± 0.022	3.711GlnLeu: 3.711 ± 0.033	0.938GlnMet: 0.938 ± 0.02	1.142GlnAsn: 1.142 ± 0.019	2.861GlnPro: 2.861 ± 0.045	3.152GlnGln: 3.152 ± 0.094	3.013GlnArg: 3.013 ± 0.032	2.791GlnSer: 2.791 ± 0.03	2.241GlnThr: 2.241 ± 0.027	2.192GlnVal: 2.192 ± 0.025	0.505GlnTrp: 0.505 ± 0.011	0.921GlnTyr: 0.921 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.883ArgAla: 5.883 ± 0.041	0.953ArgCys: 0.953 ± 0.019	4.223ArgAsp: 4.223 ± 0.038	4.146ArgGlu: 4.146 ± 0.036	2.388ArgPhe: 2.388 ± 0.024	4.574ArgGly: 4.574 ± 0.046	2.005ArgHis: 2.005 ± 0.024	2.861ArgIle: 2.861 ± 0.027	3.36ArgLys: 3.36 ± 0.038	6.915ArgLeu: 6.915 ± 0.05	1.484ArgMet: 1.484 ± 0.023	2.226ArgAsn: 2.226 ± 0.023	4.535ArgPro: 4.535 ± 0.042	3.09ArgGln: 3.09 ± 0.031	7.093ArgArg: 7.093 ± 0.071	5.336ArgSer: 5.336 ± 0.048	3.436ArgThr: 3.436 ± 0.029	4.001ArgVal: 4.001 ± 0.033	1.072ArgTrp: 1.072 ± 0.017	1.664ArgTyr: 1.664 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	7.09SerAla: 7.09 ± 0.049	0.971SerCys: 0.971 ± 0.018	4.395SerAsp: 4.395 ± 0.04	3.791SerGlu: 3.791 ± 0.035	2.813SerPhe: 2.813 ± 0.031	5.637SerGly: 5.637 ± 0.046	1.918SerHis: 1.918 ± 0.025	3.28SerIle: 3.28 ± 0.036	3.325SerLys: 3.325 ± 0.036	7.491SerLeu: 7.491 ± 0.063	1.757SerMet: 1.757 ± 0.023	2.41SerAsn: 2.41 ± 0.032	5.849SerPro: 5.849 ± 0.058	3.134SerGln: 3.134 ± 0.039	5.906SerArg: 5.906 ± 0.047	9.09SerSer: 9.09 ± 0.077	4.876SerThr: 4.876 ± 0.054	4.7SerVal: 4.7 ± 0.037	1.098SerTrp: 1.098 ± 0.02	1.796SerTyr: 1.796 ± 0.031	0.001SerXaa: 0.001 ± 0.0
Thr	5.591ThrAla: 5.591 ± 0.04	0.712ThrCys: 0.712 ± 0.016	2.852ThrAsp: 2.852 ± 0.029	2.736ThrGlu: 2.736 ± 0.038	1.774ThrPhe: 1.774 ± 0.024	3.946ThrGly: 3.946 ± 0.04	1.12ThrHis: 1.12 ± 0.016	2.412ThrIle: 2.412 ± 0.028	2.234ThrLys: 2.234 ± 0.03	4.953ThrLeu: 4.953 ± 0.046	1.282ThrMet: 1.282 ± 0.02	1.59ThrAsn: 1.59 ± 0.021	4.085ThrPro: 4.085 ± 0.047	1.829ThrGln: 1.829 ± 0.023	3.341ThrArg: 3.341 ± 0.032	4.72ThrSer: 4.72 ± 0.046	4.13ThrThr: 4.13 ± 0.063	3.638ThrVal: 3.638 ± 0.037	0.742ThrTrp: 0.742 ± 0.015	1.27ThrTyr: 1.27 ± 0.02	0.001ThrXaa: 0.001 ± 0.0
Val	6.139ValAla: 6.139 ± 0.047	0.936ValCys: 0.936 ± 0.017	4.322ValAsp: 4.322 ± 0.038	4.011ValGlu: 4.011 ± 0.035	2.444ValPhe: 2.444 ± 0.029	4.265ValGly: 4.265 ± 0.034	1.384ValHis: 1.384 ± 0.021	2.587ValIle: 2.587 ± 0.03	2.85ValLys: 2.85 ± 0.031	5.824ValLeu: 5.824 ± 0.046	1.465ValMet: 1.465 ± 0.021	2.035ValAsn: 2.035 ± 0.025	3.648ValPro: 3.648 ± 0.033	2.308ValGln: 2.308 ± 0.025	4.211ValArg: 4.211 ± 0.034	4.89ValSer: 4.89 ± 0.04	3.467ValThr: 3.467 ± 0.032	5.014ValVal: 5.014 ± 0.046	0.87ValTrp: 0.87 ± 0.017	1.619ValTyr: 1.619 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.019	0.204TrpCys: 0.204 ± 0.008	0.869TrpAsp: 0.869 ± 0.017	0.802TrpGlu: 0.802 ± 0.015	0.495TrpPhe: 0.495 ± 0.01	0.819TrpGly: 0.819 ± 0.015	0.386TrpHis: 0.386 ± 0.011	0.657TrpIle: 0.657 ± 0.012	0.674TrpLys: 0.674 ± 0.014	1.401TrpLeu: 1.401 ± 0.026	0.367TrpMet: 0.367 ± 0.009	0.553TrpAsn: 0.553 ± 0.013	0.662TrpPro: 0.662 ± 0.014	0.548TrpGln: 0.548 ± 0.011	1.103TrpArg: 1.103 ± 0.02	1.001TrpSer: 1.001 ± 0.018	0.927TrpThr: 0.927 ± 0.015	0.75TrpVal: 0.75 ± 0.014	0.273TrpTrp: 0.273 ± 0.011	0.353TrpTyr: 0.353 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.955TyrAla: 1.955 ± 0.027	0.377TyrCys: 0.377 ± 0.01	1.586TyrAsp: 1.586 ± 0.022	1.334TyrGlu: 1.334 ± 0.025	0.95TyrPhe: 0.95 ± 0.018	2.009TyrGly: 2.009 ± 0.031	0.692TyrHis: 0.692 ± 0.014	0.996TyrIle: 0.996 ± 0.015	0.91TyrLys: 0.91 ± 0.018	2.353TyrLeu: 2.353 ± 0.026	0.577TyrMet: 0.577 ± 0.013	0.85TyrAsn: 0.85 ± 0.017	1.29TyrPro: 1.29 ± 0.023	0.933TyrGln: 0.933 ± 0.016	1.726TyrArg: 1.726 ± 0.022	1.727TyrSer: 1.727 ± 0.026	1.222TyrThr: 1.222 ± 0.032	1.556TyrVal: 1.556 ± 0.021	0.397TyrTrp: 0.397 ± 0.012	0.736TyrTyr: 0.736 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 7618 proteins (3739367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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