Amino acid dipepetide frequency for Actinomadura bangladeshensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.504AlaAla: 22.504 ± 0.158	1.12AlaCys: 1.12 ± 0.023	8.369AlaAsp: 8.369 ± 0.059	9.001AlaGlu: 9.001 ± 0.076	3.795AlaPhe: 3.795 ± 0.039	14.166AlaGly: 14.166 ± 0.091	2.703AlaHis: 2.703 ± 0.032	4.112AlaIle: 4.112 ± 0.051	2.816AlaLys: 2.816 ± 0.042	14.163AlaLeu: 14.163 ± 0.101	2.674AlaMet: 2.674 ± 0.037	1.893AlaAsn: 1.893 ± 0.026	6.87AlaPro: 6.87 ± 0.058	3.326AlaGln: 3.326 ± 0.039	11.05AlaArg: 11.05 ± 0.075	5.775AlaSer: 5.775 ± 0.05	6.283AlaThr: 6.283 ± 0.07	12.041AlaVal: 12.041 ± 0.081	1.952AlaTrp: 1.952 ± 0.025	2.633AlaTyr: 2.633 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.036CysAla: 1.036 ± 0.02	0.09CysCys: 0.09 ± 0.006	0.521CysAsp: 0.521 ± 0.017	0.435CysGlu: 0.435 ± 0.015	0.221CysPhe: 0.221 ± 0.009	1.029CysGly: 1.029 ± 0.021	0.204CysHis: 0.204 ± 0.009	0.164CysIle: 0.164 ± 0.008	0.127CysLys: 0.127 ± 0.007	0.718CysLeu: 0.718 ± 0.015	0.139CysMet: 0.139 ± 0.008	0.139CysAsn: 0.139 ± 0.008	0.509CysPro: 0.509 ± 0.015	0.167CysGln: 0.167 ± 0.008	0.643CysArg: 0.643 ± 0.017	0.403CysSer: 0.403 ± 0.012	0.47CysThr: 0.47 ± 0.016	0.664CysVal: 0.664 ± 0.016	0.119CysTrp: 0.119 ± 0.007	0.178CysTyr: 0.178 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.04AspAla: 8.04 ± 0.065	0.388AspCys: 0.388 ± 0.014	3.953AspAsp: 3.953 ± 0.05	4.134AspGlu: 4.134 ± 0.045	1.61AspPhe: 1.61 ± 0.026	6.584AspGly: 6.584 ± 0.059	1.426AspHis: 1.426 ± 0.022	1.965AspIle: 1.965 ± 0.027	1.066AspLys: 1.066 ± 0.024	6.821AspLeu: 6.821 ± 0.061	0.969AspMet: 0.969 ± 0.019	0.858AspAsn: 0.858 ± 0.021	4.686AspPro: 4.686 ± 0.051	1.452AspGln: 1.452 ± 0.026	5.374AspArg: 5.374 ± 0.043	1.998AspSer: 1.998 ± 0.028	2.652AspThr: 2.652 ± 0.033	5.27AspVal: 5.27 ± 0.051	0.956AspTrp: 0.956 ± 0.022	1.192AspTyr: 1.192 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.204GluAla: 7.204 ± 0.063	0.375GluCys: 0.375 ± 0.011	2.912GluAsp: 2.912 ± 0.038	3.39GluGlu: 3.39 ± 0.049	1.551GluPhe: 1.551 ± 0.025	4.03GluGly: 4.03 ± 0.038	1.637GluHis: 1.637 ± 0.025	2.555GluIle: 2.555 ± 0.033	1.317GluLys: 1.317 ± 0.025	6.49GluLeu: 6.49 ± 0.055	1.023GluMet: 1.023 ± 0.02	1.011GluAsn: 1.011 ± 0.017	3.577GluPro: 3.577 ± 0.044	2.036GluGln: 2.036 ± 0.036	5.902GluArg: 5.902 ± 0.056	2.444GluSer: 2.444 ± 0.032	2.92GluThr: 2.92 ± 0.037	4.539GluVal: 4.539 ± 0.047	0.789GluTrp: 0.789 ± 0.018	1.162GluTyr: 1.162 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.921PheAla: 3.921 ± 0.042	0.292PheCys: 0.292 ± 0.01	2.012PheAsp: 2.012 ± 0.029	1.489PheGlu: 1.489 ± 0.024	0.871PhePhe: 0.871 ± 0.021	3.227PheGly: 3.227 ± 0.039	0.613PheHis: 0.613 ± 0.016	0.81PheIle: 0.81 ± 0.019	0.537PheLys: 0.537 ± 0.017	2.609PheLeu: 2.609 ± 0.036	0.44PheMet: 0.44 ± 0.014	0.564PheAsn: 0.564 ± 0.018	1.406PhePro: 1.406 ± 0.024	0.703PheGln: 0.703 ± 0.015	1.89PheArg: 1.89 ± 0.028	1.338PheSer: 1.338 ± 0.023	2.01PheThr: 2.01 ± 0.032	2.282PheVal: 2.282 ± 0.031	0.432PheTrp: 0.432 ± 0.012	0.597PheTyr: 0.597 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.333GlyAla: 11.333 ± 0.088	0.849GlyCys: 0.849 ± 0.02	5.695GlyAsp: 5.695 ± 0.052	5.311GlyGlu: 5.311 ± 0.051	2.96GlyPhe: 2.96 ± 0.038	9.501GlyGly: 9.501 ± 0.083	2.268GlyHis: 2.268 ± 0.034	3.529GlyIle: 3.529 ± 0.044	2.288GlyLys: 2.288 ± 0.028	9.715GlyLeu: 9.715 ± 0.072	2.122GlyMet: 2.122 ± 0.029	1.632GlyAsn: 1.632 ± 0.029	5.416GlyPro: 5.416 ± 0.051	2.365GlyGln: 2.365 ± 0.038	8.904GlyArg: 8.904 ± 0.071	4.722GlySer: 4.722 ± 0.05	6.116GlyThr: 6.116 ± 0.06	7.697GlyVal: 7.697 ± 0.064	1.738GlyTrp: 1.738 ± 0.029	2.274GlyTyr: 2.274 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.691HisAla: 2.691 ± 0.036	0.219HisCys: 0.219 ± 0.009	1.372HisAsp: 1.372 ± 0.023	1.165HisGlu: 1.165 ± 0.023	0.608HisPhe: 0.608 ± 0.015	2.39HisGly: 2.39 ± 0.031	0.625HisHis: 0.625 ± 0.018	0.732HisIle: 0.732 ± 0.018	0.303HisLys: 0.303 ± 0.011	2.338HisLeu: 2.338 ± 0.03	0.376HisMet: 0.376 ± 0.013	0.337HisAsn: 0.337 ± 0.013	1.653HisPro: 1.653 ± 0.026	0.549HisGln: 0.549 ± 0.015	2.119HisArg: 2.119 ± 0.029	0.887HisSer: 0.887 ± 0.019	1.054HisThr: 1.054 ± 0.024	1.769HisVal: 1.769 ± 0.028	0.351HisTrp: 0.351 ± 0.013	0.494HisTyr: 0.494 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.37IleAla: 5.37 ± 0.049	0.292IleCys: 0.292 ± 0.012	2.494IleAsp: 2.494 ± 0.037	2.304IleGlu: 2.304 ± 0.035	0.811IlePhe: 0.811 ± 0.019	3.935IleGly: 3.935 ± 0.038	0.568IleHis: 0.568 ± 0.014	1.132IleIle: 1.132 ± 0.025	0.758IleLys: 0.758 ± 0.019	2.611IleLeu: 2.611 ± 0.036	0.538IleMet: 0.538 ± 0.016	0.717IleAsn: 0.717 ± 0.018	1.867IlePro: 1.867 ± 0.03	0.732IleGln: 0.732 ± 0.02	2.458IleArg: 2.458 ± 0.032	1.662IleSer: 1.662 ± 0.032	2.287IleThr: 2.287 ± 0.032	3.258IleVal: 3.258 ± 0.037	0.411IleTrp: 0.411 ± 0.012	0.568IleTyr: 0.568 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.842LysAla: 2.842 ± 0.038	0.123LysCys: 0.123 ± 0.007	1.226LysAsp: 1.226 ± 0.025	1.074LysGlu: 1.074 ± 0.023	0.451LysPhe: 0.451 ± 0.015	1.755LysGly: 1.755 ± 0.028	0.405LysHis: 0.405 ± 0.014	0.944LysIle: 0.944 ± 0.021	0.705LysLys: 0.705 ± 0.02	1.852LysLeu: 1.852 ± 0.03	0.402LysMet: 0.402 ± 0.014	0.456LysAsn: 0.456 ± 0.014	1.267LysPro: 1.267 ± 0.022	0.652LysGln: 0.652 ± 0.018	1.544LysArg: 1.544 ± 0.025	1.042LysSer: 1.042 ± 0.022	1.217LysThr: 1.217 ± 0.027	1.885LysVal: 1.885 ± 0.032	0.265LysTrp: 0.265 ± 0.009	0.425LysTyr: 0.425 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.615LeuAla: 15.615 ± 0.113	0.827LeuCys: 0.827 ± 0.019	6.947LeuAsp: 6.947 ± 0.061	4.882LeuGlu: 4.882 ± 0.049	2.623LeuPhe: 2.623 ± 0.041	9.299LeuGly: 9.299 ± 0.074	2.162LeuHis: 2.162 ± 0.031	3.544LeuIle: 3.544 ± 0.045	1.931LeuLys: 1.931 ± 0.035	10.814LeuLeu: 10.814 ± 0.092	1.634LeuMet: 1.634 ± 0.024	1.766LeuAsn: 1.766 ± 0.031	6.377LeuPro: 6.377 ± 0.052	2.109LeuGln: 2.109 ± 0.032	9.122LeuArg: 9.122 ± 0.075	4.955LeuSer: 4.955 ± 0.044	6.346LeuThr: 6.346 ± 0.054	8.611LeuVal: 8.611 ± 0.076	1.283LeuTrp: 1.283 ± 0.027	1.808LeuTyr: 1.808 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.471MetAla: 2.471 ± 0.035	0.138MetCys: 0.138 ± 0.007	1.006MetAsp: 1.006 ± 0.02	0.817MetGlu: 0.817 ± 0.02	0.545MetPhe: 0.545 ± 0.016	1.399MetGly: 1.399 ± 0.025	0.353MetHis: 0.353 ± 0.012	0.763MetIle: 0.763 ± 0.018	0.441MetLys: 0.441 ± 0.014	1.955MetLeu: 1.955 ± 0.03	0.342MetMet: 0.342 ± 0.012	0.449MetAsn: 0.449 ± 0.012	1.219MetPro: 1.219 ± 0.024	0.446MetGln: 0.446 ± 0.015	1.712MetArg: 1.712 ± 0.026	1.302MetSer: 1.302 ± 0.022	1.526MetThr: 1.526 ± 0.025	1.369MetVal: 1.369 ± 0.027	0.237MetTrp: 0.237 ± 0.01	0.327MetTyr: 0.327 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.224AsnAla: 2.224 ± 0.033	0.167AsnCys: 0.167 ± 0.009	0.958AsnAsp: 0.958 ± 0.02	0.833AsnGlu: 0.833 ± 0.017	0.439AsnPhe: 0.439 ± 0.014	1.895AsnGly: 1.895 ± 0.039	0.371AsnHis: 0.371 ± 0.013	0.629AsnIle: 0.629 ± 0.016	0.368AsnLys: 0.368 ± 0.013	1.69AsnLeu: 1.69 ± 0.032	0.306AsnMet: 0.306 ± 0.012	0.346AsnAsn: 0.346 ± 0.014	1.313AsnPro: 1.313 ± 0.028	0.451AsnGln: 0.451 ± 0.015	1.316AsnArg: 1.316 ± 0.024	0.733AsnSer: 0.733 ± 0.019	0.988AsnThr: 0.988 ± 0.022	1.471AsnVal: 1.471 ± 0.027	0.26AsnTrp: 0.26 ± 0.011	0.401AsnTyr: 0.401 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.726ProAla: 8.726 ± 0.071	0.372ProCys: 0.372 ± 0.012	4.807ProAsp: 4.807 ± 0.054	4.217ProGlu: 4.217 ± 0.048	1.624ProPhe: 1.624 ± 0.028	7.106ProGly: 7.106 ± 0.072	1.282ProHis: 1.282 ± 0.023	1.637ProIle: 1.637 ± 0.027	1.205ProLys: 1.205 ± 0.021	5.271ProLeu: 5.271 ± 0.045	1.16ProMet: 1.16 ± 0.023	0.919ProAsn: 0.919 ± 0.02	4.154ProPro: 4.154 ± 0.059	1.507ProGln: 1.507 ± 0.029	4.169ProArg: 4.169 ± 0.044	3.304ProSer: 3.304 ± 0.042	2.673ProThr: 2.673 ± 0.035	5.289ProVal: 5.289 ± 0.052	0.926ProTrp: 0.926 ± 0.019	1.313ProTyr: 1.313 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.443GlnAla: 3.443 ± 0.039	0.175GlnCys: 0.175 ± 0.009	1.278GlnAsp: 1.278 ± 0.023	1.264GlnGlu: 1.264 ± 0.024	0.676GlnPhe: 0.676 ± 0.018	2.06GlnGly: 2.06 ± 0.029	0.548GlnHis: 0.548 ± 0.013	1.165GlnIle: 1.165 ± 0.022	0.581GlnLys: 0.581 ± 0.019	2.498GlnLeu: 2.498 ± 0.033	0.498GlnMet: 0.498 ± 0.015	0.486GlnAsn: 0.486 ± 0.017	1.489GlnPro: 1.489 ± 0.032	0.981GlnGln: 0.981 ± 0.031	2.271GlnArg: 2.271 ± 0.033	1.113GlnSer: 1.113 ± 0.022	1.233GlnThr: 1.233 ± 0.022	2.32GlnVal: 2.32 ± 0.032	0.422GlnTrp: 0.422 ± 0.013	0.525GlnTyr: 0.525 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.648ArgAla: 10.648 ± 0.072	0.638ArgCys: 0.638 ± 0.017	5.12ArgAsp: 5.12 ± 0.043	4.951ArgGlu: 4.951 ± 0.054	2.532ArgPhe: 2.532 ± 0.037	6.298ArgGly: 6.298 ± 0.054	2.184ArgHis: 2.184 ± 0.031	3.339ArgIle: 3.339 ± 0.041	1.659ArgLys: 1.659 ± 0.034	9.715ArgLeu: 9.715 ± 0.078	1.963ArgMet: 1.963 ± 0.028	1.416ArgAsn: 1.416 ± 0.028	5.661ArgPro: 5.661 ± 0.058	2.183ArgGln: 2.183 ± 0.03	9.03ArgArg: 9.03 ± 0.073	3.933ArgSer: 3.933 ± 0.042	5.155ArgThr: 5.155 ± 0.041	6.427ArgVal: 6.427 ± 0.058	1.48ArgTrp: 1.48 ± 0.025	1.904ArgTyr: 1.904 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.089SerAla: 6.089 ± 0.055	0.388SerCys: 0.388 ± 0.013	2.557SerAsp: 2.557 ± 0.034	2.215SerGlu: 2.215 ± 0.031	1.454SerPhe: 1.454 ± 0.024	5.656SerGly: 5.656 ± 0.054	0.901SerHis: 0.901 ± 0.019	1.526SerIle: 1.526 ± 0.026	0.948SerLys: 0.948 ± 0.023	4.505SerLeu: 4.505 ± 0.044	1.078SerMet: 1.078 ± 0.021	0.784SerAsn: 0.784 ± 0.02	3.069SerPro: 3.069 ± 0.048	1.085SerGln: 1.085 ± 0.02	3.737SerArg: 3.737 ± 0.04	2.553SerSer: 2.553 ± 0.037	2.579SerThr: 2.579 ± 0.037	3.81SerVal: 3.81 ± 0.036	0.845SerTrp: 0.845 ± 0.018	1.118SerTyr: 1.118 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.027ThrAla: 8.027 ± 0.066	0.451ThrCys: 0.451 ± 0.015	3.095ThrAsp: 3.095 ± 0.039	2.832ThrGlu: 2.832 ± 0.032	1.638ThrPhe: 1.638 ± 0.029	6.485ThrGly: 6.485 ± 0.054	1.021ThrHis: 1.021 ± 0.021	1.923ThrIle: 1.923 ± 0.028	1.023ThrLys: 1.023 ± 0.021	5.363ThrLeu: 5.363 ± 0.049	1.091ThrMet: 1.091 ± 0.022	0.89ThrAsn: 0.89 ± 0.024	3.624ThrPro: 3.624 ± 0.039	1.126ThrGln: 1.126 ± 0.023	4.054ThrArg: 4.054 ± 0.04	2.861ThrSer: 2.861 ± 0.042	3.14ThrThr: 3.14 ± 0.044	5.435ThrVal: 5.435 ± 0.051	0.913ThrTrp: 0.913 ± 0.02	1.178ThrTyr: 1.178 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.849ValAla: 10.849 ± 0.071	0.723ValCys: 0.723 ± 0.016	4.784ValAsp: 4.784 ± 0.049	4.635ValGlu: 4.635 ± 0.044	2.474ValPhe: 2.474 ± 0.032	6.302ValGly: 6.302 ± 0.055	1.989ValHis: 1.989 ± 0.034	3.141ValIle: 3.141 ± 0.037	1.708ValLys: 1.708 ± 0.027	9.661ValLeu: 9.661 ± 0.069	1.484ValMet: 1.484 ± 0.025	1.684ValAsn: 1.684 ± 0.026	5.58ValPro: 5.58 ± 0.05	2.121ValGln: 2.121 ± 0.032	7.517ValArg: 7.517 ± 0.062	4.069ValSer: 4.069 ± 0.046	5.319ValThr: 5.319 ± 0.049	7.72ValVal: 7.72 ± 0.074	1.085ValTrp: 1.085 ± 0.025	1.583ValTyr: 1.583 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.662TrpAla: 1.662 ± 0.023	0.16TrpCys: 0.16 ± 0.008	0.9TrpAsp: 0.9 ± 0.021	0.709TrpGlu: 0.709 ± 0.017	0.511TrpPhe: 0.511 ± 0.014	1.057TrpGly: 1.057 ± 0.024	0.381TrpHis: 0.381 ± 0.01	0.569TrpIle: 0.569 ± 0.015	0.347TrpLys: 0.347 ± 0.012	1.715TrpLeu: 1.715 ± 0.023	0.289TrpMet: 0.289 ± 0.012	0.414TrpAsn: 0.414 ± 0.015	0.845TrpPro: 0.845 ± 0.017	0.489TrpGln: 0.489 ± 0.015	1.52TrpArg: 1.52 ± 0.025	0.854TrpSer: 0.854 ± 0.02	1.093TrpThr: 1.093 ± 0.026	0.945TrpVal: 0.945 ± 0.02	0.353TrpTrp: 0.353 ± 0.012	0.347TrpTyr: 0.347 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.032	0.187TyrCys: 0.187 ± 0.009	1.388TyrAsp: 1.388 ± 0.029	1.207TyrGlu: 1.207 ± 0.023	0.65TyrPhe: 0.65 ± 0.016	2.264TyrGly: 2.264 ± 0.031	0.391TyrHis: 0.391 ± 0.014	0.592TyrIle: 0.592 ± 0.015	0.406TyrLys: 0.406 ± 0.013	2.151TyrLeu: 2.151 ± 0.033	0.29TyrMet: 0.29 ± 0.011	0.401TyrAsn: 0.401 ± 0.013	1.081TyrPro: 1.081 ± 0.019	0.548TyrGln: 0.548 ± 0.016	1.9TyrArg: 1.9 ± 0.029	0.948TyrSer: 0.948 ± 0.02	1.109TyrThr: 1.109 ± 0.02	1.625TyrVal: 1.625 ± 0.029	0.342TyrTrp: 0.342 ± 0.01	0.464TyrTyr: 0.464 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7888 proteins (2512395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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