Amino acid dipepetide frequency for Arthrobacter sp. ERGS1:01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.381AlaAla: 21.381 ± 0.209	0.766AlaCys: 0.766 ± 0.027	7.418AlaAsp: 7.418 ± 0.09	7.457AlaGlu: 7.457 ± 0.089	3.817AlaPhe: 3.817 ± 0.058	13.624AlaGly: 13.624 ± 0.133	2.445AlaHis: 2.445 ± 0.044	5.443AlaIle: 5.443 ± 0.08	4.067AlaLys: 4.067 ± 0.078	13.754AlaLeu: 13.754 ± 0.12	3.135AlaMet: 3.135 ± 0.054	3.313AlaAsn: 3.313 ± 0.077	6.264AlaPro: 6.264 ± 0.094	4.186AlaGln: 4.186 ± 0.067	7.66AlaArg: 7.66 ± 0.083	6.687AlaSer: 6.687 ± 0.074	7.442AlaThr: 7.442 ± 0.088	11.679AlaVal: 11.679 ± 0.109	1.71AlaTrp: 1.71 ± 0.041	2.373AlaTyr: 2.373 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.718CysAla: 0.718 ± 0.026	0.06CysCys: 0.06 ± 0.007	0.353CysAsp: 0.353 ± 0.017	0.305CysGlu: 0.305 ± 0.015	0.194CysPhe: 0.194 ± 0.012	0.682CysGly: 0.682 ± 0.021	0.128CysHis: 0.128 ± 0.01	0.286CysIle: 0.286 ± 0.018	0.121CysLys: 0.121 ± 0.009	0.519CysLeu: 0.519 ± 0.021	0.108CysMet: 0.108 ± 0.009	0.144CysAsn: 0.144 ± 0.011	0.318CysPro: 0.318 ± 0.02	0.166CysGln: 0.166 ± 0.012	0.336CysArg: 0.336 ± 0.015	0.353CysSer: 0.353 ± 0.016	0.434CysThr: 0.434 ± 0.019	0.468CysVal: 0.468 ± 0.022	0.096CysTrp: 0.096 ± 0.009	0.132CysTyr: 0.132 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.721AspAla: 7.721 ± 0.095	0.303AspCys: 0.303 ± 0.016	3.118AspAsp: 3.118 ± 0.061	2.902AspGlu: 2.902 ± 0.056	1.977AspPhe: 1.977 ± 0.043	5.809AspGly: 5.809 ± 0.086	1.25AspHis: 1.25 ± 0.037	2.408AspIle: 2.408 ± 0.045	1.308AspLys: 1.308 ± 0.037	5.279AspLeu: 5.279 ± 0.073	0.998AspMet: 0.998 ± 0.025	1.195AspAsn: 1.195 ± 0.034	3.608AspPro: 3.608 ± 0.063	1.461AspGln: 1.461 ± 0.036	3.076AspArg: 3.076 ± 0.066	2.836AspSer: 2.836 ± 0.053	2.806AspThr: 2.806 ± 0.051	4.821AspVal: 4.821 ± 0.08	0.918AspTrp: 0.918 ± 0.034	1.288AspTyr: 1.288 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.386GluAla: 6.386 ± 0.079	0.266GluCys: 0.266 ± 0.013	2.548GluAsp: 2.548 ± 0.05	2.733GluGlu: 2.733 ± 0.064	1.755GluPhe: 1.755 ± 0.036	3.423GluGly: 3.423 ± 0.051	1.308GluHis: 1.308 ± 0.034	2.575GluIle: 2.575 ± 0.056	1.639GluLys: 1.639 ± 0.041	6.954GluLeu: 6.954 ± 0.092	1.033GluMet: 1.033 ± 0.033	1.494GluAsn: 1.494 ± 0.034	2.637GluPro: 2.637 ± 0.05	1.977GluGln: 1.977 ± 0.04	3.695GluArg: 3.695 ± 0.068	2.905GluSer: 2.905 ± 0.05	2.823GluThr: 2.823 ± 0.051	3.871GluVal: 3.871 ± 0.056	0.687GluTrp: 0.687 ± 0.024	0.995GluTyr: 0.995 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.354PheAla: 4.354 ± 0.057	0.243PheCys: 0.243 ± 0.014	2.127PheAsp: 2.127 ± 0.043	1.6PheGlu: 1.6 ± 0.035	1.221PhePhe: 1.221 ± 0.033	3.427PheGly: 3.427 ± 0.043	0.669PheHis: 0.669 ± 0.024	1.461PheIle: 1.461 ± 0.043	0.794PheLys: 0.794 ± 0.03	3.085PheLeu: 3.085 ± 0.059	0.674PheMet: 0.674 ± 0.023	1.015PheAsn: 1.015 ± 0.03	1.556PhePro: 1.556 ± 0.037	0.844PheGln: 0.844 ± 0.026	1.709PheArg: 1.709 ± 0.04	2.136PheSer: 2.136 ± 0.046	2.358PheThr: 2.358 ± 0.047	2.612PheVal: 2.612 ± 0.056	0.503PheTrp: 0.503 ± 0.019	0.723PheTyr: 0.723 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.451GlyAla: 10.451 ± 0.109	0.6GlyCys: 0.6 ± 0.022	4.069GlyAsp: 4.069 ± 0.063	4.29GlyGlu: 4.29 ± 0.068	3.317GlyPhe: 3.317 ± 0.056	7.571GlyGly: 7.571 ± 0.102	2.092GlyHis: 2.092 ± 0.041	4.877GlyIle: 4.877 ± 0.06	2.997GlyLys: 2.997 ± 0.05	9.482GlyLeu: 9.482 ± 0.092	2.211GlyMet: 2.211 ± 0.049	2.424GlyAsn: 2.424 ± 0.051	4.097GlyPro: 4.097 ± 0.066	2.876GlyGln: 2.876 ± 0.053	5.73GlyArg: 5.73 ± 0.087	5.447GlySer: 5.447 ± 0.07	6.352GlyThr: 6.352 ± 0.078	7.641GlyVal: 7.641 ± 0.091	1.649GlyTrp: 1.649 ± 0.042	2.411GlyTyr: 2.411 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.317HisAla: 2.317 ± 0.047	0.151HisCys: 0.151 ± 0.011	1.155HisAsp: 1.155 ± 0.034	1.07HisGlu: 1.07 ± 0.032	0.733HisPhe: 0.733 ± 0.026	2.152HisGly: 2.152 ± 0.044	0.622HisHis: 0.622 ± 0.024	0.816HisIle: 0.816 ± 0.028	0.483HisLys: 0.483 ± 0.018	2.13HisLeu: 2.13 ± 0.037	0.398HisMet: 0.398 ± 0.019	0.498HisAsn: 0.498 ± 0.019	1.458HisPro: 1.458 ± 0.035	0.686HisGln: 0.686 ± 0.026	1.426HisArg: 1.426 ± 0.036	1.133HisSer: 1.133 ± 0.03	1.108HisThr: 1.108 ± 0.029	1.619HisVal: 1.619 ± 0.033	0.359HisTrp: 0.359 ± 0.016	0.502HisTyr: 0.502 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.017IleAla: 6.017 ± 0.081	0.349IleCys: 0.349 ± 0.017	2.786IleAsp: 2.786 ± 0.049	2.424IleGlu: 2.424 ± 0.047	1.551IlePhe: 1.551 ± 0.04	4.391IleGly: 4.391 ± 0.064	0.893IleHis: 0.893 ± 0.03	2.064IleIle: 2.064 ± 0.045	1.314IleLys: 1.314 ± 0.038	4.194IleLeu: 4.194 ± 0.066	0.923IleMet: 0.923 ± 0.03	1.384IleAsn: 1.384 ± 0.034	2.512IlePro: 2.512 ± 0.051	1.112IleGln: 1.112 ± 0.034	2.52IleArg: 2.52 ± 0.042	2.727IleSer: 2.727 ± 0.048	2.996IleThr: 2.996 ± 0.056	3.877IleVal: 3.877 ± 0.065	0.549IleTrp: 0.549 ± 0.023	0.91IleTyr: 0.91 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.715LysAla: 3.715 ± 0.072	0.11LysCys: 0.11 ± 0.01	1.693LysAsp: 1.693 ± 0.043	1.354LysGlu: 1.354 ± 0.043	0.882LysPhe: 0.882 ± 0.029	2.02LysGly: 2.02 ± 0.042	0.574LysHis: 0.574 ± 0.023	1.421LysIle: 1.421 ± 0.04	1.015LysLys: 1.015 ± 0.034	2.783LysLeu: 2.783 ± 0.051	0.681LysMet: 0.681 ± 0.027	0.844LysAsn: 0.844 ± 0.024	1.57LysPro: 1.57 ± 0.039	0.801LysGln: 0.801 ± 0.025	1.548LysArg: 1.548 ± 0.042	1.648LysSer: 1.648 ± 0.041	1.758LysThr: 1.758 ± 0.042	2.444LysVal: 2.444 ± 0.052	0.366LysTrp: 0.366 ± 0.018	0.713LysTyr: 0.713 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.633LeuAla: 15.633 ± 0.123	0.661LeuCys: 0.661 ± 0.025	6.168LeuAsp: 6.168 ± 0.083	5.154LeuGlu: 5.154 ± 0.072	3.088LeuPhe: 3.088 ± 0.061	9.587LeuGly: 9.587 ± 0.103	2.001LeuHis: 2.001 ± 0.04	4.418LeuIle: 4.418 ± 0.076	2.581LeuLys: 2.581 ± 0.054	10.456LeuLeu: 10.456 ± 0.121	2.102LeuMet: 2.102 ± 0.041	2.586LeuAsn: 2.586 ± 0.045	5.631LeuPro: 5.631 ± 0.066	2.765LeuGln: 2.765 ± 0.052	6.563LeuArg: 6.563 ± 0.086	6.153LeuSer: 6.153 ± 0.078	6.189LeuThr: 6.189 ± 0.079	8.713LeuVal: 8.713 ± 0.109	1.331LeuTrp: 1.331 ± 0.036	1.688LeuTyr: 1.688 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.961MetAla: 2.961 ± 0.056	0.121MetCys: 0.121 ± 0.009	1.164MetAsp: 1.164 ± 0.032	0.99MetGlu: 0.99 ± 0.027	0.635MetPhe: 0.635 ± 0.024	1.723MetGly: 1.723 ± 0.039	0.367MetHis: 0.367 ± 0.017	0.982MetIle: 0.982 ± 0.031	0.651MetLys: 0.651 ± 0.024	2.041MetLeu: 2.041 ± 0.04	0.427MetMet: 0.427 ± 0.019	0.689MetAsn: 0.689 ± 0.027	1.199MetPro: 1.199 ± 0.032	0.503MetGln: 0.503 ± 0.018	1.237MetArg: 1.237 ± 0.03	1.603MetSer: 1.603 ± 0.034	1.782MetThr: 1.782 ± 0.037	1.868MetVal: 1.868 ± 0.044	0.243MetTrp: 0.243 ± 0.013	0.369MetTyr: 0.369 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.291AsnAla: 3.291 ± 0.059	0.166AsnCys: 0.166 ± 0.011	1.466AsnAsp: 1.466 ± 0.037	1.153AsnGlu: 1.153 ± 0.032	0.919AsnPhe: 0.919 ± 0.03	2.578AsnGly: 2.578 ± 0.044	0.545AsnHis: 0.545 ± 0.022	1.134AsnIle: 1.134 ± 0.032	0.753AsnLys: 0.753 ± 0.024	2.45AsnLeu: 2.45 ± 0.049	0.532AsnMet: 0.532 ± 0.02	0.816AsnAsn: 0.816 ± 0.028	2.059AsnPro: 2.059 ± 0.041	0.791AsnGln: 0.791 ± 0.025	1.536AsnArg: 1.536 ± 0.037	1.482AsnSer: 1.482 ± 0.038	1.672AsnThr: 1.672 ± 0.101	2.126AsnVal: 2.126 ± 0.046	0.405AsnTrp: 0.405 ± 0.017	0.677AsnTyr: 0.677 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.193ProAla: 8.193 ± 0.105	0.202ProCys: 0.202 ± 0.014	3.385ProAsp: 3.385 ± 0.059	3.549ProGlu: 3.549 ± 0.053	1.736ProPhe: 1.736 ± 0.033	5.339ProGly: 5.339 ± 0.087	1.077ProHis: 1.077 ± 0.032	1.833ProIle: 1.833 ± 0.037	1.369ProLys: 1.369 ± 0.035	4.963ProLeu: 4.963 ± 0.063	1.065ProMet: 1.065 ± 0.033	1.319ProAsn: 1.319 ± 0.035	1.992ProPro: 1.992 ± 0.045	1.583ProGln: 1.583 ± 0.031	2.709ProArg: 2.709 ± 0.059	3.084ProSer: 3.084 ± 0.053	3.05ProThr: 3.05 ± 0.053	4.792ProVal: 4.792 ± 0.062	0.834ProTrp: 0.834 ± 0.032	1.057ProTyr: 1.057 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.93GlnAla: 3.93 ± 0.052	0.161GlnCys: 0.161 ± 0.012	1.441GlnAsp: 1.441 ± 0.035	1.414GlnGlu: 1.414 ± 0.031	0.967GlnPhe: 0.967 ± 0.028	2.35GlnGly: 2.35 ± 0.043	0.649GlnHis: 0.649 ± 0.026	1.502GlnIle: 1.502 ± 0.035	0.838GlnLys: 0.838 ± 0.024	3.58GlnLeu: 3.58 ± 0.057	0.676GlnMet: 0.676 ± 0.024	0.713GlnAsn: 0.713 ± 0.026	1.479GlnPro: 1.479 ± 0.034	1.167GlnGln: 1.167 ± 0.033	2.151GlnArg: 2.151 ± 0.047	1.672GlnSer: 1.672 ± 0.04	1.562GlnThr: 1.562 ± 0.038	2.35GlnVal: 2.35 ± 0.045	0.59GlnTrp: 0.59 ± 0.023	0.637GlnTyr: 0.637 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.917ArgAla: 6.917 ± 0.079	0.324ArgCys: 0.324 ± 0.014	3.28ArgAsp: 3.28 ± 0.053	3.62ArgGlu: 3.62 ± 0.055	2.02ArgPhe: 2.02 ± 0.041	4.517ArgGly: 4.517 ± 0.067	1.543ArgHis: 1.543 ± 0.033	3.095ArgIle: 3.095 ± 0.057	1.824ArgLys: 1.824 ± 0.04	6.338ArgLeu: 6.338 ± 0.083	1.426ArgMet: 1.426 ± 0.033	1.778ArgAsn: 1.778 ± 0.045	3.122ArgPro: 3.122 ± 0.061	2.014ArgGln: 2.014 ± 0.045	4.91ArgArg: 4.91 ± 0.088	3.546ArgSer: 3.546 ± 0.063	3.803ArgThr: 3.803 ± 0.057	4.453ArgVal: 4.453 ± 0.068	0.98ArgTrp: 0.98 ± 0.029	1.373ArgTyr: 1.373 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.309SerAla: 7.309 ± 0.091	0.35SerCys: 0.35 ± 0.017	2.764SerAsp: 2.764 ± 0.053	2.622SerGlu: 2.622 ± 0.043	1.98SerPhe: 1.98 ± 0.039	5.703SerGly: 5.703 ± 0.079	1.113SerHis: 1.113 ± 0.032	2.648SerIle: 2.648 ± 0.043	1.536SerLys: 1.536 ± 0.037	5.813SerLeu: 5.813 ± 0.074	1.441SerMet: 1.441 ± 0.032	1.509SerAsn: 1.509 ± 0.041	3.104SerPro: 3.104 ± 0.048	1.626SerGln: 1.626 ± 0.034	3.546SerArg: 3.546 ± 0.057	3.589SerSer: 3.589 ± 0.064	3.714SerThr: 3.714 ± 0.056	4.778SerVal: 4.778 ± 0.069	1.01SerTrp: 1.01 ± 0.03	1.465SerTyr: 1.465 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	8.285ThrAla: 8.285 ± 0.103	0.262ThrCys: 0.262 ± 0.015	3.222ThrAsp: 3.222 ± 0.061	2.948ThrGlu: 2.948 ± 0.05	2.084ThrPhe: 2.084 ± 0.04	5.919ThrGly: 5.919 ± 0.079	1.163ThrHis: 1.163 ± 0.032	2.915ThrIle: 2.915 ± 0.052	1.505ThrLys: 1.505 ± 0.039	6.309ThrLeu: 6.309 ± 0.066	1.19ThrMet: 1.19 ± 0.033	1.512ThrAsn: 1.512 ± 0.045	3.856ThrPro: 3.856 ± 0.056	1.587ThrGln: 1.587 ± 0.042	3.075ThrArg: 3.075 ± 0.056	3.506ThrSer: 3.506 ± 0.058	3.979ThrThr: 3.979 ± 0.077	6.014ThrVal: 6.014 ± 0.077	0.782ThrTrp: 0.782 ± 0.024	1.151ThrTyr: 1.151 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.066ValAla: 11.066 ± 0.112	0.576ValCys: 0.576 ± 0.02	4.891ValAsp: 4.891 ± 0.062	4.408ValGlu: 4.408 ± 0.069	2.785ValPhe: 2.785 ± 0.048	6.676ValGly: 6.676 ± 0.086	1.697ValHis: 1.697 ± 0.04	4.138ValIle: 4.138 ± 0.06	2.181ValLys: 2.181 ± 0.048	9.266ValLeu: 9.266 ± 0.105	1.846ValMet: 1.846 ± 0.04	2.28ValAsn: 2.28 ± 0.066	4.819ValPro: 4.819 ± 0.064	2.34ValGln: 2.34 ± 0.048	5.053ValArg: 5.053 ± 0.07	4.954ValSer: 4.954 ± 0.064	5.38ValThr: 5.38 ± 0.066	8.235ValVal: 8.235 ± 0.115	1.018ValTrp: 1.018 ± 0.028	1.441ValTyr: 1.441 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.564TrpAla: 1.564 ± 0.033	0.112TrpCys: 0.112 ± 0.01	0.813TrpAsp: 0.813 ± 0.029	0.666TrpGlu: 0.666 ± 0.022	0.591TrpPhe: 0.591 ± 0.022	1.065TrpGly: 1.065 ± 0.031	0.347TrpHis: 0.347 ± 0.017	0.735TrpIle: 0.735 ± 0.027	0.4TrpLys: 0.4 ± 0.019	1.801TrpLeu: 1.801 ± 0.044	0.346TrpMet: 0.346 ± 0.015	0.49TrpAsn: 0.49 ± 0.019	0.737TrpPro: 0.737 ± 0.027	0.613TrpGln: 0.613 ± 0.025	1.002TrpArg: 1.002 ± 0.028	0.85TrpSer: 0.85 ± 0.032	0.867TrpThr: 0.867 ± 0.03	1.066TrpVal: 1.066 ± 0.033	0.291TrpTrp: 0.291 ± 0.016	0.296TrpTyr: 0.296 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.41TyrAla: 2.41 ± 0.048	0.138TyrCys: 0.138 ± 0.01	1.22TyrAsp: 1.22 ± 0.031	1.044TyrGlu: 1.044 ± 0.029	0.858TyrPhe: 0.858 ± 0.026	2.027TyrGly: 2.027 ± 0.038	0.335TyrHis: 0.335 ± 0.016	0.742TyrIle: 0.742 ± 0.025	0.566TyrLys: 0.566 ± 0.022	2.269TyrLeu: 2.269 ± 0.041	0.343TyrMet: 0.343 ± 0.015	0.549TyrAsn: 0.549 ± 0.024	1.113TyrPro: 1.113 ± 0.029	0.73TyrGln: 0.73 ± 0.026	1.404TyrArg: 1.404 ± 0.035	1.308TyrSer: 1.308 ± 0.031	1.189TyrThr: 1.189 ± 0.034	1.626TyrVal: 1.626 ± 0.034	0.332TyrTrp: 0.332 ± 0.017	0.515TyrTyr: 0.515 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3894 proteins (1235914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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