Amino acid dipepetide frequency for Ramlibacter tataouinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.869AlaAla: 18.869 ± 0.185	1.411AlaCys: 1.411 ± 0.037	6.058AlaAsp: 6.058 ± 0.075	6.45AlaGlu: 6.45 ± 0.085	4.188AlaPhe: 4.188 ± 0.065	11.75AlaGly: 11.75 ± 0.12	2.634AlaHis: 2.634 ± 0.04	5.344AlaIle: 5.344 ± 0.068	3.953AlaLys: 3.953 ± 0.077	14.573AlaLeu: 14.573 ± 0.143	3.611AlaMet: 3.611 ± 0.05	2.832AlaAsn: 2.832 ± 0.051	6.375AlaPro: 6.375 ± 0.099	6.004AlaGln: 6.004 ± 0.071	9.658AlaArg: 9.658 ± 0.113	6.71AlaSer: 6.71 ± 0.087	5.939AlaThr: 5.939 ± 0.082	9.28AlaVal: 9.28 ± 0.089	2.083AlaTrp: 2.083 ± 0.045	2.525AlaTyr: 2.525 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.247CysAla: 1.247 ± 0.031	0.108CysCys: 0.108 ± 0.009	0.55CysAsp: 0.55 ± 0.02	0.588CysGlu: 0.588 ± 0.021	0.309CysPhe: 0.309 ± 0.016	1.051CysGly: 1.051 ± 0.031	0.279CysHis: 0.279 ± 0.015	0.418CysIle: 0.418 ± 0.017	0.229CysLys: 0.229 ± 0.013	0.855CysLeu: 0.855 ± 0.027	0.22CysMet: 0.22 ± 0.012	0.22CysAsn: 0.22 ± 0.012	0.509CysPro: 0.509 ± 0.018	0.25CysGln: 0.25 ± 0.013	0.627CysArg: 0.627 ± 0.025	0.493CysSer: 0.493 ± 0.019	0.466CysThr: 0.466 ± 0.022	0.758CysVal: 0.758 ± 0.026	0.149CysTrp: 0.149 ± 0.011	0.205CysTyr: 0.205 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.739AspAla: 6.739 ± 0.105	0.457AspCys: 0.457 ± 0.016	2.429AspAsp: 2.429 ± 0.051	3.272AspGlu: 3.272 ± 0.057	1.975AspPhe: 1.975 ± 0.043	4.354AspGly: 4.354 ± 0.062	1.058AspHis: 1.058 ± 0.03	2.265AspIle: 2.265 ± 0.048	1.828AspLys: 1.828 ± 0.044	5.188AspLeu: 5.188 ± 0.065	1.185AspMet: 1.185 ± 0.028	1.136AspAsn: 1.136 ± 0.036	3.06AspPro: 3.06 ± 0.052	1.527AspGln: 1.527 ± 0.036	3.296AspArg: 3.296 ± 0.051	2.256AspSer: 2.256 ± 0.053	2.313AspThr: 2.313 ± 0.05	3.906AspVal: 3.906 ± 0.067	0.945AspTrp: 0.945 ± 0.033	1.33AspTyr: 1.33 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.055GluAla: 7.055 ± 0.081	0.442GluCys: 0.442 ± 0.022	2.35GluAsp: 2.35 ± 0.05	2.757GluGlu: 2.757 ± 0.062	2.01GluPhe: 2.01 ± 0.037	4.116GluGly: 4.116 ± 0.06	1.353GluHis: 1.353 ± 0.039	2.731GluIle: 2.731 ± 0.053	1.947GluLys: 1.947 ± 0.046	6.309GluLeu: 6.309 ± 0.076	1.306GluMet: 1.306 ± 0.033	1.211GluAsn: 1.211 ± 0.029	2.705GluPro: 2.705 ± 0.044	2.593GluGln: 2.593 ± 0.049	4.83GluArg: 4.83 ± 0.074	2.632GluSer: 2.632 ± 0.046	2.4GluThr: 2.4 ± 0.045	4.282GluVal: 4.282 ± 0.069	0.814GluTrp: 0.814 ± 0.025	1.1GluTyr: 1.1 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.474PheAla: 4.474 ± 0.063	0.399PheCys: 0.399 ± 0.016	2.519PheAsp: 2.519 ± 0.042	2.162PheGlu: 2.162 ± 0.043	1.36PhePhe: 1.36 ± 0.034	3.558PheGly: 3.558 ± 0.053	0.742PheHis: 0.742 ± 0.024	1.542PheIle: 1.542 ± 0.034	1.131PheLys: 1.131 ± 0.034	2.99PheLeu: 2.99 ± 0.052	0.858PheMet: 0.858 ± 0.027	1.042PheAsn: 1.042 ± 0.031	1.628PhePro: 1.628 ± 0.038	1.031PheGln: 1.031 ± 0.029	2.092PheArg: 2.092 ± 0.039	2.09PheSer: 2.09 ± 0.04	1.898PheThr: 1.898 ± 0.042	2.807PheVal: 2.807 ± 0.051	0.541PheTrp: 0.541 ± 0.021	0.866PheTyr: 0.866 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.942GlyAla: 9.942 ± 0.109	0.972GlyCys: 0.972 ± 0.031	4.053GlyAsp: 4.053 ± 0.072	4.883GlyGlu: 4.883 ± 0.066	3.396GlyPhe: 3.396 ± 0.054	7.523GlyGly: 7.523 ± 0.122	1.941GlyHis: 1.941 ± 0.044	4.07GlyIle: 4.07 ± 0.065	3.415GlyLys: 3.415 ± 0.058	8.76GlyLeu: 8.76 ± 0.095	2.432GlyMet: 2.432 ± 0.042	2.265GlyAsn: 2.265 ± 0.073	3.397GlyPro: 3.397 ± 0.06	3.425GlyGln: 3.425 ± 0.06	5.882GlyArg: 5.882 ± 0.075	4.706GlySer: 4.706 ± 0.077	4.483GlyThr: 4.483 ± 0.081	6.737GlyVal: 6.737 ± 0.07	1.556GlyTrp: 1.556 ± 0.039	2.283GlyTyr: 2.283 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.79HisAla: 2.79 ± 0.045	0.289HisCys: 0.289 ± 0.016	1.118HisAsp: 1.118 ± 0.032	1.245HisGlu: 1.245 ± 0.033	0.865HisPhe: 0.865 ± 0.025	2.181HisGly: 2.181 ± 0.043	0.575HisHis: 0.575 ± 0.019	0.898HisIle: 0.898 ± 0.027	0.557HisLys: 0.557 ± 0.022	2.192HisLeu: 2.192 ± 0.044	0.528HisMet: 0.528 ± 0.022	0.481HisAsn: 0.481 ± 0.02	1.485HisPro: 1.485 ± 0.036	0.673HisGln: 0.673 ± 0.023	1.485HisArg: 1.485 ± 0.036	1.014HisSer: 1.014 ± 0.025	0.992HisThr: 0.992 ± 0.029	1.616HisVal: 1.616 ± 0.035	0.432HisTrp: 0.432 ± 0.02	0.624HisTyr: 0.624 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.19IleAla: 6.19 ± 0.066	0.415IleCys: 0.415 ± 0.017	2.814IleAsp: 2.814 ± 0.05	3.078IleGlu: 3.078 ± 0.056	1.236IlePhe: 1.236 ± 0.033	4.155IleGly: 4.155 ± 0.067	0.857IleHis: 0.857 ± 0.024	1.437IleIle: 1.437 ± 0.035	1.372IleLys: 1.372 ± 0.037	3.227IleLeu: 3.227 ± 0.055	0.766IleMet: 0.766 ± 0.023	1.309IleAsn: 1.309 ± 0.034	2.097IlePro: 2.097 ± 0.042	1.273IleGln: 1.273 ± 0.031	2.614IleArg: 2.614 ± 0.047	2.197IleSer: 2.197 ± 0.043	2.374IleThr: 2.374 ± 0.049	3.572IleVal: 3.572 ± 0.053	0.446IleTrp: 0.446 ± 0.021	1.012IleTyr: 1.012 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.091LysAla: 4.091 ± 0.068	0.184LysCys: 0.184 ± 0.012	1.739LysAsp: 1.739 ± 0.042	1.628LysGlu: 1.628 ± 0.039	1.04LysPhe: 1.04 ± 0.033	2.577LysGly: 2.577 ± 0.047	0.668LysHis: 0.668 ± 0.024	1.489LysIle: 1.489 ± 0.032	1.419LysLys: 1.419 ± 0.044	3.685LysLeu: 3.685 ± 0.058	0.89LysMet: 0.89 ± 0.028	0.909LysAsn: 0.909 ± 0.028	2.084LysPro: 2.084 ± 0.042	1.176LysGln: 1.176 ± 0.032	2.257LysArg: 2.257 ± 0.044	1.789LysSer: 1.789 ± 0.043	1.78LysThr: 1.78 ± 0.038	2.671LysVal: 2.671 ± 0.053	0.372LysTrp: 0.372 ± 0.014	0.736LysTyr: 0.736 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.482LeuAla: 15.482 ± 0.148	0.999LeuCys: 0.999 ± 0.031	5.497LeuAsp: 5.497 ± 0.063	5.443LeuGlu: 5.443 ± 0.074	3.378LeuPhe: 3.378 ± 0.055	8.746LeuGly: 8.746 ± 0.1	2.247LeuHis: 2.247 ± 0.04	3.845LeuIle: 3.845 ± 0.07	3.756LeuLys: 3.756 ± 0.054	10.869LeuLeu: 10.869 ± 0.147	2.53LeuMet: 2.53 ± 0.05	2.528LeuAsn: 2.528 ± 0.045	6.008LeuPro: 6.008 ± 0.071	4.04LeuGln: 4.04 ± 0.053	7.65LeuArg: 7.65 ± 0.094	5.62LeuSer: 5.62 ± 0.069	5.012LeuThr: 5.012 ± 0.067	8.06LeuVal: 8.06 ± 0.095	1.338LeuTrp: 1.338 ± 0.04	1.996LeuTyr: 1.996 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.096MetAla: 3.096 ± 0.059	0.208MetCys: 0.208 ± 0.014	1.181MetAsp: 1.181 ± 0.029	1.166MetGlu: 1.166 ± 0.03	0.762MetPhe: 0.762 ± 0.026	1.947MetGly: 1.947 ± 0.042	0.526MetHis: 0.526 ± 0.022	0.986MetIle: 0.986 ± 0.029	1.192MetLys: 1.192 ± 0.031	2.723MetLeu: 2.723 ± 0.052	0.614MetMet: 0.614 ± 0.022	0.876MetAsn: 0.876 ± 0.028	1.481MetPro: 1.481 ± 0.036	1.05MetGln: 1.05 ± 0.026	1.846MetArg: 1.846 ± 0.042	1.575MetSer: 1.575 ± 0.039	1.476MetThr: 1.476 ± 0.03	1.716MetVal: 1.716 ± 0.038	0.236MetTrp: 0.236 ± 0.013	0.441MetTyr: 0.441 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.068AsnAla: 3.068 ± 0.056	0.271AsnCys: 0.271 ± 0.015	1.187AsnAsp: 1.187 ± 0.038	1.29AsnGlu: 1.29 ± 0.029	0.999AsnPhe: 0.999 ± 0.028	2.142AsnGly: 2.142 ± 0.064	0.475AsnHis: 0.475 ± 0.016	1.179AsnIle: 1.179 ± 0.035	0.791AsnLys: 0.791 ± 0.03	2.496AsnLeu: 2.496 ± 0.048	0.562AsnMet: 0.562 ± 0.02	0.722AsnAsn: 0.722 ± 0.023	1.809AsnPro: 1.809 ± 0.045	0.835AsnGln: 0.835 ± 0.023	1.615AsnArg: 1.615 ± 0.036	1.145AsnSer: 1.145 ± 0.033	1.281AsnThr: 1.281 ± 0.038	1.983AsnVal: 1.983 ± 0.05	0.414AsnTrp: 0.414 ± 0.017	0.716AsnTyr: 0.716 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.487ProAla: 7.487 ± 0.096	0.381ProCys: 0.381 ± 0.018	2.978ProAsp: 2.978 ± 0.049	3.457ProGlu: 3.457 ± 0.056	1.847ProPhe: 1.847 ± 0.039	5.052ProGly: 5.052 ± 0.064	1.152ProHis: 1.152 ± 0.031	1.822ProIle: 1.822 ± 0.039	1.589ProLys: 1.589 ± 0.036	5.164ProLeu: 5.164 ± 0.062	1.329ProMet: 1.329 ± 0.033	1.297ProAsn: 1.297 ± 0.032	2.9ProPro: 2.9 ± 0.061	2.307ProGln: 2.307 ± 0.042	3.263ProArg: 3.263 ± 0.06	2.643ProSer: 2.643 ± 0.047	2.447ProThr: 2.447 ± 0.056	4.463ProVal: 4.463 ± 0.06	0.829ProTrp: 0.829 ± 0.025	1.171ProTyr: 1.171 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.694GlnAla: 5.694 ± 0.076	0.305GlnCys: 0.305 ± 0.016	1.64GlnAsp: 1.64 ± 0.036	1.785GlnGlu: 1.785 ± 0.038	1.316GlnPhe: 1.316 ± 0.033	3.182GlnGly: 3.182 ± 0.051	0.875GlnHis: 0.875 ± 0.025	1.488GlnIle: 1.488 ± 0.035	1.13GlnLys: 1.13 ± 0.03	4.334GlnLeu: 4.334 ± 0.076	0.904GlnMet: 0.904 ± 0.026	0.742GlnAsn: 0.742 ± 0.025	2.266GlnPro: 2.266 ± 0.042	1.895GlnGln: 1.895 ± 0.045	3.269GlnArg: 3.269 ± 0.061	1.863GlnSer: 1.863 ± 0.04	1.6GlnThr: 1.6 ± 0.036	3.289GlnVal: 3.289 ± 0.05	0.684GlnTrp: 0.684 ± 0.022	0.734GlnTyr: 0.734 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.293ArgAla: 8.293 ± 0.096	0.64ArgCys: 0.64 ± 0.024	3.615ArgAsp: 3.615 ± 0.066	4.726ArgGlu: 4.726 ± 0.072	2.811ArgPhe: 2.811 ± 0.054	5.026ArgGly: 5.026 ± 0.063	1.937ArgHis: 1.937 ± 0.043	3.483ArgIle: 3.483 ± 0.051	2.286ArgLys: 2.286 ± 0.048	7.902ArgLeu: 7.902 ± 0.106	1.978ArgMet: 1.978 ± 0.04	1.701ArgAsn: 1.701 ± 0.035	3.36ArgPro: 3.36 ± 0.053	2.925ArgGln: 2.925 ± 0.053	5.386ArgArg: 5.386 ± 0.083	3.557ArgSer: 3.557 ± 0.054	3.212ArgThr: 3.212 ± 0.056	5.277ArgVal: 5.277 ± 0.073	1.256ArgTrp: 1.256 ± 0.034	1.857ArgTyr: 1.857 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.17SerAla: 6.17 ± 0.093	0.495SerCys: 0.495 ± 0.019	2.516SerAsp: 2.516 ± 0.046	2.538SerGlu: 2.538 ± 0.049	2.162SerPhe: 2.162 ± 0.043	5.158SerGly: 5.158 ± 0.083	1.14SerHis: 1.14 ± 0.03	2.297SerIle: 2.297 ± 0.047	1.484SerLys: 1.484 ± 0.036	5.376SerLeu: 5.376 ± 0.08	1.406SerMet: 1.406 ± 0.033	1.329SerAsn: 1.329 ± 0.038	2.851SerPro: 2.851 ± 0.052	1.794SerGln: 1.794 ± 0.035	3.657SerArg: 3.657 ± 0.059	2.807SerSer: 2.807 ± 0.048	2.601SerThr: 2.601 ± 0.053	3.782SerVal: 3.782 ± 0.053	0.833SerTrp: 0.833 ± 0.023	1.348SerTyr: 1.348 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.787ThrAla: 5.787 ± 0.076	0.381ThrCys: 0.381 ± 0.018	2.218ThrAsp: 2.218 ± 0.059	2.307ThrGlu: 2.307 ± 0.05	1.74ThrPhe: 1.74 ± 0.037	4.743ThrGly: 4.743 ± 0.076	1.081ThrHis: 1.081 ± 0.03	2.123ThrIle: 2.123 ± 0.056	1.263ThrLys: 1.263 ± 0.034	5.638ThrLeu: 5.638 ± 0.072	1.085ThrMet: 1.085 ± 0.029	1.14ThrAsn: 1.14 ± 0.042	3.401ThrPro: 3.401 ± 0.058	1.785ThrGln: 1.785 ± 0.039	3.39ThrArg: 3.39 ± 0.051	2.548ThrSer: 2.548 ± 0.062	2.544ThrThr: 2.544 ± 0.059	4.167ThrVal: 4.167 ± 0.077	0.717ThrTrp: 0.717 ± 0.029	1.043ThrTyr: 1.043 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.693ValAla: 9.693 ± 0.106	0.733ValCys: 0.733 ± 0.021	4.089ValAsp: 4.089 ± 0.059	4.298ValGlu: 4.298 ± 0.064	2.808ValPhe: 2.808 ± 0.053	5.686ValGly: 5.686 ± 0.076	1.671ValHis: 1.671 ± 0.033	3.533ValIle: 3.533 ± 0.056	2.611ValLys: 2.611 ± 0.05	8.356ValLeu: 8.356 ± 0.092	1.958ValMet: 1.958 ± 0.046	2.17ValAsn: 2.17 ± 0.056	4.249ValPro: 4.249 ± 0.066	2.875ValGln: 2.875 ± 0.052	5.414ValArg: 5.414 ± 0.072	4.019ValSer: 4.019 ± 0.064	4.289ValThr: 4.289 ± 0.095	6.542ValVal: 6.542 ± 0.077	0.988ValTrp: 0.988 ± 0.028	1.617ValTyr: 1.617 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.469TrpAla: 1.469 ± 0.034	0.182TrpCys: 0.182 ± 0.012	0.718TrpAsp: 0.718 ± 0.024	0.614TrpGlu: 0.614 ± 0.021	0.602TrpPhe: 0.602 ± 0.023	1.073TrpGly: 1.073 ± 0.029	0.353TrpHis: 0.353 ± 0.016	0.692TrpIle: 0.692 ± 0.025	0.54TrpLys: 0.54 ± 0.021	2.055TrpLeu: 2.055 ± 0.048	0.451TrpMet: 0.451 ± 0.02	0.469TrpAsn: 0.469 ± 0.021	0.754TrpPro: 0.754 ± 0.023	0.757TrpGln: 0.757 ± 0.028	1.276TrpArg: 1.276 ± 0.035	0.851TrpSer: 0.851 ± 0.026	0.796TrpThr: 0.796 ± 0.026	1.042TrpVal: 1.042 ± 0.028	0.311TrpTrp: 0.311 ± 0.017	0.334TrpTyr: 0.334 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.612TyrAla: 2.612 ± 0.042	0.26TyrCys: 0.26 ± 0.014	1.251TyrAsp: 1.251 ± 0.084	1.257TyrGlu: 1.257 ± 0.035	0.927TyrPhe: 0.927 ± 0.029	2.098TyrGly: 2.098 ± 0.045	0.475TyrHis: 0.475 ± 0.018	0.8TyrIle: 0.8 ± 0.024	0.69TyrLys: 0.69 ± 0.022	2.351TyrLeu: 2.351 ± 0.044	0.485TyrMet: 0.485 ± 0.021	0.601TyrAsn: 0.601 ± 0.027	1.163TyrPro: 1.163 ± 0.03	0.782TyrGln: 0.782 ± 0.025	1.719TyrArg: 1.719 ± 0.039	1.227TyrSer: 1.227 ± 0.028	1.197TyrThr: 1.197 ± 0.037	1.649TyrVal: 1.649 ± 0.037	0.393TyrTrp: 0.393 ± 0.017	0.595TyrTyr: 0.595 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4136 proteins (1329615 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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