Amino acid dipepetide frequency for Marinilactibacillus sp. 15R

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.049AlaAla: 5.049 ± 0.113
0.474AlaCys: 0.474 ± 0.027
3.487AlaAsp: 3.487 ± 0.082
4.908AlaGlu: 4.908 ± 0.099
2.947AlaPhe: 2.947 ± 0.076
4.636AlaGly: 4.636 ± 0.087
1.185AlaHis: 1.185 ± 0.043
5.621AlaIle: 5.621 ± 0.099
4.193AlaLys: 4.193 ± 0.096
6.683AlaLeu: 6.683 ± 0.093
1.711AlaMet: 1.711 ± 0.049
2.763AlaAsn: 2.763 ± 0.063
1.758AlaPro: 1.758 ± 0.05
2.36AlaGln: 2.36 ± 0.063
2.412AlaArg: 2.412 ± 0.061
3.912AlaSer: 3.912 ± 0.079
3.52AlaThr: 3.52 ± 0.076
4.837AlaVal: 4.837 ± 0.094
0.494AlaTrp: 0.494 ± 0.029
2.366AlaTyr: 2.366 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.027
0.062CysCys: 0.062 ± 0.01
0.274CysAsp: 0.274 ± 0.02
0.332CysGlu: 0.332 ± 0.025
0.22CysPhe: 0.22 ± 0.019
0.437CysGly: 0.437 ± 0.026
0.146CysHis: 0.146 ± 0.016
0.347CysIle: 0.347 ± 0.022
0.29CysLys: 0.29 ± 0.022
0.449CysLeu: 0.449 ± 0.025
0.119CysMet: 0.119 ± 0.011
0.213CysAsn: 0.213 ± 0.016
0.235CysPro: 0.235 ± 0.017
0.152CysGln: 0.152 ± 0.013
0.198CysArg: 0.198 ± 0.018
0.347CysSer: 0.347 ± 0.02
0.325CysThr: 0.325 ± 0.02
0.3CysVal: 0.3 ± 0.025
0.047CysTrp: 0.047 ± 0.007
0.188CysTyr: 0.188 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.427AspAla: 3.427 ± 0.075
0.26AspCys: 0.26 ± 0.02
2.632AspAsp: 2.632 ± 0.077
4.742AspGlu: 4.742 ± 0.101
2.568AspPhe: 2.568 ± 0.06
3.391AspGly: 3.391 ± 0.083
1.116AspHis: 1.116 ± 0.036
4.437AspIle: 4.437 ± 0.075
3.726AspLys: 3.726 ± 0.079
5.493AspLeu: 5.493 ± 0.099
1.478AspMet: 1.478 ± 0.051
2.297AspAsn: 2.297 ± 0.07
2.026AspPro: 2.026 ± 0.056
2.375AspGln: 2.375 ± 0.062
2.341AspArg: 2.341 ± 0.054
3.359AspSer: 3.359 ± 0.068
3.069AspThr: 3.069 ± 0.066
3.436AspVal: 3.436 ± 0.075
0.588AspTrp: 0.588 ± 0.03
2.559AspTyr: 2.559 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.454GluAla: 5.454 ± 0.113
0.305GluCys: 0.305 ± 0.021
4.397GluAsp: 4.397 ± 0.111
7.973GluGlu: 7.973 ± 0.138
2.76GluPhe: 2.76 ± 0.062
4.223GluGly: 4.223 ± 0.09
1.3GluHis: 1.3 ± 0.037
6.184GluIle: 6.184 ± 0.108
6.719GluLys: 6.719 ± 0.103
7.532GluLeu: 7.532 ± 0.105
2.386GluMet: 2.386 ± 0.06
4.772GluAsn: 4.772 ± 0.08
1.984GluPro: 1.984 ± 0.055
3.518GluGln: 3.518 ± 0.076
3.252GluArg: 3.252 ± 0.077
4.368GluSer: 4.368 ± 0.081
4.601GluThr: 4.601 ± 0.081
5.611GluVal: 5.611 ± 0.086
0.826GluTrp: 0.826 ± 0.027
2.691GluTyr: 2.691 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
2.44PheAla: 2.44 ± 0.058
0.244PheCys: 0.244 ± 0.018
2.783PheAsp: 2.783 ± 0.063
3.058PheGlu: 3.058 ± 0.065
2.123PhePhe: 2.123 ± 0.055
3.085PheGly: 3.085 ± 0.078
0.71PheHis: 0.71 ± 0.029
3.664PheIle: 3.664 ± 0.079
2.734PheLys: 2.734 ± 0.059
4.134PheLeu: 4.134 ± 0.091
0.997PheMet: 0.997 ± 0.039
2.211PheAsn: 2.211 ± 0.053
1.497PhePro: 1.497 ± 0.047
1.435PheGln: 1.435 ± 0.045
1.417PheArg: 1.417 ± 0.04
3.47PheSer: 3.47 ± 0.08
2.547PheThr: 2.547 ± 0.06
2.673PheVal: 2.673 ± 0.066
0.432PheTrp: 0.432 ± 0.026
1.749PheTyr: 1.749 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.351GlyAla: 4.351 ± 0.101
0.348GlyCys: 0.348 ± 0.022
3.032GlyAsp: 3.032 ± 0.066
4.478GlyGlu: 4.478 ± 0.087
3.208GlyPhe: 3.208 ± 0.073
4.363GlyGly: 4.363 ± 0.093
1.25GlyHis: 1.25 ± 0.046
6.058GlyIle: 6.058 ± 0.102
4.656GlyLys: 4.656 ± 0.085
6.159GlyLeu: 6.159 ± 0.114
1.924GlyMet: 1.924 ± 0.054
2.857GlyAsn: 2.857 ± 0.073
1.468GlyPro: 1.468 ± 0.048
1.939GlyGln: 1.939 ± 0.056
2.439GlyArg: 2.439 ± 0.065
3.854GlySer: 3.854 ± 0.073
4.028GlyThr: 4.028 ± 0.078
4.605GlyVal: 4.605 ± 0.086
0.715GlyTrp: 0.715 ± 0.031
2.807GlyTyr: 2.807 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.061HisAla: 1.061 ± 0.041
0.123HisCys: 0.123 ± 0.014
0.92HisAsp: 0.92 ± 0.037
1.279HisGlu: 1.279 ± 0.048
0.943HisPhe: 0.943 ± 0.038
1.167HisGly: 1.167 ± 0.042
0.54HisHis: 0.54 ± 0.03
1.414HisIle: 1.414 ± 0.046
1.09HisLys: 1.09 ± 0.045
1.881HisLeu: 1.881 ± 0.058
0.479HisMet: 0.479 ± 0.025
0.773HisAsn: 0.773 ± 0.036
0.943HisPro: 0.943 ± 0.039
0.703HisGln: 0.703 ± 0.033
0.715HisArg: 0.715 ± 0.035
1.262HisSer: 1.262 ± 0.039
1.067HisThr: 1.067 ± 0.034
1.084HisVal: 1.084 ± 0.037
0.169HisTrp: 0.169 ± 0.013
0.842HisTyr: 0.842 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.791IleAla: 5.791 ± 0.106
0.484IleCys: 0.484 ± 0.025
5.062IleAsp: 5.062 ± 0.086
6.655IleGlu: 6.655 ± 0.106
3.323IlePhe: 3.323 ± 0.067
5.769IleGly: 5.769 ± 0.093
1.514IleHis: 1.514 ± 0.046
6.281IleIle: 6.281 ± 0.117
5.082IleLys: 5.082 ± 0.093
7.551IleLeu: 7.551 ± 0.121
1.753IleMet: 1.753 ± 0.054
3.826IleAsn: 3.826 ± 0.076
3.263IlePro: 3.263 ± 0.068
3.13IleGln: 3.13 ± 0.074
3.146IleArg: 3.146 ± 0.063
5.363IleSer: 5.363 ± 0.093
4.292IleThr: 4.292 ± 0.077
5.405IleVal: 5.405 ± 0.102
0.622IleTrp: 0.622 ± 0.032
2.56IleTyr: 2.56 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.482LysAla: 4.482 ± 0.086
0.244LysCys: 0.244 ± 0.02
3.941LysAsp: 3.941 ± 0.085
7.431LysGlu: 7.431 ± 0.125
2.03LysPhe: 2.03 ± 0.06
4.034LysGly: 4.034 ± 0.085
1.192LysHis: 1.192 ± 0.04
4.949LysIle: 4.949 ± 0.092
6.194LysLys: 6.194 ± 0.126
5.911LysLeu: 5.911 ± 0.102
2.216LysMet: 2.216 ± 0.057
3.969LysAsn: 3.969 ± 0.085
1.922LysPro: 1.922 ± 0.057
3.259LysGln: 3.259 ± 0.071
3.246LysArg: 3.246 ± 0.077
4.001LysSer: 4.001 ± 0.093
3.773LysThr: 3.773 ± 0.076
4.804LysVal: 4.804 ± 0.091
0.709LysTrp: 0.709 ± 0.029
2.329LysTyr: 2.329 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.474LeuAla: 6.474 ± 0.107
0.44LeuCys: 0.44 ± 0.022
5.323LeuAsp: 5.323 ± 0.086
7.243LeuGlu: 7.243 ± 0.119
4.641LeuPhe: 4.641 ± 0.093
5.896LeuGly: 5.896 ± 0.099
1.567LeuHis: 1.567 ± 0.046
7.448LeuIle: 7.448 ± 0.108
7.049LeuLys: 7.049 ± 0.098
9.351LeuLeu: 9.351 ± 0.148
2.53LeuMet: 2.53 ± 0.058
5.238LeuAsn: 5.238 ± 0.085
3.529LeuPro: 3.529 ± 0.07
3.018LeuGln: 3.018 ± 0.074
3.416LeuArg: 3.416 ± 0.077
7.327LeuSer: 7.327 ± 0.11
5.671LeuThr: 5.671 ± 0.09
5.934LeuVal: 5.934 ± 0.086
0.657LeuTrp: 0.657 ± 0.029
3.306LeuTyr: 3.306 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
1.758MetAla: 1.758 ± 0.055
0.088MetCys: 0.088 ± 0.01
1.691MetAsp: 1.691 ± 0.05
1.896MetGlu: 1.896 ± 0.054
0.876MetPhe: 0.876 ± 0.036
1.653MetGly: 1.653 ± 0.052
0.41MetHis: 0.41 ± 0.023
2.359MetIle: 2.359 ± 0.055
2.196MetLys: 2.196 ± 0.051
2.157MetLeu: 2.157 ± 0.052
0.767MetMet: 0.767 ± 0.037
1.699MetAsn: 1.699 ± 0.046
0.91MetPro: 0.91 ± 0.036
0.976MetGln: 0.976 ± 0.038
1.116MetArg: 1.116 ± 0.037
1.769MetSer: 1.769 ± 0.055
1.665MetThr: 1.665 ± 0.044
1.653MetVal: 1.653 ± 0.051
0.171MetTrp: 0.171 ± 0.017
0.73MetTyr: 0.73 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.858AsnAla: 2.858 ± 0.058
0.277AsnCys: 0.277 ± 0.022
2.758AsnAsp: 2.758 ± 0.058
4.126AsnGlu: 4.126 ± 0.076
1.933AsnPhe: 1.933 ± 0.055
3.638AsnGly: 3.638 ± 0.08
1.12AsnHis: 1.12 ± 0.04
3.896AsnIle: 3.896 ± 0.081
3.576AsnLys: 3.576 ± 0.08
4.568AsnLeu: 4.568 ± 0.083
1.198AsnMet: 1.198 ± 0.04
2.401AsnAsn: 2.401 ± 0.064
2.065AsnPro: 2.065 ± 0.051
2.576AsnGln: 2.576 ± 0.062
2.243AsnArg: 2.243 ± 0.059
2.78AsnSer: 2.78 ± 0.078
2.518AsnThr: 2.518 ± 0.06
3.062AsnVal: 3.062 ± 0.054
0.564AsnTrp: 0.564 ± 0.032
1.916AsnTyr: 1.916 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.073ProAla: 2.073 ± 0.062
0.151ProCys: 0.151 ± 0.013
2.009ProAsp: 2.009 ± 0.049
3.12ProGlu: 3.12 ± 0.067
1.626ProPhe: 1.626 ± 0.049
1.95ProGly: 1.95 ± 0.052
0.671ProHis: 0.671 ± 0.032
2.644ProIle: 2.644 ± 0.071
1.999ProLys: 1.999 ± 0.053
3.078ProLeu: 3.078 ± 0.063
0.765ProMet: 0.765 ± 0.036
1.677ProAsn: 1.677 ± 0.048
0.628ProPro: 0.628 ± 0.036
0.985ProGln: 0.985 ± 0.037
1.031ProArg: 1.031 ± 0.037
2.015ProSer: 2.015 ± 0.059
1.879ProThr: 1.879 ± 0.052
2.501ProVal: 2.501 ± 0.063
0.302ProTrp: 0.302 ± 0.024
1.347ProTyr: 1.347 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.7GlnAla: 2.7 ± 0.065
0.173GlnCys: 0.173 ± 0.018
1.849GlnAsp: 1.849 ± 0.053
3.024GlnGlu: 3.024 ± 0.063
1.677GlnPhe: 1.677 ± 0.048
1.947GlnGly: 1.947 ± 0.047
0.652GlnHis: 0.652 ± 0.029
2.885GlnIle: 2.885 ± 0.061
2.941GlnLys: 2.941 ± 0.066
4.001GlnLeu: 4.001 ± 0.09
1.089GlnMet: 1.089 ± 0.045
2.008GlnAsn: 2.008 ± 0.053
1.011GlnPro: 1.011 ± 0.039
1.544GlnGln: 1.544 ± 0.054
1.337GlnArg: 1.337 ± 0.048
2.44GlnSer: 2.44 ± 0.069
2.219GlnThr: 2.219 ± 0.066
2.507GlnVal: 2.507 ± 0.062
0.306GlnTrp: 0.306 ± 0.019
1.614GlnTyr: 1.614 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.234ArgAla: 2.234 ± 0.058
0.152ArgCys: 0.152 ± 0.016
1.872ArgAsp: 1.872 ± 0.05
3.072ArgGlu: 3.072 ± 0.07
1.771ArgPhe: 1.771 ± 0.048
2.189ArgGly: 2.189 ± 0.065
0.68ArgHis: 0.68 ± 0.03
3.2ArgIle: 3.2 ± 0.072
3.202ArgLys: 3.202 ± 0.079
3.906ArgLeu: 3.906 ± 0.078
1.198ArgMet: 1.198 ± 0.034
2.045ArgAsn: 2.045 ± 0.057
1.251ArgPro: 1.251 ± 0.051
1.511ArgGln: 1.511 ± 0.054
1.798ArgArg: 1.798 ± 0.055
2.27ArgSer: 2.27 ± 0.054
2.15ArgThr: 2.15 ± 0.058
2.503ArgVal: 2.503 ± 0.059
0.32ArgTrp: 0.32 ± 0.022
1.586ArgTyr: 1.586 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.97SerAla: 3.97 ± 0.075
0.277SerCys: 0.277 ± 0.02
3.458SerAsp: 3.458 ± 0.075
4.865SerGlu: 4.865 ± 0.089
3.063SerPhe: 3.063 ± 0.071
4.561SerGly: 4.561 ± 0.092
1.147SerHis: 1.147 ± 0.04
5.552SerIle: 5.552 ± 0.108
4.324SerLys: 4.324 ± 0.099
6.451SerLeu: 6.451 ± 0.107
1.597SerMet: 1.597 ± 0.043
3.12SerAsn: 3.12 ± 0.079
1.869SerPro: 1.869 ± 0.049
2.246SerGln: 2.246 ± 0.062
2.486SerArg: 2.486 ± 0.064
4.321SerSer: 4.321 ± 0.102
3.498SerThr: 3.498 ± 0.081
4.247SerVal: 4.247 ± 0.074
0.586SerTrp: 0.586 ± 0.028
2.413SerTyr: 2.413 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
3.744ThrAla: 3.744 ± 0.085
0.248ThrCys: 0.248 ± 0.02
3.367ThrAsp: 3.367 ± 0.073
4.132ThrGlu: 4.132 ± 0.081
2.521ThrPhe: 2.521 ± 0.066
4.182ThrGly: 4.182 ± 0.084
1.093ThrHis: 1.093 ± 0.038
4.935ThrIle: 4.935 ± 0.085
3.413ThrLys: 3.413 ± 0.073
5.539ThrLeu: 5.539 ± 0.085
1.397ThrMet: 1.397 ± 0.04
2.71ThrAsn: 2.71 ± 0.069
2.139ThrPro: 2.139 ± 0.051
1.879ThrGln: 1.879 ± 0.052
1.892ThrArg: 1.892 ± 0.053
3.475ThrSer: 3.475 ± 0.085
3.239ThrThr: 3.239 ± 0.069
4.277ThrVal: 4.277 ± 0.08
0.416ThrTrp: 0.416 ± 0.026
2.072ThrTyr: 2.072 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.46ValAla: 4.46 ± 0.085
0.433ValCys: 0.433 ± 0.024
3.76ValAsp: 3.76 ± 0.083
5.266ValGlu: 5.266 ± 0.094
2.914ValPhe: 2.914 ± 0.073
4.302ValGly: 4.302 ± 0.086
1.148ValHis: 1.148 ± 0.041
5.466ValIle: 5.466 ± 0.108
4.271ValLys: 4.271 ± 0.081
6.509ValLeu: 6.509 ± 0.107
1.818ValMet: 1.818 ± 0.045
3.151ValAsn: 3.151 ± 0.069
2.394ValPro: 2.394 ± 0.06
2.323ValGln: 2.323 ± 0.06
2.48ValArg: 2.48 ± 0.067
4.721ValSer: 4.721 ± 0.077
3.9ValThr: 3.9 ± 0.077
4.59ValVal: 4.59 ± 0.083
0.484ValTrp: 0.484 ± 0.024
2.27ValTyr: 2.27 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.025
0.042TrpCys: 0.042 ± 0.008
0.463TrpAsp: 0.463 ± 0.027
0.638TrpGlu: 0.638 ± 0.027
0.39TrpPhe: 0.39 ± 0.024
0.556TrpGly: 0.556 ± 0.032
0.188TrpHis: 0.188 ± 0.016
0.875TrpIle: 0.875 ± 0.036
0.634TrpLys: 0.634 ± 0.031
0.924TrpLeu: 0.924 ± 0.035
0.302TrpMet: 0.302 ± 0.021
0.532TrpAsn: 0.532 ± 0.023
0.179TrpPro: 0.179 ± 0.015
0.329TrpGln: 0.329 ± 0.022
0.345TrpArg: 0.345 ± 0.021
0.552TrpSer: 0.552 ± 0.03
0.532TrpThr: 0.532 ± 0.027
0.478TrpVal: 0.478 ± 0.025
0.103TrpTrp: 0.103 ± 0.012
0.329TrpTyr: 0.329 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.167TyrAla: 2.167 ± 0.052
0.228TyrCys: 0.228 ± 0.019
2.243TyrAsp: 2.243 ± 0.058
2.617TyrGlu: 2.617 ± 0.057
1.868TyrPhe: 1.868 ± 0.053
2.559TyrGly: 2.559 ± 0.064
0.83TyrHis: 0.83 ± 0.034
2.657TyrIle: 2.657 ± 0.068
2.346TyrLys: 2.346 ± 0.059
3.78TyrLeu: 3.78 ± 0.074
0.814TyrMet: 0.814 ± 0.031
1.814TyrAsn: 1.814 ± 0.055
1.381TyrPro: 1.381 ± 0.041
1.668TyrGln: 1.668 ± 0.042
1.598TyrArg: 1.598 ± 0.045
2.444TyrSer: 2.444 ± 0.061
2.177TyrThr: 2.177 ± 0.055
2.154TyrVal: 2.154 ± 0.05
0.331TyrTrp: 0.331 ± 0.025
1.69TyrTyr: 1.69 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2486 proteins (740988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski