Amino acid dipepetide frequency for Pelobium manganitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.127AlaAla: 5.127 ± 0.089	0.77AlaCys: 0.77 ± 0.03	4.812AlaAsp: 4.812 ± 0.071	4.817AlaGlu: 4.817 ± 0.077	3.927AlaPhe: 3.927 ± 0.06	5.319AlaGly: 5.319 ± 0.088	1.326AlaHis: 1.326 ± 0.035	5.464AlaIle: 5.464 ± 0.084	5.874AlaLys: 5.874 ± 0.078	7.614AlaLeu: 7.614 ± 0.101	1.789AlaMet: 1.789 ± 0.047	4.306AlaAsn: 4.306 ± 0.082	2.364AlaPro: 2.364 ± 0.045	3.412AlaGln: 3.412 ± 0.058	2.313AlaArg: 2.313 ± 0.053	5.029AlaSer: 5.029 ± 0.076	4.285AlaThr: 4.285 ± 0.078	5.228AlaVal: 5.228 ± 0.07	0.826AlaTrp: 0.826 ± 0.025	3.081AlaTyr: 3.081 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.625CysAla: 0.625 ± 0.026	0.143CysCys: 0.143 ± 0.011	0.379CysAsp: 0.379 ± 0.017	0.418CysGlu: 0.418 ± 0.019	0.448CysPhe: 0.448 ± 0.021	0.679CysGly: 0.679 ± 0.024	0.196CysHis: 0.196 ± 0.014	0.587CysIle: 0.587 ± 0.024	0.521CysLys: 0.521 ± 0.021	0.779CysLeu: 0.779 ± 0.027	0.149CysMet: 0.149 ± 0.011	0.398CysAsn: 0.398 ± 0.019	0.344CysPro: 0.344 ± 0.022	0.248CysGln: 0.248 ± 0.015	0.304CysArg: 0.304 ± 0.016	0.52CysSer: 0.52 ± 0.023	0.403CysThr: 0.403 ± 0.021	0.493CysVal: 0.493 ± 0.019	0.084CysTrp: 0.084 ± 0.01	0.294CysTyr: 0.294 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.463AspAla: 4.463 ± 0.068	0.417AspCys: 0.417 ± 0.019	2.794AspAsp: 2.794 ± 0.061	3.739AspGlu: 3.739 ± 0.062	3.466AspPhe: 3.466 ± 0.056	3.926AspGly: 3.926 ± 0.067	0.857AspHis: 0.857 ± 0.025	3.775AspIle: 3.775 ± 0.054	3.927AspLys: 3.927 ± 0.065	5.336AspLeu: 5.336 ± 0.071	1.13AspMet: 1.13 ± 0.034	2.529AspAsn: 2.529 ± 0.058	1.835AspPro: 1.835 ± 0.049	1.575AspGln: 1.575 ± 0.04	1.919AspArg: 1.919 ± 0.043	2.723AspSer: 2.723 ± 0.057	2.428AspThr: 2.428 ± 0.05	3.621AspVal: 3.621 ± 0.053	0.756AspTrp: 0.756 ± 0.029	2.605AspTyr: 2.605 ± 0.053	0.001AspXaa: 0.001 ± 0.001
Glu	4.692GluAla: 4.692 ± 0.078	0.327GluCys: 0.327 ± 0.018	2.944GluAsp: 2.944 ± 0.053	4.074GluGlu: 4.074 ± 0.083	2.479GluPhe: 2.479 ± 0.046	3.501GluGly: 3.501 ± 0.064	1.14GluHis: 1.14 ± 0.036	4.511GluIle: 4.511 ± 0.076	5.209GluLys: 5.209 ± 0.085	5.914GluLeu: 5.914 ± 0.081	1.398GluMet: 1.398 ± 0.034	3.626GluAsn: 3.626 ± 0.061	1.585GluPro: 1.585 ± 0.036	2.525GluGln: 2.525 ± 0.057	2.725GluArg: 2.725 ± 0.057	2.991GluSer: 2.991 ± 0.052	3.088GluThr: 3.088 ± 0.058	4.035GluVal: 4.035 ± 0.067	0.618GluTrp: 0.618 ± 0.027	1.927GluTyr: 1.927 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.899PheAla: 3.899 ± 0.057	0.512PheCys: 0.512 ± 0.021	3.13PheAsp: 3.13 ± 0.052	3.035PheGlu: 3.035 ± 0.056	2.622PhePhe: 2.622 ± 0.064	3.644PheGly: 3.644 ± 0.066	0.741PheHis: 0.741 ± 0.026	3.378PheIle: 3.378 ± 0.071	3.637PheLys: 3.637 ± 0.061	4.447PheLeu: 4.447 ± 0.078	1.088PheMet: 1.088 ± 0.026	2.982PheAsn: 2.982 ± 0.051	1.707PhePro: 1.707 ± 0.04	1.33PheGln: 1.33 ± 0.037	1.786PheArg: 1.786 ± 0.036	3.825PheSer: 3.825 ± 0.071	2.961PheThr: 2.961 ± 0.059	3.124PheVal: 3.124 ± 0.057	0.628PheTrp: 0.628 ± 0.03	2.157PheTyr: 2.157 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.966GlyAla: 4.966 ± 0.081	0.578GlyCys: 0.578 ± 0.028	3.369GlyAsp: 3.369 ± 0.074	3.659GlyGlu: 3.659 ± 0.063	3.7GlyPhe: 3.7 ± 0.063	4.813GlyGly: 4.813 ± 0.099	1.187GlyHis: 1.187 ± 0.034	5.156GlyIle: 5.156 ± 0.082	5.554GlyLys: 5.554 ± 0.067	6.433GlyLeu: 6.433 ± 0.093	1.602GlyMet: 1.602 ± 0.041	3.733GlyAsn: 3.733 ± 0.069	1.491GlyPro: 1.491 ± 0.079	2.17GlyGln: 2.17 ± 0.047	2.433GlyArg: 2.433 ± 0.044	4.07GlySer: 4.07 ± 0.081	4.06GlyThr: 4.06 ± 0.079	4.421GlyVal: 4.421 ± 0.071	0.856GlyTrp: 0.856 ± 0.031	2.838GlyTyr: 2.838 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.109HisAla: 1.109 ± 0.032	0.212HisCys: 0.212 ± 0.013	0.855HisAsp: 0.855 ± 0.031	0.876HisGlu: 0.876 ± 0.031	1.103HisPhe: 1.103 ± 0.031	1.102HisGly: 1.102 ± 0.033	0.552HisHis: 0.552 ± 0.022	1.385HisIle: 1.385 ± 0.04	1.088HisLys: 1.088 ± 0.031	1.967HisLeu: 1.967 ± 0.046	0.304HisMet: 0.304 ± 0.016	0.936HisAsn: 0.936 ± 0.033	1.011HisPro: 1.011 ± 0.031	0.96HisGln: 0.96 ± 0.029	0.752HisArg: 0.752 ± 0.026	1.046HisSer: 1.046 ± 0.03	0.88HisThr: 0.88 ± 0.028	0.952HisVal: 0.952 ± 0.029	0.23HisTrp: 0.23 ± 0.016	0.83HisTyr: 0.83 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.068IleAla: 6.068 ± 0.086	0.677IleCys: 0.677 ± 0.022	3.913IleAsp: 3.913 ± 0.057	4.181IleGlu: 4.181 ± 0.067	3.122IlePhe: 3.122 ± 0.058	4.725IleGly: 4.725 ± 0.067	1.196IleHis: 1.196 ± 0.035	4.697IleIle: 4.697 ± 0.081	5.267IleLys: 5.267 ± 0.074	6.001IleLeu: 6.001 ± 0.086	1.184IleMet: 1.184 ± 0.03	4.169IleAsn: 4.169 ± 0.061	2.905IlePro: 2.905 ± 0.058	2.225IleGln: 2.225 ± 0.051	2.614IleArg: 2.614 ± 0.043	5.098IleSer: 5.098 ± 0.07	3.856IleThr: 3.856 ± 0.058	4.164IleVal: 4.164 ± 0.075	0.692IleTrp: 0.692 ± 0.027	2.724IleTyr: 2.724 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	6.045LysAla: 6.045 ± 0.084	0.335LysCys: 0.335 ± 0.018	4.241LysAsp: 4.241 ± 0.062	4.936LysGlu: 4.936 ± 0.085	2.87LysPhe: 2.87 ± 0.049	4.691LysGly: 4.691 ± 0.086	1.461LysHis: 1.461 ± 0.036	5.411LysIle: 5.411 ± 0.065	5.696LysLys: 5.696 ± 0.092	6.662LysLeu: 6.662 ± 0.083	1.895LysMet: 1.895 ± 0.043	4.874LysAsn: 4.874 ± 0.069	2.95LysPro: 2.95 ± 0.053	3.154LysGln: 3.154 ± 0.062	2.842LysArg: 2.842 ± 0.058	4.429LysSer: 4.429 ± 0.066	4.499LysThr: 4.499 ± 0.059	4.633LysVal: 4.633 ± 0.067	0.779LysTrp: 0.779 ± 0.029	2.853LysTyr: 2.853 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.727LeuAla: 7.727 ± 0.092	0.81LeuCys: 0.81 ± 0.028	4.858LeuAsp: 4.858 ± 0.072	5.168LeuGlu: 5.168 ± 0.082	4.686LeuPhe: 4.686 ± 0.087	5.992LeuGly: 5.992 ± 0.091	1.688LeuHis: 1.688 ± 0.038	6.37LeuIle: 6.37 ± 0.104	7.901LeuLys: 7.901 ± 0.094	9.366LeuLeu: 9.366 ± 0.125	2.23LeuMet: 2.23 ± 0.047	5.999LeuAsn: 5.999 ± 0.091	3.936LeuPro: 3.936 ± 0.063	3.792LeuGln: 3.792 ± 0.068	3.644LeuArg: 3.644 ± 0.061	7.169LeuSer: 7.169 ± 0.078	5.069LeuThr: 5.069 ± 0.067	5.75LeuVal: 5.75 ± 0.086	0.949LeuTrp: 0.949 ± 0.03	3.286LeuTyr: 3.286 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.86MetAla: 1.86 ± 0.041	0.144MetCys: 0.144 ± 0.01	1.23MetAsp: 1.23 ± 0.039	1.318MetGlu: 1.318 ± 0.038	0.817MetPhe: 0.817 ± 0.03	1.478MetGly: 1.478 ± 0.041	0.395MetHis: 0.395 ± 0.02	1.261MetIle: 1.261 ± 0.036	1.809MetLys: 1.809 ± 0.037	2.102MetLeu: 2.102 ± 0.045	0.619MetMet: 0.619 ± 0.027	1.14MetAsn: 1.14 ± 0.031	1.047MetPro: 1.047 ± 0.032	0.929MetGln: 0.929 ± 0.03	0.975MetArg: 0.975 ± 0.031	1.223MetSer: 1.223 ± 0.032	0.925MetThr: 0.925 ± 0.027	1.412MetVal: 1.412 ± 0.036	0.217MetTrp: 0.217 ± 0.014	0.647MetTyr: 0.647 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.369AsnAla: 4.369 ± 0.07	0.427AsnCys: 0.427 ± 0.022	2.638AsnAsp: 2.638 ± 0.051	2.943AsnGlu: 2.943 ± 0.056	3.02AsnPhe: 3.02 ± 0.062	4.277AsnGly: 4.277 ± 0.073	1.053AsnHis: 1.053 ± 0.031	4.232AsnIle: 4.232 ± 0.06	3.881AsnLys: 3.881 ± 0.064	5.505AsnLeu: 5.505 ± 0.078	1.109AsnMet: 1.109 ± 0.024	3.343AsnAsn: 3.343 ± 0.075	2.786AsnPro: 2.786 ± 0.047	2.317AsnGln: 2.317 ± 0.046	2.311AsnArg: 2.311 ± 0.05	3.402AsnSer: 3.402 ± 0.065	3.124AsnThr: 3.124 ± 0.068	3.388AsnVal: 3.388 ± 0.063	0.769AsnTrp: 0.769 ± 0.026	2.755AsnTyr: 2.755 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.958ProAla: 2.958 ± 0.061	0.23ProCys: 0.23 ± 0.014	2.258ProAsp: 2.258 ± 0.049	2.686ProGlu: 2.686 ± 0.052	1.909ProPhe: 1.909 ± 0.041	2.273ProGly: 2.273 ± 0.05	0.72ProHis: 0.72 ± 0.027	2.354ProIle: 2.354 ± 0.048	2.547ProLys: 2.547 ± 0.056	3.343ProLeu: 3.343 ± 0.049	0.769ProMet: 0.769 ± 0.028	2.159ProAsn: 2.159 ± 0.041	0.903ProPro: 0.903 ± 0.03	1.632ProGln: 1.632 ± 0.05	1.042ProArg: 1.042 ± 0.033	2.289ProSer: 2.289 ± 0.042	1.865ProThr: 1.865 ± 0.042	2.685ProVal: 2.685 ± 0.051	0.402ProTrp: 0.402 ± 0.019	1.443ProTyr: 1.443 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.872GlnAla: 2.872 ± 0.044	0.195GlnCys: 0.195 ± 0.015	1.701GlnAsp: 1.701 ± 0.039	2.212GlnGlu: 2.212 ± 0.046	1.642GlnPhe: 1.642 ± 0.037	2.017GlnGly: 2.017 ± 0.095	0.847GlnHis: 0.847 ± 0.028	2.738GlnIle: 2.738 ± 0.051	3.33GlnLys: 3.33 ± 0.072	3.997GlnLeu: 3.997 ± 0.065	0.892GlnMet: 0.892 ± 0.031	2.466GlnAsn: 2.466 ± 0.053	1.316GlnPro: 1.316 ± 0.034	2.249GlnGln: 2.249 ± 0.061	1.491GlnArg: 1.491 ± 0.035	2.285GlnSer: 2.285 ± 0.049	2.215GlnThr: 2.215 ± 0.051	2.291GlnVal: 2.291 ± 0.041	0.375GlnTrp: 0.375 ± 0.016	1.327GlnTyr: 1.327 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.478ArgAla: 2.478 ± 0.048	0.262ArgCys: 0.262 ± 0.016	1.933ArgAsp: 1.933 ± 0.044	2.25ArgGlu: 2.25 ± 0.052	2.104ArgPhe: 2.104 ± 0.035	2.188ArgGly: 2.188 ± 0.056	0.647ArgHis: 0.647 ± 0.025	2.799ArgIle: 2.799 ± 0.051	2.945ArgLys: 2.945 ± 0.056	3.719ArgLeu: 3.719 ± 0.062	0.962ArgMet: 0.962 ± 0.032	2.193ArgAsn: 2.193 ± 0.047	1.319ArgPro: 1.319 ± 0.04	1.38ArgGln: 1.38 ± 0.041	1.547ArgArg: 1.547 ± 0.043	2.073ArgSer: 2.073 ± 0.043	1.849ArgThr: 1.849 ± 0.04	2.335ArgVal: 2.335 ± 0.047	0.474ArgTrp: 0.474 ± 0.02	1.79ArgTyr: 1.79 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.049SerAla: 5.049 ± 0.069	0.53SerCys: 0.53 ± 0.023	3.182SerAsp: 3.182 ± 0.058	3.384SerGlu: 3.384 ± 0.056	3.587SerPhe: 3.587 ± 0.06	4.771SerGly: 4.771 ± 0.088	1.117SerHis: 1.117 ± 0.033	4.348SerIle: 4.348 ± 0.064	4.286SerLys: 4.286 ± 0.06	6.351SerLeu: 6.351 ± 0.08	1.121SerMet: 1.121 ± 0.028	3.418SerAsn: 3.418 ± 0.064	2.306SerPro: 2.306 ± 0.052	2.09SerGln: 2.09 ± 0.043	2.307SerArg: 2.307 ± 0.052	3.984SerSer: 3.984 ± 0.072	3.372SerThr: 3.372 ± 0.062	4.252SerVal: 4.252 ± 0.059	0.724SerTrp: 0.724 ± 0.029	2.843SerTyr: 2.843 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.637ThrAla: 4.637 ± 0.074	0.344ThrCys: 0.344 ± 0.019	3.258ThrAsp: 3.258 ± 0.06	3.185ThrGlu: 3.185 ± 0.056	2.744ThrPhe: 2.744 ± 0.054	4.163ThrGly: 4.163 ± 0.089	0.876ThrHis: 0.876 ± 0.026	3.654ThrIle: 3.654 ± 0.062	3.336ThrLys: 3.336 ± 0.058	5.391ThrLeu: 5.391 ± 0.074	0.903ThrMet: 0.903 ± 0.028	2.686ThrAsn: 2.686 ± 0.057	2.384ThrPro: 2.384 ± 0.048	1.901ThrGln: 1.901 ± 0.041	1.648ThrArg: 1.648 ± 0.045	3.3ThrSer: 3.3 ± 0.067	2.937ThrThr: 2.937 ± 0.069	3.885ThrVal: 3.885 ± 0.072	0.582ThrTrp: 0.582 ± 0.028	2.181ThrTyr: 2.181 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.039ValAla: 5.039 ± 0.08	0.618ValCys: 0.618 ± 0.024	3.475ValAsp: 3.475 ± 0.058	3.697ValGlu: 3.697 ± 0.063	3.485ValPhe: 3.485 ± 0.066	3.976ValGly: 3.976 ± 0.067	1.036ValHis: 1.036 ± 0.03	4.269ValIle: 4.269 ± 0.066	4.923ValLys: 4.923 ± 0.07	6.297ValLeu: 6.297 ± 0.079	1.405ValMet: 1.405 ± 0.037	3.741ValAsn: 3.741 ± 0.066	2.324ValPro: 2.324 ± 0.045	2.054ValGln: 2.054 ± 0.045	2.222ValArg: 2.222 ± 0.046	4.412ValSer: 4.412 ± 0.064	3.285ValThr: 3.285 ± 0.059	4.374ValVal: 4.374 ± 0.073	0.713ValTrp: 0.713 ± 0.024	2.601ValTyr: 2.601 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.798TrpAla: 0.798 ± 0.026	0.126TrpCys: 0.126 ± 0.012	0.714TrpAsp: 0.714 ± 0.029	0.678TrpGlu: 0.678 ± 0.025	0.579TrpPhe: 0.579 ± 0.022	0.798TrpGly: 0.798 ± 0.028	0.242TrpHis: 0.242 ± 0.015	0.676TrpIle: 0.676 ± 0.026	0.764TrpLys: 0.764 ± 0.03	1.141TrpLeu: 1.141 ± 0.036	0.341TrpMet: 0.341 ± 0.018	0.636TrpAsn: 0.636 ± 0.024	0.322TrpPro: 0.322 ± 0.019	0.486TrpGln: 0.486 ± 0.021	0.527TrpArg: 0.527 ± 0.02	0.606TrpSer: 0.606 ± 0.02	0.625TrpThr: 0.625 ± 0.021	0.684TrpVal: 0.684 ± 0.027	0.183TrpTrp: 0.183 ± 0.013	0.432TrpTyr: 0.432 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.903TyrAla: 2.903 ± 0.053	0.357TyrCys: 0.357 ± 0.018	2.138TyrAsp: 2.138 ± 0.049	2.053TyrGlu: 2.053 ± 0.044	2.321TyrPhe: 2.321 ± 0.049	2.754TyrGly: 2.754 ± 0.051	0.87TyrHis: 0.87 ± 0.027	2.416TyrIle: 2.416 ± 0.045	2.757TyrLys: 2.757 ± 0.047	4.024TyrLeu: 4.024 ± 0.057	0.66TyrMet: 0.66 ± 0.025	2.314TyrAsn: 2.314 ± 0.054	1.633TyrPro: 1.633 ± 0.041	2.03TyrGln: 2.03 ± 0.044	1.845TyrArg: 1.845 ± 0.041	2.548TyrSer: 2.548 ± 0.053	2.27TyrThr: 2.27 ± 0.053	2.22TyrVal: 2.22 ± 0.04	0.499TyrTrp: 0.499 ± 0.02	1.873TyrTyr: 1.873 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3301 proteins (1151223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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