Amino acid dipepetide frequency for Ehrlichia canis (strain Jake)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.978AlaAla: 3.978 ± 0.164
0.952AlaCys: 0.952 ± 0.058
2.557AlaAsp: 2.557 ± 0.095
2.882AlaGlu: 2.882 ± 0.125
2.312AlaPhe: 2.312 ± 0.106
3.214AlaGly: 3.214 ± 0.139
1.131AlaHis: 1.131 ± 0.051
5.418AlaIle: 5.418 ± 0.139
3.866AlaLys: 3.866 ± 0.125
5.583AlaLeu: 5.583 ± 0.155
1.414AlaMet: 1.414 ± 0.068
2.758AlaAsn: 2.758 ± 0.103
1.344AlaPro: 1.344 ± 0.064
1.854AlaGln: 1.854 ± 0.091
2.188AlaArg: 2.188 ± 0.106
4.003AlaSer: 4.003 ± 0.144
2.529AlaThr: 2.529 ± 0.106
4.214AlaVal: 4.214 ± 0.165
0.306AlaTrp: 0.306 ± 0.04
1.914AlaTyr: 1.914 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.901CysAla: 0.901 ± 0.06
0.408CysCys: 0.408 ± 0.046
1.099CysAsp: 1.099 ± 0.077
0.768CysGlu: 0.768 ± 0.042
0.729CysPhe: 0.729 ± 0.044
1.076CysGly: 1.076 ± 0.064
0.341CysHis: 0.341 ± 0.031
1.647CysIle: 1.647 ± 0.101
1.118CysLys: 1.118 ± 0.06
1.36CysLeu: 1.36 ± 0.074
0.401CysMet: 0.401 ± 0.043
1.255CysAsn: 1.255 ± 0.068
0.417CysPro: 0.417 ± 0.045
0.44CysGln: 0.44 ± 0.035
0.592CysArg: 0.592 ± 0.048
1.271CysSer: 1.271 ± 0.082
0.889CysThr: 0.889 ± 0.065
1.182CysVal: 1.182 ± 0.071
0.099CysTrp: 0.099 ± 0.018
0.796CysTyr: 0.796 ± 0.059
0.0CysXaa: 0.0 ± 0.0
Asp
2.774AspAla: 2.774 ± 0.105
0.713AspCys: 0.713 ± 0.053
3.166AspAsp: 3.166 ± 0.176
3.019AspGlu: 3.019 ± 0.145
2.835AspPhe: 2.835 ± 0.105
2.752AspGly: 2.752 ± 0.121
0.924AspHis: 0.924 ± 0.057
5.889AspIle: 5.889 ± 0.146
4.44AspLys: 4.44 ± 0.175
5.115AspLeu: 5.115 ± 0.133
1.274AspMet: 1.274 ± 0.072
3.997AspAsn: 3.997 ± 0.129
1.5AspPro: 1.5 ± 0.084
1.717AspGln: 1.717 ± 0.112
1.806AspArg: 1.806 ± 0.079
3.758AspSer: 3.758 ± 0.145
2.847AspThr: 2.847 ± 0.111
4.249AspVal: 4.249 ± 0.138
0.376AspTrp: 0.376 ± 0.038
2.163AspTyr: 2.163 ± 0.09
0.0AspXaa: 0.0 ± 0.0
Glu
2.898GluAla: 2.898 ± 0.11
0.809GluCys: 0.809 ± 0.053
3.207GluAsp: 3.207 ± 0.117
4.163GluGlu: 4.163 ± 0.153
2.354GluPhe: 2.354 ± 0.086
2.64GluGly: 2.64 ± 0.096
1.411GluHis: 1.411 ± 0.083
5.376GluIle: 5.376 ± 0.162
4.653GluLys: 4.653 ± 0.153
5.296GluLeu: 5.296 ± 0.141
1.44GluMet: 1.44 ± 0.073
3.656GluAsn: 3.656 ± 0.13
1.175GluPro: 1.175 ± 0.064
2.086GluGln: 2.086 ± 0.122
1.978GluArg: 1.978 ± 0.094
4.185GluSer: 4.185 ± 0.167
2.201GluThr: 2.201 ± 0.092
3.968GluVal: 3.968 ± 0.151
0.334GluTrp: 0.334 ± 0.031
2.261GluTyr: 2.261 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.503PheAla: 2.503 ± 0.101
0.882PheCys: 0.882 ± 0.058
2.376PheAsp: 2.376 ± 0.075
1.885PheGlu: 1.885 ± 0.07
2.494PhePhe: 2.494 ± 0.105
2.729PheGly: 2.729 ± 0.106
0.987PheHis: 0.987 ± 0.055
4.475PheIle: 4.475 ± 0.136
2.503PheLys: 2.503 ± 0.087
4.258PheLeu: 4.258 ± 0.145
0.984PheMet: 0.984 ± 0.052
3.045PheAsn: 3.045 ± 0.088
1.468PhePro: 1.468 ± 0.067
1.099PheGln: 1.099 ± 0.072
1.299PheArg: 1.299 ± 0.056
4.386PheSer: 4.386 ± 0.151
2.29PheThr: 2.29 ± 0.082
2.79PheVal: 2.79 ± 0.095
0.315PheTrp: 0.315 ± 0.037
1.911PheTyr: 1.911 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
3.137GlyAla: 3.137 ± 0.137
1.035GlyCys: 1.035 ± 0.085
2.949GlyAsp: 2.949 ± 0.152
2.873GlyGlu: 2.873 ± 0.113
2.376GlyPhe: 2.376 ± 0.085
3.599GlyGly: 3.599 ± 0.166
1.057GlyHis: 1.057 ± 0.053
5.615GlyIle: 5.615 ± 0.149
4.421GlyLys: 4.421 ± 0.155
4.688GlyLeu: 4.688 ± 0.126
1.468GlyMet: 1.468 ± 0.067
3.341GlyAsn: 3.341 ± 0.119
1.252GlyPro: 1.252 ± 0.076
1.497GlyGln: 1.497 ± 0.071
1.952GlyArg: 1.952 ± 0.08
3.956GlySer: 3.956 ± 0.123
2.586GlyThr: 2.586 ± 0.08
4.134GlyVal: 4.134 ± 0.109
0.459GlyTrp: 0.459 ± 0.046
2.421GlyTyr: 2.421 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
1.159HisAla: 1.159 ± 0.062
0.306HisCys: 0.306 ± 0.034
1.223HisAsp: 1.223 ± 0.058
1.061HisGlu: 1.061 ± 0.056
0.965HisPhe: 0.965 ± 0.052
1.248HisGly: 1.248 ± 0.061
0.487HisHis: 0.487 ± 0.04
1.933HisIle: 1.933 ± 0.081
1.487HisLys: 1.487 ± 0.064
1.761HisLeu: 1.761 ± 0.07
0.452HisMet: 0.452 ± 0.038
1.71HisAsn: 1.71 ± 0.107
0.834HisPro: 0.834 ± 0.05
0.637HisGln: 0.637 ± 0.055
0.697HisArg: 0.697 ± 0.044
1.481HisSer: 1.481 ± 0.089
1.0HisThr: 1.0 ± 0.049
1.357HisVal: 1.357 ± 0.065
0.175HisTrp: 0.175 ± 0.02
0.952HisTyr: 0.952 ± 0.061
0.0HisXaa: 0.0 ± 0.0
Ile
6.004IleAla: 6.004 ± 0.165
1.666IleCys: 1.666 ± 0.082
5.433IleAsp: 5.433 ± 0.143
5.57IleGlu: 5.57 ± 0.15
4.22IlePhe: 4.22 ± 0.127
5.504IleGly: 5.504 ± 0.189
1.771IleHis: 1.771 ± 0.087
8.838IleIle: 8.838 ± 0.244
7.102IleLys: 7.102 ± 0.179
8.841IleLeu: 8.841 ± 0.201
2.242IleMet: 2.242 ± 0.093
6.386IleAsn: 6.386 ± 0.164
3.268IlePro: 3.268 ± 0.141
2.71IleGln: 2.71 ± 0.102
3.169IleArg: 3.169 ± 0.098
8.408IleSer: 8.408 ± 0.217
5.293IleThr: 5.293 ± 0.183
6.252IleVal: 6.252 ± 0.158
0.462IleTrp: 0.462 ± 0.042
2.946IleTyr: 2.946 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
3.628LysAla: 3.628 ± 0.135
1.153LysCys: 1.153 ± 0.069
4.07LysAsp: 4.07 ± 0.136
4.921LysGlu: 4.921 ± 0.145
3.296LysPhe: 3.296 ± 0.122
3.0LysGly: 3.0 ± 0.111
1.618LysHis: 1.618 ± 0.06
7.246LysIle: 7.246 ± 0.179
6.491LysLys: 6.491 ± 0.186
7.392LysLeu: 7.392 ± 0.196
1.841LysMet: 1.841 ± 0.093
5.316LysAsn: 5.316 ± 0.137
1.803LysPro: 1.803 ± 0.07
2.739LysGln: 2.739 ± 0.1
2.507LysArg: 2.507 ± 0.099
5.497LysSer: 5.497 ± 0.166
3.226LysThr: 3.226 ± 0.114
5.255LysVal: 5.255 ± 0.17
0.443LysTrp: 0.443 ± 0.042
3.01LysTyr: 3.01 ± 0.1
0.0LysXaa: 0.0 ± 0.0
Leu
4.956LeuAla: 4.956 ± 0.12
1.844LeuCys: 1.844 ± 0.077
4.895LeuAsp: 4.895 ± 0.14
5.22LeuGlu: 5.22 ± 0.153
4.019LeuPhe: 4.019 ± 0.133
5.051LeuGly: 5.051 ± 0.138
2.172LeuHis: 2.172 ± 0.095
8.179LeuIle: 8.179 ± 0.216
6.822LeuLys: 6.822 ± 0.178
10.389LeuLeu: 10.389 ± 0.251
2.341LeuMet: 2.341 ± 0.123
5.688LeuAsn: 5.688 ± 0.123
3.64LeuPro: 3.64 ± 0.132
3.443LeuGln: 3.443 ± 0.128
3.519LeuArg: 3.519 ± 0.104
9.185LeuSer: 9.185 ± 0.185
4.331LeuThr: 4.331 ± 0.116
5.666LeuVal: 5.666 ± 0.131
0.678LeuTrp: 0.678 ± 0.045
3.796LeuTyr: 3.796 ± 0.123
0.0LeuXaa: 0.0 ± 0.0
Met
1.134MetAla: 1.134 ± 0.081
0.42MetCys: 0.42 ± 0.036
1.035MetAsp: 1.035 ± 0.054
1.026MetGlu: 1.026 ± 0.059
1.178MetPhe: 1.178 ± 0.065
1.118MetGly: 1.118 ± 0.058
0.608MetHis: 0.608 ± 0.038
2.035MetIle: 2.035 ± 0.081
1.736MetLys: 1.736 ± 0.077
3.179MetLeu: 3.179 ± 0.111
0.586MetMet: 0.586 ± 0.041
1.264MetAsn: 1.264 ± 0.062
0.787MetPro: 0.787 ± 0.062
1.003MetGln: 1.003 ± 0.069
0.997MetArg: 0.997 ± 0.048
2.198MetSer: 2.198 ± 0.08
0.968MetThr: 0.968 ± 0.052
1.414MetVal: 1.414 ± 0.056
0.147MetTrp: 0.147 ± 0.017
1.0MetTyr: 1.0 ± 0.062
0.0MetXaa: 0.0 ± 0.0
Asn
3.376AsnAla: 3.376 ± 0.103
0.917AsnCys: 0.917 ± 0.056
3.36AsnAsp: 3.36 ± 0.112
3.029AsnGlu: 3.029 ± 0.09
3.048AsnPhe: 3.048 ± 0.112
2.965AsnGly: 2.965 ± 0.09
1.178AsnHis: 1.178 ± 0.061
7.621AsnIle: 7.621 ± 0.223
5.252AsnLys: 5.252 ± 0.139
6.112AsnLeu: 6.112 ± 0.149
1.497AsnMet: 1.497 ± 0.062
5.449AsnAsn: 5.449 ± 0.194
2.178AsnPro: 2.178 ± 0.099
1.994AsnGln: 1.994 ± 0.088
1.968AsnArg: 1.968 ± 0.082
4.761AsnSer: 4.761 ± 0.147
3.851AsnThr: 3.851 ± 0.12
4.558AsnVal: 4.558 ± 0.16
0.293AsnTrp: 0.293 ± 0.036
2.433AsnTyr: 2.433 ± 0.104
0.0AsnXaa: 0.0 ± 0.0
Pro
1.494ProAla: 1.494 ± 0.091
0.427ProCys: 0.427 ± 0.039
1.694ProAsp: 1.694 ± 0.077
2.086ProGlu: 2.086 ± 0.122
1.331ProPhe: 1.331 ± 0.07
1.736ProGly: 1.736 ± 0.088
0.666ProHis: 0.666 ± 0.05
2.777ProIle: 2.777 ± 0.111
2.038ProLys: 2.038 ± 0.097
2.72ProLeu: 2.72 ± 0.093
0.551ProMet: 0.551 ± 0.037
1.79ProAsn: 1.79 ± 0.086
0.739ProPro: 0.739 ± 0.059
1.013ProGln: 1.013 ± 0.059
0.933ProArg: 0.933 ± 0.053
2.315ProSer: 2.315 ± 0.07
1.522ProThr: 1.522 ± 0.079
2.277ProVal: 2.277 ± 0.128
0.245ProTrp: 0.245 ± 0.03
1.258ProTyr: 1.258 ± 0.082
0.0ProXaa: 0.0 ± 0.0
Gln
1.672GlnAla: 1.672 ± 0.058
0.592GlnCys: 0.592 ± 0.048
2.274GlnAsp: 2.274 ± 0.097
2.468GlnGlu: 2.468 ± 0.11
1.217GlnPhe: 1.217 ± 0.054
1.678GlnGly: 1.678 ± 0.082
0.978GlnHis: 0.978 ± 0.062
2.612GlnIle: 2.612 ± 0.089
2.363GlnLys: 2.363 ± 0.1
3.051GlnLeu: 3.051 ± 0.11
0.755GlnMet: 0.755 ± 0.05
2.252GlnAsn: 2.252 ± 0.104
0.86GlnPro: 0.86 ± 0.071
1.379GlnGln: 1.379 ± 0.103
1.258GlnArg: 1.258 ± 0.071
2.478GlnSer: 2.478 ± 0.104
1.162GlnThr: 1.162 ± 0.066
2.268GlnVal: 2.268 ± 0.098
0.197GlnTrp: 0.197 ± 0.024
1.596GlnTyr: 1.596 ± 0.082
0.0GlnXaa: 0.0 ± 0.0
Arg
1.905ArgAla: 1.905 ± 0.09
0.557ArgCys: 0.557 ± 0.045
1.889ArgAsp: 1.889 ± 0.091
2.045ArgGlu: 2.045 ± 0.105
1.643ArgPhe: 1.643 ± 0.088
1.87ArgGly: 1.87 ± 0.084
0.624ArgHis: 0.624 ± 0.049
3.144ArgIle: 3.144 ± 0.089
2.691ArgLys: 2.691 ± 0.114
3.452ArgLeu: 3.452 ± 0.142
0.965ArgMet: 0.965 ± 0.052
2.233ArgAsn: 2.233 ± 0.097
1.013ArgPro: 1.013 ± 0.058
1.156ArgGln: 1.156 ± 0.074
1.468ArgArg: 1.468 ± 0.082
2.593ArgSer: 2.593 ± 0.11
1.44ArgThr: 1.44 ± 0.068
2.293ArgVal: 2.293 ± 0.097
0.213ArgTrp: 0.213 ± 0.028
1.513ArgTyr: 1.513 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.328SerAla: 4.328 ± 0.141
1.306SerCys: 1.306 ± 0.08
4.72SerAsp: 4.72 ± 0.19
4.472SerGlu: 4.472 ± 0.176
3.459SerPhe: 3.459 ± 0.112
5.093SerGly: 5.093 ± 0.168
1.548SerHis: 1.548 ± 0.071
8.192SerIle: 8.192 ± 0.186
5.424SerLys: 5.424 ± 0.16
7.182SerLeu: 7.182 ± 0.152
1.876SerMet: 1.876 ± 0.078
5.109SerAsn: 5.109 ± 0.143
1.965SerPro: 1.965 ± 0.077
2.624SerGln: 2.624 ± 0.095
2.803SerArg: 2.803 ± 0.138
7.325SerSer: 7.325 ± 0.281
4.156SerThr: 4.156 ± 0.196
5.736SerVal: 5.736 ± 0.171
0.535SerTrp: 0.535 ± 0.042
3.255SerTyr: 3.255 ± 0.125
0.0SerXaa: 0.0 ± 0.0
Thr
2.704ThrAla: 2.704 ± 0.093
0.752ThrCys: 0.752 ± 0.043
2.58ThrAsp: 2.58 ± 0.088
2.602ThrGlu: 2.602 ± 0.124
1.946ThrPhe: 1.946 ± 0.09
3.042ThrGly: 3.042 ± 0.107
1.105ThrHis: 1.105 ± 0.072
4.421ThrIle: 4.421 ± 0.136
3.252ThrLys: 3.252 ± 0.1
4.787ThrLeu: 4.787 ± 0.137
1.006ThrMet: 1.006 ± 0.044
2.895ThrAsn: 2.895 ± 0.14
1.87ThrPro: 1.87 ± 0.113
1.796ThrGln: 1.796 ± 0.095
1.589ThrArg: 1.589 ± 0.075
4.096ThrSer: 4.096 ± 0.141
2.93ThrThr: 2.93 ± 0.133
3.284ThrVal: 3.284 ± 0.082
0.318ThrTrp: 0.318 ± 0.041
1.615ThrTyr: 1.615 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
3.765ValAla: 3.765 ± 0.135
1.185ValCys: 1.185 ± 0.074
3.965ValAsp: 3.965 ± 0.144
3.774ValGlu: 3.774 ± 0.187
3.064ValPhe: 3.064 ± 0.123
3.914ValGly: 3.914 ± 0.13
1.226ValHis: 1.226 ± 0.071
6.57ValIle: 6.57 ± 0.182
5.382ValLys: 5.382 ± 0.158
6.774ValLeu: 6.774 ± 0.155
1.749ValMet: 1.749 ± 0.1
4.137ValAsn: 4.137 ± 0.142
2.182ValPro: 2.182 ± 0.1
2.188ValGln: 2.188 ± 0.106
2.363ValArg: 2.363 ± 0.107
5.644ValSer: 5.644 ± 0.173
3.315ValThr: 3.315 ± 0.115
4.911ValVal: 4.911 ± 0.134
0.357ValTrp: 0.357 ± 0.038
2.099ValTyr: 2.099 ± 0.09
0.0ValXaa: 0.0 ± 0.0
Trp
0.236TrpAla: 0.236 ± 0.032
0.124TrpCys: 0.124 ± 0.017
0.36TrpAsp: 0.36 ± 0.042
0.28TrpGlu: 0.28 ± 0.034
0.338TrpPhe: 0.338 ± 0.037
0.325TrpGly: 0.325 ± 0.035
0.159TrpHis: 0.159 ± 0.023
0.58TrpIle: 0.58 ± 0.051
0.468TrpLys: 0.468 ± 0.047
0.701TrpLeu: 0.701 ± 0.055
0.14TrpMet: 0.14 ± 0.022
0.436TrpAsn: 0.436 ± 0.037
0.194TrpPro: 0.194 ± 0.021
0.296TrpGln: 0.296 ± 0.03
0.258TrpArg: 0.258 ± 0.032
0.42TrpSer: 0.42 ± 0.051
0.22TrpThr: 0.22 ± 0.034
0.363TrpVal: 0.363 ± 0.035
0.064TrpTrp: 0.064 ± 0.013
0.322TrpTyr: 0.322 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.866TyrAla: 1.866 ± 0.065
0.739TyrCys: 0.739 ± 0.06
2.459TyrAsp: 2.459 ± 0.097
1.949TyrGlu: 1.949 ± 0.08
1.857TyrPhe: 1.857 ± 0.087
2.261TyrGly: 2.261 ± 0.097
0.936TyrHis: 0.936 ± 0.052
3.519TyrIle: 3.519 ± 0.107
2.94TyrLys: 2.94 ± 0.118
3.194TyrLeu: 3.194 ± 0.103
0.847TyrMet: 0.847 ± 0.044
3.128TyrAsn: 3.128 ± 0.126
1.124TyrPro: 1.124 ± 0.068
1.44TyrGln: 1.44 ± 0.077
1.36TyrArg: 1.36 ± 0.071
3.147TyrSer: 3.147 ± 0.121
1.831TyrThr: 1.831 ± 0.09
2.395TyrVal: 2.395 ± 0.085
0.268TyrTrp: 0.268 ± 0.025
1.685TyrTyr: 1.685 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 921 proteins (313982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski