Amino acid dipepetide frequency for Beihai sipunculid worm virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.184AlaAla: 8.184 ± 0.654
0.39AlaCys: 0.39 ± 0.385
3.897AlaAsp: 3.897 ± 1.991
3.507AlaGlu: 3.507 ± 0.369
3.507AlaPhe: 3.507 ± 0.869
8.184AlaGly: 8.184 ± 0.036
1.169AlaHis: 1.169 ± 0.702
3.118AlaIle: 3.118 ± 0.635
4.677AlaLys: 4.677 ± 1.571
6.625AlaLeu: 6.625 ± 2.741
1.169AlaMet: 1.169 ± 0.083
2.728AlaAsn: 2.728 ± 0.218
3.507AlaPro: 3.507 ± 0.25
2.338AlaGln: 2.338 ± 0.785
3.897AlaArg: 3.897 ± 1.103
2.728AlaSer: 2.728 ± 0.837
5.456AlaThr: 5.456 ± 0.436
4.677AlaVal: 4.677 ± 0.286
0.0AlaTrp: 0.0 ± 0.0
1.559AlaTyr: 1.559 ± 0.936
0.0AlaXaa: 0.0 ± 0.0
Cys
0.779CysAla: 0.779 ± 0.468
0.39CysCys: 0.39 ± 0.234
0.39CysAsp: 0.39 ± 0.385
0.779CysGlu: 0.779 ± 0.151
0.39CysPhe: 0.39 ± 0.234
0.779CysGly: 0.779 ± 0.151
0.39CysHis: 0.39 ± 0.385
0.0CysIle: 0.0 ± 0.0
0.39CysLys: 0.39 ± 0.234
0.39CysLeu: 0.39 ± 0.234
1.169CysMet: 1.169 ± 0.083
1.169CysAsn: 1.169 ± 0.702
0.39CysPro: 0.39 ± 0.234
0.0CysGln: 0.0 ± 0.0
0.39CysArg: 0.39 ± 0.385
0.39CysSer: 0.39 ± 0.234
0.779CysThr: 0.779 ± 0.468
0.779CysVal: 0.779 ± 0.468
0.0CysTrp: 0.0 ± 0.0
1.949CysTyr: 1.949 ± 0.067
0.0CysXaa: 0.0 ± 0.0
Asp
6.235AspAla: 6.235 ± 2.443
0.779AspCys: 0.779 ± 0.151
5.066AspAsp: 5.066 ± 1.289
4.287AspGlu: 4.287 ± 0.099
1.949AspPhe: 1.949 ± 0.686
4.287AspGly: 4.287 ± 1.337
0.779AspHis: 0.779 ± 0.151
3.118AspIle: 3.118 ± 0.603
5.066AspLys: 5.066 ± 0.051
3.507AspLeu: 3.507 ± 0.869
1.169AspMet: 1.169 ± 0.083
1.949AspAsn: 1.949 ± 0.686
3.897AspPro: 3.897 ± 1.372
0.779AspGln: 0.779 ± 0.769
2.728AspArg: 2.728 ± 1.019
4.677AspSer: 4.677 ± 0.904
2.728AspThr: 2.728 ± 0.837
2.728AspVal: 2.728 ± 2.074
0.39AspTrp: 0.39 ± 0.385
2.338AspTyr: 2.338 ± 1.404
0.0AspXaa: 0.0 ± 0.0
Glu
3.118GluAla: 3.118 ± 1.872
1.169GluCys: 1.169 ± 0.083
2.338GluAsp: 2.338 ± 1.071
5.066GluGlu: 5.066 ± 1.186
3.507GluPhe: 3.507 ± 1.487
3.118GluGly: 3.118 ± 0.635
1.949GluHis: 1.949 ± 1.17
1.949GluIle: 1.949 ± 0.551
4.677GluLys: 4.677 ± 0.333
6.235GluLeu: 6.235 ± 1.269
1.949GluMet: 1.949 ± 0.551
1.559GluAsn: 1.559 ± 0.317
2.728GluPro: 2.728 ± 0.218
2.728GluGln: 2.728 ± 0.401
1.169GluArg: 1.169 ± 0.083
3.507GluSer: 3.507 ± 0.25
2.338GluThr: 2.338 ± 0.452
5.456GluVal: 5.456 ± 0.436
0.39GluTrp: 0.39 ± 0.234
4.287GluTyr: 4.287 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
1.949PheAla: 1.949 ± 0.067
0.39PheCys: 0.39 ± 0.234
4.677PheAsp: 4.677 ± 0.952
4.287PheGlu: 4.287 ± 1.337
1.169PhePhe: 1.169 ± 0.535
3.507PheGly: 3.507 ± 0.25
0.779PheHis: 0.779 ± 0.151
1.949PheIle: 1.949 ± 1.17
1.949PheLys: 1.949 ± 0.686
5.066PheLeu: 5.066 ± 1.186
1.559PheMet: 1.559 ± 0.317
2.338PheAsn: 2.338 ± 0.167
4.677PhePro: 4.677 ± 0.333
1.949PheGln: 1.949 ± 0.067
2.338PheArg: 2.338 ± 0.452
1.949PheSer: 1.949 ± 0.067
3.897PheThr: 3.897 ± 0.135
3.118PheVal: 3.118 ± 0.016
1.169PheTrp: 1.169 ± 1.154
1.559PheTyr: 1.559 ± 0.301
0.0PheXaa: 0.0 ± 0.0
Gly
5.066GlyAla: 5.066 ± 0.051
0.779GlyCys: 0.779 ± 0.468
4.287GlyAsp: 4.287 ± 1.757
2.338GlyGlu: 2.338 ± 0.452
3.897GlyPhe: 3.897 ± 1.721
3.507GlyGly: 3.507 ± 0.25
1.169GlyHis: 1.169 ± 0.702
5.066GlyIle: 5.066 ± 0.567
6.625GlyLys: 6.625 ± 0.885
5.456GlyLeu: 5.456 ± 0.801
1.559GlyMet: 1.559 ± 0.301
4.677GlyAsn: 4.677 ± 2.76
1.169GlyPro: 1.169 ± 0.083
1.559GlyGln: 1.559 ± 1.539
1.559GlyArg: 1.559 ± 0.317
4.287GlySer: 4.287 ± 0.718
4.287GlyThr: 4.287 ± 0.099
5.846GlyVal: 5.846 ± 0.821
2.338GlyTrp: 2.338 ± 1.071
1.169GlyTyr: 1.169 ± 0.702
0.0GlyXaa: 0.0 ± 0.0
His
1.559HisAla: 1.559 ± 0.317
0.39HisCys: 0.39 ± 0.385
0.779HisAsp: 0.779 ± 0.151
1.949HisGlu: 1.949 ± 0.551
0.779HisPhe: 0.779 ± 0.151
1.559HisGly: 1.559 ± 0.317
0.39HisHis: 0.39 ± 0.234
1.169HisIle: 1.169 ± 0.702
1.169HisLys: 1.169 ± 0.535
1.169HisLeu: 1.169 ± 0.702
0.39HisMet: 0.39 ± 0.385
0.0HisAsn: 0.0 ± 0.0
0.779HisPro: 0.779 ± 0.151
0.0HisGln: 0.0 ± 0.0
0.779HisArg: 0.779 ± 0.468
2.728HisSer: 2.728 ± 0.401
1.559HisThr: 1.559 ± 0.301
1.169HisVal: 1.169 ± 0.702
0.0HisTrp: 0.0 ± 0.0
1.559HisTyr: 1.559 ± 0.301
0.0HisXaa: 0.0 ± 0.0
Ile
5.846IleAla: 5.846 ± 1.035
0.0IleCys: 0.0 ± 0.0
2.728IleAsp: 2.728 ± 0.218
2.338IleGlu: 2.338 ± 0.167
5.066IlePhe: 5.066 ± 1.289
2.338IleGly: 2.338 ± 0.452
0.779IleHis: 0.779 ± 0.151
2.728IleIle: 2.728 ± 0.401
1.559IleLys: 1.559 ± 0.301
4.677IleLeu: 4.677 ± 1.571
1.169IleMet: 1.169 ± 0.702
3.118IleAsn: 3.118 ± 0.635
1.559IlePro: 1.559 ± 0.317
0.779IleGln: 0.779 ± 0.151
2.728IleArg: 2.728 ± 0.401
4.287IleSer: 4.287 ± 0.52
4.287IleThr: 4.287 ± 0.52
3.507IleVal: 3.507 ± 0.988
0.39IleTrp: 0.39 ± 0.234
1.169IleTyr: 1.169 ± 0.702
0.0IleXaa: 0.0 ± 0.0
Lys
3.118LysAla: 3.118 ± 0.635
1.559LysCys: 1.559 ± 0.936
2.338LysAsp: 2.338 ± 0.785
4.677LysGlu: 4.677 ± 2.808
2.338LysPhe: 2.338 ± 0.452
3.507LysGly: 3.507 ± 0.369
1.949LysHis: 1.949 ± 1.17
1.949LysIle: 1.949 ± 0.067
3.118LysLys: 3.118 ± 1.253
5.456LysLeu: 5.456 ± 0.436
1.169LysMet: 1.169 ± 0.083
1.559LysAsn: 1.559 ± 0.301
3.118LysPro: 3.118 ± 1.222
2.728LysGln: 2.728 ± 0.218
2.728LysArg: 2.728 ± 0.837
4.677LysSer: 4.677 ± 1.571
4.287LysThr: 4.287 ± 1.955
3.118LysVal: 3.118 ± 0.016
1.559LysTrp: 1.559 ± 0.317
3.897LysTyr: 3.897 ± 1.721
0.0LysXaa: 0.0 ± 0.0
Leu
7.015LeuAla: 7.015 ± 0.5
1.169LeuCys: 1.169 ± 0.702
5.456LeuAsp: 5.456 ± 0.183
6.625LeuGlu: 6.625 ± 0.972
3.118LeuPhe: 3.118 ± 0.016
2.728LeuGly: 2.728 ± 0.218
1.949LeuHis: 1.949 ± 0.686
3.897LeuIle: 3.897 ± 1.103
7.015LeuLys: 7.015 ± 2.975
6.625LeuLeu: 6.625 ± 1.503
3.897LeuMet: 3.897 ± 1.721
5.456LeuAsn: 5.456 ± 1.055
3.507LeuPro: 3.507 ± 1.487
3.118LeuGln: 3.118 ± 0.603
3.507LeuArg: 3.507 ± 0.25
6.625LeuSer: 6.625 ± 0.353
6.235LeuThr: 6.235 ± 0.032
4.677LeuVal: 4.677 ± 0.952
1.559LeuTrp: 1.559 ± 0.301
1.169LeuTyr: 1.169 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.728MetAla: 2.728 ± 1.019
0.779MetCys: 0.779 ± 0.769
1.949MetAsp: 1.949 ± 1.17
1.949MetGlu: 1.949 ± 0.551
1.169MetPhe: 1.169 ± 0.083
2.338MetGly: 2.338 ± 0.452
0.39MetHis: 0.39 ± 0.234
1.949MetIle: 1.949 ± 0.067
1.169MetLys: 1.169 ± 0.083
2.338MetLeu: 2.338 ± 0.167
0.779MetMet: 0.779 ± 0.468
0.779MetAsn: 0.779 ± 0.151
0.779MetPro: 0.779 ± 0.769
3.118MetGln: 3.118 ± 0.016
1.559MetArg: 1.559 ± 0.936
3.507MetSer: 3.507 ± 0.25
1.169MetThr: 1.169 ± 0.083
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.39MetTyr: 0.39 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
2.728AsnAla: 2.728 ± 1.638
0.0AsnCys: 0.0 ± 0.0
1.559AsnAsp: 1.559 ± 0.92
3.897AsnGlu: 3.897 ± 0.484
1.949AsnPhe: 1.949 ± 0.686
3.118AsnGly: 3.118 ± 0.603
1.559AsnHis: 1.559 ± 0.317
3.118AsnIle: 3.118 ± 0.016
1.559AsnLys: 1.559 ± 0.317
4.677AsnLeu: 4.677 ± 1.523
0.0AsnMet: 0.0 ± 0.0
3.118AsnAsn: 3.118 ± 1.84
4.287AsnPro: 4.287 ± 0.52
1.949AsnGln: 1.949 ± 1.305
0.39AsnArg: 0.39 ± 0.385
2.728AsnSer: 2.728 ± 1.456
2.728AsnThr: 2.728 ± 0.837
3.897AsnVal: 3.897 ± 1.991
0.0AsnTrp: 0.0 ± 0.0
4.287AsnTyr: 4.287 ± 1.757
0.0AsnXaa: 0.0 ± 0.0
Pro
1.949ProAla: 1.949 ± 0.686
0.39ProCys: 0.39 ± 0.385
1.169ProAsp: 1.169 ± 0.083
1.949ProGlu: 1.949 ± 1.17
3.897ProPhe: 3.897 ± 0.754
1.949ProGly: 1.949 ± 0.686
1.559ProHis: 1.559 ± 0.317
2.728ProIle: 2.728 ± 1.456
1.949ProLys: 1.949 ± 1.17
4.287ProLeu: 4.287 ± 0.52
3.507ProMet: 3.507 ± 0.189
1.949ProAsn: 1.949 ± 0.067
1.559ProPro: 1.559 ± 0.92
1.559ProGln: 1.559 ± 0.92
2.728ProArg: 2.728 ± 0.401
3.897ProSer: 3.897 ± 1.103
3.897ProThr: 3.897 ± 0.754
2.728ProVal: 2.728 ± 0.837
0.779ProTrp: 0.779 ± 0.151
1.169ProTyr: 1.169 ± 0.535
0.0ProXaa: 0.0 ± 0.0
Gln
2.338GlnAla: 2.338 ± 0.785
0.0GlnCys: 0.0 ± 0.0
1.949GlnAsp: 1.949 ± 1.305
1.559GlnGlu: 1.559 ± 0.317
3.118GlnPhe: 3.118 ± 1.253
2.728GlnGly: 2.728 ± 0.837
1.169GlnHis: 1.169 ± 0.535
1.949GlnIle: 1.949 ± 1.305
0.0GlnLys: 0.0 ± 0.0
3.118GlnLeu: 3.118 ± 0.603
1.949GlnMet: 1.949 ± 0.686
2.338GlnAsn: 2.338 ± 1.69
1.169GlnPro: 1.169 ± 0.535
1.949GlnGln: 1.949 ± 1.305
3.897GlnArg: 3.897 ± 1.103
2.338GlnSer: 2.338 ± 1.071
2.728GlnThr: 2.728 ± 2.693
2.338GlnVal: 2.338 ± 1.404
0.39GlnTrp: 0.39 ± 0.234
1.169GlnTyr: 1.169 ± 0.083
0.0GlnXaa: 0.0 ± 0.0
Arg
3.897ArgAla: 3.897 ± 0.135
0.779ArgCys: 0.779 ± 0.151
2.728ArgAsp: 2.728 ± 0.401
1.949ArgGlu: 1.949 ± 0.551
3.507ArgPhe: 3.507 ± 0.369
3.118ArgGly: 3.118 ± 1.253
0.0ArgHis: 0.0 ± 0.0
2.338ArgIle: 2.338 ± 0.167
3.507ArgLys: 3.507 ± 0.25
2.338ArgLeu: 2.338 ± 0.785
1.169ArgMet: 1.169 ± 0.083
1.559ArgAsn: 1.559 ± 0.301
2.338ArgPro: 2.338 ± 0.452
1.949ArgGln: 1.949 ± 1.17
3.507ArgArg: 3.507 ± 1.487
2.338ArgSer: 2.338 ± 1.071
3.507ArgThr: 3.507 ± 0.25
3.897ArgVal: 3.897 ± 1.103
0.0ArgTrp: 0.0 ± 0.0
2.338ArgTyr: 2.338 ± 1.071
0.0ArgXaa: 0.0 ± 0.0
Ser
4.677SerAla: 4.677 ± 0.286
1.169SerCys: 1.169 ± 0.702
2.728SerAsp: 2.728 ± 0.837
3.507SerGlu: 3.507 ± 0.869
3.507SerPhe: 3.507 ± 0.25
6.625SerGly: 6.625 ± 0.972
1.169SerHis: 1.169 ± 0.083
4.677SerIle: 4.677 ± 0.333
3.507SerLys: 3.507 ± 0.369
8.574SerLeu: 8.574 ± 1.039
1.949SerMet: 1.949 ± 0.889
1.949SerAsn: 1.949 ± 0.067
2.728SerPro: 2.728 ± 0.218
3.897SerGln: 3.897 ± 1.372
3.897SerArg: 3.897 ± 0.754
5.066SerSer: 5.066 ± 0.567
2.728SerThr: 2.728 ± 0.837
5.066SerVal: 5.066 ± 1.186
1.169SerTrp: 1.169 ± 0.083
2.338SerTyr: 2.338 ± 1.071
0.0SerXaa: 0.0 ± 0.0
Thr
2.728ThrAla: 2.728 ± 0.401
0.0ThrCys: 0.0 ± 0.0
4.287ThrAsp: 4.287 ± 0.52
3.897ThrGlu: 3.897 ± 0.135
3.118ThrPhe: 3.118 ± 0.635
3.507ThrGly: 3.507 ± 0.988
0.39ThrHis: 0.39 ± 0.234
3.897ThrIle: 3.897 ± 1.372
3.507ThrLys: 3.507 ± 0.25
4.677ThrLeu: 4.677 ± 0.952
1.949ThrMet: 1.949 ± 0.551
3.118ThrAsn: 3.118 ± 1.222
2.728ThrPro: 2.728 ± 1.456
2.338ThrGln: 2.338 ± 0.785
3.507ThrArg: 3.507 ± 0.988
6.625ThrSer: 6.625 ± 2.209
4.287ThrThr: 4.287 ± 1.138
7.405ThrVal: 7.405 ± 0.504
0.779ThrTrp: 0.779 ± 0.151
2.728ThrTyr: 2.728 ± 0.401
0.0ThrXaa: 0.0 ± 0.0
Val
5.066ValAla: 5.066 ± 0.567
0.779ValCys: 0.779 ± 0.468
5.066ValAsp: 5.066 ± 1.289
3.507ValGlu: 3.507 ± 0.25
1.949ValPhe: 1.949 ± 0.067
5.456ValGly: 5.456 ± 0.801
1.169ValHis: 1.169 ± 0.535
3.897ValIle: 3.897 ± 0.135
3.897ValLys: 3.897 ± 1.103
5.456ValLeu: 5.456 ± 1.674
1.169ValMet: 1.169 ± 0.083
4.287ValAsn: 4.287 ± 1.138
3.897ValPro: 3.897 ± 0.484
2.338ValGln: 2.338 ± 0.167
1.949ValArg: 1.949 ± 0.686
4.677ValSer: 4.677 ± 0.286
7.015ValThr: 7.015 ± 1.356
7.405ValVal: 7.405 ± 1.353
0.0ValTrp: 0.0 ± 0.0
3.507ValTyr: 3.507 ± 0.25
0.0ValXaa: 0.0 ± 0.0
Trp
0.39TrpAla: 0.39 ± 0.385
0.0TrpCys: 0.0 ± 0.0
1.169TrpAsp: 1.169 ± 0.083
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.779TrpGly: 0.779 ± 0.151
0.0TrpHis: 0.0 ± 0.0
0.39TrpIle: 0.39 ± 0.234
0.39TrpLys: 0.39 ± 0.234
1.169TrpLeu: 1.169 ± 0.083
0.0TrpMet: 0.0 ± 0.0
1.169TrpAsn: 1.169 ± 0.535
0.0TrpPro: 0.0 ± 0.0
1.169TrpGln: 1.169 ± 1.154
1.169TrpArg: 1.169 ± 0.083
1.559TrpSer: 1.559 ± 0.301
0.39TrpThr: 0.39 ± 0.234
0.39TrpVal: 0.39 ± 0.385
0.39TrpTrp: 0.39 ± 0.234
0.779TrpTyr: 0.779 ± 0.151
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.949TyrAla: 1.949 ± 0.067
0.779TyrCys: 0.779 ± 0.468
3.897TyrAsp: 3.897 ± 0.484
1.169TyrGlu: 1.169 ± 0.083
2.338TyrPhe: 2.338 ± 0.785
3.507TyrGly: 3.507 ± 0.369
1.169TyrHis: 1.169 ± 0.535
1.169TyrIle: 1.169 ± 0.702
3.118TyrLys: 3.118 ± 0.635
3.507TyrLeu: 3.507 ± 0.25
0.779TyrMet: 0.779 ± 0.468
2.728TyrAsn: 2.728 ± 0.837
0.779TyrPro: 0.779 ± 0.468
1.949TyrGln: 1.949 ± 1.305
2.338TyrArg: 2.338 ± 0.785
2.728TyrSer: 2.728 ± 0.837
1.169TyrThr: 1.169 ± 0.702
4.287TyrVal: 4.287 ± 0.52
0.0TyrTrp: 0.0 ± 0.0
0.779TyrTyr: 0.779 ± 0.468
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski