Amino acid dipepetide frequency for Tumebacillus avium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.797AlaAla: 9.797 ± 0.125	0.676AlaCys: 0.676 ± 0.023	5.034AlaAsp: 5.034 ± 0.063	7.071AlaGlu: 7.071 ± 0.086	3.557AlaPhe: 3.557 ± 0.05	7.42AlaGly: 7.42 ± 0.078	1.843AlaHis: 1.843 ± 0.033	4.62AlaIle: 4.62 ± 0.059	4.567AlaLys: 4.567 ± 0.077	9.71AlaLeu: 9.71 ± 0.108	2.498AlaMet: 2.498 ± 0.043	2.768AlaAsn: 2.768 ± 0.047	3.302AlaPro: 3.302 ± 0.061	3.568AlaGln: 3.568 ± 0.057	4.086AlaArg: 4.086 ± 0.06	4.32AlaSer: 4.32 ± 0.063	4.351AlaThr: 4.351 ± 0.061	7.605AlaVal: 7.605 ± 0.082	0.983AlaTrp: 0.983 ± 0.026	3.019AlaTyr: 3.019 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.598CysAla: 0.598 ± 0.02	0.108CysCys: 0.108 ± 0.01	0.404CysAsp: 0.404 ± 0.018	0.443CysGlu: 0.443 ± 0.017	0.325CysPhe: 0.325 ± 0.014	0.679CysGly: 0.679 ± 0.024	0.187CysHis: 0.187 ± 0.012	0.397CysIle: 0.397 ± 0.017	0.32CysLys: 0.32 ± 0.015	0.797CysLeu: 0.797 ± 0.025	0.179CysMet: 0.179 ± 0.012	0.238CysAsn: 0.238 ± 0.013	0.344CysPro: 0.344 ± 0.018	0.284CysGln: 0.284 ± 0.012	0.42CysArg: 0.42 ± 0.017	0.463CysSer: 0.463 ± 0.018	0.414CysThr: 0.414 ± 0.017	0.481CysVal: 0.481 ± 0.02	0.097CysTrp: 0.097 ± 0.008	0.294CysTyr: 0.294 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.831AspAla: 4.831 ± 0.069	0.372AspCys: 0.372 ± 0.016	2.535AspAsp: 2.535 ± 0.054	3.7AspGlu: 3.7 ± 0.056	2.162AspPhe: 2.162 ± 0.042	4.195AspGly: 4.195 ± 0.063	1.175AspHis: 1.175 ± 0.028	2.766AspIle: 2.766 ± 0.046	2.382AspLys: 2.382 ± 0.049	6.244AspLeu: 6.244 ± 0.078	1.134AspMet: 1.134 ± 0.033	1.573AspAsn: 1.573 ± 0.038	2.573AspPro: 2.573 ± 0.055	1.829AspGln: 1.829 ± 0.036	3.0AspArg: 3.0 ± 0.05	2.282AspSer: 2.282 ± 0.041	2.63AspThr: 2.63 ± 0.038	4.243AspVal: 4.243 ± 0.059	0.745AspTrp: 0.745 ± 0.024	1.677AspTyr: 1.677 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.558GluAla: 6.558 ± 0.084	0.401GluCys: 0.401 ± 0.019	3.136GluAsp: 3.136 ± 0.056	5.632GluGlu: 5.632 ± 0.085	2.327GluPhe: 2.327 ± 0.041	4.141GluGly: 4.141 ± 0.049	1.818GluHis: 1.818 ± 0.036	4.204GluIle: 4.204 ± 0.06	3.905GluLys: 3.905 ± 0.055	8.438GluLeu: 8.438 ± 0.112	2.118GluMet: 2.118 ± 0.044	2.162GluAsn: 2.162 ± 0.04	2.173GluPro: 2.173 ± 0.04	4.222GluGln: 4.222 ± 0.072	4.957GluArg: 4.957 ± 0.071	3.073GluSer: 3.073 ± 0.053	3.883GluThr: 3.883 ± 0.052	4.891GluVal: 4.891 ± 0.057	0.838GluTrp: 0.838 ± 0.026	2.071GluTyr: 2.071 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.881PheAla: 3.881 ± 0.06	0.36PheCys: 0.36 ± 0.016	2.574PheAsp: 2.574 ± 0.044	2.693PheGlu: 2.693 ± 0.05	1.828PhePhe: 1.828 ± 0.039	3.145PheGly: 3.145 ± 0.052	0.928PheHis: 0.928 ± 0.026	1.862PheIle: 1.862 ± 0.042	1.412PheLys: 1.412 ± 0.036	4.346PheLeu: 4.346 ± 0.062	0.923PheMet: 0.923 ± 0.025	1.23PheAsn: 1.23 ± 0.026	1.497PhePro: 1.497 ± 0.036	1.551PheGln: 1.551 ± 0.032	1.977PheArg: 1.977 ± 0.039	2.37PheSer: 2.37 ± 0.039	2.32PheThr: 2.32 ± 0.042	3.091PheVal: 3.091 ± 0.047	0.541PheTrp: 0.541 ± 0.022	1.367PheTyr: 1.367 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.317GlyAla: 6.317 ± 0.066	0.659GlyCys: 0.659 ± 0.023	3.973GlyAsp: 3.973 ± 0.059	5.14GlyGlu: 5.14 ± 0.072	2.974GlyPhe: 2.974 ± 0.052	5.886GlyGly: 5.886 ± 0.112	1.684GlyHis: 1.684 ± 0.038	4.662GlyIle: 4.662 ± 0.063	4.227GlyLys: 4.227 ± 0.074	7.513GlyLeu: 7.513 ± 0.094	2.207GlyMet: 2.207 ± 0.045	2.45GlyAsn: 2.45 ± 0.073	2.113GlyPro: 2.113 ± 0.044	3.281GlyGln: 3.281 ± 0.046	3.928GlyArg: 3.928 ± 0.066	3.99GlySer: 3.99 ± 0.058	4.605GlyThr: 4.605 ± 0.074	6.45GlyVal: 6.45 ± 0.067	1.014GlyTrp: 1.014 ± 0.03	2.752GlyTyr: 2.752 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.715HisAla: 1.715 ± 0.036	0.203HisCys: 0.203 ± 0.011	1.188HisAsp: 1.188 ± 0.032	1.462HisGlu: 1.462 ± 0.033	0.994HisPhe: 0.994 ± 0.026	1.761HisGly: 1.761 ± 0.042	0.744HisHis: 0.744 ± 0.029	1.15HisIle: 1.15 ± 0.028	0.844HisLys: 0.844 ± 0.025	2.453HisLeu: 2.453 ± 0.044	0.457HisMet: 0.457 ± 0.018	0.73HisAsn: 0.73 ± 0.021	1.304HisPro: 1.304 ± 0.031	0.943HisGln: 0.943 ± 0.03	1.328HisArg: 1.328 ± 0.035	1.15HisSer: 1.15 ± 0.026	1.114HisThr: 1.114 ± 0.024	1.546HisVal: 1.546 ± 0.034	0.28HisTrp: 0.28 ± 0.014	0.75HisTyr: 0.75 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.495IleAla: 5.495 ± 0.062	0.566IleCys: 0.566 ± 0.018	3.226IleAsp: 3.226 ± 0.047	4.122IleGlu: 4.122 ± 0.051	1.942IlePhe: 1.942 ± 0.041	5.144IleGly: 5.144 ± 0.064	1.121IleHis: 1.121 ± 0.029	2.835IleIle: 2.835 ± 0.05	2.46IleLys: 2.46 ± 0.055	5.177IleLeu: 5.177 ± 0.069	1.126IleMet: 1.126 ± 0.032	1.91IleAsn: 1.91 ± 0.041	2.565IlePro: 2.565 ± 0.046	1.975IleGln: 1.975 ± 0.04	3.0IleArg: 3.0 ± 0.047	3.211IleSer: 3.211 ± 0.047	3.158IleThr: 3.158 ± 0.051	4.099IleVal: 4.099 ± 0.066	0.662IleTrp: 0.662 ± 0.021	1.567IleTyr: 1.567 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.158LysAla: 4.158 ± 0.061	0.229LysCys: 0.229 ± 0.012	2.254LysAsp: 2.254 ± 0.05	3.5LysGlu: 3.5 ± 0.069	1.539LysPhe: 1.539 ± 0.035	3.467LysGly: 3.467 ± 0.058	1.001LysHis: 1.001 ± 0.03	2.948LysIle: 2.948 ± 0.045	3.059LysLys: 3.059 ± 0.073	4.89LysLeu: 4.89 ± 0.063	1.554LysMet: 1.554 ± 0.033	1.711LysAsn: 1.711 ± 0.041	1.832LysPro: 1.832 ± 0.043	2.303LysGln: 2.303 ± 0.048	2.938LysArg: 2.938 ± 0.046	2.4LysSer: 2.4 ± 0.053	2.839LysThr: 2.839 ± 0.05	3.619LysVal: 3.619 ± 0.062	0.564LysTrp: 0.564 ± 0.022	1.385LysTyr: 1.385 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	10.187LeuAla: 10.187 ± 0.125	0.932LeuCys: 0.932 ± 0.027	5.525LeuAsp: 5.525 ± 0.072	6.954LeuGlu: 6.954 ± 0.082	4.706LeuPhe: 4.706 ± 0.072	7.515LeuGly: 7.515 ± 0.078	2.633LeuHis: 2.633 ± 0.047	5.804LeuIle: 5.804 ± 0.073	4.587LeuLys: 4.587 ± 0.069	12.209LeuLeu: 12.209 ± 0.162	2.503LeuMet: 2.503 ± 0.044	3.53LeuAsn: 3.53 ± 0.048	5.484LeuPro: 5.484 ± 0.13	5.442LeuGln: 5.442 ± 0.092	5.756LeuArg: 5.756 ± 0.087	6.631LeuSer: 6.631 ± 0.074	6.556LeuThr: 6.556 ± 0.081	7.353LeuVal: 7.353 ± 0.072	1.068LeuTrp: 1.068 ± 0.032	3.339LeuTyr: 3.339 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.257MetAla: 2.257 ± 0.049	0.152MetCys: 0.152 ± 0.01	1.039MetAsp: 1.039 ± 0.027	1.74MetGlu: 1.74 ± 0.034	1.035MetPhe: 1.035 ± 0.024	1.69MetGly: 1.69 ± 0.038	0.522MetHis: 0.522 ± 0.019	1.825MetIle: 1.825 ± 0.035	1.59MetLys: 1.59 ± 0.036	2.774MetLeu: 2.774 ± 0.048	0.858MetMet: 0.858 ± 0.027	1.066MetAsn: 1.066 ± 0.028	1.16MetPro: 1.16 ± 0.032	1.213MetGln: 1.213 ± 0.032	1.432MetArg: 1.432 ± 0.034	1.636MetSer: 1.636 ± 0.031	1.685MetThr: 1.685 ± 0.032	1.811MetVal: 1.811 ± 0.034	0.227MetTrp: 0.227 ± 0.012	0.71MetTyr: 0.71 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.728AsnAla: 2.728 ± 0.052	0.261AsnCys: 0.261 ± 0.015	1.521AsnAsp: 1.521 ± 0.037	1.964AsnGlu: 1.964 ± 0.034	1.29AsnPhe: 1.29 ± 0.029	2.913AsnGly: 2.913 ± 0.064	0.639AsnHis: 0.639 ± 0.021	1.831AsnIle: 1.831 ± 0.045	1.6AsnLys: 1.6 ± 0.037	3.495AsnLeu: 3.495 ± 0.058	0.903AsnMet: 0.903 ± 0.025	1.248AsnAsn: 1.248 ± 0.041	1.846AsnPro: 1.846 ± 0.037	1.351AsnGln: 1.351 ± 0.04	2.008AsnArg: 2.008 ± 0.043	1.65AsnSer: 1.65 ± 0.04	1.883AsnThr: 1.883 ± 0.039	2.483AsnVal: 2.483 ± 0.047	0.448AsnTrp: 0.448 ± 0.021	1.153AsnTyr: 1.153 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.594ProAla: 3.594 ± 0.061	0.233ProCys: 0.233 ± 0.012	2.804ProAsp: 2.804 ± 0.054	3.585ProGlu: 3.585 ± 0.052	1.943ProPhe: 1.943 ± 0.04	3.135ProGly: 3.135 ± 0.058	1.014ProHis: 1.014 ± 0.029	2.104ProIle: 2.104 ± 0.042	1.837ProLys: 1.837 ± 0.036	4.546ProLeu: 4.546 ± 0.086	0.954ProMet: 0.954 ± 0.025	1.577ProAsn: 1.577 ± 0.029	1.392ProPro: 1.392 ± 0.037	1.821ProGln: 1.821 ± 0.036	1.671ProArg: 1.671 ± 0.038	2.387ProSer: 2.387 ± 0.039	2.274ProThr: 2.274 ± 0.048	3.58ProVal: 3.58 ± 0.049	0.446ProTrp: 0.446 ± 0.022	1.323ProTyr: 1.323 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.332GlnAla: 4.332 ± 0.067	0.177GlnCys: 0.177 ± 0.009	2.144GlnAsp: 2.144 ± 0.036	3.621GlnGlu: 3.621 ± 0.065	1.471GlnPhe: 1.471 ± 0.034	3.134GlnGly: 3.134 ± 0.056	0.984GlnHis: 0.984 ± 0.026	2.314GlnIle: 2.314 ± 0.044	2.339GlnLys: 2.339 ± 0.045	4.624GlnLeu: 4.624 ± 0.091	1.171GlnMet: 1.171 ± 0.032	1.579GlnAsn: 1.579 ± 0.043	1.774GlnPro: 1.774 ± 0.04	2.314GlnGln: 2.314 ± 0.06	2.156GlnArg: 2.156 ± 0.043	2.096GlnSer: 2.096 ± 0.041	2.475GlnThr: 2.475 ± 0.044	3.325GlnVal: 3.325 ± 0.053	0.402GlnTrp: 0.402 ± 0.016	1.218GlnTyr: 1.218 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.115ArgAla: 4.115 ± 0.06	0.35ArgCys: 0.35 ± 0.016	2.85ArgAsp: 2.85 ± 0.05	4.277ArgGlu: 4.277 ± 0.068	2.282ArgPhe: 2.282 ± 0.039	3.515ArgGly: 3.515 ± 0.053	1.181ArgHis: 1.181 ± 0.032	3.311ArgIle: 3.311 ± 0.051	2.615ArgLys: 2.615 ± 0.048	5.99ArgLeu: 5.99 ± 0.09	1.772ArgMet: 1.772 ± 0.041	1.73ArgAsn: 1.73 ± 0.032	2.251ArgPro: 2.251 ± 0.045	2.202ArgGln: 2.202 ± 0.043	2.867ArgArg: 2.867 ± 0.06	2.757ArgSer: 2.757 ± 0.041	3.004ArgThr: 3.004 ± 0.056	3.829ArgVal: 3.829 ± 0.058	0.639ArgTrp: 0.639 ± 0.02	1.855ArgTyr: 1.855 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.61SerAla: 4.61 ± 0.067	0.399SerCys: 0.399 ± 0.019	2.747SerAsp: 2.747 ± 0.048	3.206SerGlu: 3.206 ± 0.045	2.628SerPhe: 2.628 ± 0.042	4.751SerGly: 4.751 ± 0.065	1.041SerHis: 1.041 ± 0.025	2.995SerIle: 2.995 ± 0.051	2.469SerLys: 2.469 ± 0.057	5.689SerLeu: 5.689 ± 0.064	1.524SerMet: 1.524 ± 0.032	1.713SerAsn: 1.713 ± 0.042	2.192SerPro: 2.192 ± 0.042	1.952SerGln: 1.952 ± 0.043	2.712SerArg: 2.712 ± 0.051	2.91SerSer: 2.91 ± 0.055	2.914SerThr: 2.914 ± 0.053	4.042SerVal: 4.042 ± 0.06	0.669SerTrp: 0.669 ± 0.02	1.997SerTyr: 1.997 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.623ThrAla: 5.623 ± 0.071	0.391ThrCys: 0.391 ± 0.019	2.917ThrAsp: 2.917 ± 0.056	3.598ThrGlu: 3.598 ± 0.051	2.301ThrPhe: 2.301 ± 0.039	4.961ThrGly: 4.961 ± 0.067	1.121ThrHis: 1.121 ± 0.028	3.125ThrIle: 3.125 ± 0.06	2.242ThrLys: 2.242 ± 0.051	6.228ThrLeu: 6.228 ± 0.081	1.441ThrMet: 1.441 ± 0.033	1.69ThrAsn: 1.69 ± 0.046	2.946ThrPro: 2.946 ± 0.047	1.921ThrGln: 1.921 ± 0.041	2.465ThrArg: 2.465 ± 0.046	3.084ThrSer: 3.084 ± 0.052	3.255ThrThr: 3.255 ± 0.083	4.73ThrVal: 4.73 ± 0.082	0.606ThrTrp: 0.606 ± 0.024	1.962ThrTyr: 1.962 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	6.483ValAla: 6.483 ± 0.074	0.652ValCys: 0.652 ± 0.023	3.726ValAsp: 3.726 ± 0.06	5.434ValGlu: 5.434 ± 0.065	2.863ValPhe: 2.863 ± 0.047	5.085ValGly: 5.085 ± 0.068	1.549ValHis: 1.549 ± 0.029	4.502ValIle: 4.502 ± 0.068	3.658ValLys: 3.658 ± 0.06	8.567ValLeu: 8.567 ± 0.093	1.935ValMet: 1.935 ± 0.035	2.568ValAsn: 2.568 ± 0.052	3.718ValPro: 3.718 ± 0.068	3.412ValGln: 3.412 ± 0.052	4.115ValArg: 4.115 ± 0.055	4.197ValSer: 4.197 ± 0.054	4.776ValThr: 4.776 ± 0.087	5.664ValVal: 5.664 ± 0.076	0.876ValTrp: 0.876 ± 0.025	2.209ValTyr: 2.209 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.022	0.088TrpCys: 0.088 ± 0.01	0.541TrpAsp: 0.541 ± 0.021	0.788TrpGlu: 0.788 ± 0.026	0.503TrpPhe: 0.503 ± 0.02	0.773TrpGly: 0.773 ± 0.026	0.213TrpHis: 0.213 ± 0.011	0.605TrpIle: 0.605 ± 0.022	0.676TrpLys: 0.676 ± 0.022	1.464TrpLeu: 1.464 ± 0.032	0.395TrpMet: 0.395 ± 0.017	0.512TrpAsn: 0.512 ± 0.02	0.355TrpPro: 0.355 ± 0.015	0.736TrpGln: 0.736 ± 0.024	0.606TrpArg: 0.606 ± 0.022	0.763TrpSer: 0.763 ± 0.024	0.612TrpThr: 0.612 ± 0.019	0.759TrpVal: 0.759 ± 0.022	0.162TrpTrp: 0.162 ± 0.012	0.381TrpTyr: 0.381 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.669TyrAla: 2.669 ± 0.047	0.265TyrCys: 0.265 ± 0.014	1.908TyrAsp: 1.908 ± 0.078	2.019TyrGlu: 2.019 ± 0.044	1.227TyrPhe: 1.227 ± 0.035	2.517TyrGly: 2.517 ± 0.046	0.715TyrHis: 0.715 ± 0.022	1.503TyrIle: 1.503 ± 0.037	1.403TyrLys: 1.403 ± 0.031	3.558TyrLeu: 3.558 ± 0.053	0.771TyrMet: 0.771 ± 0.02	1.232TyrAsn: 1.232 ± 0.034	1.401TyrPro: 1.401 ± 0.033	1.327TyrGln: 1.327 ± 0.028	1.97TyrArg: 1.97 ± 0.037	1.789TyrSer: 1.789 ± 0.036	1.86TyrThr: 1.86 ± 0.043	2.388TyrVal: 2.388 ± 0.045	0.508TyrTrp: 0.508 ± 0.022	1.17TyrTyr: 1.17 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4330 proteins (1477804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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